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Article ; Online: CABANA - the (not so) neutral study.

Markides, Vias

2018 Volume 39, Issue 30, Page(s) 2769

Language	English
Publishing date	2018-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehy380
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Beyond pulmonary vein isolation for persistent atrial fibrillation: sequential high-resolution mapping to guide ablation.

Malaczynska-Rajpold, Katarzyna / Jarman, Julian / Shi, Rui / Wright, Piers / Wong, Tom / Markides, Vias

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2022 Volume 65, Issue 1, Page(s) 53–62

Abstract: Purpose: We aimed to evaluate whether outcomes with ablation in persistent (PsAF) and long-standing persistent (LsPsAF) AF can be improved beyond what can be achieved with pulmonary vein isolation (PVI) alone, using individualized mapping to guide ... ...

Abstract	Purpose: We aimed to evaluate whether outcomes with ablation in persistent (PsAF) and long-standing persistent (LsPsAF) AF can be improved beyond what can be achieved with pulmonary vein isolation (PVI) alone, using individualized mapping to guide ablation. Methods: We studied 20 pts (15 M, 68 ± 11y) with PsAF (14) or LsPsAF (6) referred for first-time AF ablation. Following antral PVI, individualized mapping (IM) was performed using a high-density mapping catheter stably and fully deployed for 30 s at each of 23 ± 9 sites per patient. Activation data were reviewed, and an ablation strategy designed to intersect areas of focal and rotational activity. Mean follow-up was 429 ± 131 days. The study population was compared to a matched contemporary control cohort (CC) of 20 consecutive patients undergoing conventional ablation. Results: Despite the IM group having a higher median comorbidities score, 3.5 vs. 2.5 in the CC group, indicating potentially more complex patients and more advanced substrate, cumulative freedom from AF after a single procedure was achieved in 94% of patients in the IM group vs. 75% in the CC group at 1 year and remained the same in both groups at the conclusion of the study (p = 0.02). There was a similar trend in atrial arrhythmia-free survival between both groups (84% vs. 67% at 1 year) that did not reach statistical significance. The procedure duration was longer in the IM group by a median of 31.5 min (p = 0.004). Conclusions: Individualized mapping to guide AF ablation appears to achieve significantly greater AF-free survival compared to conventional PVI when applied as a primary ablation treatment. The results of this pilot study need to be confirmed in a larger, randomized trial.
MeSH term(s)	Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Catheter Ablation/methods ; Humans ; Pilot Projects ; Pulmonary Veins/surgery ; Recurrence ; Treatment Outcome
Language	English
Publishing date	2022-01-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-021-01115-7
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Zs.A 5214: Show issues

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Article ; Online: An early multicenter experience of the novel high-density star-shaped mapping catheter in complex arrhythmias.

Sarkozy, Andrea / Vijgen, Johan / De Potter, Tom / Schilling, Richard / Markides, Vias

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2022 Volume 64, Issue 1, Page(s) 223–232

Abstract: Purpose: We aimed to assess the feasibility, safety, and operator feedback of a novel star-shaped high-density mapping catheter containing 48 platinum-iridium mapping electrodes distributed across eight spines.: Methods: This prospective, single-arm, ...

Abstract	Purpose: We aimed to assess the feasibility, safety, and operator feedback of a novel star-shaped high-density mapping catheter containing 48 platinum-iridium mapping electrodes distributed across eight spines. Methods: This prospective, single-arm, first-in-human study was conducted at five European sites. Primary endpoints were completion of pre-ablation mapping requirements, obtaining clinically indicated mapping with the new catheter without resorting to non-study mapping catheters, and incidence of serious adverse events (SAEs). Physician feedback survey assessed catheter performance, including deployment, ease of use, and mapping results. The subjects were followed for 7 days post-procedure. Results: Of 31 patients enrolled (11 ventricular tachycardia [VT], 10 scar-related atrial tachycardia [AT]/atypical atrial flutter [AFL], and 10 persistent atrial fibrillation [PsAF]), 28 had study catheter inserted for mapping purposes. Pre-ablation mapping was achieved in 23/28 patients (82.1%). Median of total pre-ablation mapping times were 121.0, 72.5, and 31.5 min for the VT, scar-related AT/atypical AFL, and PsAF subgroups, respectively. More than two-thirds of mapping points acquired were used to generate CARTO maps relevant for ablation. All 16 patients who had conduction channel(s), gaps(s), or critical isthmus identified had the areas successfully mapped. The ability to deploy, maneuver, and reach the atria and ventricles using the catheter was rated positively for most procedures. Only one SAE (heart failure) was reported, unrelated to the device. Conclusion: The study results demonstrate the feasibility of the OCTARAY catheter to successfully map complex arrhythmias with good safety profile. Operator feedback indicates satisfaction with ease of use and maneuverability of the catheter.
MeSH term(s)	Atrial Fibrillation/surgery ; Atrial Flutter/surgery ; Catheter Ablation/methods ; Catheters ; Cicatrix/surgery ; Humans ; Prospective Studies ; Tachycardia, Ventricular/surgery
Language	English
Publishing date	2022-03-26
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-022-01176-2
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Article ; Online: Angiotensin Converting Enzyme 2 May Mediate Disease Severity In COVID-19.

Gue, Ying Xuan / Kanji, Rahim / Markides, Vias / Gorog, Diana Adrienne

The American journal of cardiology

2020 Volume 130, Page(s) 161–162

MeSH term(s)	Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/physiopathology ; Gene Expression Regulation ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Pneumonia, Viral/physiopathology ; Risk Factors ; SARS-CoV-2
Chemical Substances	Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-06-09
Publishing country	United States
Document type	Letter
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2020.06.002
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Article: Relevance of electrical connectivity between the coronary sinus and the left atrial appendage for the intentional electrical isolation of the left atrial appendage in treating persistent atrial fibrillation: Insights from the LEIO-AF study.

Ibrahim, Mokhtar / Panikker, Sandeep / Lim, Eric / Markides, Vias / Wong, Tom

HeartRhythm case reports

2018 Volume 4, Issue 9, Page(s) 420–424

Language	English
Publishing date	2018-06-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2018.06.007
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Article: Angiotensin Converting Enzyme 2 May Mediate Disease Severity In COVID-19

Gue, Ying Xuan / Kanji, Rahim / Markides, Vias / Gorog, Diana Adrienne

Am J Cardiol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #591974
Database	COVID19

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Article: Conduction system pacing learning curve: Left bundle pacing compared to His bundle pacing.

O'Connor, Matthew / Shi, Rui / Kramer, Daniel B / Riad, Omar / Hunnybun, Daniel / Jarman, Julian W E / Foran, John / Cantor, Emily / Markides, Vias / Wong, Tom

International journal of cardiology. Heart & vasculature

2023 Volume 44, Page(s) 101171

Abstract: Introduction: Conduction system pacing (CSP), consisting of His bundle pacing (HBP) or left bundle branch area pacing (LBBAP) is a rapidly developing field. These pacing techniques result in single lead left ventricular resynchronisation. Understanding ... ...

Abstract	Introduction: Conduction system pacing (CSP), consisting of His bundle pacing (HBP) or left bundle branch area pacing (LBBAP) is a rapidly developing field. These pacing techniques result in single lead left ventricular resynchronisation. Understanding of the associated learning curve of the two techniques is an important consideration for new implanters/implanting centres. Methods: We conducted a review of the first 30 cases of both HBP and LBBAP at The Royal Brompton Hospital. The procedural duration and fluoroscopy time were used as surrogates for the learning curve of each technique. Results: Patient characteristics were similar in HBP and LBBAP groups; LV ejection fraction (46% vs 54%, p = 0.08), pre-procedural QRS duration (119 ms vs 128 ms, p = 0.32).Mean procedural duration was shorter for LBBAP than for HBP (87 vs 107mins, p = 0.04) and the drop in procedural duration was more marked in LBBAP, plateauing and remaining low at 80mins after the initial 10 cases. Fluoroscopic screening time mirrored procedural duration (8 min vs 16 min, p < 0.01). Discussion/conclusion: Our data suggest that the CSP learning curve was shorter for LBBAP than for HBP and appears to plateaux after the first 10 cases, however the HBP learning curve is longer with continued improvement over the first 30 cases. The shorter learning curve of LBBAP in conjunction with the superior electrical parameters and simplified programming mean the establishment of a CSP program is potentially easier with LBBAP compared to with HBP.
Language	English
Publishing date	2023-01-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2023.101171
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Article ; Online: Angiotensin Converting Enzyme 2 May Mediate Disease Severity In COVID-19

Gue, Ying Xuan / Kanji, Rahim / Markides, Vias / Gorog, Diana Adrienne

The American Journal of Cardiology

2020 Volume 130, Page(s) 161–162

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2020.06.002
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Left Atrial Function Predicts Atrial Arrhythmia Recurrence Following Ablation of Long-Standing Persistent Atrial Fibrillation.

Khan, Habib Rehman / Yakupoglu, Haci Yakup / Kralj-Hans, Ines / Haldar, Shouvik / Bahrami, Toufan / Clague, Jonathan / De Souza, Anthony / Hussain, Wajid / Jarman, Julian / Jones, David Gareth / Salukhe, Tushar / Markides, Vias / Gupta, Dhiraj / Khattar, Rajdeep / Wong, Tom

Circulation. Cardiovascular imaging

2023 Volume 16, Issue 6, Page(s) e015352

Abstract: Background: Left atrial (LA) function following catheter or surgical ablation of de-novo long-standing persistent atrial fibrillation (AF) and its impact on AF recurrence was studied in patients participating in the CASA-AF trial (Catheter Ablation vs. ... ...

Abstract	Background: Left atrial (LA) function following catheter or surgical ablation of de-novo long-standing persistent atrial fibrillation (AF) and its impact on AF recurrence was studied in patients participating in the CASA-AF trial (Catheter Ablation vs. Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation). Methods: All patients underwent echocardiography preablation, 3 and 12 months post-ablation. LA structure and function were assessed by 2-dimensional volume and speckle tracking strain measurements of LA reservoir, conduit, and contractile strain. Left ventricular diastolic function was measured using transmitral Doppler filling velocities and myocardial tissue Doppler velocities to derive the e', E/e', and E/A ratios. Continuous rhythm monitoring was achieved using an implantable loop recorder. Results: Eighty-three patients had echocardiographic data suitable for analysis. Their mean age was 63.6±9.7 years, 73.5% were male, had AF for 22.8±11.6 months, and had a mean LA maximum volume of 48.8±13.8 mL/m Conclusions: Following ablation for long-standing persistent AF, improvement in LA function was greater in those who maintained sinus rhythm. LA contractile strain at 3 months was the most important determinant of AF recurrence following ablation. Registration: URL: https://www. Clinicaltrials: gov; Unique identifier: NCT02755688.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Middle Aged ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Atrial Function, Left ; Catheter Ablation/methods ; Echocardiography/methods ; Heart Atria/diagnostic imaging ; Heart Atria/surgery ; Recurrence ; Treatment Outcome
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2435045-X
ISSN	1942-0080 ; 1941-9651
ISSN (online)	1942-0080
ISSN	1941-9651
DOI	10.1161/CIRCIMAGING.123.015352
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Article ; Online: Anatomic, histologic, and mechanical features of the right atrium: implications for leadless atrial pacemaker implantation.

O'Connor, Matthew / Barbero, Umberto / Kramer, Daniel B / Lee, Angela / Hua, Alina / Ismail, Tevfik / McCarthy, Karen P / Niederer, Steven / Rinaldi, Christopher A / Markides, Vias / Clarke, John-Ross D / Babu-Narayan, Sonya / Ho, Siew Yen / Wong, Tom

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2023 Volume 25, Issue 9

Abstract: Background: Leadless pacemakers (LPs) may mitigate the risk of lead failure and pocket infection related to conventional transvenous pacemakers. Atrial LPs are currently being investigated. However, the optimal and safest implant site is not known.: ... ...

Abstract	Background: Leadless pacemakers (LPs) may mitigate the risk of lead failure and pocket infection related to conventional transvenous pacemakers. Atrial LPs are currently being investigated. However, the optimal and safest implant site is not known. Objectives: We aimed to evaluate the right atrial (RA) anatomy and the adjacent structures using complementary analytic models [gross anatomy, cardiac magnetic resonance imaging (MRI), and computer simulation], to identify the optimal safest location to implant an atrial LP human. Methods and results: Wall thickness and anatomic relationships of the RA were studied in 45 formalin-preserved human hearts. In vivo RA anatomy was assessed in 100 cardiac MRI scans. Finally, 3D collision modelling was undertaken assessing for mechanical device interaction. Three potential locations for an atrial LP were identified; the right atrial appendage (RAA) base, apex, and RA lateral wall. The RAA base had a wall thickness of 2.7 ± 1.6 mm, with a low incidence of collision in virtual implants. The anteromedial recess of the RAA apex had a wall thickness of only 1.3 ± 0.4 mm and minimal interaction in the collision modelling. The RA lateral wall thickness was 2.6 ± 0.9 mm but is in close proximity to the phrenic nerve and sinoatrial artery. Conclusions: Based on anatomical review and 3D modelling, the best compromise for an atrial LP implantation may be the RAA base (low incidence of collision, relatively thick myocardial tissue, and without proximity to relevant epicardial structures); the anteromedial recess of the RAA apex and lateral wall are alternate sites. The mid-RAA, RA/superior vena cava junction, and septum appear to be sub-optimal fixation locations.
MeSH term(s)	Humans ; Atrial Fibrillation ; Vena Cava, Superior ; Computer Simulation ; Lipopolysaccharides ; Cardiac Pacing, Artificial/methods ; Heart Atria ; Pacemaker, Artificial
Chemical Substances	Lipopolysaccharides
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euad235
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