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  1. Article ; Online: Four-dimensional computational ultrasound imaging of brain hemodynamics.

    Brown, Michael D / Generowicz, Bastian S / Dijkhuizen, Stephanie / Koekkoek, Sebastiaan K E / Strydis, Christos / Bosch, Johannes G / Arvanitis, Petros / Springeling, Geert / Leus, Geert J T / De Zeeuw, Chris I / Kruizinga, Pieter

    Science advances

    2024  Volume 10, Issue 3, Page(s) eadk7957

    Abstract: Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ... ...

    Abstract Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain hemodynamics in awake and anesthetized mice.
    MeSH term(s) Mice ; Animals ; Brain/diagnostic imaging ; Ultrasonography ; Hemodynamics ; Wakefulness
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adk7957
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  2. Article ; Online: Treating Microalbuminuria-Cosmetic Exercises with Urine Chemistry or Effective Reduction of Clinical Events?: Effects of Fosinopril and Pravastatin on Cardiovascular Events in Subjects with Microalbuminuria. Circulation 110: 2809-2816, 2004.

    Asselbergs, F W / Diercks, G F / Hillege, H L / van Boven, A J / Janssen, W M / Voors, A A / de Zeeuw, D / de Jong, P E / van Veldhuisen, D J / van Gilst, W H

    Journal of the American Society of Nephrology : JASN

    2023  Volume 16, Issue 5, Page(s) 1159–1163

    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/01.asn.0000926712.23079.0b
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  3. Article ; Online: Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice.

    Jaarsma, Dick / Birkisdóttir, Maria B / van Vossen, Randy / Oomen, Demi W G D / Akhiyat, Oussama / Vermeij, Wilbert P / Koekkoek, Sebastiaan K E / De Zeeuw, Chris I / Bosman, Laurens W J

    Neurobiology of disease

    2024  Volume 192, Page(s) 106422

    Abstract: Gait ataxia is one of the most common and impactful consequences of cerebellar dysfunction. Purkinje cells, the sole output neurons of the cerebellar cortex, are often involved in the underlying pathology, but their specific functions during locomotor ... ...

    Abstract Gait ataxia is one of the most common and impactful consequences of cerebellar dysfunction. Purkinje cells, the sole output neurons of the cerebellar cortex, are often involved in the underlying pathology, but their specific functions during locomotor control in health and disease remain obfuscated. We aimed to describe the effect of gradual adult-onset Purkinje cell degeneration on gaiting patterns in mice, and to determine whether two different mechanisms that both lead to Purkinje cell degeneration cause different patterns in the development of gait ataxia. Using the ErasmusLadder together with a newly developed limb detection algorithm and machine learning-based classification, we subjected mice to a challenging locomotor task with detailed analysis of single limb parameters, intralimb coordination and whole-body movement. We tested two Purkinje cell-specific mouse models, one involving stochastic cell death due to impaired DNA repair mechanisms (Pcp2-Ercc1
    MeSH term(s) Humans ; Mice ; Animals ; Purkinje Cells/metabolism ; Gait Ataxia/metabolism ; Gait Ataxia/pathology ; Mice, Transgenic ; Spinocerebellar Ataxias/genetics ; Neurons/pathology ; Cerebellum/pathology ; Disease Models, Animal
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2024.106422
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  4. Article: Diminished antiproteinuric effect of the angiotensin receptor blocker losartan during high potassium intake in patients with CKD.

    Wouda, Rosa D / Waanders, Femke / de Zeeuw, Dick / Navis, Gerjan / Vogt, Liffert

    Clinical kidney journal

    2021  Volume 14, Issue 10, Page(s) 2170–2176

    Abstract: Background: Angiotensin II type 1 receptor blockers (ARBs) lower blood pressure (BP) and proteinuria and reduce renal disease progression in many-but not all-patients. Reduction of dietary sodium intake improves these effects of ARBs. Dietary potassium ... ...

    Abstract Background: Angiotensin II type 1 receptor blockers (ARBs) lower blood pressure (BP) and proteinuria and reduce renal disease progression in many-but not all-patients. Reduction of dietary sodium intake improves these effects of ARBs. Dietary potassium intake affects BP and proteinuria. We set out to address the effect of potassium intake on BP and proteinuria response to losartan in non-diabetic proteinuric chronic kidney disease (CKD) patients.
    Methods: We performed a
    Results: Mean potassium intake was stable during all six treatment periods. Losartan and losartan/HCT lowered BP and proteinuria in all treatment groups. Patients with high potassium intake showed no difference in the BP effects compared with patients with low potassium intake. The antiproteinuric response to losartan monotherapy and losartan combined with HCT during the habitual sodium diet was significantly diminished in patients with high potassium intake (20% versus 41%, P
    Conclusions: In proteinuric CKD patients, the proteinuria, but not BP-lowering response to losartan during a habitual high-sodium diet was hampered during high potassium intake. Differences disappeared after sodium status change by LS diet.
    Language English
    Publishing date 2021-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfab031
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  5. Article ; Online: The paradox created by commenting on large clinical trial results.

    de Zeeuw, D / Meyer, C

    Diabetes, obesity & metabolism

    2015  Volume 17, Issue 1, Page(s) 1–2

    MeSH term(s) Cardiovascular Diseases/mortality ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/drug therapy ; Female ; Humans ; Kidney Failure, Chronic/prevention & control ; Male ; Oleanolic Acid/analogs & derivatives ; Renal Insufficiency, Chronic/drug therapy
    Chemical Substances Oleanolic Acid (6SMK8R7TGJ)
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.12392
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  6. Article ; Online: Unilateral L2-Level DRG-stimulation evokes bilateral CPG-Like motor response in a patient with chronic pain.

    Soloukey, Sadaf / de Rooij, Judith D / Drenthen, Judith / De Zeeuw, Chris I / Huygen, Frank J P M / Harhangi, Biswadjiet S

    Brain stimulation

    2020  Volume 13, Issue 6, Page(s) 1719–1721

    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Letter
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2020.09.021
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  7. Article ; Online: Bilateral L2 dorsal root ganglion-stimulation suppresses lower limb spasticity following chronic motor complete Spinal Cord Injury: A case report.

    Soloukey, Sadaf / Drenthen, Judith / Osterthun, Rutger / de Rooij, Judith D / De Zeeuw, Chris I / Huygen, Frank J P M / Harhangi, Biswadjiet S

    Brain stimulation

    2020  Volume 13, Issue 3, Page(s) 637–639

    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2020.02.005
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  8. Article ; Online: Salt-The Forgotten Renal Risk Factor: Sodium Intake Affects Urinary Albumin Excretion Especially in Overweight Subjects. J Intern Med 256: 324-330, 2004.

    Verhave, J C / Hillege, H L / Burgerhof, J G M / Janssen, W M T / Gansevoort, R T / Navis, G J / de Zeeuw, D / de Jong, P E

    Journal of the American Society of Nephrology : JASN

    2021  Volume 16, Issue 3, Page(s) 571–573

    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/01.asn.0000926696.99984.f5
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  9. Article ; Online: Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries: A proof-of-concept study.

    Soloukey, S / Collée, E / Verhoef, L / Satoer, D D / Dirven, C M F / Bos, E M / Schouten, J W / Generowicz, B S / Mastik, F / De Zeeuw, C I / Koekkoek, S K E / Vincent, A J P E / Smits, M / Kruizinga, P

    NeuroImage

    2023  Volume 283, Page(s) 120435

    Abstract: Accurate, depth-resolved functional imaging is key in both understanding and treatment of the human brain. A new sonography-based imaging technique named functional Ultrasound (fUS) uniquely combines high sensitivity with submillimeter-subsecond ... ...

    Abstract Accurate, depth-resolved functional imaging is key in both understanding and treatment of the human brain. A new sonography-based imaging technique named functional Ultrasound (fUS) uniquely combines high sensitivity with submillimeter-subsecond spatiotemporal resolution available in large fields-of-view. In this proof-of-concept study we show that: (A) fUS reveals the same eloquent regions as found by fMRI while concomitantly visualizing in-vivo microvascular morphology underlying these functional hemodynamics and (B) fUS-based functional maps are confirmed by Electrocortical Stimulation Mapping (ESM), the current gold-standard in awake neurosurgical practice. This unique cross-modality experiment was performed using motor, visual and language-related functional tasks in patients undergoing awake brain tumor resection. The current work serves as an important milestone towards further maturity of fUS as well as a novel avenue to increase our understanding of hemodynamics-based functional brain imaging.
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Wakefulness/physiology ; Brain Mapping/methods ; Brain/diagnostic imaging ; Brain/surgery ; Brain/physiology ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2023.120435
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  10. Article ; Online: Controlling absence seizures from the cerebellar nuclei via activation of the G

    Schwitalla, Jan Claudius / Pakusch, Johanna / Mücher, Brix / Brückner, Alexander / Depke, Dominic Alexej / Fenzl, Thomas / De Zeeuw, Chris I / Kros, Lieke / Hoebeek, Freek E / Mark, Melanie D

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 4, Page(s) 197

    Abstract: Absence seizures (ASs) are characterized by pathological electrographic oscillations in the cerebral cortex and thalamus, which are called spike-and-wave discharges (SWDs). Subcortical structures, such as the cerebellum, may well contribute to the ... ...

    Abstract Absence seizures (ASs) are characterized by pathological electrographic oscillations in the cerebral cortex and thalamus, which are called spike-and-wave discharges (SWDs). Subcortical structures, such as the cerebellum, may well contribute to the emergence of ASs, but the cellular and molecular underpinnings remain poorly understood. Here we show that the genetic ablation of P/Q-type calcium channels in cerebellar granule cells (quirky) or Purkinje cells (purky) leads to recurrent SWDs with the purky model showing the more severe phenotype. The quirky mouse model showed irregular action potential firing of their cerebellar nuclei (CN) neurons as well as rhythmic firing during the wave of their SWDs. The purky model also showed irregular CN firing, in addition to a reduced firing rate and rhythmicity during the spike of the SWDs. In both models, the incidence of SWDs could be decreased by increasing CN activity via activation of the G
    MeSH term(s) Action Potentials/physiology ; Animals ; Cerebellar Nuclei ; Epilepsy, Absence/genetics ; Mice ; Seizures/genetics ; Signal Transduction
    Language English
    Publishing date 2022-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04221-5
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