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Article ; Online: Posterior circulation lesions are more frequently associated with early seizures after a stroke

Argjend Shala / Afrim Blyta / Nexhmedin Shala / Dren Boshnjaku / Pranvera Ibrahimi / Fisnik Jashari

Italian Journal of Medicine, Vol 18, Iss

2024 Volume 1

Abstract: Background. Early seizures (ES) following stroke are prevalent among the elderly population, representing the most common type of acquired seizures. This study aimed to determine the incidence of ES and investigate potential associations with various ... ...

Abstract	Background. Early seizures (ES) following stroke are prevalent among the elderly population, representing the most common type of acquired seizures. This study aimed to determine the incidence of ES and investigate potential associations with various clinical and radiological factors. Materials and Methods. 260 stroke patients (mean age 72±13.2, 48.5% females) were prospectively enrolled and followed. Baseline demographic data, clinical data, stroke subtype, ES occurrence, National Institutes of Health Stroke Scale (NIHSS) scores, and Alberta Stroke Program Early CT Score (ASPECT) were collected and analyzed. Results. ES was observed in 11.6% of patients with ischemic stroke compared to 7.1% among patients with hemorrhagic stroke. ES occurred more frequently in those with posterior circulation stroke (18.5% vs. 7.1%, P=0.008) and those with NIHSS >15 (19.4% vs. 8.4%, P=0.04). In a logistic regression analysis that adjusted for vascular risk factors and NIHSS, posterior circulation stroke remained significantly associated with ES, with an odds ratio of 3.14 (95% CI 1.20 to 7.73, P=0.012). Conclusions. This study revealed that ES following stroke is more common in patients with posterior circulation lesions. These findings emphasize the need for further investigation into additional factors that may influence ES occurrence and its impact on stroke management and patient outcomes.
Keywords	Stroke ; early seizures ; posterior circulation stroke ; NIHSS ; ASPECT ; Medicine ; R
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective Study from a Single Center in Kosovo.

Komoni, Edmond / Jashari, Fisnik / Boshnjaku, Dren / Myftiu, Blerim / Pushka, Melihate / Blyta, Afrim / Nallbani-Komoni, Rajmonda

Medical science monitor : international medical journal of experimental and clinical research

2024 Volume 30, Page(s) e942992

Abstract: BACKGROUND Multiple sclerosis (MS) is treated with disease-modifying therapies (DMTs) that can increase susceptibility to viral infections. This retrospective study aimed to evaluate the presentation, management, and outcomes of patients with MS on DMTs ... ...

Abstract	BACKGROUND Multiple sclerosis (MS) is treated with disease-modifying therapies (DMTs) that can increase susceptibility to viral infections. This retrospective study aimed to evaluate the presentation, management, and outcomes of patients with MS on DMTs admitted with symptoms of COVID-19 to a single center in Prishtina, Kosovo between March 2020 and April 2022. MATERIAL AND METHODS In this observational, single-center study, we included 282 patients with MS (mean age 37.8±11, 64.9% females), of whom 272 (96.4%) had confirmed COVID-19 infection, either through the presence of antibodies in the serum or a positive PCR test. RESULTS Most patients with COVID-19 infection were either asymptomatic or mildly symptomatic, while 11 patients were hospitalized due to moderate to severe symptoms. Among those with severe infection, 2 patients have died. Patients with moderate and severe COVID-19 had more advanced MS disease (P=0.001) and higher disability scales (P<0.001). In a logistic regression analysis, advanced MS remained significantly associated with worse symptoms, even after adjusting for other risk factors, with a relative risk (RR) of 2.8 (95% CI=1.1-6.6, P=0.018). MS patients on anti-CD20 DMTs more frequently experienced moderate and severe symptoms (RR=2.1, 95% CI=1.1-4.0, P=0.012). Anti-SARS-CoV-2 IgG was also lower in patients treated with anti-CD20. Notably, patients receiving vitamin D supplementation experienced a lower frequency of moderate to severe symptoms (P=0.007). CONCLUSIONS Patients with advanced MS exhibiting higher disability scales and those on anti-CD20 therapy faced an increased risk of experiencing more pronounced symptoms after COVID-19 infection. Patients on vitamin D supplementation had better clinical outcomes.
MeSH term(s)	Female ; Humans ; Male ; Antibodies, Viral ; Blindness ; COVID-19/complications ; Kosovo/epidemiology ; Multiple Sclerosis/complications ; Retrospective Studies ; Risk Factors ; Vitamin D ; Adult ; Middle Aged
Chemical Substances	Antibodies, Viral ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.942992
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Article ; Online: EVALUATION OF VISION-RELATED QUALITY OF LIFE IN PATIENTS AFTER VITRECTOMY FOLLOWING IDIOPATHIC EPIRETINAL MEMBRANE.

Bajraktari, Gentian / Jukić, Tomislav / Vukojević, Nenad / Oroz, Martin / Bertetić, Andrea Radolović / Jashari, Fisnik

Retina (Philadelphia, Pa.)

2023 Volume 43, Issue 8, Page(s) 1331–1339

Abstract: Purpose: To evaluate the impact of different intraocular tamponades on the vision-related quality of life (VRQOL) after idiopathic epiretinal membrane (IEM) surgery with epiretinal membrane peeling.: Methods: We prospectively enrolled 50 patients ... ...

Abstract	Purpose: To evaluate the impact of different intraocular tamponades on the vision-related quality of life (VRQOL) after idiopathic epiretinal membrane (IEM) surgery with epiretinal membrane peeling. Methods: We prospectively enrolled 50 patients diagnosed with IEM who underwent pars plana vitrectomy. Patients were consecutively assigned to either the air tamponade (air) group (25 patients) or the balanced salt solution (BSS) tamponade group (25 patients). The following data were collected before and after surgery and compared between the two groups: VRQOL, best-corrected visual acuity, intraocular pressure, metamorphopsia, contrast sensitivity, and central macular thickness. Results: Pars plana vitrectomy was performed in 50 eyes. At baseline, there were no significant differences between the two groups. At 6 months postoperatively, VRQOL ( P < 0.001), best-corrected visual acuity ( P < 0.001), central macular thickness ( P < 0.001), contrast sensitivity ( P < 0.001), and metamorphopsia ( P < 0.001) improved significantly in comparison with baseline, without significant differences between the air tamponade and BSS groups. Conclusion: Removing IEM significantly improved visual function and VRQOL. Despite improvements, this study showed no difference postoperatively whether air or BSS tamponade was used during surgery. As a result, air tamponade may not be a mandatory treatment for IEM surgery and provides no additional advantage compared with BSS tamponade.
MeSH term(s)	Humans ; Epiretinal Membrane/surgery ; Vitrectomy ; Quality of Life ; Visual Acuity ; Retina ; Sodium Chloride ; Vision Disorders
Chemical Substances	Sodium Chloride (451W47IQ8X)
Language	English
Publishing date	2023-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000003821
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Article: Baló Concentric Sclerosis Mimicking Encephalitis with Seizures and Progressive Aphasia in a 26-Year-Old Woman: A Challenging Diagnostic Dilemma.

Shala, Nexhmedin / Tolaj, Ilir / Jashari, Fisnik / Malazogu, Edita / Shala, Argjend / Bajraktari, Gentiant / Ahmetgjekaj, Ilir / Dreshaj, Shemsedin

Case reports in neurology

2023 Volume 15, Issue 1, Page(s) 227–232

Abstract: Introduction: Baló's concentric sclerosis (BCS) is a rare subtype of multiple sclerosis characterized by inflammatory demyelination within the central nervous system.: Case presentation: This case report presents a challenging diagnostic scenario ... ...

Abstract	Introduction: Baló's concentric sclerosis (BCS) is a rare subtype of multiple sclerosis characterized by inflammatory demyelination within the central nervous system. Case presentation: This case report presents a challenging diagnostic scenario involving a 26-year-old woman diagnosed with BCS. Despite treatment, her condition did not ameliorate, and magnetic resonance imaging (MRI) findings remained unchanged. A subsequent stereotactic biopsy revealed tumefactive Balo disease, highlighting the intricate diagnostic and therapeutic issues surrounding BCS. Conclusion: The juxtacortical location of the BCS lesion, as observed in our case, suggests an unfavourable prognosis due to treatment-resistant seizures.
Language	English
Publishing date	2023-10-06
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2505302-4
ISSN	1662-680X
ISSN	1662-680X
DOI	10.1159/000534358
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Article ; Online: Adherence to interferon β treatment in Kosovan multiple sclerosis registry

Blerim Myftiu / Edmond Komoni / Edita Malazogu / Fisnik Jashari / Shpresa Beqiri Rashiti / Melihate Pushka / Adnan Biqku / Syzana Aliçkaj Prebreza / Valbona Rrahmani Spanca / Jehona Rrustemi Bytyqi / Nexhmedin Shala / Afrim Blyta

Italian Journal of Medicine, Vol 18, Iss

2024 Volume 1

Abstract: Background. Because of side effects, adherence to the treatment with β interferons in multiple sclerosis (MS) is low, leading to decreased treatment efficacy. This can be challenging, especially in healthcare systems where these medications are the only ... ...

Abstract	Background. Because of side effects, adherence to the treatment with β interferons in multiple sclerosis (MS) is low, leading to decreased treatment efficacy. This can be challenging, especially in healthcare systems where these medications are the only therapeutic option for the treatment of MS. Materials and Methods. The number of missed doses was calculated as a difference between the number of doses a patient had to withdraw from the treatment start to the cut-off date and the real number of doses taken from the MS unit. Missed doses were compared to gender, age, time since the diagnosis, time from the diagnosis to the treatment start, clinical type of MS, expanded disability status scale (EDSS), and duration of the treatment. Results. The adherence rate during the follow-up period was 73.8%. Patients above 40 years of age (P<0.005), higher EDSS (P<0.001), longer duration of the disease (P<0.001), longer waiting time from the diagnosis to the treatment initiation (P<0.001), and longer time on interferons (P<0.001) had lower adherence rates to the treatment. Conclusions. The findings were in correlation with studies that have used similar criteria for the determination of adherence and supported reports that adherence rate decreases with time and poses a challenge to the overall efficacy of the treatment.
Keywords	β interferon ; DMTs ; multiple sclerosis ; adherence rate ; Medicine ; R
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
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Article: A 14-Year-Old Male Patient with Kawasaki Disease Presented with Stroke after COVID-19.

Shala, Nexhmedin / Jashari, Fisnik / Boshnjaku, Dren / Shala, Argjend / Ibrahimi, Pranvera / Kukaj, Vera / Dreshaj, Shemsedin

Case reports in infectious diseases

2021 Volume 2021, Page(s) 5576440

Abstract: According to several studies, children represent only about 2% of the patients affected by the current SARS-CoV-2, and most often, they are asymptomatic. However, there is a concern about a vascular inflammatory disease which is similar to Kawasaki ... ...

Abstract	According to several studies, children represent only about 2% of the patients affected by the current SARS-CoV-2, and most often, they are asymptomatic. However, there is a concern about a vascular inflammatory disease which is similar to Kawasaki disease observed in children and adolescents weeks after infection. We report a case of Kawasaki disease presented with ischemic stroke in a 14-year-old male patient following SARS-Cov-2 infection.
Language	English
Publishing date	2021-06-12
Publishing country	Egypt
Document type	Case Reports
ZDB-ID	2627642-2
ISSN	2090-6633 ; 2090-6625
ISSN (online)	2090-6633
ISSN	2090-6625
DOI	10.1155/2021/5576440
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Article ; Online: Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Patients Receiving 4-6 Cycles of Platinum-Based and Taxane-Based Chemotherapy: A Prospective, Single-Center Study from Kosovo.

Myftiu, Blerim / Hundozi, Zylfije / Sermaxhaj, Faton / Blyta, Afrim / Shala, Nexhmedin / Jashari, Fisnik / Qorraj Bytyqi, Hasime / Hyseni, Ekrem / Kurtishi, Ilir

Medical science monitor : international medical journal of experimental and clinical research

2022 Volume 28, Page(s) e937856

Abstract: BACKGROUND Chemotherapy-induced peripheral neuropathy (CIPN) is most commonly associated with platinum-based drugs, taxanes, and vinca alkaloids. This prospective study from a single center in Kosovo aimed to evaluate CIPN in 120 patients receiving 4-6 ... ...

Abstract	BACKGROUND Chemotherapy-induced peripheral neuropathy (CIPN) is most commonly associated with platinum-based drugs, taxanes, and vinca alkaloids. This prospective study from a single center in Kosovo aimed to evaluate CIPN in 120 patients receiving 4-6 cycles of platinum-based and taxane-based chemotherapy. MATERIAL AND METHODS One hundred twenty patients underwent neurological examination and nerve conduction studies (NCS) before chemotherapy, and after 4 to 6 cycles of treatment. Sixty patients were treated with platinum-based chemotherapy, 30 were treated with taxane-based chemotherapy, and 22 patients received a combination of platinum- and taxane-based chemotherapy. The most commonly used platinum-based compounds were oxaliplatin and carboplatin, whereas the most commonly used taxane medications were paclitaxel and docetaxel. Presence of neuropathy was confirmed with neurological examination of electrophysiological criteria applicable for polyneuropathies. Total Neuropathy Score (TNSr) was used to combine clinical and electrophysiological values. RESULTS Around 90% of patients self-reported neuropathic symptoms, and in 60% of them polyneuropathy was present in NCS. All sensory and motor nerves had significantly lower amplitudes (P<0.01). Platinum-based agents caused more pronounced decrease in ulnar nerve compound motor action potential (CMAP) (P<0.05); when used solely or in combination with taxanes, they caused significant decrease in tibial nerve CMAP (P<0.01). TNSr did not reach statistical significance between groups; only clinical muscle strength showed pronounced weakness in the combined protocol (P<0.05). CONCLUSIONS These findings support previous studies and show that CIPN, including sensory and motor symptoms, is commonly associated with chemotherapy. Platinum-based chemotherapy agents were more commonly associated with ulnar and tibial nerve damage in this study population.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Bridged-Ring Compounds ; Humans ; Kosovo ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/drug therapy ; Platinum/adverse effects ; Platinum Compounds/adverse effects ; Prospective Studies ; Taxoids/adverse effects
Chemical Substances	Antineoplastic Agents ; Bridged-Ring Compounds ; Platinum Compounds ; Taxoids ; taxane (1605-68-1) ; Platinum (49DFR088MY)
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.937856
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Article ; Online: Individualizing Treatment Approaches for Epileptic Patients with Glucose Transporter Type1 (GLUT-1) Deficiency

Armond Daci / Adnan Bozalija / Fisnik Jashari / Shaip Krasniqi

International Journal of Molecular Sciences, Vol 19, Iss 1, p

2018 Volume 122

Abstract: Monogenic and polygenic mutations are important contributors in patients suffering from epilepsy, including metabolic epilepsies which are inborn errors of metabolism with a good respond to specific dietetic treatments. Heterozygous variation in solute ... ...

Abstract	Monogenic and polygenic mutations are important contributors in patients suffering from epilepsy, including metabolic epilepsies which are inborn errors of metabolism with a good respond to specific dietetic treatments. Heterozygous variation in solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) and mutations of the GLUT1/SLC2A2 gene results in the failure of glucose transport, which is related with a glucose type-1 transporter (GLUT1) deficiency syndrome (GLUT1DS). GLUT1 deficiency syndrome is a treatable disorder of glucose transport into the brain caused by a variety of mutations in the SLC2A1 gene which are the cause of different neurological disorders also with different types of epilepsy and related clinical phenotypes. Since patients continue to experience seizures due to a pharmacoresistance, an early clinical diagnosis associated with specific genetic testing in SLC2A1 pathogenic variants in clinical phenotypes could predict pure drug response and might improve safety and efficacy of treatment with the initiation of an alternative energy source including ketogenic or analog diets in such patients providing individualized strategy approaches.
Keywords	glucose transporter type-1 deficiency ; SLC2A1 ; epilepsy ; pharmacogenomic ; diet ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616 ; 610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Individualizing Treatment Approaches for Epileptic Patients with Glucose Transporter Type1 (GLUT-1) Deficiency.

Daci, Armond / Bozalija, Adnan / Jashari, Fisnik / Krasniqi, Shaip

International journal of molecular sciences

2018 Volume 19, Issue 1

Abstract	Monogenic and polygenic mutations are important contributors in patients suffering from epilepsy, including metabolic epilepsies which are inborn errors of metabolism with a good respond to specific dietetic treatments. Heterozygous variation in solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) and mutations of the GLUT1/SLC2A2 gene results in the failure of glucose transport, which is related with a glucose type-1 transporter (GLUT1) deficiency syndrome (GLUT1DS). GLUT1 deficiency syndrome is a treatable disorder of glucose transport into the brain caused by a variety of mutations in the SLC2A1 gene which are the cause of different neurological disorders also with different types of epilepsy and related clinical phenotypes. Since patients continue to experience seizures due to a pharmacoresistance, an early clinical diagnosis associated with specific genetic testing in SLC2A1 pathogenic variants in clinical phenotypes could predict pure drug response and might improve safety and efficacy of treatment with the initiation of an alternative energy source including ketogenic or analog diets in such patients providing individualized strategy approaches.
MeSH term(s)	Anticonvulsants/therapeutic use ; Epilepsy/diagnosis ; Epilepsy/drug therapy ; Epilepsy/genetics ; Genetic Testing/methods ; Glucose Transporter Type 1/deficiency ; Glucose Transporter Type 1/genetics ; Humans ; Pharmacogenetics/methods ; Precision Medicine/methods
Chemical Substances	Anticonvulsants ; Glucose Transporter Type 1 ; SLC2A1 protein, human
Language	English
Publishing date	2018-01-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms19010122
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Article ; Online: TRANSIENT ISCHEMIC ATTACK AS THE INITIAL PRESENTATION OF TAKAYASU ARTERITIS IN A YOUNG WOMAN

Dren Boshnjaku / Fisnik Jashari / Bujar Gjikolli / Edmond Komoni / Melihate Pushka / Argjend Shala / Vera Kukaj / Nexhmedin Shala

Romanian Journal of Neurology, Vol 20, Iss 2, Pp 233-

A CASE REPORT

2021 Volume 236

Abstract: Takayasu arteritis (TA) is a challenging chronic inflammatory vasculitis of large vessels with unknown etiology. It usually affects the aorta and its main branches and in few cases it affects other arteries like pulmonary and coronary. We report a case ... ...

Abstract	Takayasu arteritis (TA) is a challenging chronic inflammatory vasculitis of large vessels with unknown etiology. It usually affects the aorta and its main branches and in few cases it affects other arteries like pulmonary and coronary. We report a case of a young woman with transient ischemic attack (TIA) as the initial presentation followed later by ischemic limb syndrome and then ischemic stroke. Lack of specific diagnostic biomarkers for this disease makes early diagnosis and treatment challenging.
Keywords	takayasu arteritis ; flair ; dwi ; azathioprine ; large vessel ; vasculitis ; carotid artery ; middle cerebral artery ; frontal-parietal lobe ; occlusion ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Amaltea Medical Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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