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Article: [Effect of jian yan ling on serum lipids, apoprotein and lipoprotein-a].

Lu, D C / Su, Z J / Rui, T

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

1994 Volume 14, Issue 3, Page(s) 142–4, 131–2

Abstract: Effect of Jian Yan Ling (JYL, mainly consisted of Succinum, Pteria margaritifers and ...

Abstract	Effect of Jian Yan Ling (JYL, mainly consisted of Succinum, Pteria margaritifers and Astragalus membranaceus etc.) on serum lipids was studied by double-blind method in 128 hyperlipemia patients. Patients were divided randomly into two groups, the test groups (64 cases) treated with JYL, while the other 64 cases treated with placebo as control for 3 months. Serum total cholesterol (TC), triglyceride (TG), TC-high density lipolipid-cholesterol (TC-HDL-C), apoproteins were observed before and after treatment. Results showed that the TC, TG, apoproteins and lipoprotein-a of test group were all dropped significantly after JYL treatment (P < 0.01). The results suggested that JYL could regulate the blood lipids and could also exert an effect of antiatherosclerosis through reducing blood lipoprotein-a level. It is worth while to use JYL as an antihyperlipemic agent clinically.
MeSH term(s)	Apolipoproteins A/metabolism ; Apolipoproteins B/metabolism ; Astragalus membranaceus ; Capsules ; Cholesterol/blood ; Cholesterol, HDL/blood ; Double-Blind Method ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Hyperlipidemias/blood ; Hyperlipidemias/drug therapy ; Hypolipidemic Agents/therapeutic use ; Lipoprotein(a)/blood ; Male ; Middle Aged ; Triglycerides/blood
Chemical Substances	Apolipoproteins A ; Apolipoproteins B ; Capsules ; Cholesterol, HDL ; Drugs, Chinese Herbal ; Hypolipidemic Agents ; Lipoprotein(a) ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	Chinese
Publishing date	1994-03
Publishing country	China
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Myelodysplastic syndrome-like response after voriconazole treatment of systemic lupus erythematosus complicated with fungal infection: a case report.

Xie, Guang-Liang / Wang, Xiao-Su / Hu, Ling-Yan / Wang, Yi / Gu, Xiangchen / Xu, Yan-Qiu

Frontiers in medicine

2023 Volume 10, Page(s) 1286649

Abstract: Background: Voriconazole is mainly used to treat progressive and potentially life-threatening infections in immunocompromised patients. The adverse drug reactions related to voriconazole are varied. In some rare cases, the use of voriconazole can result ...

Abstract	Background: Voriconazole is mainly used to treat progressive and potentially life-threatening infections in immunocompromised patients. The adverse drug reactions related to voriconazole are varied. In some rare cases, the use of voriconazole can result in myelodysplastic syndrome (MDS)-like adverse reactions. Case presentation: Here, we present a rare case of systemic lupus erythematosus patient with a fungal infection that developed MDS-like adverse reactions after treatment with voriconazole. The patient was admitted to the hospital because of 3 days of chest tightness and dyspnea. After the admission, the patient's sputum culture showed Conclusion: This case reminded us that when using voriconazole for treatment, individual differences in patients should be considered, and the blood concentration of voriconazole should be closely monitored. Otherwise, potential drugs that affect voriconazole metabolism should be noted, and related adverse symptoms of patients should be closely observed during medication to reduce the occurrence of adverse drug events.
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1286649
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Co-production of xylooligosaccharides and glucose from birch sawdust by hot water pretreatment and enzymatic hydrolysis.

Fang, Lingyan / Su, Yan / Wang, Peng / Lai, Chenhuan / Huang, Caoxing / Ling, Zhe / Yong, Qiang

Bioresource technology

2022 Volume 348, Page(s) 126795

Abstract: A green method for co-production of value-added xylooligosaccharides (XOS) and glucose from birch was demonstrated using hot water pretreatment. Effects of pretreatment severity factor (Log ... ...

Abstract	A green method for co-production of value-added xylooligosaccharides (XOS) and glucose from birch was demonstrated using hot water pretreatment. Effects of pretreatment severity factor (Log R
MeSH term(s)	Betula ; Glucose ; Glucuronates ; Hydrolysis ; Oligosaccharides ; Water
Chemical Substances	Glucuronates ; Oligosaccharides ; xylooligosaccharide ; Water (059QF0KO0R) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2022.126795
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Article ; Online: Myelodysplastic syndrome-like response after voriconazole treatment of systemic lupus erythematosus complicated with fungal infection

Guang-Liang Xie / Xiao-Su Wang / Ling-Yan Hu / Yi Wang / Xiangchen Gu / Yan-Qiu Xu

Frontiers in Medicine, Vol

a case report

2023 Volume 10

Abstract: BackgroundVoriconazole is mainly used to treat progressive and potentially life-threatening infections in immunocompromised patients. The adverse drug reactions related to voriconazole are varied. In some rare cases, the use of voriconazole can result in ...

Abstract	BackgroundVoriconazole is mainly used to treat progressive and potentially life-threatening infections in immunocompromised patients. The adverse drug reactions related to voriconazole are varied. In some rare cases, the use of voriconazole can result in myelodysplastic syndrome (MDS)-like adverse reactions.Case presentationHere, we present a rare case of systemic lupus erythematosus patient with a fungal infection that developed MDS-like adverse reactions after treatment with voriconazole. The patient was admitted to the hospital because of 3 days of chest tightness and dyspnea. After the admission, the patient’s sputum culture showed Candida albicans infection, and voriconazole was prescribed to be taken orally. After using voriconazole, drug-related adverse reactions such as visual impairment, nausea, vomiting, hiccup, middle and lower abdominal pain, disorders of consciousness, delirium, hallucination, slow response, and subcutaneous ecchymosis appeared, as well as the gradually increased serum creatinine, oliguria, and aggravated lower limb edema. In addition, there was a decrease in peripheral blood cells, and MDS-like changes in bone marrow were indicated by bone marrow biopsy. After discontinuing voriconazole, drug-related adverse symptoms disappeared, and hematocytopenia and the changes in MDS were significantly improved, which was confirmed by a subsequent bone marrow puncture at a 6 months interval.ConclusionThis case reminded us that when using voriconazole for treatment, individual differences in patients should be considered, and the blood concentration of voriconazole should be closely monitored. Otherwise, potential drugs that affect voriconazole metabolism should be noted, and related adverse symptoms of patients should be closely observed during medication to reduce the occurrence of adverse drug events.
Keywords	voriconazole ; myelodysplastic syndrome ; hematocytopenia ; adverse drug reaction ; case report ; systemic lupus erythematosus ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Coproduction of xylooligosaccharides and monosaccharides from hardwood by a combination of acetic acid pretreatment, mechanical refining and enzymatic hydrolysis.

Su, Yan / Fang, Lingyan / Wang, Peng / Lai, Chenhuan / Huang, Caoxing / Ling, Zhe / Yong, Qiang

Bioresource technology

2022 Volume 358, Page(s) 127365

Abstract: Sequential biorefinery treatments of acetic acid (HAC) pretreatment, Papir Forsknings Institutet (PFI) milling and enzymatic hydrolysis were demonstrated for coproduction of xylooligosaccharides (XOS) and fermentable monosaccharides. Results indicated ... ...

Abstract	Sequential biorefinery treatments of acetic acid (HAC) pretreatment, Papir Forsknings Institutet (PFI) milling and enzymatic hydrolysis were demonstrated for coproduction of xylooligosaccharides (XOS) and fermentable monosaccharides. Results indicated that 36.2% XOS (50.8% X2-X3) and 17.0% low DP xylans were achieved using a HAC pretreatment with a combined severity factor of 0.78. The HAC pretreatment resulted in a XOS-rich prehydrolyzate with a low molecular weight of 1.28 kDa. The endo-xylanase hydrolysis was conducted on the pretreatment liquor to elevate XOS yield and the content of higher-value X2-X3. Moreover, fermentable glucose production from the pretreated residue increased by 2.3 folds when introducing an additional step of PFI refining prior to enzymatic digestion. Properties of substrate including cellulose accessibility, crystallite size, crystalline index and water retention value were in close relationships with enzymatic digestibility. The implementation of proposed biorefinery process will give more insights into the efficient construction of a wood-derived sugar platform.
MeSH term(s)	Acetic Acid ; Glucuronates ; Hydrolysis ; Monosaccharides ; Oligosaccharides ; Xylose
Chemical Substances	Glucuronates ; Monosaccharides ; Oligosaccharides ; xylooligosaccharide ; Xylose (A1TA934AKO) ; Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2022.127365
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14.

Liu, Qianjin / Jiao, Lijin / Ye, Mao-Sen / Ma, Zhiyu / Yu, Jinsong / Su, Ling-Yan / Zou, Wei-Yin / Yang, Lu-Xiu / Chen, Chang / Yao, Yong-Gang

Cellular & molecular immunology

2024

Abstract: Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases. However, the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unknown. In this study, we demonstrated ...

Abstract	Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases. However, the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unknown. In this study, we demonstrated that S-nitrosoglutathione reductase (GSNOR) deficiency in macrophages leads to significant increases in the Nlrp3 and Il-1β expression levels and interleukin-1β (IL-1β) secretion in response to NLRP3 inflammasome stimulation. Furthermore, in vivo experiments utilizing Gsnor
Language	English
Publishing date	2024-04-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-024-01155-9
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Article: Coproduction of xylooligosaccharides and monosaccharides from hardwood by a combination of acetic acid pretreatment, mechanical refining and enzymatic hydrolysis

Su, Yan / Fang, Lingyan / Wang, Peng / Lai, Chenhuan / Huang, Caoxing / Ling, Zhe / Yong, Qiang

Bioresource technology. 2022 May 20,

2022

Abstract	Sequential biorefinery treatments of acetic acid (HAC) pretreatment, Papir Forsknings Institutet (PFI) milling and enzymatic hydrolysis were demonstrated for coproduction of xylooligosaccharides (XOS) and fermentable monosaccharides. Results indicated that 36.2% XOS (50.8% X2-X3) and 17.0% low DP xylans were achieved using a HAC pretreatment with a combined severity factor of 0.78. The HAC pretreatment resulted in a XOS-rich prehydrolyzate with a low molecular weight of 1.28 kDa. The endo-xylanase hydrolysis was conducted on the pretreatment liquor to elevate XOS yield and the content of higher-value X2-X3. Moreover, fermentable glucose production from the pretreated residue increased by 2.3 folds when introducing an additional step of PFI refining prior to enzymatic digestion. Properties of substrate including cellulose accessibility, crystallite size, crystalline index and water retention value were in close relationships with enzymatic digestibility. The implementation of proposed biorefinery process will give more insights into the efficient construction of a wood-derived sugar platform.
Keywords	acetic acid ; biorefining ; cellulose ; crystallites ; endo-1,4-beta-xylanase ; enzymatic hydrolysis ; glucose ; hardwood ; hydrolysis ; molecular weight ; xylooligosaccharides
Language	English
Dates of publication	2022-0520
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2022.127365
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Molecular Mechanism of Neuroprotective Effect of Melatonin on Morphine Addiction and Analgesic Tolerance: an Update.

Su, Ling-Yan / Liu, Qianjin / Jiao, Lijin / Yao, Yong-Gang

Molecular neurobiology

2021 Volume 58, Issue 9, Page(s) 4628–4638

Abstract: Drug addiction is a global health problem and continues to place an enormous financial burden on society. This addiction is characterized by drug dependence sensitization and craving. Morphine has been widely used for pain relief, but chronic ... ...

Abstract	Drug addiction is a global health problem and continues to place an enormous financial burden on society. This addiction is characterized by drug dependence sensitization and craving. Morphine has been widely used for pain relief, but chronic administration of morphine causes analgesic tolerance, hyperalgesia, and addiction, all of which limit its clinical usage. Alterations of multiple molecular pathways have been reported to be involved in the development of drug addiction, including mitochondrial dysfunction, excessive oxidative stress and nitric oxide stress, and increased levels of apoptosis, autophagy, and neuroinflammation. Preclinical and clinical studies have shown that the co-administration of melatonin with morphine leads to a reversal of these affected pathways. In addition, murine models have shown that melatonin improves morphine-induced analgesic tolerance and addictive behaviors, such as behavioral sensitization, reward effect, and physical dependence. In this review, we attempt to summarize the recent findings about the beneficial effect and molecular mechanism of melatonin on mitochondrial dysfunction, uncontrolled autophagy, and neuroinflammation in morphine addiction and morphine analgesic tolerance. We propose that melatonin might be a useful supplement in the treatment opiate abuse.
MeSH term(s)	Autophagy/drug effects ; Drug Tolerance ; Humans ; Melatonin/pharmacology ; Mitochondria/drug effects ; Morphine/pharmacology ; Morphine Dependence/physiopathology ; Neuroprotective Agents/pharmacology ; Pain Measurement
Chemical Substances	Neuroprotective Agents ; Morphine (76I7G6D29C) ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2021-06-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-021-02448-0
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Article: Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries.

Xu, Lingyan / Ling, Jiawei / Su, Chang / Su, Yu-Wen / Xu, Yan / Jiang, Zhenzhou

Frontiers in medicine

2021 Volume 8, Page(s) 756435

Abstract: Indoleamine 2,3-dioxygenase (IDO) is one of the initial rate-limiting enzymes of the kynurenine pathway (KP), which causes immune suppression and induction of T cell anergy. It is associated with the imbalance of immune homeostasis in numerous diseases ... ...

Abstract	Indoleamine 2,3-dioxygenase (IDO) is one of the initial rate-limiting enzymes of the kynurenine pathway (KP), which causes immune suppression and induction of T cell anergy. It is associated with the imbalance of immune homeostasis in numerous diseases including cancer, chronic viral infection, allergy, and autoimmune diseases. Recently, IDO has extended its role to liver field. In this review, we summarize the dysregulation and potentials of IDO in the emerging field of liver injuries, as well as current challenges for IDO targets. In particular, we discuss unexpected conclusions against previous work published. IDO is induced by pro-inflammatory cytokines in liver dysfunction and exerts an immunosuppressive effect, whereas the improvement of liver injury may require consideration of multiple factors besides IDO.
Language	English
Publishing date	2021-11-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.756435
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Article: Co-production of xylooligosaccharides and glucose from birch sawdust by hot water pretreatment and enzymatic hydrolysis

Fang, Lingyan / Su, Yan / Wang, Peng / Lai, Chenhuan / Huang, Caoxing / Ling, Zhe / Yong, Qiang

Bioresource technology. 2022 Mar., v. 348

2022

Abstract	A green method for co-production of value-added xylooligosaccharides (XOS) and glucose from birch was demonstrated using hot water pretreatment. Effects of pretreatment severity factor (Log R₀) on XOS production and enzymatic hydrolysis were investigated. At Log R₀ of 4.05 (180 °C, 50 min), the maximum hydrolysis yield (80.8%) was obtained. At Log R₀ of 3.91 (170 °C, 70 min), the maximum XOS yield (46.1%) was obtained, however the hydrolysis yield decreased to 70.3%. To achieve both the high XOS yield and high glucose output, Tween 80 addition (0.075 g/g cellulose) was employed, leading to an improvement in hydrolysis yield from 70.3% to 89.4%. From a mass balance perspective, 104.6 g of XOS and 372.9 g of glucose could be produced from 1000 g birch. These results demonstrated that birch sawdust is a promising lignocellulosic material for co-production of XOS and glucose.
Keywords	Betula ; cellulose ; enzymatic hydrolysis ; glucose ; hydrolysis ; lignocellulose ; polysorbates ; sawdust ; technology ; value added ; xylooligosaccharides
Language	English
Dates of publication	2022-03
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2022.126795
Database	NAL-Catalogue (AGRICOLA)

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