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  1. Article ; Online: Targeted Therapeutic Drug Monitoring for Direct Oral Anticoagulants: What Is Its Potential Place and Can It Limit Black Swan Events?

    Wyse, D George

    The Canadian journal of cardiology

    2018  Volume 34, Issue 11, Page(s) 1393–1395

    MeSH term(s) Administration, Oral ; Anticoagulants ; Anticonvulsants ; Drug Monitoring ; Humans
    Chemical Substances Anticoagulants ; Anticonvulsants
    Language English
    Publishing date 2018-08-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2018.08.006
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  2. Article ; Online: Rate Control Versus Rhythm Control in the ORBIT-AF Registry: The Beat Goes On.

    Wyse, D George

    JACC. Clinical electrophysiology

    2016  Volume 2, Issue 2, Page(s) 230–232

    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Editorial
    ISSN 2405-5018
    ISSN (online) 2405-5018
    DOI 10.1016/j.jacep.2015.11.005
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  3. Article ; Online: In overweight or obese patients with atrial fibrillation, a weight reduction program reduced symptoms.

    Wyse, D George

    Annals of internal medicine

    2014  Volume 160, Issue 6, Page(s) JC6

    MeSH term(s) Cardiovascular Diseases ; Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Smoking/adverse effects
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2014-03-18
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-160-6-201403180-02006
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  4. Article ; Online: Death and digoxin: stop me if you've heard this one before.

    Wyse, D George

    The Canadian journal of cardiology

    2014  Volume 30, Issue 10, Page(s) 1145–1147

    MeSH term(s) Anti-Arrhythmia Agents/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/mortality ; Brain Ischemia/epidemiology ; Digoxin/adverse effects ; Humans ; Stroke/epidemiology
    Chemical Substances Anti-Arrhythmia Agents ; Digoxin (73K4184T59)
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2014.05.003
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  5. Article ; Online: ACP Journal Club. Short-term was less effective than long-term flecainide for preventing recurrent AF after cardioversion.

    Wyse, D George

    Annals of internal medicine

    2012  Volume 157, Issue 6, Page(s) JC3–9

    Language English
    Publishing date 2012-09-18
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-157-6-201209180-02009
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  6. Article ; Online: A critical perspective on the role of catheter ablation in management of atrial fibrillation.

    Wyse, D George

    The Canadian journal of cardiology

    2013  Volume 29, Issue 10, Page(s) 1150–1157

    Abstract: Catheter ablation for atrial fibrillation (AF) is a procedural treatment option that has yet to find its final place in AF rhythm management. So far, other than pulmonary vein isolation, it does not have an indisputable mechanistic basis. It is empirical, ...

    Abstract Catheter ablation for atrial fibrillation (AF) is a procedural treatment option that has yet to find its final place in AF rhythm management. So far, other than pulmonary vein isolation, it does not have an indisputable mechanistic basis. It is empirical, not truly individualized on the basis of a diagnostic procedure. Success for the procedure is usually couched in terms of a measure of recurrence of AF. Existing data concerning recurrence have several confounders. Recurrence data are often subjective: They are based on surveys and symptoms rather than objective electrocardiogram (ECG) determination of recurrence, patients are highly selected, concurrent use of antiarrhythmic drugs is included or excluded, redo procedures may or may not be included, and follow-up is frequently a year or less. The nature of the AF (paroxysmal, persistent, long-standing persistent) greatly impacts success rates, which range from 20% to 85%. The procedure is probably infrequently a lifelong "cure" for AF. Best estimate of the risk of a complication from each procedure is about 4.5%, the commonest being tamponade (1.3%), vascular access complications (1.5%), and stroke or transient ischemic attach (1%). Risk of a fatal complication is estimated at 0.15%. There is no convincing evidence that the procedure decreases the risk of death, stroke, or hospitalization for heart failure, but the available randomized trials have enrolled patients inappropriate for assessment of impact on these clinical outcomes. Much remains to be done. Currently the procedure is indicated for relief of symptoms in selected patients, usually who have failed antiarrhythmic drug therapy.
    MeSH term(s) Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Catheter Ablation/methods ; Electrocardiography ; Humans ; Pulmonary Veins/physiopathology ; Pulmonary Veins/surgery ; Recurrence ; Treatment Outcome
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 2013-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2013.03.001
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  7. Article ; Online: Idiopathic atrial fibrillation: a rose by any other name?

    Wyse, D George

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2012  Volume 14, Issue 2, Page(s) 151–152

    MeSH term(s) Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/epidemiology ; Heart Atria/diagnostic imaging ; Humans ; Hypertension/diagnostic imaging ; Hypertension/epidemiology ; Ultrasonography
    Language English
    Publishing date 2012-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/eur423
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    Zs.A 5434: Show issues Location:
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  8. Article ; Online: Lenient versus strict rate control in atrial fibrillation some devils in the details.

    Wyse, D George

    Journal of the American College of Cardiology

    2011  Volume 58, Issue 9, Page(s) 950–952

    MeSH term(s) Atrial Fibrillation/drug therapy ; Atrial Fibrillation/physiopathology ; Female ; Heart Rate/physiology ; Humans ; Male ; Ventricular Remodeling/physiology
    Language English
    Publishing date 2011-08-23
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2011.04.028
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    Zs.MO 196: Show issues

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  9. Article ; Online: It's health care delivery, stupid: implementing the New Canadian Cardiovascular Society atrial fibrillation treatment guidelines.

    Wyse, D George

    The Canadian journal of cardiology

    2011  Volume 27, Issue 1, Page(s) 14–18

    MeSH term(s) Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/therapy ; Canada ; Catheter Ablation/trends ; Cooperative Behavior ; Delivery of Health Care/trends ; Diffusion of Innovation ; Evidence-Based Medicine/trends ; Forecasting ; Guideline Adherence/trends ; Health Plan Implementation/trends ; Humans ; Interdisciplinary Communication ; Patient Care Team/trends ; Practice Guidelines as Topic ; Societies, Medical
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 2011-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2010.11.006
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  10. Article ; Online: Change is coming: Lead, follow, or get out of the way.

    Wyse, D George

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2009  Volume 25, Issue 3, Page(s) 163–165

    MeSH term(s) Cardiac Pacing, Artificial/trends ; Cardiology/trends ; Electric Countershock/trends ; Electrophysiologic Techniques, Cardiac/trends ; Forecasting
    Language English
    Publishing date 2009-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-009-9406-7
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