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Article ; Online: Profiling rhythmicity of bile salt hydrolase activity in the gut lumen with a rapid fluorescence assay.

Kombala, Chathuri J / Agrawal, Neha / Sveistyte, Agne / Karatsoreos, Ilia N / Van Dongen, Hans P A / Brandvold, Kristoffer R

Organic & biomolecular chemistry

2023 Volume 21, Issue 19, Page(s) 4028–4038

Abstract: Diurnal rhythmicity of cellular function is key to survival for most organisms on Earth. Many circadian functions are driven by the brain, but regulation of a separate set of peripheral rhythms remains poorly understood. The gut microbiome is a potential ...

Abstract	Diurnal rhythmicity of cellular function is key to survival for most organisms on Earth. Many circadian functions are driven by the brain, but regulation of a separate set of peripheral rhythms remains poorly understood. The gut microbiome is a potential candidate for regulation of host peripheral rhythms, and this study sought to specifically examine the process of microbial bile salt biotransformation. To enable this work, an assay for bile salt hydrolase (BSH) that could work with small quantities of stool samples was necessary. Using a turn-on fluorescence probe, we developed a rapid and inexpensive assay to detect BSH enzyme activity with concentrations as low as 6-25 μM, which is considerably more robust than prior approaches. We successfully applied this rhodamine-based assay to detect BSH activity in a wide range of biological samples such as recombinant protein, whole cells, fecal samples, and gut lumen content from mice. We were able to detect significant BSH activity in small amounts of mouse fecal/gut content (20-50 mg) within 2 h, which illustrates its potential for use in various biological/clinical applications. Using this assay, we investigated the diurnal fluctuations of BSH activity in the large intestine of mice. By using time restricted feeding conditions, we provided direct evidence of 24 h rhythmicity in microbiome BSH activity levels and showed that this rhythmicity is influenced by feeding patterns. Our novel function-centric approach has potential to aid in the discovery of therapeutic, diet, or lifestyle interventions for correction of circadian perturbations linked to bile metabolism.
MeSH term(s)	Animals ; Mice ; Fluorescence ; Amidohydrolases/metabolism ; Bile Acids and Salts ; Circadian Rhythm
Chemical Substances	choloylglycine hydrolase (EC 3.5.1.24) ; Amidohydrolases (EC 3.5.-) ; Bile Acids and Salts
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob02257e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Central retinal vein occlusion post ChAdOx1 nCoV-19 vaccination - can it be explained by the two-hit hypothesis?

Parakh, Shweta / Maheshwari, Shrey / Das, Shrutanjoy / Vaish, Hans / Luthra, Gaurav / Agrawal, Rupesh / Gupta, Vishali / Luthra, Saurabh

Journal of ophthalmic inflammation and infection

2022 Volume 12, Issue 1, Page(s) 34

Abstract: Purpose: To report a case of central retinal vein occlusion (CRVO) seven days following the first dose of ChAdOx1 nCoV-19 vaccine and propose a hypothesis for the possible underlying pathogenesis.: Observation: A 31-year-old male presented with CRVO ... ...

Abstract	Purpose: To report a case of central retinal vein occlusion (CRVO) seven days following the first dose of ChAdOx1 nCoV-19 vaccine and propose a hypothesis for the possible underlying pathogenesis. Observation: A 31-year-old male presented with CRVO with cystoid macular edema, one week after receiving his first ChAdOx1 nCoV-19 vaccine dose. Apart from mild hyperhomocysteinemia, no major thrombophilic or systemic risk factors were found. Anti-platelet factor 4 antibodies, specific for vaccine-induced immune thrombotic thrombocytopenia, were also negative. However, he tested strongly positive (> 250 U/mL) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG spike antibodies, 2 weeks post the first dose - suggestive of a prior subclinical infection. Conclusion: COVID-19 is known to be associated with an altered host one-carbon metabolism resulting in hyperhomocysteinemia. We hypothesize that a prior subclinical infection with COVID-19, the first hit, may have led to hyperhomocysteinemia in our patient and vaccination must have been the second hit that triggered the thrombotic event. Further studies, including correlation of thrombotic complications with IgG antibody titres post-vaccination, are essential in order to better understand the pathogenesis of such events.
Language	English
Publishing date	2022-10-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2592309-2
ISSN	1869-5760
ISSN	1869-5760
DOI	10.1186/s12348-022-00311-4
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Article ; Online: Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler.

Laber, Samantha / Strobel, Sophie / Mercader, Josep M / Dashti, Hesam / Dos Santos, Felipe R C / Kubitz, Phil / Jackson, Maya / Ainbinder, Alina / Honecker, Julius / Agrawal, Saaket / Garborcauskas, Garrett / Stirling, David R / Leong, Aaron / Figueroa, Katherine / Sinnott-Armstrong, Nasa / Kost-Alimova, Maria / Deodato, Giacomo / Harney, Alycen / Way, Gregory P /

Saadat, Alham / Harken, Sierra / Reibe-Pal, Saskia / Ebert, Hannah / Zhang, Yixin / Calabuig-Navarro, Virtu / McGonagle, Elizabeth / Stefek, Adam / Dupuis, Josée / Cimini, Beth A / Hauner, Hans / Udler, Miriam S / Carpenter, Anne E / Florez, Jose C / Lindgren, Cecilia / Jacobs, Suzanne B R / Claussnitzer, Melina

Cell genomics

2023 Volume 3, Issue 7, Page(s) 100346

Abstract: A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by genetic risk variants and effector genes. Here, we introduce LipocyteProfiler, a cardiometabolic-disease- ... ...

Abstract	A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by genetic risk variants and effector genes. Here, we introduce LipocyteProfiler, a cardiometabolic-disease-oriented high-content image-based profiling tool that enables evaluation of thousands of morphological and cellular profiles that can be systematically linked to genes and genetic variants relevant to cardiometabolic disease. We show that LipocyteProfiler allows surveillance of diverse cellular programs by generating rich context- and process-specific cellular profiles across hepatocyte and adipocyte cell-state transitions. We use LipocyteProfiler to identify known and novel cellular mechanisms altered by polygenic risk of metabolic disease, including insulin resistance, fat distribution, and the polygenic contribution to lipodystrophy. LipocyteProfiler paves the way for large-scale forward and reverse deep phenotypic profiling in lipocytes and provides a framework for the unbiased identification of causal relationships between genetic variants and cellular programs relevant to human disease.
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ISSN	2666-979X
ISSN (online)	2666-979X
DOI	10.1016/j.xgen.2023.100346
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Article: Use of L-929 cell line for phototoxicity assessment.

Ray, R S / Agrawal, N / Sharma, A / Hans, R K

Toxicology in vitro : an international journal published in association with BIBRA

2008 Volume 22, Issue 7, Page(s) 1775–1781

Abstract: L-929 is an adherent type of mouse fibroblast cell line was known as an alternate test system for toxicity assessment. Its photosensitivity towards ultraviolet radiation (UVR) was studied under the exposure to various intensities of UVA, UVB and sunlight. ...

Abstract	L-929 is an adherent type of mouse fibroblast cell line was known as an alternate test system for toxicity assessment. Its photosensitivity towards ultraviolet radiation (UVR) was studied under the exposure to various intensities of UVA, UVB and sunlight. MTT assay was used for cell viability under UVR alone or in combination with chlorpromazine. UVB intensity below 0.6mW/cm2 did not show phototoxicity till 150min (min) exposure. UVA intensity up to 1.5mW/cm2 for 180min exposure did not alter the cell viability, but at 2.0 and 3.0mW/cm2 showed reduced cell viability beyond 90 and 60min, respectively. Sunlight exposure showed a loss in cell viability beyond 60min. Chlorpromazine showed a dose dependent phototoxic response under UVA, UVB and sunlight exposure. The study suggests the suitability of L-929, as an in vitro test system for the phototoxicity, which was compared with NIH-3T3 cell line. Therefore, L-929 cell line may also be used for phototoxicity assessment. The system provides information regarding the lethality of higher intensities of UVR and its importance in view of increasing UV intensities on the earth's surface due to ozone depletion. Our results suggest that a small change in UVR intensity (especially UVB) in sunlight may increase the risk of phototoxicity.
MeSH term(s)	Animals ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Chlorpromazine/administration & dosage ; Chlorpromazine/toxicity ; Dose-Response Relationship, Drug ; Fibroblasts/drug effects ; Fibroblasts/radiation effects ; L Cells (Cell Line) ; Mice ; NIH 3T3 Cells ; Sunlight ; Time Factors ; Toxicity Tests/methods ; Ultraviolet Rays
Chemical Substances	Chlorpromazine (U42B7VYA4P)
Language	English
Publishing date	2008-10
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2008.06.015
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Article: Chronic Oral Administration of Mineral Oil Compared With Corn Oil: Effects on Gut Permeability and Plasma Inflammatory and Lipid Biomarkers.

Pieterman, Elsbet J / Princen, Hans M G / Jarke, Annica / Nilsson, Ralf / Cavallin, Anders / Bergenholm, Linnéa / Henricsson, Marcus / Gopaul, V Sashi / Agrawal, Rahul / Nissen, Steven E / Hurt-Camejo, Eva

Frontiers in pharmacology

2021 Volume 12, Page(s) 681455

Abstract: We investigated the effects of chronic oral administration of mineral oil, versus corn oil as control, on intestinal permeability, inflammatory markers, and plasma lipids in APOE*3-Leiden.CETP mice. Mice received mineral oil or corn oil 15 or 30 μL/mouse/ ...

Abstract	We investigated the effects of chronic oral administration of mineral oil, versus corn oil as control, on intestinal permeability, inflammatory markers, and plasma lipids in APOE*3-Leiden.CETP mice. Mice received mineral oil or corn oil 15 or 30 μL/mouse/day for 16 weeks (15 mice/group). Intestinal permeability was increased with mineral versus corn oil 30 µL/day, shown by increased mean plasma FITC-dextran concentrations 2 h post-administration (11 weeks: 1.5 versus 1.1 μg/ml,
Language	English
Publishing date	2021-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.681455
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Article ; Online: Eligibility and Radiologic Assessment for Adjuvant Clinical Trials in Kidney Cancer.

JAMA oncology

2019 Volume 6, Issue 1, Page(s) 133–141

Abstract: Purpose: To harmonize the eligibility criteria and radiologic disease assessment definitions in clinical trials of adjuvant therapy for renal cell carcinoma (RCC).: Method: On November 28, 2017, US-based experts in RCC clinical trials, including ... ...

Abstract	Purpose: To harmonize the eligibility criteria and radiologic disease assessment definitions in clinical trials of adjuvant therapy for renal cell carcinoma (RCC). Method: On November 28, 2017, US-based experts in RCC clinical trials, including medical oncologists, urologic oncologists, regulators, biostatisticians, radiologists, and patient advocates, convened at a public workshop to discuss eligibility for trial entry and radiologic criteria for assessing disease recurrence in adjuvant trials in RCC. Multiple virtual meetings were conducted to address the issues identified at the workshop. Results: The key workshop conclusions for adjuvant RCC therapy clinical trials were as follows. First, patients with non-clear cell RCC could be routinely included, preferably in an independent cohort. Second, patients with T3-4, N+M0, and microscopic R1 RCC tumors may gain the greatest advantages from adjuvant therapy. Third, trials of agents not excreted by the kidney should not exclude patients with severe renal insufficiency. Fourth, therapy can begin 4 to 16 weeks after the surgical procedure. Fifth, patients undergoing radical or partial nephrectomy should be equally eligible. Sixth, patients with microscopically positive soft tissue or vascular margins without gross residual or radiologic disease may be included in trials. Seventh, all suspicious regional lymph nodes should be fully resected. Eighth, computed tomography should be performed within 4 weeks before trial enrollment; for patients with renal insufficiency who cannot undergo computed tomography with contrast, noncontrast chest computed tomography and magnetic resonance imaging of the abdomen and pelvis with gadolinium should be performed. Ninth, when feasible, biopsy should be undertaken to identify any malignant disease. Tenth, when biopsy is not feasible, a uniform approach should be used to evaluate indeterminate radiologic findings to identify what constitutes no evidence of disease at trial entry and what constitutes radiologic evidence of disease. Eleventh, a uniform approach for establishing the date of recurrence should be included in any trial design. Twelfth, patient perspectives on the use of placebo, conditions for unblinding, and research biopsies should be considered carefully during the conduct of an adjuvant trial. Conclusions and relevance: The discussions suggested that a uniform approach to eligibility criteria and radiologic disease assessment will lead to more consistently interpretable trial results in the adjuvant RCC therapy setting.
MeSH term(s)	Carcinoma, Renal Cell/diagnostic imaging ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/pathology ; Clinical Trials as Topic ; Humans ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/therapy ; Margins of Excision ; Neoplasm Recurrence, Local/surgery ; Nephrectomy
Language	English
Publishing date	2019-12-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2019.4117
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Article: Phototoxicity assessment of drugs and cosmetic products using E. coli.

Verma, K / Agrawal, N / Misra, R B / Farooq, M / Hans, R K

Toxicology in vitro : an international journal published in association with BIBRA

2008 Volume 22, Issue 1, Page(s) 249–253

Abstract: A gram negative bacteria Escherichia coli (Dh5alpha strain) was developed as an alternate test system of phototoxicity. Eight drugs (antibiotics) and cosmetic products (eight face creams) were examined for their phototoxicity using this test system. Five ...

Abstract	A gram negative bacteria Escherichia coli (Dh5alpha strain) was developed as an alternate test system of phototoxicity. Eight drugs (antibiotics) and cosmetic products (eight face creams) were examined for their phototoxicity using this test system. Five known phototoxic compounds were used to validate the test system. UVA-radiation induced phototoxicity of these compounds was tested by agar gel diffusion assay. Decrease in colony forming units (CFU) was taken as an end point of phototoxicity. The phototoxic compounds and antibiotics produced significant reduction in CFU (p<0.001) at 80 microg/ml concentrations under exposure to UVA-radiation (5.4-10.8 J/cm(2)). One face cream was found phototoxic and produced significant decrease in CFU of E. coli at 1.0mg/ml concentration under UVA exposure (10.8 J/cm(2)). The minimum effective concentration of tetracycline and dose of UVA-radiation were also determined by observing growth inhibition of E. coli through disc diffusion assay. The observations suggested that E. coli can be used as an alternative test system for phototoxicity evaluation of chemicals. A battery of test systems is required to conclude the toxic/phototoxic potential of a chemical agent. In view of the speed, easiness, sensitivity and low cost, E. coli is introduced as one of the alternate test system for phototoxicity studies in safety evaluation of various chemical ingredients or formulations used in cosmetics and drugs.
MeSH term(s)	Animal Testing Alternatives/methods ; Anti-Bacterial Agents/toxicity ; Colony Count, Microbial ; Cosmetics/toxicity ; Dermatitis, Phototoxic/etiology ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Microbial Sensitivity Tests/methods ; Toxicity Tests/methods ; Ultraviolet Rays
Chemical Substances	Anti-Bacterial Agents ; Cosmetics
Language	English
Publishing date	2008-02
Publishing country	England
Document type	Journal Article
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2007.08.009
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Zs.A 2223: Show issues

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Article ; Online: Photoacoustic Imaging of Human Vasculature Using LED versus Laser Illumination: A Comparison Study on Tissue Phantoms and In Vivo Humans.

Agrawal, Sumit / Kuniyil Ajith Singh, Mithun / Johnstonbaugh, Kerrick / C Han, David / R Pameijer, Colette / Kothapalli, Sri-Rajasekhar

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 2

Abstract: Vascular diseases are becoming an epidemic with an increasing aging population and increases in obesity and type II diabetes. Point-of-care (POC) diagnosis and monitoring of vascular diseases is an unmet medical need. Photoacoustic imaging (PAI) provides ...

Abstract	Vascular diseases are becoming an epidemic with an increasing aging population and increases in obesity and type II diabetes. Point-of-care (POC) diagnosis and monitoring of vascular diseases is an unmet medical need. Photoacoustic imaging (PAI) provides label-free multiparametric information of deep vasculature based on strong absorption of light photons by hemoglobin molecules. However, conventional PAI systems use bulky nanosecond lasers which hinders POC applications. Recently, light-emitting diodes (LEDs) have emerged as cost-effective and portable optical sources for the PAI of living subjects. However, state-of-art LED arrays carry significantly lower optical energy (<0.5 mJ/pulse) and high pulse repetition frequencies (PRFs) (4 KHz) compared to the high-power laser sources (100 mJ/pulse) with low PRFs of 10 Hz. Given these tradeoffs between portability, cost, optical energy and frame rate, this work systematically studies the deep tissue PAI performance of LED and laser illuminations to help select a suitable source for a given biomedical application. To draw a fair comparison, we developed a fiberoptic array that delivers laser illumination similar to the LED array and uses the same ultrasound transducer and data acquisition platform for PAI with these two illuminations. Several controlled studies on tissue phantoms demonstrated that portable LED arrays with high frame averaging show higher signal-to-noise ratios (SNRs) of up to 30 mm depth, and the high-energy laser source was found to be more effective for imaging depths greater than 30 mm at similar frame rates. Label-free in vivo imaging of human hand vasculature studies further confirmed that the vascular contrast from LED-PAI is similar to laser-PAI for up to 2 cm depths. Therefore, LED-PAI systems have strong potential to be a mobile health care technology for diagnosing vascular diseases such as peripheral arterial disease and stroke in POC and resource poor settings.
MeSH term(s)	Aged ; Cardiovascular System/diagnostic imaging ; Diabetes Mellitus, Type 2 ; Diagnostic Imaging ; Humans ; Lighting ; Phantoms, Imaging ; Photoacoustic Techniques
Language	English
Publishing date	2021-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21020424
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Article ; Online: Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.

Nucleic acids research

2017 Volume 45, Issue 18, Page(s) 10595–10613

Abstract: The integrity of genome is a prerequisite for healthy life. Indeed, defects in DNA repair have been associated with several human diseases, including tissue-fibrosis, neurodegeneration and cancer. Despite decades of extensive research, the spatio- ... ...

Abstract	The integrity of genome is a prerequisite for healthy life. Indeed, defects in DNA repair have been associated with several human diseases, including tissue-fibrosis, neurodegeneration and cancer. Despite decades of extensive research, the spatio-mechanical processes of double-strand break (DSB)-repair, especially the auxiliary factor(s) that can stimulate accurate and timely repair, have remained elusive. Here, we report an ATM-kinase dependent, unforeseen function of the nuclear isoform of the Receptor for Advanced Glycation End-products (nRAGE) in DSB-repair. RAGE is phosphorylated at Serine376 and Serine389 by the ATM kinase and is recruited to the site of DNA-DSBs via an early DNA damage response. nRAGE preferentially co-localized with the MRE11 nuclease subunit of the MRN complex and orchestrates its nucleolytic activity to the ATR kinase signaling. This promotes efficient RPA2S4-S8 and CHK1S345 phosphorylation and thereby prevents cellular senescence, IPF and carcinoma formation. Accordingly, loss of RAGE causatively linked to perpetual DSBs signaling, cellular senescence and fibrosis. Importantly, in a mouse model of idiopathic pulmonary fibrosis (RAGE-/-), reconstitution of RAGE efficiently restored DSB-repair and reversed pathological anomalies. Collectively, this study identifies nRAGE as a master regulator of DSB-repair, the absence of which orchestrates persistent DSB signaling to senescence, tissue-fibrosis and oncogenesis.
MeSH term(s)	Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Nucleus/enzymology ; Cell Nucleus/metabolism ; Cellular Senescence ; DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA Repair ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/metabolism ; Homeostasis ; Lung/physiopathology ; MRE11 Homologue Protein ; Mice, Inbred C57BL ; Mice, Knockout ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/physiopathology ; Receptor for Advanced Glycation End Products/genetics ; Receptor for Advanced Glycation End Products/metabolism ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Signal Transduction
Chemical Substances	Ager protein, mouse ; DNA-Binding Proteins ; Mre11a protein, mouse ; Receptor for Advanced Glycation End Products ; DNA (9007-49-2) ; Atr protein, mouse (EC 2.7.1.-) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; MRE11 Homologue Protein (EC 3.1.-) ; DNA Repair Enzymes (EC 6.5.1.-)
Language	English
Publishing date	2017-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkx705
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Zs.A 1067: Show issues

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Article ; Online: Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs.

Gopaul, V Sashi / Pieterman, Elsbet J / Princen, Hans M G / Bergenholm, Linnéa / Lundborg, Eva / Cavallin, Anders / Johansson, Magnus J / Hawthorne, Glen / Björkbom, Anders / Hammarberg, Maria / Li, XueQing / Jarke, Annica / Bright, Jonathan / Svensson, Lena / Jansson-Löfmark, Rasmus / Abrahamsson, Bertil / Agrawal, Rahul / Hurt-Camejo, Eva

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2021 Volume 161, Page(s) 105776

Abstract: We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a ... ...

Abstract	We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a lipophilic statin, in C57BL/6NCrl mice. The chemical structure of M1 in mice was confirmed as ortho-hydroxy β-oxidized atorvastatin. Atorvastatin and M1 pharmacokinetics and inflammatory markers were assessed in C57BL6/J mice given atorvastatin 5 mg/kg/day or 10 mg/kg/day, as a single dose or for 21 days, with or without 10 µL or 30 µL mineral oil. No consistent differences in plasma exposure of atorvastatin or M1 were observed in mice after single or repeat dosing of atorvastatin with or without mineral oil. However, mice administered atorvastatin 10 mg/kg with 30 µL mineral oil for 21 days had significantly increased plasma levels of serum amyloid A (mean 9.6 µg/mL vs 7.9 µg/mL without mineral oil; p < 0.01) and significantly increased proportions of C62L
MeSH term(s)	Animals ; Atorvastatin ; Dogs ; Heptanoic Acids ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Mice ; Mice, Inbred C57BL ; Mineral Oil ; Pravastatin ; Pyrroles
Chemical Substances	Heptanoic Acids ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Pyrroles ; Mineral Oil (8020-83-5) ; Atorvastatin (A0JWA85V8F) ; Pravastatin (KXO2KT9N0G)
Language	English
Publishing date	2021-03-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2021.105776
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