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Article ; Online: Precision patterning: How inner hair cells "hop" to it.

Webber, Jemma L / García-Añoveros, Jaime

2023 Volume 9, Issue 8, Page(s) eadg8662

Abstract: A combination of Notch-mediated lateral inhibition, mechanical forces, and differential adhesion generates a single row of alternating inner hair and supporting cells. ...

Abstract	A combination of Notch-mediated lateral inhibition, mechanical forces, and differential adhesion generates a single row of alternating inner hair and supporting cells.
MeSH term(s)	Hair Cells, Auditory, Inner ; Membrane Proteins ; Cell Differentiation ; Receptors, Notch
Chemical Substances	Membrane Proteins ; Receptors, Notch
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adg8662
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Axodendritic versus axosomatic cochlear efferent termination is determined by afferent type in a hierarchical logic of circuit formation.

Webber, Jemma L / Clancy, John C / Zhou, Yingjie / Yraola, Natalia / Homma, Kazuaki / García-Añoveros, Jaime

Science advances

2021 Volume 7, Issue 4

Abstract: Hearing involves a stereotyped neural network communicating cochlea and brain. How this sensorineural circuit assembles is largely unknown. The cochlea houses two types of mechanosensory hair cells differing in function (sound transmission versus ... ...

Abstract	Hearing involves a stereotyped neural network communicating cochlea and brain. How this sensorineural circuit assembles is largely unknown. The cochlea houses two types of mechanosensory hair cells differing in function (sound transmission versus amplification) and location (inner versus outer compartments). Inner (IHCs) and outer hair cells (OHCs) are each innervated by a distinct pair of afferent and efferent neurons: IHCs are contacted by type I afferents receiving axodendritic efferent contacts; OHCs are contacted by type II afferents and axosomatically terminating efferents. Using an
Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abd8637
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Article ; Online: Regulation of autophagy by p38alpha MAPK.

Webber, Jemma L

Autophagy

2010 Volume 6, Issue 2, Page(s) 292–293

MeSH term(s)	Animals ; Autophagy/physiology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mitogen-Activated Protein Kinase 14/metabolism
Chemical Substances	Membrane Proteins ; Mitogen-Activated Protein Kinase 14 (EC 2.7.11.24)
Language	English
Publishing date	2010-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.4161/auto.6.2.11128
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Zs.A 6741: Show issues

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Article ; Online: Long-range integration of repressive and patterning inputs.

Webber, Jemma L / Rebay, Ilaria

Cell cycle (Georgetown, Tex.)

2014 Volume 13, Issue 11, Page(s) 1653–1654

MeSH term(s)	Animals ; Drosophila ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Enhancer Elements, Genetic/genetics ; Eye Proteins/metabolism ; Gene Expression Regulation, Developmental/physiology ; Genetic Engineering/methods ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Models, Biological ; Repressor Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	AOP protein, Drosophila ; Drosophila Proteins ; Eye Proteins ; Homeodomain Proteins ; Repressor Proteins ; Transcription Factors ; eve protein, Drosophila
Language	English
Publishing date	2014-05-08
Publishing country	United States
Document type	Editorial
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.29146
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Zs.A 5881: Show issues

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Article ; Online: Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression.

Hope, C Matthew / Webber, Jemma L / Tokamov, Sherzod A / Rebay, Ilaria

eLife

2018 Volume 7

Abstract: During development, transcriptional complexes at enhancers regulate gene expression in complex spatiotemporal patterns. To achieve robust expression without spurious activation, the affinity and specificity of transcription ... ...

Abstract	During development, transcriptional complexes at enhancers regulate gene expression in complex spatiotemporal patterns. To achieve robust expression without spurious activation, the affinity and specificity of transcription factor
MeSH term(s)	Alleles ; Animals ; Cell Lineage ; Cell Nucleus/metabolism ; DNA/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Eye Proteins/metabolism ; Models, Biological ; Mutagenesis/genetics ; Mutation/genetics ; Photoreceptor Cells, Invertebrate/cytology ; Photoreceptor Cells, Invertebrate/metabolism ; Polymerization ; Protein Aggregates ; Protein Binding ; Repressor Proteins/metabolism ; Signal Transduction ; Transcription Factors/metabolism ; Transcription, Genetic
Chemical Substances	AOP protein, Drosophila ; Drosophila Proteins ; Eye Proteins ; Protein Aggregates ; Repressor Proteins ; Transcription Factors ; DNA (9007-49-2)
Language	English
Publishing date	2018-11-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.37545
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Article ; Online: Chromatin occupancy patterns of the ETS repressor Yan: a mechanism for buffering gene expression against noise?

Webber, Jemma L / Rebay, Ilaria

Fly

2013 Volume 7, Issue 2, Page(s) 92–98

Abstract: Developmental programs are driven by transcription factors that coordinate precise patterns of gene expression. While recent publications have described the importance of coordinated action of transcriptional activators at multiple cis-regulatory modules ...

Abstract	Developmental programs are driven by transcription factors that coordinate precise patterns of gene expression. While recent publications have described the importance of coordinated action of transcriptional activators at multiple cis-regulatory modules or enhancers, the contribution of sequence-specific repressors to overall regulation and robustness of gene expression has been difficult to ascertain. The Ets transcriptional repressor Yan functions as part of a conserved network downstream of receptor tyrosine kinase (RTK) signaling in Drosophila. This network displays switch-like responsiveness to RTK signaling, with the transition from a high-Yan to a low-Yan state induced by mitogen-activated protein kinase (MAPK)-mediated phosphorylation and inactivation of Yan. The ability of Yan to self-associate through a conserved sterile α motif (SAM) is essential for Yan's repressive ability, and has been suggested to allow spreading of Yan repressive complexes along chromatin. Such a mechanism has the potential to confer both signal responsiveness and robustness to the Yan network. To explore this spreading model, we compared the genome-wide chromatin binding profiles of wild-type vs. monomeric Yan. Consistent with the starting prediction, we found that wild type chromatin occupancy at genes encoding crucial developmental regulators and core signaling pathway components occurs as clusters of peaks that "spread" over multiple kilobases. However monomeric Yan, which fails to rescue a yan null mutation and displays significantly impaired repressive ability, exhibits a broadly similar occupancy profile to that of wild-type Yan, with multi-kilobase binding at developmentally important genes. This unexpected result suggests that SAM-mediated self-association does not mediate Yan recruitment to DNA or chromatin spreading, and raises the questions of why developmentally important genes require extensive Yan chromatin occupancy and how SAM-mediated polymerization might contribute to active repressive mechanisms in this context. In this Extra View article we discuss potential mechanisms by which Yan self-association and extended chromatin occupancy may contribute to robust regulation of gene expression.
MeSH term(s)	Animals ; Chromatin/metabolism ; Chromosomes, Insect ; Drosophila/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila Proteins/physiology ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Eye Proteins/physiology ; Gene Expression Regulation ; Models, Genetic ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Repressor Proteins/physiology ; Signal Transduction
Chemical Substances	AOP protein, Drosophila ; Chromatin ; Drosophila Proteins ; Eye Proteins ; Repressor Proteins
Language	English
Publishing date	2013-04-01
Publishing country	United States
Document type	Journal Article
ISSN	1933-6942
ISSN (online)	1933-6942
DOI	10.4161/fly.24162
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Article ; Online: Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.

Boisclair Lachance, Jean-François / Webber, Jemma L / Hong, Lu / Dinner, Aaron R / Rebay, Ilaria

Genes & development

2018 Volume 32, Issue 5-6, Page(s) 389–401

Abstract: ... ...

Abstract	Cis
MeSH term(s)	Animals ; Cell Differentiation/genetics ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Drosophila Proteins/chemistry ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/embryology ; Drosophila melanogaster/genetics ; Embryo, Nonmammalian ; Enhancer Elements, Genetic/genetics ; Eye Proteins/chemistry ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Gene Expression Regulation, Developmental/genetics ; Homeodomain Proteins/chemistry ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Models, Molecular ; Myocardium/cytology ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Organogenesis/genetics ; Protein Binding ; Protein Structure, Quaternary ; Protein Transport ; Proto-Oncogene Proteins/chemistry ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	AOP protein, Drosophila ; DNA-Binding Proteins ; Drosophila Proteins ; Eye Proteins ; Homeodomain Proteins ; Nerve Tissue Proteins ; Proto-Oncogene Proteins ; Repressor Proteins ; Transcription Factors ; eve protein, Drosophila ; pnt protein, Drosophila
Language	English
Publishing date	2018-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.307132.117
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Zs.A 2292: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 54: Show issues

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Article ; Online: Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in

Webber, Jemma L / Zhang, Jie / Massey, Alex / Sanchez-Luege, Nicelio / Rebay, Ilaria

Development (Cambridge, England)

2018 Volume 145, Issue 13

Abstract: The acquisition of cellular identity during development depends on precise spatiotemporal regulation of gene expression, with combinatorial interactions between transcription factors, accessory proteins and the basal transcription machinery together ... ...

Abstract	The acquisition of cellular identity during development depends on precise spatiotemporal regulation of gene expression, with combinatorial interactions between transcription factors, accessory proteins and the basal transcription machinery together translating complex signaling inputs into appropriate gene expression outputs. The opposing repressive and activating inputs of the
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Gene Expression Regulation/physiology ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-ets/genetics ; Proto-Oncogene Proteins c-ets/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	AOP protein, Drosophila ; Basic Helix-Loop-Helix Transcription Factors ; DNA-Binding Proteins ; Drosophila Proteins ; Eye Proteins ; Nerve Tissue Proteins ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-ets ; Repressor Proteins ; Transcription Factors ; gro protein, Drosophila ; pnt protein, Drosophila
Language	English
Publishing date	2018-07-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.165985
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Zs.MG 91: Show issues

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Article: Chromatin occupancy patterns of the ETS repressor Yan

Webber, Jemma L / Rebay, Ilaria

Fly. 2013 Apr. 21, v. 7, no. 2

A mechanism for buffering gene expression against noise?

2013

Abstract	Developmental programs are driven by transcription factors that coordinate precise patterns of gene expression. While recent publications have described the importance of coordinated action of transcriptional activators at multiple cis-regulatory modules or enhancers, the contribution of sequence-specific repressors to overall regulation and robustness of gene expression has been difficult to ascertain. The Ets transcriptional repressor Yan functions as part of a conserved network downstream of receptor tyrosine kinase (RTK) signaling in Drosophila. This network displays switch-like responsiveness to RTK signaling, with the transition from a high-Yan to a low-Yan state induced by mitogen-activated protein kinase (MAPK)-mediated phosphorylation and inactivation of Yan. The ability of Yan to self-associate through a conserved sterile α motif (SAM) is essential for Yan’s repressive ability, and has been suggested to allow spreading of Yan repressive complexes along chromatin. Such a mechanism has the potential to confer both signal responsiveness and robustness to the Yan network. To explore this spreading model, we compared the genome-wide chromatin binding profiles of wild-type vs. monomeric Yan. Consistent with the starting prediction, we found that wild type chromatin occupancy at genes encoding crucial developmental regulators and core signaling pathway components occurs as clusters of peaks that “spread” over multiple kilobases. However monomeric Yan, which fails to rescue a yan null mutation and displays significantly impaired repressive ability, exhibits a broadly similar occupancy profile to that of wild-type Yan, with multi-kilobase binding at developmentally important genes. This unexpected result suggests that SAM-mediated self-association does not mediate Yan recruitment to DNA or chromatin spreading, and raises the questions of why developmentally important genes require extensive Yan chromatin occupancy and how SAM-mediated polymerization might contribute to active repressive mechanisms in this context. In this Extra View article we discuss potential mechanisms by which Yan self-association and extended chromatin occupancy may contribute to robust regulation of gene expression.
Keywords	DNA ; Drosophila ; chromatin ; exhibitions ; gene expression ; gene expression regulation ; genes ; inactivation ; loss-of-function mutation ; models ; phosphorylation ; polymerization ; prediction ; publications ; receptor protein-tyrosine kinase ; repressor proteins ; signal transduction ; sounds ; transactivators
Language	English
Dates of publication	2013-0421
Size	p. 92-98.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-light
ISSN	1933-6942
DOI	10.4161/fly.24162
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

C Matthew Hope / Jemma L Webber / Sherzod A Tokamov / Ilaria Rebay

eLife, Vol

2018 Volume 7

Abstract	During development, transcriptional complexes at enhancers regulate gene expression in complex spatiotemporal patterns. To achieve robust expression without spurious activation, the affinity and specificity of transcription factor–DNA interactions must be precisely balanced. Protein–protein interactions among transcription factors are also critical, yet how their affinities impact enhancer output is not understood. The Drosophila transcription factor Yan provides a well-suited model to address this, as its function depends on the coordinated activities of two independent and essential domains: the DNA-binding ETS domain and the self-associating SAM domain. To explore how protein–protein affinity influences Yan function, we engineered mutants that increase SAM affinity over four orders of magnitude. This produced a dramatic subcellular redistribution of Yan into punctate structures, reduced repressive output and compromised survival. Cell-type specification and genetic interaction defects suggest distinct requirements for polymerization in different regulatory decisions. We conclude that tuned protein–protein interactions enable the dynamic spectrum of complexes that are required for proper regulation.
Keywords	ETS repressor ; photoreceptor ; eye development ; mathematical modeling ; receptor tyrosine kinase signaling ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	612 ; 570
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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