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Article ; Online: Correspondence to: "Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors".

Dobiasova, Milada

2021 Volume 335, Page(s) 148

MeSH term(s)	Atherosclerosis/diagnosis ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; Humans ; Risk Factors
Language	English
Publishing date	2021-09-04
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2021.09.004
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Article: Atherogenic index of plasma [log(triglycerides/HDL-cholesterol)]: theoretical and practical implications.

Dobiásová, Milada

Clinical chemistry

2004 Volume 50, Issue 7, Page(s) 1113–1115

MeSH term(s)	Cholesterol, HDL/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin Resistance ; Pioglitazone ; Plasma ; Randomized Controlled Trials as Topic ; Thiazolidinediones/therapeutic use ; Triglycerides/blood
Chemical Substances	Cholesterol, HDL ; Hypoglycemic Agents ; Thiazolidinediones ; Triglycerides ; Pioglitazone (X4OV71U42S)
Language	English
Publishing date	2004-06-24
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1373/clinchem.2004.033175
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Article: Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography.

Frohlich, Jiri / Dobiásová, Milada

Clinical chemistry

2003 Volume 49, Issue 11, Page(s) 1873–1880

Abstract: Background: We examined the predictive value of various clinical and biochemical markers for angiographically defined coronary artery disease (aCAD). Specifically, we assessed the value of the ratio of plasma triglyceride (TGs) to HDL-cholesterol (HDL-C) ...

Abstract	Background: We examined the predictive value of various clinical and biochemical markers for angiographically defined coronary artery disease (aCAD). Specifically, we assessed the value of the ratio of plasma triglyceride (TGs) to HDL-cholesterol (HDL-C) and the fractional esterification rate of cholesterol in plasma depleted of apolipoprotein B (apoB)-containing lipoproteins (FER(HDL)), a functional marker of HDL and LDL particle size. Methods: Patients (788 men and 320 women) undergoing coronary angiography were classified into groups with positive [aCAD(+)] and negative [aCAD(-)] findings. Patient age, body mass index, waist circumference, blood pressure (BP), medications, drinking, smoking, exercise habits, and plasma total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-unesterified cholesterol, HDL-C, TGs, FER(HDL), apoB, log(TG/HDL-C), and TC/HDL-C were assessed. Lipids and apoproteins were measured by standard laboratory procedures; FER(HDL) was determined by a radioassay. Results: Members of the aCAD(+) group were older and had a higher incidence of smoking and diabetes than those in the aCAD(-) group. The aCAD(+) group also had higher TG, apoB, FER(HDL), and log(TG/HDL-C) and lower HDL-C values. aCAD(+) women had greater waist circumference and higher plasma TC and TC/HDL-C. aCAD(+) men, but not women, had higher plasma LDL-C. In the multivariate logistic model, the significant predictors of the presence of aCAD(+) were FER(HDL), age, smoking, and diabetes. If only laboratory tests were included in the multivariate logistic model, FER(HDL) appeared as the sole predictor of aCAD(+). Log(TG/HDL-C) was an independent predictor when FER(HDL) was omitted from multivariate analysis. Conclusions: FER(HDL) was the best laboratory predictor of the presence of coronary atherosclerotic lesions.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Cholesterol/blood ; Cholesterol/metabolism ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Coronary Angiography ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/diagnostic imaging ; Esterification ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Regression Analysis ; Triglycerides/blood
Chemical Substances	Biomarkers ; Cholesterol, HDL ; Cholesterol, LDL ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2003-10-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1373/clinchem.2003.022558
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Article: Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography

Dobiášová, Milada / Frohlich, Jiri / Šedová, Michaela / Cheung, Marian C / Brown, B. Greg

Journal of lipid research JLR. 2011 Mar., v. 52, no. 3

2011

Abstract: We examined the association between rate of cholesterol esterification in plasma depleted of apolipoprotein B-containing lipoproteins (FERHDL), atherogenic index of plasma (AIP) [(log (TG/HDL-C)], concentrations, and size of lipoproteins and changes in ... ...

Abstract	We examined the association between rate of cholesterol esterification in plasma depleted of apolipoprotein B-containing lipoproteins (FERHDL), atherogenic index of plasma (AIP) [(log (TG/HDL-C)], concentrations, and size of lipoproteins and changes in coronary artery stenosis in participants in the HDL-Atherosclerosis Treatment Study. A total of 160 patients was treated with simvastatin (S), niacin (N), antioxidants (A) and placebo (P) in four regimens. FERHDL was measured using a radioassay; the size and concentration of lipoprotein subclasses were determined by nuclear magnetic resonance spectroscopy. The S+N and S+N+A therapy decreased AIP and FERHDL, reduced total VLDL (mostly the large and medium size particles), decreased total LDL particles (mostly the small size), and increased total HDL particles (mostly the large size). FERHDL and AIP correlated negatively with particle sizes of HDL and LDL, positively with VLDL particle size, and closely with each other (r = 0.729). Changes in the proportions of small and large lipoprotein particles, which were reflected by FERHDL and AIP, corresponded with findings on coronary angiography. Logistic regression analysis of the changes in the coronary stenosis showed that probability of progression was best explained by FERHDL (P = 0.005). FERHDL and AIP reflect the actual composition of the lipoprotein spectrum and thus predict both the cardiovascular risk and effectiveness of therapy. AIP is already available for use in clinical practice as it can be readily calculated from the routine lipid profile.
Language	English
Dates of publication	2011-03
Size	p. 566-571.
Publishing place	American Society for Biochemistry and Molecular Biology
Document type	Article
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography.

Dobiásová, Milada / Frohlich, Jiri / Sedová, Michaela / Cheung, Marian C / Brown, B Greg

Journal of lipid research

2011 Volume 52, Issue 3, Page(s) 566–571

Abstract: We examined the association between rate of cholesterol esterification in plasma depleted of apolipoprotein B-containing lipoproteins (FER(HDL)), atherogenic index of plasma (AIP) [(log (TG/HDL-C)], concentrations, and size of lipoproteins and changes in ...

Abstract	We examined the association between rate of cholesterol esterification in plasma depleted of apolipoprotein B-containing lipoproteins (FER(HDL)), atherogenic index of plasma (AIP) [(log (TG/HDL-C)], concentrations, and size of lipoproteins and changes in coronary artery stenosis in participants in the HDL-Atherosclerosis Treatment Study. A total of 160 patients was treated with simvastatin (S), niacin (N), antioxidants (A) and placebo (P) in four regimens. FER(HDL) was measured using a radioassay; the size and concentration of lipoprotein subclasses were determined by nuclear magnetic resonance spectroscopy. The S+N and S+N+A therapy decreased AIP and FER(HDL), reduced total VLDL (mostly the large and medium size particles), decreased total LDL particles (mostly the small size), and increased total HDL particles (mostly the large size). FER(HDL) and AIP correlated negatively with particle sizes of HDL and LDL, positively with VLDL particle size, and closely with each other (r = 0.729). Changes in the proportions of small and large lipoprotein particles, which were reflected by FER(HDL) and AIP, corresponded with findings on coronary angiography. Logistic regression analysis of the changes in the coronary stenosis showed that probability of progression was best explained by FER(HDL) (P = 0.005). FER(HDL) and AIP reflect the actual composition of the lipoprotein spectrum and thus predict both the cardiovascular risk and effectiveness of therapy. AIP is already available for use in clinical practice as it can be readily calculated from the routine lipid profile.
MeSH term(s)	Antioxidants/therapeutic use ; Apolipoproteins B/metabolism ; Atherosclerosis/blood ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Cholesterol/blood ; Cholesterol/metabolism ; Coronary Angiography ; Coronary Stenosis/complications ; Coronary Stenosis/drug therapy ; Drug Combinations ; Esterification ; Humans ; Lipoproteins/blood ; Lipoproteins/chemistry ; Niacin/therapeutic use ; Particle Size ; Simvastatin/therapeutic use
Chemical Substances	Antioxidants ; Apolipoproteins B ; Drug Combinations ; Lipoproteins ; Niacin (2679MF687A) ; Cholesterol (97C5T2UQ7J) ; Simvastatin (AGG2FN16EV)
Language	English
Publishing date	2011-01-11
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1194/jlr.P011668
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Book: Úloha lecithin-cholesterol acyltransferasy (LCAT) v metabolismu cholesterolu

Dobiásová, Milada

(Studie CSAV ; 3, 85)

1985

Author's details	Milada Dobiásová
Series title	Studie CSAV ; 3, 85
MeSH term(s)	Cardiovascular Diseases/etiology ; Cholesterol, Dietary/adverse effects
Language	Czech
Size	105 p. :, ill.
Edition	Vyd. 1.
Publisher	Academia
Publishing place	Praha
Document type	Book
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Auxarthron ostraviense sp. nov., and A. umbrinum associated with non-dermatophytic onychomycosis.

Hubka, Vit / Dobiasova, Stanislava / Lyskova, Pavlina / Mallatova, Nada / Chlebkova, Jana / Skorepova, Magdalena / Kubatova, Alena / Dobias, Radim / Chudickova, Milada / Kolarik, Miroslav

Medical mycology

2013 Volume 51, Issue 6, Page(s) 614–624

Abstract: Auxarthron is a genus within the Onygenales encompassing keratinophilic species with typical ascomata (gymnothecia) consisting of anastomosing network of thick-walled hyphae and small globose or oblate ascospores. No association of this genus with ... ...

Abstract	Auxarthron is a genus within the Onygenales encompassing keratinophilic species with typical ascomata (gymnothecia) consisting of anastomosing network of thick-walled hyphae and small globose or oblate ascospores. No association of this genus with clinically relevant cases of human or animal infection has been reported. This paper describes the isolation of an undescribed Auxarthron species as an agent of proven onychomycosis affecting almost all fingernails in a man with psoriasis. The causality of the isolated fungus was verified by repeated sampling and direct microscopy revealing irregular septate hyphae. Based on micro- and macromorphological features and unique sequence data (ITS region, benA and RPB2 gene), the isolated fungus is proposed as the new species A. ostraviense. The sibling species of A. ostraviense, A. umbrinum, was isolated from three patients with suspected onychomycosis and a detailed clinical history is provided for one of these patients. All four isolates were tested for susceptibility to selected antifungal agents. Terbinafine and clotrimazole appear to be effective in vitro. The morphological identification of Auxarthron spp. is non-trivial, time-consuming and requires cultivation media other than Sabouraud glucose agar which is routinely used in dermatomycology.
MeSH term(s)	Adult ; Antifungal Agents/pharmacology ; Clotrimazole/pharmacology ; DNA, Fungal/chemistry ; DNA, Fungal/genetics ; DNA, Ribosomal Spacer/chemistry ; DNA, Ribosomal Spacer/genetics ; Female ; Fungal Proteins/genetics ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Sequence Data ; Naphthalenes/pharmacology ; Onychomycosis/microbiology ; Onygenales/classification ; Onygenales/genetics ; Onygenales/isolation & purification ; Psoriasis/complications ; Sequence Analysis, DNA
Chemical Substances	Antifungal Agents ; DNA, Fungal ; DNA, Ribosomal Spacer ; Fungal Proteins ; Naphthalenes ; Clotrimazole (G07GZ97H65) ; terbinafine (G7RIW8S0XP)
Language	English
Publishing date	2013-08
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.3109/13693786.2013.770608
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Article: Fenofibrate and rosiglitazone improve quality of lipoproteins in patients with type 2 diabetes mellitus.

Vrablík, Michal / Dobiásová, Milada / Stulc, Tomás / Kasalová, Zdislava / Dolezalová, Radka / Prázný, Martin / Fait, Tomas / Ceska, Richard

Neuro endocrinology letters

2008 Volume 29, Issue 1, Page(s) 146–150

Abstract: Background: Particle size distribution in both HDL and LDL is reflected in the fractional esterification rate of cholesterol by lecithin cholesterol acyltransferase (LCAT) in plasma depleted of apoB containing lipoproteins (FER(HDL)). We studied FER(HDL) ...

Abstract	Background: Particle size distribution in both HDL and LDL is reflected in the fractional esterification rate of cholesterol by lecithin cholesterol acyltransferase (LCAT) in plasma depleted of apoB containing lipoproteins (FER(HDL)). We studied FER(HDL) in a group of patients with type 2 diabetes and determined the impact of two different PPAR agonists (fenofibrate and rosiglitazone) on this marker of lipoprotein particle quality. Patients and methods: 66 patients with type 2 diabetes (26 women) and 32 control subjects (19 women) were included in the study. 33 patients received fenofibrate and 33 rosiglitazone as add on therapy. Average duration of treatment was 4 months. Plasma lipoprotein glucose levels were determined using an automated analyzer (COBAS Mira, Roche). LDL cholesterol concentrations were calculated by Friedewald formula. FER(HDL) was determined by a radioassay after precipitating apo-B containing particles of plasma. The assays were performed at baseline and at the end of each treatment. SPSS base program was used for statistical evaluation. Results: Both fenofibrate and rosiglitazone resulted in a significant decrease of FER(HDL) (24.62 +/- 11.27%/h vs. 19.93 +/- 10.34%/h; 20.0 +/- 6.1%/h vs. 15.8 +/- 5.8%/h, p < 0.001). Rosiglitazone was significantly more effective in FER(HDL) lowering than fenofibrate (p < 0,02) Conclusions: Both fenofibrate and rosiglitazone improve FER(HDL) in patients with type 2 diabetes. The effect is more pronounced for rosiglitazone. Qualitative change of plasma lipoproteins reflected by FER(HDL) can contribute to antiatherogenic action of PPAR agonists. On contrary, changes of lipoprotein composition induced by PPAR agonists cannot explain adverse cardiovascular effects observed in some large clinical trials with PPAR agonists.
MeSH term(s)	Aged ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cholesterol, LDL/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Fenofibrate/adverse effects ; Fenofibrate/pharmacology ; Fenofibrate/therapeutic use ; Humans ; Lipoproteins/blood ; Male ; Middle Aged ; Peroxisome Proliferator-Activated Receptors/agonists ; Phosphatidylcholine-Sterol O-Acyltransferase/blood ; Predictive Value of Tests ; Risk Factors ; Thiazolidinediones/adverse effects ; Thiazolidinediones/pharmacology ; Thiazolidinediones/therapeutic use
Chemical Substances	Biomarkers ; Cholesterol, LDL ; Lipoproteins ; Peroxisome Proliferator-Activated Receptors ; Thiazolidinediones ; rosiglitazone (05V02F2KDG) ; Phosphatidylcholine-Sterol O-Acyltransferase (EC 2.3.1.43) ; Fenofibrate (U202363UOS)
Language	English
Publishing date	2008-02
Publishing country	Sweden
Document type	Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135951-4
ISSN	0172-780X
ISSN	0172-780X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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