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Article ; Online: Calcium balance in hemodialysis: More uncertainty than certainty.

Kirmizis, Dimitrios / Basile, Carlo

2020 Volume 33, Issue 2, Page(s) 103–108

Abstract: There is controversy about the choice of dialysate calcium concentration (DCa), with strong arguments both in favor of and against the use of a low or high DCa, as they can both be potentially harmful. Evidence suggests that calcium mass balance is ... ...

Abstract	There is controversy about the choice of dialysate calcium concentration (DCa), with strong arguments both in favor of and against the use of a low or high DCa, as they can both be potentially harmful. Evidence suggests that calcium mass balance is positive with a DCa 3.5 mEq/L, negative or neutral with the use of DCa 2.5 mEq/L, whereas both positive and negative balances have been observed with the use of DCa 3.0 mEq/L. Overall, the use of DCa >2.5 mEq/L is usually associated with an increase in serum calcium level and a decrease in serum PTH level and use of lower vitamin D analogue dose, with the opposite effects usually observed with the use of lower DCa. Most of the available evidence is from small-sized and crossover studies; hence, evidence should be regarded with caution and applied in a patient-specific manner. As there are a lot of significant unanswered questions regarding calcium balance and the optimal DCa in hemodialysis patients, further high-quality research is needed to clarify many still unclear aspects of calcium homeostasis and balance in these patients. In conclusion, with the existing evidence the choice of DCa needs to be individualized and contextualized in the setting of each patient's calcium balance needs and homeostatic response, taking also into account oral calcium intake (dietary and medicinal), any other relevant therapy administered, such as vitamin D analogues, the type of renal mineral bone disorder, and associated cardiovascular comorbidity.
MeSH term(s)	Calcium/metabolism ; Hemodialysis Solutions ; Humans ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/therapy ; Renal Dialysis
Chemical Substances	Hemodialysis Solutions ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-01-08
Publishing country	United States
Document type	Editorial
ZDB-ID	1028193-9
ISSN	1525-139X ; 0894-0959
ISSN (online)	1525-139X
ISSN	0894-0959
DOI	10.1111/sdi.12858
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Zs.A 2879: Show issues

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Article ; Online: The role of gastrointestinal factors in glucose metabolism in patients with ESRD: in need of a critical appraisal of data.

Kirmizis, Dimitrios A

Kidney international

2014 Volume 85, Issue 1, Page(s) 211–212

MeSH term(s)	Blood Glucose/metabolism ; Female ; Gastrointestinal Tract/metabolism ; Glucose Metabolism Disorders/etiology ; Humans ; Kidney Failure, Chronic/complications ; Male
Chemical Substances	Blood Glucose
Language	English
Publishing date	2014-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.2013.407
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Zs.A 797: Show issues

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Article ; Online: Exit-Site Relocation: A Novel, Straightforward Technique for Exit-Site Infections.

Kirmizis, Dimitrios / Bowes, Elaine / Ansari, Behzad / Cairns, Hugh

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

2019 Volume 39, Issue 4, Page(s) 350–355

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Catheter-Related Infections/etiology ; Catheter-Related Infections/therapy ; Catheters, Indwelling/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Peritoneal Dialysis/adverse effects ; Peritoneal Dialysis/methods ; Peritonitis/etiology ; Peritonitis/therapy ; Renal Insufficiency, Chronic/therapy ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2019-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	645010-6
ISSN	1718-4304 ; 0896-8608
ISSN (online)	1718-4304
ISSN	0896-8608
DOI	10.3747/pdi.2017.00214
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Zs.A 1936: Show issues

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Article ; Online: Frontiers in hemodialysis: Innovations and technological advances.

Basile, Carlo / Davenport, Andrew / Mitra, Sandip / Pal, Avishek / Stamatialis, Dimitrios / Chrysochou, Constantina / Kirmizis, Dimitrios

Artificial organs

2020 Volume 45, Issue 2, Page(s) 175–182

Abstract: As increasing demand for hemodialysis (HD) treatment incurs significant financial burden to healthcare systems and ecological burden as well, novel therapeutic approaches as well as innovations and technological advances are being sought that could lead ... ...

Abstract	As increasing demand for hemodialysis (HD) treatment incurs significant financial burden to healthcare systems and ecological burden as well, novel therapeutic approaches as well as innovations and technological advances are being sought that could lead to the development of purification devices such as dialyzers with improved characteristics and wearable technology. Novel knowledge such as the development of more accurate kinetic models, the development of novel HD membranes with the use of nanotechnology, novel manufacturing processes, and the latest technology in the science of materials have enabled novel solutions already marketed or on the verge of becoming commercially available. This collaborative article reviews the latest advances in HD as they were presented by the authors in a recent symposium titled "Frontiers in Haemodialysis," held on 12th December 2019 at the Royal Society of Medicine in London.
MeSH term(s)	Congresses as Topic ; Humans ; Inventions ; Kidney Failure, Chronic/therapy ; Membranes, Artificial ; Nanotechnology/trends ; Renal Dialysis/instrumentation ; Renal Dialysis/methods ; Renal Dialysis/trends ; Wearable Electronic Devices/trends
Chemical Substances	Membranes, Artificial
Language	English
Publishing date	2020-09-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.13798
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Zs.A 1463: Show issues

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Article ; Online: The effect of a single dose of BNT162b2 vaccine on the incidence of severe COVID-19 infection in patients on chronic hemodialysis: a single-centre study.

Cserep, Gabor / Morrow, David / Latchford, Karen / Jesset, Rachael / Dosa, Agnes / Kirmizis, Dimitrios

Clinical and experimental nephrology

2021 Volume 26, Issue 1, Page(s) 54–58

Abstract: Introduction: In this single-centre retrospective observational study, the 8-week safety and the efficiency of a single dose of BNT162b2 vaccine was studied in 83 HD patients.: Methods: All clinically stable adult ESRD patients on chronic HD for at ... ...

Abstract	Introduction: In this single-centre retrospective observational study, the 8-week safety and the efficiency of a single dose of BNT162b2 vaccine was studied in 83 HD patients. Methods: All clinically stable adult ESRD patients on chronic HD for at least 4 weeks were screened for participation in the study. Exclusion criteria for enrollment in the study included a medical history of COVID-19 infection within the last 12 weeks or delivery of both vaccine doses less than 8 weeks apart from each other. The same patients during the 8-week period that preceded the vaccination served as controls of themselves. The vaccine was administered intramuscularly in the deltoid muscle, on a dialysis day, at least 30 min either pre- or post-dialysis. The primary end-point of the study was severe COVID-19 infection, and/or death due to COVID-19 pneumonitis. Furthermore, all vaccinated patients were scrutinized for any local or systemic reactions within the first 7 days post-vaccination. Results: Amongst 113 adult HD patients in our Unit, in total 83 patients had the first 30 μg dose of the BNT162b2 vaccine and were considered eligible to be included in the study. The 8-week survival rate was 91% for the controls and 100% for the vaccine group. No life-threatening allergic reaction or other side-effect was observed post-vaccination. Conclusion: The BNT162b2 vaccine can be safely used in HD patients and seems to offer significant protection against the infection even after the first vaccine dose.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; BNT162 Vaccine/administration & dosage ; BNT162 Vaccine/adverse effects ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; England/epidemiology ; Female ; Humans ; Immunization Schedule ; Incidence ; Injections, Intramuscular ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Patient Safety ; Renal Dialysis ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; Young Adult
Chemical Substances	BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-07-29
Publishing country	Japan
Document type	Journal Article ; Observational Study
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-021-02118-4
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Zs.A 4922: Show issues

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Article ; Online: A call to optimize haemodialysis vascular access care in healthcare disrupted by COVID-19 pandemic.

Basile, Carlo / Lomonte, Carlo / Combe, Christian / Covic, Adrian / Kirmizis, Dimitrios / Liakopoulos, Vassilios / Mitra, Sandip

Journal of nephrology

2021 Volume 34, Issue 2, Page(s) 365–368

Abstract: The COVID-19 pandemic has resulted in major disruption to the delivery of both routine and urgent healthcare needs in many institutions across the globe. Vascular access (VA) for haemodalysis (HD) is considered the patient's lifeline and its maintenance ... ...

Abstract	The COVID-19 pandemic has resulted in major disruption to the delivery of both routine and urgent healthcare needs in many institutions across the globe. Vascular access (VA) for haemodalysis (HD) is considered the patient's lifeline and its maintenance is essential for the continuation of a life saving treatment. Prior to the COVID-19 pandemic, the provision of VA for dialysis was already constrained. Throughout the pandemic, inevitably, many patients with chronic kidney disease (CKD) have not received timely intervention for VA care. This could have a detrimental impact on dialysis patient outcomes in the near future and needs to be addressed urgently. Many societies have issued prioritisation to allow rationing based on clinical risk, mainly according to estimated urgency and need for treatment. The recommendations recently proposed by the European and American Vascular Societies in the COVID-19 pandemic era regarding the triage of various vascular operations into urgent, emergent and elective are debatable. VA creation and interventions maintain the lifeline of complex HD patients, and the indication for surgery and other interventions warrants patient-specific clinical judgement and pathways. Keeping the use of central venous catheters at a minimum, with the goal of creating the right access, in the right patient, at the right time, and for the right reasons, is mandatory. These strategies may require local modifications. Risk assessments may need specific "renal pathways" to be developed rather than applying standard surgical risk stratification. In conclusion, in order to recover from the second wave of COVID-19 and prepare for further phases, the provision of the best dialysis access, including peritoneal dialysis, will require working closely with the multidisciplinary team involved in the assessment, creation, cannulation, surveillance, maintenance, and salvage of definitive access.
MeSH term(s)	Arteriovenous Shunt, Surgical/standards ; Arteriovenous Shunt, Surgical/trends ; COVID-19/epidemiology ; Comorbidity ; Delivery of Health Care/standards ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Pandemics ; Renal Dialysis/standards ; Renal Dialysis/trends ; Risk Assessment
Language	English
Publishing date	2021-03-08
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-021-01002-4
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Zs.A 3369: Show issues

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Article: MPGN secondary to Lyme disease: the role of cryoglobulins.

Kirmizis, Dimitrios / Efstratiadis, Georgios

Clinical kidney journal

2013 Volume 6, Issue 3, Page(s) 349

Language	English
Publishing date	2013-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sft038
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Zs.A 6587: Show issues

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Article ; Online: Comment on 'Membranous glomerulonephritis secondary to Borrelia burgdorferi infection presenting as nephrotic syndrome'.

Kirmizis, Dimitrios / Chatzidimitriou, Dimitrios

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2010 Volume 25, Issue 5, Page(s) 1723–1727

MeSH term(s)	Glomerulonephritis, Membranous/etiology ; Humans ; Lyme Disease/complications ; Nephrotic Syndrome/etiology
Language	English
Publishing date	2010-05
Publishing country	England
Document type	Letter
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfq028
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

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Article ; Online: Letter by Gavriilaki et al regarding article, "Bacterial signatures in thrombus aspirates of patients with myocardial infarction".

Gavriilaki, Eleni / Kirmizis, Dimitrios / Chatzidimitriou, Dimitrios

Circulation

2013 Volume 128, Issue 15, Page(s) e236

MeSH term(s)	Female ; Humans ; Male ; Mouth Diseases/complications ; Myocardial Infarction/etiology ; Stomatognathic Diseases/complications ; Thrombosis/microbiology ; Thrombosis/pathology ; Viridans Streptococci/isolation & purification
Language	English
Publishing date	2013-10-08
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.113.003018
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Ui IV Zs.60: Show issues

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Article ; Online: Impact of inflammation on anti-oxidative effects of vitamin E-coated membrane dialyzer in patients on chronic hemodialysis.

Kirmizis, Dimitrios / Papagianni, Aikaterini / Efstratiadis, Georgios / Memmos, Dimitrios

Hemodialysis international. International Symposium on Home Hemodialysis

2014 Volume 18, Issue 4, Page(s) 751–757

Abstract: Hemodialysis (HD) with the use of vitamin E-coated membrane (VEM) dialyzers is shown to exert anti-inflammatory and antioxidative effects in patients with end-stage renal disease on HD. However, the association of baseline inflammatory status with the ... ...

Abstract	Hemodialysis (HD) with the use of vitamin E-coated membrane (VEM) dialyzers is shown to exert anti-inflammatory and antioxidative effects in patients with end-stage renal disease on HD. However, the association of baseline inflammatory status with the antioxidative effects of VEM has not been investigated thus far. Thirty-five stable end-stage renal disease patients treated with VEM for 6 months were enrolled in the present prospective, observational cohort study. For the previous 3 months minimum, 17 (48%) patients were dialyzed with a cellulose, eight (23%) patients with a hemophane, and 10 (29%) patients with a polysulfone 1.2 to 1.5 m(2) hollow fiber dialyzer. The effects of treatment on oxidized low-density lipoprotein (oxLDL) were stratified according to half percentiles of baseline serum logC-reactive protein and interleukin-6, and the association between treatment goal, arbitrarily defined as a minimum 30% decrease in baseline oxLDL, was assessed with the use of logistic regression analysis. The higher C-reactive protein and interleukin-6 half percentiles were independently and additively associated with a higher odds ratio for achieving treatment goal. Adjustment for baseline oxLDL, age, sex, HD duration, smoking, and body mass index did not attenuate the odds ratios, whereas the history of diabetes, as primary renal disease, significantly decreased the odds ratio for achieving treatment goal. Increased baseline C-reactive protein and interleukin-6 are independent, additive factors associated with the effect of VEM on oxLDL in HD patients.
MeSH term(s)	Cohort Studies ; Female ; Humans ; Inflammation/etiology ; Kidney Failure, Chronic/pathology ; Kidney Failure, Chronic/therapy ; Male ; Membranes, Artificial ; Middle Aged ; Oxidative Stress/physiology ; Prospective Studies ; Renal Dialysis/adverse effects ; Renal Dialysis/instrumentation ; Renal Dialysis/methods ; Vitamin E
Chemical Substances	Membranes, Artificial ; Vitamin E (1406-18-4)
Language	English
Publishing date	2014-10
Publishing country	Canada
Document type	Journal Article ; Observational Study
ZDB-ID	2192458-2
ISSN	1542-4758 ; 1492-7535
ISSN (online)	1542-4758
ISSN	1492-7535
DOI	10.1111/hdi.12154
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