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  1. Article ; Online: Significance of leukocytosis prior to cardiac device implantation.

    Kumar, Darpan S / Tompkins, Christine M / Veenhuyzen, George D / Henrikson, Charles A

    Pacing and clinical electrophysiology : PACE

    2018  Volume 41, Issue 9, Page(s) 1197–1200

    Abstract: Introduction: Infection remains a dreaded complication after cardiac implanted electronic device (CIED) placement. The prognostic value of the preoperative white blood cell (WBC) count, in the absence of other signs of infection, at time of CIED ... ...

    Abstract Introduction: Infection remains a dreaded complication after cardiac implanted electronic device (CIED) placement. The prognostic value of the preoperative white blood cell (WBC) count, in the absence of other signs of infection, at time of CIED placement as a predictor of postoperative infection, has not been previously examined.
    Methods: The study population included 1,247 consecutive device implantations over a 4-year period that met inclusion criteria. The association between preoperative WBC count and resultant infection postoperatively was examined. Early infection was defined as definite infection of the pocket or lead system or development of systemic infection identified <60 days after implantation. Preoperative WBC counts were obtained within 48 hours of the procedure.
    Results: Baseline characteristics of the population studied were mean age of 65 years, 66% men, and 72% Caucasian. Pacemakers, implantable cardioverter defibrillators (ICDs), and biventricular ICDs were implanted in 41%, 44%, and 15%, respectively. Average procedure time was 174 minutes ± 80. Of 1,247 device implantations, there were 10 infections (0.8%). Mean preprocedure WBC count in those diagnosed with infection was 8.1 × 10
    Conclusion: As an isolated finding, an elevated preprocedure WBC should not delay the implantation of an indicated device.
    MeSH term(s) Aged ; Antibiotic Prophylaxis ; Female ; Humans ; Leukocyte Count ; Leukocytosis/blood ; Leukocytosis/epidemiology ; Male ; Predictive Value of Tests ; Preoperative Period ; Prognosis ; Prosthesis-Related Infections/blood ; Prosthesis-Related Infections/epidemiology ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2018-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/pace.13443
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  2. Article ; Online: Cost advantage of different cardioverter-defibrillator devices.

    Veenhuyzen, George D

    Journal of the American College of Cardiology

    2006  Volume 48, Issue 2, Page(s) 418–9; author reply 419

    MeSH term(s) Arrhythmias, Cardiac/therapy ; Cost-Benefit Analysis ; Defibrillators, Implantable/adverse effects ; Defibrillators, Implantable/economics ; Defibrillators, Implantable/ethics ; Electric Countershock/adverse effects ; Electric Countershock/economics ; Electric Countershock/ethics ; Electric Countershock/instrumentation ; Electrodes, Implanted ; Equipment Design ; Ethics, Clinical ; Humans
    Language English
    Publishing date 2006-07-18
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2006.04.037
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  3. Article ; Online: Augmented wide area circumferential catheter ablation for reduction of atrial fibrillation recurrence (AWARE) trial: Design and rationale.

    Nair, Girish M / Birnie, David H / Wells, George A / Nery, Pablo B / Redpath, Calum J / Sarrazin, Jean-Francois / Roux, Jean-Francois / Parkash, Ratika / Bernier, Martin / Sterns, Laurence D / Novak, Paul / Veenhuyzen, George / Morillo, Carlos A / Singh, Sheldon M / Sturmer, Marcio / Chauhan, Vijay S / Angaran, Paul / Essebag, Vidal

    American heart journal

    2022  Volume 248, Page(s) 1–12

    Abstract: Background: Recurrence of atrial fibrillation (AF) after a pulmonary vein isolation procedure is often due to electrical reconnection of the pulmonary veins. Repeat ablation procedures may improve freedom from AF but are associated with increased risks ... ...

    Abstract Background: Recurrence of atrial fibrillation (AF) after a pulmonary vein isolation procedure is often due to electrical reconnection of the pulmonary veins. Repeat ablation procedures may improve freedom from AF but are associated with increased risks and health care costs. A novel ablation strategy in which patients receive "augmented" ablation lesions has the potential to reduce the risk of AF recurrence.
    Objective: The Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence (AWARE) Trial was designed to evaluate whether an augmented wide-area circumferential antral (WACA) ablation strategy will result in fewer atrial arrhythmia recurrences in patients with symptomatic paroxysmal AF, compared with a conventional WACA strategy.
    Methods/design: The AWARE trial was a multicenter, prospective, randomized, open, blinded endpoint trial that has completed recruitment (ClinicalTrials.gov NCT02150902). Patients were randomly assigned (1:1) to either the control arm (single WACAlesion set) or the interventional arm (augmented- double WACA lesion set performed after the initial WACA). The primary outcome was atrial tachyarrhythmia (AA; atrial tachycardia [AT], atrial flutter [AFl] or AF) recurrence between days 91 and 365 post catheter ablation. Patient follow-up included 14-day continuous ambulatory ECG monitoring at 3, 6, and 12 months after catheter ablation. Three questionnaires were administered during the trial- the EuroQuol-5D (EQ-5D) quality of life scale, the Canadian Cardiovascular Society Severity of Atrial Fibrillation scale, and a patient satisfaction scale.
    Discussion: The AWARE trial was designed to evaluate whether a novel approach to catheter ablation reduced the risk of AA recurrence in patients with symptomatic paroxysmal AF.
    MeSH term(s) Atrial Fibrillation ; Canada ; Catheter Ablation/methods ; Humans ; Prospective Studies ; Pulmonary Veins/surgery ; Quality of Life ; Recurrence ; Treatment Outcome
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2022.02.009
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  4. Article ; Online: Standard vs Augmented Ablation of Paroxysmal Atrial Fibrillation for Reduction of Atrial Fibrillation Recurrence: The AWARE Randomized Clinical Trial.

    Nair, Girish M / Birnie, David H / Nery, Pablo B / Redpath, Calum J / Sarrazin, Jean-Francois / Roux, Jean-Francois / Parkash, Ratika / Bernier, Martin / Sterns, Laurence D / Sapp, John / Novak, Paul / Veenhuyzen, George / Morillo, Carlos A / Singh, Sheldon M / Sadek, Mouhannad M / Golian, Mehrdad / Klein, Andres / Sturmer, Marcio / Chauhan, Vijay S /
    Angaran, Paul / Green, Martin S / Bernick, Jordan / Wells, George A / Essebag, Vidal

    JAMA cardiology

    2023  Volume 8, Issue 5, Page(s) 475–483

    Abstract: Importance: Recurrent atrial fibrillation (AF) commonly occurs after catheter ablation and is associated with patient morbidity and health care costs.: Objective: To evaluate the superiority of an augmented double wide-area circumferential ablation ( ... ...

    Abstract Importance: Recurrent atrial fibrillation (AF) commonly occurs after catheter ablation and is associated with patient morbidity and health care costs.
    Objective: To evaluate the superiority of an augmented double wide-area circumferential ablation (WACA) compared with a standard single WACA in preventing recurrent atrial arrhythmias (AA) (atrial tachycardia, atrial flutter, or atrial fibrillation [AF]) in patients with paroxysmal AF.
    Design, setting, and participants: This was a pragmatic, multicenter, prospective, randomized, open, blinded end point superiority clinical trial conducted at 10 university-affiliated centers in Canada. The trial enrolled patients 18 years and older with symptomatic paroxysmal AF from March 2015 to May 2017. Analysis took place between January and April 2022. Analyses were intention to treat.
    Interventions: Patients were randomized (1:1) to receive radiofrequency catheter ablation for pulmonary vein isolation with either a standard single WACA or an augmented double WACA.
    Main outcomes and measures: The primary outcome was AA recurrence between 91 and 365 days postablation. Patients underwent 42 days of ambulatory electrocardiography monitoring after ablation. Secondary outcomes included need for repeated catheter ablation and procedural and safety variables.
    Results: Of 398 patients, 195 were randomized to the single WACA (control) arm (mean [SD] age, 60.6 [9.3] years; 65 [33.3%] female) and 203 to the double WACA (experimental) arm (mean [SD] age, 61.5 [9.3] years; 66 [32.5%] female). Overall, 52 patients (26.7%) in the single WACA arm and 50 patients (24.6%) in the double WACA arm had recurrent AA at 1 year (relative risk, 0.92; 95% CI, 0.66-1.29; P = .64). Twenty patients (10.3%) in the single WACA arm and 15 patients (7.4%) in the double WACA arm underwent repeated catheter ablation (relative risk, 0.72; 95% CI, 0.38-1.36). Adjudicated serious adverse events occurred in 13 patients (6.7%) in the single WACA arm and 14 patients (6.9%) in the double WACA arm.
    Conclusions and relevance: In this randomized clinical trial of patients with paroxysmal AF, additional ablation by performing a double ablation lesion set did not result in improved freedom from recurrent AA compared with a standard single ablation set.
    Trial registration: ClinicalTrials.gov Identifier: NCT02150902.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Atrial Fibrillation/drug therapy ; Prospective Studies ; Atrial Flutter ; Pulmonary Veins/surgery ; Electrocardiography, Ambulatory ; Catheter Ablation/adverse effects
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.0212
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  5. Article ; Online: A unique form of a brady-tachy syndrome.

    Ilhan, Erkan / Quinn, F Russell / Exner, Derek V / Mitchell, L Brent / Veenhuyzen, George D

    Pacing and clinical electrophysiology : PACE

    2017  Volume 40, Issue 7, Page(s) 894–896

    MeSH term(s) Aged ; Bradycardia/diagnosis ; Humans ; Male ; Syndrome ; Tachycardia/diagnosis
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/pace.13120
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  6. Article ; Online: A conflict of evidence: AVNRT or junctional tachycardia?

    Lane, Christopher / Veenhuyzen, George D / Quinn, F Russell

    Heart rhythm

    2013  Volume 10, Issue 5, Page(s) 767–769

    MeSH term(s) Diagnosis, Differential ; Electrocardiography ; Female ; Humans ; Middle Aged ; Tachycardia, Atrioventricular Nodal Reentry/diagnosis ; Tachycardia, Ectopic Junctional/diagnosis
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2012.04.032
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    Zs.A 6278: Show issues Location:
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  7. Article ; Online: Termination of a long RP supraventricular tachycardia by carotid sinus massage.

    Ahmed, Mohammed A M / Clark, Lauren M / Mardell, Andrew / Veenhuyzen, George D / Wilton, Stephen B

    Journal of electrocardiology

    2017  Volume 50, Issue 6, Page(s) 975–977

    Abstract: Carotid sinus massage is a useful diagnostic and therapeutic maneuver in patients with supraventricular tachycardia. Abrupt tachycardia termination with carotid sinus massage typically indicates a mechanism dependent on the atrioventricular node. Here, ... ...

    Abstract Carotid sinus massage is a useful diagnostic and therapeutic maneuver in patients with supraventricular tachycardia. Abrupt tachycardia termination with carotid sinus massage typically indicates a mechanism dependent on the atrioventricular node. Here, we present the case of a 79-year-old patient presenting with a long-RP supraventricular tachycardia terminated with carotid sinus massage that was proven invasively to be due to a focal atrial tachycardia. We discuss mechanistic explanations for this unusual phenomenon and review the literature.
    MeSH term(s) Aged ; Carotid Sinus ; Echocardiography ; Electrocardiography ; Female ; Humans ; Massage/methods ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/physiopathology ; Tachycardia, Supraventricular/therapy
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 410286-1
    ISSN 1532-8430 ; 0022-0736
    ISSN (online) 1532-8430
    ISSN 0022-0736
    DOI 10.1016/j.jelectrocard.2017.06.021
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  8. Article ; Online: Mind the gap! An atrial tachycardia after catheter ablation for atrial fibrillation.

    Veenhuyzen, George D / Quinn, F Russell

    Journal of cardiovascular electrophysiology

    2009  Volume 20, Issue 8, Page(s) 949–951

    MeSH term(s) Aged ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Electrocardiography/methods ; Female ; Humans ; Tachycardia, Ectopic Atrial/etiology ; Tachycardia, Ectopic Atrial/physiopathology ; Tachycardia, Ectopic Atrial/surgery
    Language English
    Publishing date 2009-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.2009.01473.x
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  9. Article ; Online: Distinguishing focal from macroreentrant atrial tachycardias: has this job just become easier?

    Veenhuyzen, George D / Mitchell, L Brent

    Journal of cardiovascular electrophysiology

    2008  Volume 19, Issue 2, Page(s) 148–149

    MeSH term(s) Humans ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/physiopathology
    Language English
    Publishing date 2008-02
    Publishing country United States
    Document type Comment ; Comparative Study ; Editorial
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.2007.01027.x
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  10. Article ; Online: 4:2:1--a thoracic vein tachycardia.

    Coverett, Kelly O / Veenhuyzen, George D

    The Canadian journal of cardiology

    2008  Volume 24, Issue 9, Page(s) e64

    MeSH term(s) Adult ; Electrocardiography ; Female ; Humans ; Tachycardia, Ectopic Atrial/physiopathology ; Vena Cava, Superior/physiopathology
    Language English
    Publishing date 2008-09-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/s0828-282x(08)70677-9
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