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  1. Article ; Online: Fibroblast-derived

    Sefton, Elizabeth M / Gallardo, Mirialys / Tobin, Claire E / Collins, Brittany C / Colasanto, Mary P / Merrell, Allyson J / Kardon, Gabrielle

    eLife

    2022  Volume 11

    Abstract: The diaphragm is a domed muscle between the thorax and abdomen essential for breathing in mammals. Diaphragm development requires the coordinated development of muscle, connective tissue, and nerve, which are derived from different embryonic sources. ... ...

    Abstract The diaphragm is a domed muscle between the thorax and abdomen essential for breathing in mammals. Diaphragm development requires the coordinated development of muscle, connective tissue, and nerve, which are derived from different embryonic sources. Defects in diaphragm development cause the common and often lethal birth defect, congenital diaphragmatic hernias (CDH). HGF/MET signaling is required for diaphragm muscularization, but the source of HGF and the specific functions of this pathway in muscle progenitors and effects on phrenic nerve have not been explicitly tested. Using conditional mutagenesis in mice and pharmacological inhibition of MET, we demonstrate that the pleuroperitoneal folds (PPFs), transient embryonic structures that give rise to the connective tissue in the diaphragm, are the source of HGF critical for diaphragm muscularization. PPF-derived HGF is directly required for recruitment of MET+ muscle progenitors to the diaphragm and indirectly (via its effect on muscle development) required for phrenic nerve primary branching. In addition, HGF is continuously required for maintenance and motility of the pool of progenitors to enable full muscularization. Localization of HGF at the diaphragm's leading edges directs dorsal and ventral expansion of muscle and regulates its overall size and shape. Surprisingly, large muscleless regions in
    MeSH term(s) Animals ; Diaphragm ; Disease Models, Animal ; Fibroblasts/metabolism ; Hernias, Diaphragmatic, Congenital/genetics ; Mammals ; Mice ; Morphogenesis ; Phenyl Ethers/metabolism ; Thorax/metabolism
    Chemical Substances Phenyl Ethers
    Language English
    Publishing date 2022-09-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.74592
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  2. Article ; Online: Reflective supervision and reflective practice in infant mental health: A scoping review of a diverse body of literature.

    Tobin, Mary / Carney, Síle / Rogers, Elaine

    Infant mental health journal

    2023  Volume 45, Issue 1, Page(s) 79–117

    Abstract: ... of reflective supervision/consultation (RS/C). RS/C supports and facilitates relationship-based practice, and is ... in empirical research on RS/C, this scoping review aimed to give an overview of the broad range of study designs and ... outcomes by systematically charting empirical studies on RS/C in IMH-based work with children and families ...

    Abstract Reflective practice is a core component of Infant Mental Health (IMH) training and work in the form of reflective supervision/consultation (RS/C). RS/C supports and facilitates relationship-based practice, and is considered to help prevent burnout and promote work satisfaction. In response to an identified gap in empirical research on RS/C, this scoping review aimed to give an overview of the broad range of study designs and outcomes by systematically charting empirical studies on RS/C in IMH-based work with children and families. Searches of Academic Search Complete, CINAHL, MEDLINE, APA PsychArticles, APA PsycInfo, and Web of Science were supplemented with a Google Scholar search and citation searching. Following title/abstract screening (n = 233) and full-text review (n = 168), 35 reports met criteria for inclusion. Key findings were organized into four categories: Essential components and processes of RS/C; Experiences and outcomes of RS/C; Emerging issues in RS/C literature; and Measuring, researching, and reporting on RS/C. Results describe the components and experience of engaging in quality RS/C, and show that practitioners generally experience RS/C as supportive and beneficial. The existing literature has some methodological limitations and further empirical research is needed on outcomes of RS/C. Practice implications and potential future research directions are discussed.
    MeSH term(s) Child ; Infant ; Humans ; Mental Health ; Health Personnel/psychology ; Cognitive Reflection ; Thinking ; Mental Health Services
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 225602-2
    ISSN 1097-0355 ; 0163-9641
    ISSN (online) 1097-0355
    ISSN 0163-9641
    DOI 10.1002/imhj.22091
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    Zs.A 4071: Show issues Location:
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  3. Article ; Online: Parent report of physician diagnosis in pediatric food allergy: An update.

    Galic, Isabel / Warren, Christopher M / Jiang, Jialing / Tobin, Mary C / Gupta, Ruchi S

    The journal of allergy and clinical immunology. In practice

    2020  Volume 9, Issue 1, Page(s) 542–546.e2

    MeSH term(s) Child ; Food Hypersensitivity/diagnosis ; Humans ; Physicians
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.09.033
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  4. Article ; Online: Racial differences in timing of food allergen introduction.

    Brewer, Audrey G / Jiang, Jialing / Warren, Christopher M / Sharma, Hemant P / Tobin, Mary C / Assa'ad, Amal / Gupta, Ruchi S

    The journal of allergy and clinical immunology. In practice

    2021  Volume 10, Issue 1, Page(s) 329–332.e2

    MeSH term(s) Allergens ; Food Hypersensitivity ; Humans ; Race Factors
    Chemical Substances Allergens
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.10.024
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  5. Article ; Online: Sensitization to house dust mite and cockroach may mediate the racial difference in shellfish allergy.

    Thivalapill, Neil / Andy-Nweye, Aame B / Bilaver, Lucy A / Tobin, Mary C / Sharma, Hemant P / Assa'ad, Amal H / Warren, Christopher / Jiang, Jialing / Chura, Annika / Gupta, Ruchi S / Mahdavinia, Mahboobeh

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 33, Issue 8, Page(s) e13837

    MeSH term(s) Allergens ; Animals ; Antigens, Dermatophagoides ; Cockroaches ; Dermatophagoides pteronyssinus ; Dust ; Humans ; Pyroglyphidae ; Race Factors ; Shellfish Hypersensitivity
    Chemical Substances Allergens ; Antigens, Dermatophagoides ; Dust
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13837
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    Zs.A 3096: Show issues Location:
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  6. Article ; Online: Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children.

    Dileep, Anandu / Warren, Christopher / Bilaver, Lucy A / Stephen, Ellen / Andy-Nweye, Aame B / Fox, Susan / Jiang, Jialing / Newmark, Pamela J / Chura, Annika / Abdikarim, Iman / Nimmagadda, Sai R / Sharma, Hemant P / Tobin, Mary C / Assa'ad, Amal H / Gupta, Ruchi S / Mahdavinia, Mahboobeh

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 4, Page(s) 1169–1176

    Abstract: Background: Previous studies have reported that Black children with food allergy (FA) have higher risk of atopic comorbidities than White children.: Objective: Our study sought to understand if disparities in the prevalence of atopic comorbidities ... ...

    Abstract Background: Previous studies have reported that Black children with food allergy (FA) have higher risk of atopic comorbidities than White children.
    Objective: Our study sought to understand if disparities in the prevalence of atopic comorbidities among children with FA are driven by individual and community-level socioeconomic status (SES).
    Methods: We analyzed data from a prospective, multicenter cohort investigating the natural history of pediatric atopy: the Food Allergy Outcomes Related to White and African American Racial Differences (FORWARD) study. A validated, multicomponent area deprivation index (ADI) percentile score was tabulated by the census block group for each subject's home address. The association of ADI with atopic comorbidities in FA was assessed via multivariable regression analysis.
    Results: Of the 700 children in this study, the mean ADI was 37.7 (95% confidence interval: 35.6-39.7). The mean ADI was higher in children with asthma (43.3) compared with those without asthma (31.8), which remained significant after adjusting for race (P < .0001). Children with allergic rhinitis (AR) had a higher mean ADI (39.1) compared with those without (33.4) (P = .008). ADI was associated with secondhand smoking, parents' education, and household income. Black children had a higher risk for asthma after adjusting for ADI and SES-related factors.
    Conclusion: The independent association of ADI with asthma and AR, regardless of race, suggests a role of neighborhood-level socioeconomic deprivation in the development of these conditions among children with FA. Black children with FA remained at higher risk for asthma after adjusting for SES-related variables, which can indicate an independent risk for asthma in these children.
    MeSH term(s) Child ; Humans ; Prospective Studies ; Prevalence ; Hypersensitivity, Immediate ; Food Hypersensitivity/epidemiology ; Asthma/epidemiology ; Allergens ; Rhinitis, Allergic/epidemiology
    Chemical Substances Allergens
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.01.020
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  7. Article ; Online: Self-Efficacy Among Caregivers of Children With Food Allergy: A Cohort Study.

    Pappalardo, Andrea A / Herbert, Linda / Warren, Christopher / Lombard, Lisa / Ramos, Ashley / Asa'ad, Amal / Sharma, Hemant / Tobin, Mary C / Choi, Jonathan / Hultquist, Haley / Jiang, Jialing / Kulkarni, Ashwin / Mahdavinia, Mahboobeh / Vincent, Eileen / Gupta, Ruchi

    Journal of pediatric psychology

    2022  Volume 47, Issue 6, Page(s) 674–684

    Abstract: Objective: The prevalence of pediatric food allergy (FA) is increasing and, due to early disease onset, requires significant caregiver management that is associated with psychosocial burden. Caregiver perception of how they cope and handle FA-related ... ...

    Abstract Objective: The prevalence of pediatric food allergy (FA) is increasing and, due to early disease onset, requires significant caregiver management that is associated with psychosocial burden. Caregiver perception of how they cope and handle FA-related events (self-efficacy) has been linked to psychosocial outcomes in racially/geographically homogenous samples. This study explores FA-related caregiver self-efficacy and associations with FA-related caregiver quality of life (QoL) in a diverse cohort.
    Methods: Caregivers of children, diagnosed with IgE-mediated FA who identified as non-Hispanic Black or White, were recruited from U.S. academic allergy clinics. Caregivers completed demographic and medical questionnaires, the Food Allergy Self-Efficacy Scale for Parents (FASE-P), Food Allergy Independent Measure-Parent Form (FAIM), and the Food Allergy Quality of Life-Parental Burden (FAQL-PB). Bivariate and multivariate associations estimated relationships between study variables.
    Results: Caregivers of 365 children (Mage = 5.8 years, 62.2% male, 31.1% Black) were enrolled. Caregivers reported high FA self-efficacy (M = 82.06/100), moderate perceptions of risk/FA severity (FAIM: M = 3.9/7), and some limitations on the FAQL-PB (M = 3.9/7). Self-efficacy was related to lower perceptions of risk/FA severity across all demographic groups (r = -.42, p < .001). Caregivers who reported higher self-efficacy reported better QoL, particularly Black caregivers (r = .67).
    Conclusions: In this sample of caregivers of children with FA, greater self-efficacy was related to improved QoL regardless of sociodemographic factors. Caregivers' perception of risk was lower for those with greater self-efficacy. Future research into the impact of FA management on QoL among diverse caregivers is needed.
    MeSH term(s) Caregivers/psychology ; Child ; Cohort Studies ; Female ; Food Hypersensitivity/psychology ; Humans ; Male ; Quality of Life ; Self Efficacy ; Surveys and Questionnaires
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 625329-5
    ISSN 1465-735X ; 0146-8693
    ISSN (online) 1465-735X
    ISSN 0146-8693
    DOI 10.1093/jpepsy/jsab137
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    Zs.A 1713: Show issues Location:
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  8. Article ; Online: Tumor-specific cholinergic CD4

    Zheng, Chunxing / Snow, Bryan E / Elia, Andrew J / Nechanitzky, Robert / Dominguez-Brauer, Carmen / Liu, Shaofeng / Tong, Yin / Cox, Maureen A / Focaccia, Enrico / Wakeham, Andrew C / Haight, Jillian / Tobin, Chantal / Hodgson, Kelsey / Gill, Kyle T / Ma, Wei / Berger, Thorsten / Heikenwälder, Mathias / Saunders, Mary E / Fortin, Jerome /
    Leung, Suet Yi / Mak, Tak W

    Nature cancer

    2023  Volume 4, Issue 10, Page(s) 1437–1454

    Abstract: Cholinergic nerves are involved in tumor progression and dissemination. In contrast to other visceral tissues, cholinergic innervation in the hepatic parenchyma is poorly detected. It remains unclear whether there is any form of cholinergic regulation of ...

    Abstract Cholinergic nerves are involved in tumor progression and dissemination. In contrast to other visceral tissues, cholinergic innervation in the hepatic parenchyma is poorly detected. It remains unclear whether there is any form of cholinergic regulation of liver cancer. Here, we show that cholinergic T cells curtail the development of liver cancer by supporting antitumor immune responses. In a mouse multihit model of hepatocellular carcinoma (HCC), we observed activation of the adaptive immune response and induction of two populations of CD4
    MeSH term(s) Animals ; Mice ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; Programmed Cell Death 1 Receptor/genetics ; Monitoring, Immunologic ; T-Lymphocytes, Regulatory/pathology
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00624-w
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  9. Article ; Online: Racial disparity in treatment of gastroesophageal reflux disease in children with food allergy.

    Mahdavinia, Mahboobeh / Bilaver, Lucy A / Fox, Susan / Pappalardo, Andrea A / Andy-Nweye, Aame B / Sharma, Hemant P / Assa'ad, Amal H / Gupta, Ruchi S / Tobin, Mary C

    The journal of allergy and clinical immunology. In practice

    2021  Volume 10, Issue 1, Page(s) 339–342.e2

    MeSH term(s) Child ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/therapy ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/therapy ; Humans ; Infant ; Racial Groups
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.10.014
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  10. Article ; Online: Association of eosinophilic esophagitis and food pollen allergy syndrome.

    Mahdavinia, Mahboobeh / Bishehsari, Faraz / Hayat, Waqas / Elhassan, Ahmed / Tobin, Mary C / Ditto, Anne M

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2017  Volume 118, Issue 1, Page(s) 116–117

    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2016.10.012
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