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  1. Article ; Online: Efficacy of a combination therapy targeting CDK4/6 and autophagy in a mouse xenograft model of t(8;21) acute myeloid leukemia.

    Matsuo, Hidemasa / Nakatani, Kana / Harata, Yutarou / Higashitani, Moe / Ito, Yuri / Inagami, Aina / Noura, Mina / Nakahata, Tatsutoshi / Adachi, Souichi

    Biochemistry and biophysics reports

    2021  Volume 27, Page(s) 101099

    Abstract: One of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML) is t(8;21 ... Although patients with t(8;21) AML have a more favorable prognosis than other cytogenetic subgroups, relapse is ... still common and novel therapeutic approaches are needed. A recent study showed that t(8;21) AML is ...

    Abstract One of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML) is t(8;21). Although patients with t(8;21) AML have a more favorable prognosis than other cytogenetic subgroups, relapse is still common and novel therapeutic approaches are needed. A recent study showed that t(8;21) AML is characterized by
    Language English
    Publishing date 2021-08-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2021.101099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy of a combination therapy targeting CDK4/6 and autophagy in a mouse xenograft model of t(8;21) acute myeloid leukemia

    Hidemasa Matsuo / Kana Nakatani / Yutarou Harata / Moe Higashitani / Yuri Ito / Aina Inagami / Mina Noura / Tatsutoshi Nakahata / Souichi Adachi

    Biochemistry and Biophysics Reports, Vol 27, Iss , Pp 101099- (2021)

    2021  

    Abstract: One of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML) is t(8;21 ... Although patients with t(8;21) AML have a more favorable prognosis than other cytogenetic subgroups, relapse is ... still common and novel therapeutic approaches are needed. A recent study showed that t(8;21) AML is ...

    Abstract One of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML) is t(8;21). Although patients with t(8;21) AML have a more favorable prognosis than other cytogenetic subgroups, relapse is still common and novel therapeutic approaches are needed. A recent study showed that t(8;21) AML is characterized by CCND2 deregulation and that co-inhibition of CDK4/6 and autophagy induces apoptosis in t(8;21) AML cells. In this study, we examined the in vivo effects of co-inhibiting CDK4/6 and autophagy. We used a mouse model in which t(8;21)-positive Kasumi-1 cells were subcutaneously inoculated into NOD/Shi-scid IL2Rgnull mice. The mice were treated with the autophagy inhibitor chloroquine (CQ), a CDK4/6 inhibitor (either abemaciclib or palbociclib), or a CDK4/6 inhibitor plus CQ. After 20 days of treatment, tumor volume was measured, and immunostaining and transmission electron microscopy observations were performed. There was no change in tumor growth in CQ-treated mice. However, mice treated with a CDK4/6 inhibitor plus CQ had significantly less tumor growth than mice treated with a CDK4/6 inhibitor alone. CDK4/6 inhibitor treatment increased the formation of autophagosomes. The number of single-strand DNA-positive (apoptotic) cells was significantly higher in the tumors of mice treated with a CDK4/6 inhibitor plus CQ than in mice treated with either CQ or a CDK4/6 inhibitor. These results show that CDK4/6 inhibition induces autophagy, and that co-inhibition of CDK4/6 and autophagy induces apoptosis in t(8;21) AML cells in vivo. The results suggest that inhibiting CDK4/6 and autophagy could be a novel and promising therapeutic strategy in t(8;21) AML.
    Keywords Leukemia ; t(8;21) ; CDK4/6 ; Autophagy ; Apoptosis ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Subject code 616
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Mitochondrial angiotensin receptors and aging.

    Inagami, Tadashi

    Circulation research

    2011  Volume 109, Issue 12, Page(s) 1323–1324

    MeSH term(s) Animals ; Humans ; Kidney/metabolism ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Receptor, Angiotensin, Type 1/metabolism ; Receptor, Angiotensin, Type 2/metabolism ; Renin-Angiotensin System/physiology
    Chemical Substances Receptor, Angiotensin, Type 1 ; Receptor, Angiotensin, Type 2
    Language English
    Publishing date 2011-12-09
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/RES.0b013e31823f05e0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes.

    Matsuo, Hidemasa / Inagami, Aina / Ito, Yuri / Ito, Nana / Iyoda, Shinju / Harata, Yutarou / Higashitani, Moe / Shoji, Kota / Tanaka, Miu / Noura, Mina / Mikami, Takashi / Kato, Itaru / Takita, Junko / Nakahata, Tatsutoshi / Adachi, Souichi

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 123

    Abstract: Acute myeloid leukemia (AML) is a malignancy characterized by differentiation arrest of hematopoietic precursor cells. Differentiation therapy is effective for patients with acute promyelocytic leukemia; however, only a few effective differentiation ... ...

    Abstract Acute myeloid leukemia (AML) is a malignancy characterized by differentiation arrest of hematopoietic precursor cells. Differentiation therapy is effective for patients with acute promyelocytic leukemia; however, only a few effective differentiation therapies have been established for patients with other AML subtypes. In this study, seven benzimidazole anthelmintics were examined to determine the effects of differentiation on AML cells. The expression of monocyte markers (CD11b and CD14) was elevated after treatment with most benzimidazole anthelmintics. Among these drugs, parbendazole (PBZ) induced AML cell differentiation at low concentration. PBZ induced the monocyte marker expression, KLF4/DPYSL2A gene expression, and apoptosis for 21 AML cell lines with various subtypes and a primary AML sample. Finally, an in vivo analysis using an AML patient-derived xenograft mouse model showed a significant decrease in the chimerism level and prolonged survival in PBZ-treated mice. These findings could lead to a more effective differentiation therapy for AML.
    MeSH term(s) Humans ; Animals ; Mice ; Cell Differentiation ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Benzimidazoles ; Disease Models, Animal ; Anthelmintics
    Chemical Substances parbendazole (N4X8WVX2UG) ; Benzimidazoles ; Anthelmintics
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-024-05811-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Managers and corporate governance reform in Japan

    Inagami, Takeshi

    Corporate governance and managerial reform in Japan , p. 163-191

    restoring self-confidence or shareholder revolution?

    2009  , Page(s) 163–191

    Author's details Takeshi Inagami
    Keywords Corporate Governance ; Reform ; Shareholder Value ; Führungskräfte ; Vergütungssystem ; Japan
    Language English
    Size graph. Darst.
    Publisher Oxford University Press
    Publishing place Oxford [u.a.]
    Document type Article
    ISBN 978-0-19-956363-0 ; 0-19-956363-2
    Database ECONomics Information System

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  6. Article: THE MECHANISM OF THE SPECIFICITY OF TRYPSIN CATALYSIS. I. INHIBITION BY ALKYL AMMONIUM IONS.

    INAGAMI, T

    The Journal of biological chemistry

    2002  Volume 239, Page(s) 787–791

    MeSH term(s) Amines ; Ammonium Compounds ; Catalysis ; Chromatography ; Enzyme Inhibitors ; Ethylamines ; Indoles ; Ions ; Quaternary Ammonium Compounds ; Research ; Thermodynamics ; Trypsin ; Tyramine
    Chemical Substances Amines ; Ammonium Compounds ; Enzyme Inhibitors ; Ethylamines ; Indoles ; Ions ; Quaternary Ammonium Compounds ; Trypsin (EC 3.4.21.4) ; Tyramine (X8ZC7V0OX3)
    Language English
    Publishing date 2002-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Spontaneous Bacterial Peritonitis Caused by Listeria monocytogenes Associated with Ascitic Fluid Lymphocytosis: A Case Report and Review of Current Empiric Therapy.

    Yecies, Todd / Inagami, Sanae

    Case reports in hepatology

    2013  Volume 2013, Page(s) 832457

    Abstract: Spontaneous bacterial peritonitis (SBP) is a potentially deadly complication of ascites. We describe a case of SBP caused by Listeria monocytogenes in a patient with alcoholic cirrhosis. This was associated with the unusual finding of ascitic fluid ... ...

    Abstract Spontaneous bacterial peritonitis (SBP) is a potentially deadly complication of ascites. We describe a case of SBP caused by Listeria monocytogenes in a patient with alcoholic cirrhosis. This was associated with the unusual finding of ascitic fluid lymphocytosis, which previously had only been associated with tuberculoid or malignant ascites. Given increasing rates of cefotaxime-resistant SBP alongside the possibility of Listeriosis, the use of cefotaxime as first-line therapy in SBP should be reevaluated.
    Language English
    Publishing date 2013-09-15
    Publishing country United States
    Document type Journal Article
    ISSN 2090-6587
    ISSN 2090-6587
    DOI 10.1155/2013/832457
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  8. Article: Molecular biology and signaling of angiotensin receptors: an overview.

    Inagami, T

    Journal of the American Society of Nephrology : JASN

    1999  Volume 10 Suppl 11, Page(s) S2–7

    Abstract: The well known diversity of angiotensin II (AngII) action is due to the diversity of its receptors and subsequent intracellular signaling initiated by them. Both type 1 and 2 receptors (AT1 and AT2) were expression-cloned from various species. AT1 was ... ...

    Abstract The well known diversity of angiotensin II (AngII) action is due to the diversity of its receptors and subsequent intracellular signaling initiated by them. Both type 1 and 2 receptors (AT1 and AT2) were expression-cloned from various species. AT1 was shown to consist of two isoforms (AT1A and AT1B) in rodents, whereas only one AT1 was found in higher mammals. Most of the functions hitherto identified with AngII were due to AT1, but diverse functions are also being identified with AT2. Although AT1 and AT2 are both G protein-coupled receptors, their signals seem to result in opposite effects. For example, AT1 causes vascular growth by activating epidermal growth factor receptors and other tyrosine kinase systems, whereas AT2 seems to activate dephosphorylating enzymes, which in extreme situations lead to apoptosis. Results of studies with AT1A null mice or ATA X AT1B dual null mice and AT2-deleted animals indicate that AT2 works in the direction of vasorelaxation as opposed to vasoconstriction by AT1. Although AT1 works mainly through Gq/11 proteins, it has been shown that AT2 binds Gialpha2 and Gialpha3. However, the exact mechanisms of these actions are not clear and much work is required in many areas.
    MeSH term(s) Amino Acid Sequence ; Animals ; Brain/metabolism ; Gene Deletion ; Kidney/metabolism ; Molecular Sequence Data ; Receptor, Angiotensin, Type 1 ; Receptor, Angiotensin, Type 2 ; Receptors, Angiotensin/chemistry ; Receptors, Angiotensin/physiology ; Sequence Homology, Amino Acid ; Signal Transduction ; Tyrosine/chemistry
    Chemical Substances Receptor, Angiotensin, Type 1 ; Receptor, Angiotensin, Type 2 ; Receptors, Angiotensin ; Tyrosine (42HK56048U)
    Language English
    Publishing date 1999-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A memorial to Robert Tiegerstedt: the centennial of renin discovery.

    Inagami, T

    Hypertension (Dallas, Tex. : 1979)

    1998  Volume 32, Issue 6, Page(s) 953–957

    MeSH term(s) Angiotensins/history ; Animals ; Biochemistry/history ; History, 19th Century ; History, 20th Century ; Humans ; Hypertension, Renovascular/etiology ; Hypertension, Renovascular/history ; Receptors, Angiotensin/history ; Receptors, Angiotensin/metabolism ; Renin/history ; Renin/metabolism ; Renin-Angiotensin System/physiology
    Chemical Substances Angiotensins ; Receptors, Angiotensin ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 1998-12
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/01.hyp.32.6.953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Changes in the employment system and future labor policies

    Inagami, Takeshi

    Japan labor review Vol. 1, No. 1 , p. 39-51

    2004  Volume 1, Issue 1, Page(s) 39–51

    Author's details Takeshi Inagami
    Keywords Industriesoziologie ; Arbeitsmarktpolitik ; Japan
    Language English
    Publishing place Tokyo
    Document type Article
    ZDB-ID 2134650-1
    Database ECONomics Information System

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