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Article: Study of the Antimicrobial Activity of the Chinese Dong Ethnic Minority Medicine, Madeng'ai.

Tang, Zhenrong / Zhao, Yannan / Zhang, Zaiqi / Yue, Huan / Wang, Dan / Liu, Shengchun / Tang, Hua

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 3678240

Abstract: ... multidrug-resistant infections are needed. The traditional Dong ethnic minority medicines have emerged ...

Abstract	The overuse of antibiotics has contributed to the emergence of multidrug-resistant bacteria, which poses a challenging task for clinical therapy. Thus, new agents with antibiotic efficacy against multidrug-resistant infections are needed. The traditional Dong ethnic minority medicines have emerged as a new source for prodrug selection. Among them, Madeng'ai (
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/3678240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: RNA-Seq and 16S rRNA Reveals That Tian-Dong-Tang-Gan Powder Alleviates Environmental Stress-Induced Decline in Immune and Antioxidant Function and Gut Microbiota Dysbiosis in

Xie, Xiao-Dong / Zhou, Ying / Sun, Yu-Bo / Yi, Shou-Li / Zhao, Yi / Chen, Qi / Xie, Ying-Hong / Cao, Mi-Xia / Yu, Mei-Ling / Wei, Ying-Yi / Zhang, Ling / Hu, Ting-Jun

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Ammonia stress and nitrite stress can induce immune depression and oxidative stress ... ...

Abstract	Ammonia stress and nitrite stress can induce immune depression and oxidative stress in
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061262
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Qi-Dong-Huo-Xue-Yin balances the immune microenvironment to protect against LPS induced acute lung injury.

Zhao, Tian / Wang, Le / Zhang, Yongjun / Ye, Wu / Liu, Juan / Wu, Haiyan / Wang, Fei / Tang, Tingyu / Li, Zhijun

Frontiers in pharmacology

2023 Volume 14, Page(s) 1200058

Abstract: ... of a traditional Chinese medicine, Qi-Dong-Huo-Xue-Yin (QD), in protecting against LPS induced acute lung injury in mouse models ...

Abstract	COVID-19 induces acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and leads to severe immunological changes that threatens the lives of COVID-19 victims. Studies have shown that both the regulatory T cells and macrophages were deranged in COVID-19-induced ALI. Herbal drugs have long been utilized to adjust the immune microenvironment in ALI. However, the underlying mechanisms of herbal drug mediated ALI protection are largely unknown. This study aims to understand the cellular mechanism of a traditional Chinese medicine, Qi-Dong-Huo-Xue-Yin (QD), in protecting against LPS induced acute lung injury in mouse models. Our data showed that QD intrinsically promotes Foxp3 transcription via promoting acetylation of the Foxp3 promoter in CD4
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1200058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: ‘Yan Dong’: A New Cultivar of Xanthoceras sorbifolium Bunge

Lian, Chen / Li, Yuyan / Li, Haiying / Zhao, Yaxin / Zhou, Juan / Wang, Sijie / Lian, Jingran / Ao, Yan

HortScience. 2022 Sept., v. 57, no. 9

2022

Abstract: Yellow-horn (Xanthoceras sorbifolium Bunge), a plant endemic to northern China, is resistant to drought, cold, saline stress, and barren soil, but cannot withstand excess moisture (Ao et al., 2012). Yellow-horn has been cultivated for more than 6000 ... ...

Abstract	Yellow-horn (Xanthoceras sorbifolium Bunge), a plant endemic to northern China, is resistant to drought, cold, saline stress, and barren soil, but cannot withstand excess moisture (Ao et al., 2012). Yellow-horn has been cultivated for more than 6000 years in China. It is an oilseed crop, and the oil content of the seeds can be as high as 65%. The oil can be used for cooking, as well as for medicine and biofuel production (Liu et al., 2017). The seed oil has traditionally been used for cooking and lighting. In recent years, the development and use of biodiesel produced from yellow-horn have received increased attention as a result of the energy crisis. The seed kernels of yellow-horn are rich in nutrients and contain 55% crude fat, 15% soluble sugar, and mineral elements (Xie and Zhang, 2018). Yellow-horn is widely distributed and shows extensive morphological variation, especially in flower type and color. It is also widely used as a landscaping tree species (Gao et al., 2002; Xu et al., 2010). Because of its high ecological, economic, and ornamental value, the cultivation of yellow-horn has received much attention in China in recent years.
Keywords	Xanthoceras sorbifolium ; biodiesel ; cold ; color ; crude fat ; cultivars ; drought ; energy ; flowers ; fuel production ; medicine ; oilseed crops ; ornamental value ; salt stress ; seed oils ; soil ; sugars ; trees ; China
Language	English
Dates of publication	2022-09
Size	p. 1057-1058.
Publishing place	American Society for Horticultural Science
Document type	Article
ISSN	2327-9834
DOI	10.21273/HORTSCI16695-22
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Feihu Dong, a New Hotspot Cave of Subterranean Biodiversity from China

Huang, Sunbin / Zhao, Mingzhi / Luo, Xiaozhu / Bedos, Anne / Wang, Yong / Chocat, Marc / Tian, Mingyi / Liu, Weixin

Diversity. 2023 July 30, v. 15, no. 8

2023

Abstract: ... limited. Currently, only Ganxiao Dong, located in Huanjiang, Guangxi, has been reported as a hotspot ... likely. Feihu Dong, one of these potential hotspot caves, has been systematically investigated ... Dong has demonstrated that it currently holds the highest number of known cave animal species in China ...

Abstract	China is a country with abundant karst landscapes, but research on cave biodiversity is still limited. Currently, only Ganxiao Dong, located in Huanjiang, Guangxi, has been reported as a hotspot for cave biodiversity. Many of the world’s most troglomorphic species in the major groups of cave animals have been recently discovered in China, making the existence of many more hotspots in the country likely. Feihu Dong, one of these potential hotspot caves, has been systematically investigated to complement a preliminary species list of 1995, leading to the discovery of 62 species of animals from the cave. Among them, 27 are considered troglobionts or stygobionts, 26 are considered troglophiles or stygophiles, and nine are classified as trogloxenes or stygoxenes. Research on the cave biodiversity of Feihu Dong has demonstrated that it currently holds the highest number of known cave animal species in China. Among the most remarkable features of this fauna is the co-occurrence of five species of cave-obligate beetles, all modified for cave life. The biological survey was limited to a small part of the cave. Several habitats (like guano) have not been investigated so far, and several important cave groups have been insufficiently or not sampled (like Ostracoda). Meanwhile, the system increases in length with each new caving expedition. Further discoveries of cave organisms in Feihu Dong are therefore expected. As Feihu Dong and Ganxiao Dong are the only caves in China that have been extensively studied for a large range of organisms, and as they are located in karstic areas that are similar in richness to other regions of southern China, it can be confidently assumed that several other caves of high biodiversity will be discovered in the coming years.
Keywords	Ostracoda ; animal manures ; animals ; aquifers ; biodiversity ; fauna ; karsts ; surveys ; China
Language	English
Dates of publication	2023-0730
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2518137-3
ISSN	1424-2818
ISSN	1424-2818
DOI	10.3390/d15080902
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of medical herbs in Tian-Dong-Tang-Gan powder on the oxidative stress induced by ammonia and nitrite in Litopenaeus vannamei

Xie, Xiao-Dong / Cao, Mi-Xia / Chen, Qi / Yu, Mei-Ling / Liu, Qing-Yun / Zhao, Yong-Zhen / Zhang, Ling / Hu, Ting-Jun

Aquaculture. 2022 Feb. 15, v. 548

2022

Abstract: In order to evaluate the effect of different doses of Tian-Dong-Tang-Gan powder (TDTGP ...

Abstract	In order to evaluate the effect of different doses of Tian-Dong-Tang-Gan powder (TDTGP) on the immune function of Litopenaeus vannamei, and the molecular mechanism of anti-ammonia stress and anti-nitrite stress, and screening for the best dose, a 35-day feeding experiment and a 72-h ammonia stress or nitrite stress experiment were carried out. The results showed that when compared with the blank control group, the different doses of TDTGP could increase the body weight (BW), percent weight gain (PWG), body length (BL) and percent body length growth (PBLG), and the activities of acid phosphatase (ACP), phenol oxidase (PO), inducible nitric oxide synthase (i-NOS) and the total antioxidant capacity (T-AOC) in the hemolymph of L. vannamei during the feeding experiment, and the effect of TDTGP-4 treatment group was the best. When exposed ammonia or nitrite stress for 72 h, the PO activity was decreased in the hemolymphs, and the mRNA expression of PPO, MT, GSH-Px, Mn-SOD, HSP70 and HIF-1α in the hepatopancreas of L. vannamei. However, different TDTGP doses were fed to the shrimp followed by the application of ammonia and nitrite stresses. The activities of ACP, PO, i-NOS and T-AOC in the hemolymphs remained stable, and the mRNA expression of PPO, ACP, metallothionein (MT), glutathione peroxidase (GSH-Px), superoxide dismutase (Mn-SOD), heat shock protein 70 (HSP70), Hypoxia inducible factor 1α (HIF-1α) and other factors in the hepatopancreas could be maintained or improved to varying degrees in comparison with the blank control group and positive group. These results indicated that the TDTGP can improve growth performance and non-specific immune response of L. vannamei, and by maintaining the mRNA expression of the antioxidative stress factor, such as MT, GSH-PX, Mn-SOD, HSP70, HIF-1α and PPO and ACP in the hepatopancreas, acting against the damage of hepatopancreas caused by ammonia and nitrite stress in L. vannamei. The changes in BW, WG, activities of PO and ACP, and mRNA expression levels of PO, Mn-SOD and ACP indicated that the optimum supplement of dietary TDTGP should be 4 g per·kg.
Keywords	Litopenaeus vannamei ; acid phosphatase ; ammonia ; antioxidant activity ; aquaculture ; body length ; body weight ; gene expression ; glutathione peroxidase ; growth performance ; heat-shock protein 70 ; hemolymph ; hepatopancreas ; hypoxia ; immune response ; inducible nitric oxide synthase ; metallothionein ; monophenol monooxygenase ; nitrites ; oxidative stress ; shrimp ; superoxide dismutase ; weight gain
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2021.737584
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Study of the Antimicrobial Activity of the Chinese Dong Ethnic Minority Medicine, Madeng’ai

Zhenrong Tang / Yannan Zhao / Zaiqi Zhang / Huan Yue / Dan Wang / Shengchun Liu / Hua Tang

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: ... multidrug-resistant infections are needed. The traditional Dong ethnic minority medicines have emerged ... the antimicrobial activities of Dong medicine Madeng’ai were evaluated both in vitro and in vivo. S. aureus, E. coli ... of cutaneous wounds. Madeng’ai, a newly discovered Dong ethnic minority medicine possesses considerable ...

Abstract	The overuse of antibiotics has contributed to the emergence of multidrug-resistant bacteria, which poses a challenging task for clinical therapy. Thus, new agents with antibiotic efficacy against multidrug-resistant infections are needed. The traditional Dong ethnic minority medicines have emerged as a new source for prodrug selection. Among them, Madeng’ai (PotentillafreynianaBornm) is widely used by the folk for anti-infection and wound healing, although the mechanisms remain unclear. In this study, the antimicrobial activities of Dong medicine Madeng’ai were evaluated both in vitro and in vivo. S. aureus, E. coli, E. faecalis, P. aeruginosa, K. pneumoniae, and A. baumannii were cultured in LB media, different concentrations of Madeng’ai powder solution were added to the LB agar plates to evaluate minimal inhibitory concentration. An animal study was performed on a mouse excisional wound model combined with bacterial solution injection in the wound area. After Madeng’ai or PBS treatment, hematoxylin and eosin analysis were used for pathological analysis of skin tissues from the infected area. Madeng’ai powder solution over 2 mg/mL concentration completely inhibited E. coli growth. At 4.0 mg/mL, Madeng’ai significantly inhibited the growth of E. faecalis, Pseudomonas aeruginosa (PAE), Klebsiella pneumoniae, and Acinetobacter baumannii. The mouse model revealed that Madeng’ai could suppress the growth of MRSA and PAE and accelerate healing of cutaneous wounds. Madeng’ai, a newly discovered Dong ethnic minority medicine possesses considerable antimicrobial activity against both human normal pathogenic bacteria and multiresistance bacteria such as Pseudomonas aeruginosa, S. aureus, and Acinetobacter baumannii. Therefore, Madeng’ai has great potential for further study and clinical application.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: RNA-Seq and 16S rRNA Reveals That Tian–Dong–Tang–Gan Powder Alleviates Environmental Stress-Induced Decline in Immune and Antioxidant Function and Gut Microbiota Dysbiosis in Litopenaeus vannami

Xie, Xiao-Dong / Zhou, Ying / Sun, Yu-Bo / Yi, Shou-Li / Zhao, Yi / Chen, Qi / Xie, Ying-Hong / Cao, Mi-Xia / Yu, Mei-Ling / Wei, Ying-Yi / Zhang, Ling / Hu, Ting-Jun

Antioxidants. 2023 June 12, v. 12, no. 6

2023

Abstract: ... resistance to nitrite stress improved after Tian–Dong–Tang–Gan Powder (TDTGP) treatment, but the mechanism is ...

Abstract	Ammonia stress and nitrite stress can induce immune depression and oxidative stress in Litopenaeus vannami (L. vannamei). Earlier reports showed that L. vannamei immunity, resistance to ammonia stress, and resistance to nitrite stress improved after Tian–Dong–Tang–Gan Powder (TDTGP) treatment, but the mechanism is not clear. In this study, three thousand L. vannamei were fed different doses of TDTGP for 35 days and then subjected to ammonia and nitrite stress treatments for 72 h. Transcriptome and 16-Seq ribosomal RNA gene sequencing (16S rRNA-seq) were used to analyze hepatopancreas gene expression and changes in gut microbiota abundance in each group. The results showed that after TDTGP treatment, hepatopancreas mRNA expression levels of immunity- and antioxidant-related genes were increased, the abundance of Vibrionaceae in the gut microbiota was decreased, and the abundance of Rhodobacteraceae and Flavobacteriaceae was increased. In addition, after TDTGP treatment, the effects of ammonia and nitrite stress on the mRNA expression of Pu, cat-4, PPAF2, HO, Hsp90b1, etc. were reduced and the disruption of the gut microbiota was alleviated. In short, TDTGP can regulate the immunity and antioxidant of L. vannamei by increasing the expression levels of immunity- and antioxidant-related genes and regulating the abundance of Rhodobacteraceae and Flavobacteriaceae in the gut microbiota.
Keywords	Flavobacteriaceae ; Litopenaeus ; Rhodobacteraceae ; Vibrionaceae ; ammonia ; antioxidant activity ; antioxidants ; decline ; dysbiosis ; gene expression ; genes ; hepatopancreas ; immunity ; intestinal microorganisms ; nitrites ; oxidative stress ; ribosomal RNA ; sequence analysis ; transcriptome
Language	English
Dates of publication	2023-0612
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061262
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Deciphering potential pharmacological mechanism of Sha-Shen-Mai-Dong decoction on primary Sjogren's syndrome.

Jiang, Yuepeng / Zhao, Xiaoxuan / Yu, Jie / Wang, Qiao / Wen, Chengping / Huang, Lin

BMC complementary medicine and therapies

2021 Volume 21, Issue 1, Page(s) 79

Abstract: Background: Sha-Shen-Mai-Dong decoction (SSMD) is a classical prescription widely used in primary ...

Abstract	Background: Sha-Shen-Mai-Dong decoction (SSMD) is a classical prescription widely used in primary Sjogren's Syndrome (pSS) therapy. This study aims to explore the potential pharmacological mechanism of SSMD on pSS. Methods: Active components of SSMD were obtained from Traditional Chinese Medicine Integrative Database and Traditional Chinese Medicine Systems Pharmacology databases and targets of SSMD were predicted by Pharmmapper and STITCH database. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were carried out to explore the function characteristics of SSMD. The expression matrix of microarray of pSS was obtained from Gene Expression Omnibus and we obtained 162 differentially expressed genes (DEGs). Protein-protein interaction (PPI) networks were constructed to identify the hub targets. Principal component analysis (PCA) and molecular docking were conducted to further elucidate the possibility of SSMD for pSS. Results: SSMD contained a total of 1056 active components, corresponding to 88 targets, among which peripheral myelin protein 2(PMP2), androgen receptor (AR) and glutamic acid decarboxylase 1(GAD1) are associated with multiple active components in SSMD and may be the core targets. Moreover, these targets were closely related to tissue pathological injury in SS, such as lacrimal gland, salivary gland and nervous system injury. GO and KEGG analysis showed that 88 targets enriched in REDOX process, transcriptional regulation and negative regulation of apoptosis process. Besides, SSMD may influence the cell proliferation, gene transcription through regulating Ras and cAMP-related signaling pathways. In addition, SSMD may show effects on immune regulation, such as macrophage differentiation, Toll-like receptor 4 signaling pathway and T-helper 1 in SS. Moreover, PPI network suggested that FN1, MMP-9 may be the hub targets in SSMD. Result of PCA and molecular docking analysis further determined the feasibility of SSMD in treating pSS. Conclusion: SSMD can regulate multiple biological processes by virtue of its multiple active components, thus showing prominent advantage in the treatment of pSS. The discovery of active ingredients and targets in SSMD provides valuable resources for drug research and development for pSS.
MeSH term(s)	Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Gene Ontology ; Humans ; Medicine, Chinese Traditional ; Molecular Docking Simulation ; Protein Interaction Maps/drug effects ; Proteins/genetics ; Proteins/metabolism ; Signal Transduction ; Sjogren's Syndrome/drug therapy ; Sjogren's Syndrome/genetics ; Sjogren's Syndrome/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Proteins
Language	English
Publishing date	2021-03-01
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-021-03257-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regularity of Wind-dispelling Medication Prescribed by LI Dong-Yuan

W.A.N.G. Zhao-Yi / H.U.A.N.G. Zheng-De / Y.A.N.G. Ping / R.E.N. Ting / L.I. Xin-Hui

Digital Chinese Medicine, Vol 3, Iss 1, Pp 20-

A Data Mining Technology-based Study

2020 Volume 33

Abstract: ... medication was prescribed by LI Dong-Yuan and many doctors of his school of thought and to provide ... of these medications. Methods: Original data on wind-dispelling medication described in LI Dong-Yuan’s works were ... of data processing softwares, such as SPSS 22.0, Modeler 18.0 and xMiner. By reviewing LI Dong-Yuan's writings ...

Abstract	Objective: To extract and analyze information on the regularity with which wind-dispelling medication was prescribed by LI Dong-Yuan and many doctors of his school of thought and to provide theoretical basis and ideas for modern clinical application to facilitate the use, research, and development of these medications. Methods: Original data on wind-dispelling medication described in LI Dong-Yuan’s works were collected, sorted and organized. Data mining and comprehensive analysis were performed by using a series of data processing softwares, such as SPSS 22.0, Modeler 18.0 and xMiner. By reviewing LI Dong-Yuan's writings on wind-dispelling medication, the number of prescriptions for wind-dispelling medication were counted. Frequency of use of wind-dispelling medication was determined, and association rules analysis, factor analysis, and core drug network analysis were used to reveal associations of the symptoms of syndromes and treatment with wind-dispelling medication and to reveal the regularity with which these medications were prescribed by LI Dong-Yuan. Results: A total of 356 prescriptions and 121 flavors of wind-dispelling medication were observed. Among them, five kinds of medicinal properties, seven kinds of medicinal tastes, and 12 kinds of meridians were identified. Furthermore, herbs were divided into 18 categories according to their efficacy. Statistical analysis showed that there were 23 wind-dispelling medications that were prescribed with a frequency of ≥ 60. The mainly used drugs were Saposhnikoviae Radix (Fang Feng, 防风), Bupleuri Radix (Chai Hu, 柴胡), Cimicifugae Rhizoma (Sheng Ma, 升麻), Notopterygii Rhizoma Et Radix (Qiang Huo, 羌活), Puerariae Lobatae Radix (Ge Gen, 葛根), Chuanxiong Rhizoma (Chuan Xiong, 川芎), and Ephedrae Herba (Ma Huang, 麻黄). In addition, we analyzed the association rules wind-dispelling medication and obtained 23 one-to-one drug association rules and 11 multiple-to-one drug association rules. The core drug network analysis data visualization showed core drugs used in the ...
Keywords	Medicine ; R ; Other systems of medicine ; RZ201-999
Subject code	306 ; 551
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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