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  1. Article ; Online: Hepatocyte-specific deletion of

    Liu, Chunhong / Li, Xinzhi / Yao, Zhicheng / Li, Xueying / Chen, Zheng

    Genes & diseases

    2023  Volume 11, Issue 1, Page(s) 57–59

    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.02.048
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  2. Article ; Online: Insights into the contrasting effects of sulfidation on dechlorination of chlorinated aliphatic hydrocarbons by zero-valent iron.

    Sun, Yuankui / Zheng, Kaiwei / Du, Xueying / Qin, Hejie / Guan, Xiaohong

    Water research

    2024  Volume 255, Page(s) 121494

    Abstract: Contrasting effects of sulfidation on contaminants reduction by zero-valent iron (ZVI) has been reported in literature but the underlying mechanisms remain unclear. Here, under well-controlled conditions, we compared the performance of ZVI and sulfidated ...

    Abstract Contrasting effects of sulfidation on contaminants reduction by zero-valent iron (ZVI) has been reported in literature but the underlying mechanisms remain unclear. Here, under well-controlled conditions, we compared the performance of ZVI and sulfidated ZVI (S-ZVI) toward a series of chlorinated compounds. Results revealed that, although S-ZVI was more reactive than ZVI toward hexachloroethane, pentachloroethane, tetrachloroethylene, and trichloroethene, sulfidation hindered the dechlorination of the other ten tested chlorinated aliphatics by a factor of 1.5-125. Moreover, S-ZVI may lead to an accumulation of toxic partially-dechlorinated products. Analogous to its effects on ZVI reactivity, sulfidation also exerted positive, negligible, or negative effects on the electron efficiency of ZVI. Solvent kinetic isotope effect analysis suggested that direct electron transfer rather than reaction with atomic hydrogen was the dominant reduction mechanism in S-ZVI system. Hence, the sulfidation enhancing effects could be expected only when direct electron transfer is the preferred reduction route for target contaminants. Furthermore, linear free energy relationships analysis indicated one-electron reduction potential could be used to predict the transformation of chlorinated ethanes by S-ZVI, whereas for chlorinated ethenes, their adsorption properties on S-ZVI determined the dechlorination process. All these findings may offer guidance for the decision-making regarding the application of S-ZVI.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2024.121494
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  3. Article ; Online: Sustainability-Oriented Low-Carbon Innovation in SOEs

    Guangyao Yu / Qinqin Zheng / Xueying Lin / Kaiqi Yuan

    Sustainability, Vol 15, Iss 23, p

    A Case Study of Shanghai Metro

    2023  Volume 16216

    Abstract: State-owned enterprises (SOEs) encounter various constraints on sustainability in low-carbon development due to institutional hybridity. This study aimed to examine how SOEs develop sustainability-oriented innovation (SOI) toward low-carbon development. ... ...

    Abstract State-owned enterprises (SOEs) encounter various constraints on sustainability in low-carbon development due to institutional hybridity. This study aimed to examine how SOEs develop sustainability-oriented innovation (SOI) toward low-carbon development. Drawing on a case study of Shanghai Metro, we developed a process model for sustainability-oriented low-carbon innovation (SLI) in SOEs. The model illustrated that implementing a national low-carbon strategy introduces environmental, social, and financial constraints on sustaining value pluralism for SOEs, triggering the actors to develop SLI involving sensing and idea generation, configuration, and transformation, resulting in innovative low-carbon operational processes, products/services, and business models which reconcile environmental benefits, financial returns, and social welfare. This paper enriches the emerging research on SOI and extends the existing understanding of low-carbon innovation. Beyond this, the findings also offer a new lens of SLI to the conventional research and managerial practices concerning SOEs’ hybridity and low-carbon development.
    Keywords sustainability-oriented innovation ; low-carbon development ; sustainable development perspective ; innovation process ; SOEs ; case study ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 690
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles.

    Zheng, Yixuan / Wang, Hui / Li, Xueying / Xie, Jing / Fan, Junming / Ren, Sichong

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1371874

    Abstract: Chronic kidney disease (CKD) is a progressive disorder characterized by structural and functional changes in the kidneys, providing a global health challenge with significant impacts on mortality rates. Extracellular vesicles (EVs), are vital in the ... ...

    Abstract Chronic kidney disease (CKD) is a progressive disorder characterized by structural and functional changes in the kidneys, providing a global health challenge with significant impacts on mortality rates. Extracellular vesicles (EVs), are vital in the physiological and pathological processes associated with CKD. They have been shown to modulate key pathways involved in renal injury, including inflammation, fibrosis, apoptosis, and oxidative stress. Currently, the application research of EVs in the diagnosis and treatment of CKD is highly prevalent. However, there is currently a lack of standardized guidelines for their application, and various methodologies have advantages and limitations. Consequently, we present an comprehensive summary elucidating the multifaceted involvement of EVs in both physiological and pathological aspects in CKD. Furthermore, we explore their potential as biomarkers and diverse therapeutic roles in CKD. This review provides an overview of the current state of research on application of EVs in the diagnosis and therapeutic management of CKD.
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1371874
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  5. Article ; Online: Correction to: Association Between Bowel Wall Thickening and Long-Term Outcomes in Decompensated Liver Cirrhosis.

    Wang, Xueying / Ding, Min / Wang, Weiwei / Zheng, Xiaojie / Philips, Cyriac Abby / Méndez-Sánchez, Nahum / Jin, Hongxu / Qi, Xingshun

    Advances in therapy

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-024-02828-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2101: Show issues Location:
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  6. Article ; Online: Screening of efficient salicylaldoxime reactivators for DFP and paraoxon-inhibited acetylcholinesterase.

    Wei, Zhao / Zhang, Dongxu / Liu, Xueying / Nie, Huifang / Ouyang, Qin / Zhang, Xinlei / Zheng, Zhibing

    RSC medicinal chemistry

    2024  Volume 15, Issue 4, Page(s) 1225–1235

    Abstract: Previously we reported two salicylaldoxime conjugates (L7R3 and L7R5) showing equal or even higher reactivating efficiency for both organophosphorus nerve agent and pesticide inhibited acetylcholinesterase in comparison to obidoxime and HI-6. In this ... ...

    Abstract Previously we reported two salicylaldoxime conjugates (L7R3 and L7R5) showing equal or even higher reactivating efficiency for both organophosphorus nerve agent and pesticide inhibited acetylcholinesterase in comparison to obidoxime and HI-6. In this study, L7R3 and L7R5 were selected as lead compounds and refined by employing a fragment-based drug design strategy, and a total of 32 novel salicylaldoxime conjugates were constructed and screened for DFP and paraoxon inhibited acetylcholinesterase. The findings demonstrate that the conjugate L73R3, which contains a 4-nitrophenyl group, exhibited a higher reactivation efficacy against paraoxon-inhibited acetylcholinesterase compared to obidoxime and HI-6. It was confirmed that the combination of a 4-pyridinyl or 4-nitrophenyl peripheral site ligand, a piperazine linker and a methyl or chloro-substituted salicylaldoxime could construct efficient nonquaternary oxime reactivators. The results hold promise for developing a new generation of highly effective antidotes for organophosphate poisoning.
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d3md00628j
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  7. Article: Characterization and Performance Evaluation of Metakaolin-Based Geopolymer Foams Obtained by Adding Palm Olein as the Foam Stabilizer.

    Yu, Qinglin / Li, Xueying / Wang, Zheng / Xue, Jing

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 10

    Abstract: Geopolymer foams with different pore structures can be used in construction, water treatment, and heavy metal adsorption. The preparation of high porosity geopolymer foams using vegetable oil as a foam stabilizer is a feasible and cost-effective route. ... ...

    Abstract Geopolymer foams with different pore structures can be used in construction, water treatment, and heavy metal adsorption. The preparation of high porosity geopolymer foams using vegetable oil as a foam stabilizer is a feasible and cost-effective route. In this study, metakaolin-based geopolymer foams with hierarchical pore structures were fabricated by adding H
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15103570
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  8. Article ; Online: Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway.

    Xueying, Zheng / Liang, Guo / Siyi, Lai / Fengyue, L I / Mingli, Liang / Wanting, Liu / Chun, Meng / Guanghui, Liu

    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

    2024  Volume 44, Issue 2, Page(s) 268–276

    Abstract: Objective: To investigate the effects of emodin on alkali burn-induced corneal inflammation and neovascularization.: Methods: The ability of emodin to target vascular endothelial growth factor receptor 2 (VEGFR2) was predicted by molecular docking. ... ...

    Abstract Objective: To investigate the effects of emodin on alkali burn-induced corneal inflammation and neovascularization.
    Methods: The ability of emodin to target vascular endothelial growth factor receptor 2 (VEGFR2) was predicted by molecular docking. The effects of emodin on the invasion, migration, and proliferation of human umbilical vein endothelial cells (HUVEC) were determined by cell counting kit-8, Transwell, and tube formation assays. Analysis of apoptosis was performed by flow cytometry. CD31 levels were examined by immunofluorescence. The abundance and phosphorylation state of VEGFR2, protein kinase B (Akt), signal transducer and activator of transcription 3 (STAT3), and P38 were examined by immunoblot analysis. Corneal alkali burn was performed on 40 mice. Animals were divided randomly into two groups, and the alkali-burned eyes were then treated with drops of either 10 μM emodin or phosphate buffered saline (PBS) four times a day. Slit-lamp microscopy was used to evaluate inflammation and corneal neovascularization (CNV) in all eyes on Days 0, 7, 10, and 14. The mice were killed humanely 14 d after the alkali burn, and their corneas were removed and preserved at －80 ℃ until histological study or protein extraction.
    Results: Molecular docking confirmed that emodin was able to target VEGFR2. The findings revealed that emodin decreased the invasion, migration, angiogenesis, and proliferation of HUVEC in a dose-dependent manner. In mice, emodin suppressed corneal inflammatory cell infiltration and inhibited the development of corneal neovascularization induced by alkali burn. Compared to those of the PBS-treated group, lower VEGFR2 expression and CD31 levels were found in the emodin-treated group. Emodin dramatically decreased the expression of VEGFR2, p-VEGFR2, p-Akt, p-STAT3, and p-P38 in VEGF-treated HUVEC.
    Conclusion: This study provides a new avenue for evaluating the molecular mechanisms underlying corneal inflammation and neovascularization. Emodin might be a promising new therapeutic option for corneal alkali burns.
    MeSH term(s) Humans ; Mice ; Animals ; Corneal Neovascularization/drug therapy ; Corneal Neovascularization/genetics ; Corneal Neovascularization/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Burns, Chemical/drug therapy ; Burns, Chemical/metabolism ; Burns, Chemical/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Emodin ; Vascular Endothelial Growth Factor Receptor-2/genetics ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Molecular Docking Simulation ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/genetics ; Signal Transduction ; Human Umbilical Vein Endothelial Cells ; Inflammation/drug therapy ; Disease Models, Animal
    Chemical Substances Vascular Endothelial Growth Factor A ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Emodin (KA46RNI6HN) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
    Language English
    Publishing date 2024-03-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 603186-9
    ISSN 2589-451X ; 0254-6272 ; 0255-2922
    ISSN (online) 2589-451X ; 0254-6272
    ISSN 0255-2922
    DOI 10.19852/j.cnki.jtcm.20240203.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2564: Show issues Location:
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  9. Article ; Online: Aquaporin-3 promotes proliferation and inflammation in hepatocellular carcinoma.

    Wang, Yao / Wu, Yalan / Li, Xueying / Song, Weiwei / Zheng, Fengling / Mo, Xiaoying / Luo, Yi / Li, Yun / Chen, Song / Luo, Huanhuan

    Genes & diseases

    2023  Volume 11, Issue 4, Page(s) 101029

    Language English
    Publishing date 2023-07-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.06.004
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  10. Article ; Online: Cardiovascular diseases consequences of type 1, type 2 diabetes mellitus and glycemic traits: A Mendelian randomization study.

    Zhang, Pan / Zhang, Zihang / Zhong, Jinghui / Zheng, Xueying / Zhou, Junling / Sun, Wen

    Diabetes research and clinical practice

    2024  Volume 208, Page(s) 111094

    Abstract: Objective: This Mendelian randomization (MR) study aimed to investigate the relationships between type 1 diabetes (T1D), type 2 diabetes (T2D), and glycemic traits, including fasting insulin, fasting glucose, and HbA1c, with cardiovascular diseases ( ... ...

    Abstract Objective: This Mendelian randomization (MR) study aimed to investigate the relationships between type 1 diabetes (T1D), type 2 diabetes (T2D), and glycemic traits, including fasting insulin, fasting glucose, and HbA1c, with cardiovascular diseases (CVDs).
    Methods: We selected genetic instruments for predisposition to T1D, T2D, fasting insulin, fasting glucose, and HbA1c based on published genome-wide association studies. Using a 2-Sample MR approach, we assessed associations with 12 common CVDs sourced from the FinnGen and UK Biobank studies, along with stroke subtypes obtained from the GIGASTROKE and MEGASTROKE Consortium.
    Results: T1D was associated with SVS. T2D showed associations with AIS, LAA, CES, SVS, coronary heart disease, myocardial infarction, pulmonary embolism, DVT of lower extremities, peripheral vascular diseases. Genetically predicted higher HbA1c levels were associated with eight CVDs. The results of MVMR aligned with the primary findings for T1D and T2D.
    Conclusions: T1D and T2D exhibit different genetic predisposition to CVDs. BMI, LDL, and HDL play intermediary roles in connecting TID and T2D to specific types of CVDs, providing insights into the potential underlying pathways and mechanisms involved in these relationships. Strategies aimed at achieving sustained reductions in HbA1c levels may offer potential for reducing the risk of various CVDs.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/complications ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/complications ; Glycated Hemoglobin ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/complications ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Blood Glucose/metabolism ; Insulin/metabolism ; Polymorphism, Single Nucleotide
    Chemical Substances Glycated Hemoglobin ; Blood Glucose ; Insulin
    Language English
    Publishing date 2024-01-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2024.111094
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
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