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Article ; Online: C

Bellasio, Chandra / Stuart-Williams, Hilary / Farquhar, Graham D / Flexas, Jaume

2023 Volume 240, Issue 6, Page(s) 2239–2252

Abstract: The high productive potential, heat resilience, and greater water use efficiency of C ...

Abstract	The high productive potential, heat resilience, and greater water use efficiency of C
MeSH term(s)	Zea mays/metabolism ; Triticum/metabolism ; Sorghum/metabolism ; Helianthus/metabolism ; Dehydration/metabolism ; Photosynthesis/physiology ; Plant Leaves/physiology ; Water/metabolism ; Crops, Agricultural/metabolism ; Edible Grain/metabolism ; Carbon Dioxide/metabolism
Chemical Substances	Water (059QF0KO0R) ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.19299
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Article: C. elegans

DeGroot, Melisa S / Williams, Byron / Chang, Timothy Y / Maas Gamboa, Maria L / Larus, Isabel / Fromme, J Christopher / Liu, Jun

bioRxiv : the preprint server for biology

2023

Abstract: Secreted modular calcium binding (SMOC) proteins are conserved matricellular proteins found in organisms ... ...

Abstract	Secreted modular calcium binding (SMOC) proteins are conserved matricellular proteins found in organisms from
Language	English
Publishing date	2023-01-08
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.06.523017
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Article: Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc.

Williams, Jason S / Higgins, Adam T / Stott, Katie J / Thomas, Carly / Farrell, Lydia / Bonnet, Cleo S / Peneva, Severina / Derrick, Anna V / Hay, Trevor / Wang, Tianqi / Morgan, Claire / Dwyer, Sarah / D'Ambrogio, Joshua / Hogan, Catherine / Smalley, Matthew J / Parry, Lee / Dyson, Paul

Cell & bioscience

2024 Volume 14, Issue 1, Page(s) 38

Abstract: ... to perform intracellular infection and deliver effective RNA and protein knockdown of the target gene c-Myc ...

Abstract	Background: Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-targeting bacteria have been harnessed to deliver plasmid-expressed therapeutic interfering RNA to a range of solid tumours. A major limitation to clinical translation of this is the short-term nature of RNA interference in vivo due to plasmid instability. To overcome this, we sought to develop tumour-targeting attenuated bacteria that stably express shRNA by virtue of integration of an expression cassette within the bacterial chromosome and demonstrate therapeutic efficacy in vitro and in vivo. Results: The attenuated tumour targeting Salmonella typhimurium SL7207 strain was modified to carry chromosomally integrated shRNA expression cassettes at the xylA locus. The colorectal cancer cell lines SW480, HCT116 and breast cancer cell line MCF7 were used to demonstrate the ability of these modified strains to perform intracellular infection and deliver effective RNA and protein knockdown of the target gene c-Myc. In vivo therapeutic efficacy was demonstrated using the Lgr5creER Conclusions: In summary we have demonstrated that tumour tropic bacteria can be modified to safely deliver therapeutic levels of gene knockdown. This technology has the potential to specifically target primary and secondary solid tumours with personalised therapeutic payloads, providing new multi-cancer detection and treatment options with minimal off-target effects. Further understanding of the tropism mechanisms and impact on host immunity and microbiome is required to progress to clinical translation.
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-024-01206-8
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Article ; Online: Observation of New Ω_{c}^{0} States Decaying to the Ξ_{c}^{+}K^{-} Final State.

Aaij, R / Abdelmotteleb, A S W / Abellan Beteta, C / Abudinén, F / Ackernley, T / Adeva, B / Adinolfi, M / Adlarson, P / Afsharnia, H / Agapopoulou, C / Aidala, C A / Ajaltouni, Z / Akar, S / Akiba, K / Albicocco, P / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A /

Aliouche, Z / Alvarez Cartelle, P / Amalric, R / Amato, S / Amey, J L / Amhis, Y / An, L / Anderlini, L / Andersson, M / Andreianov, A / Andreotti, M / Andreou, D / Ao, D / Archilli, F / Artamonov, A / Artuso, M / Aslanides, E / Atzeni, M / Audurier, B / Bachiller Perea, I B / Bachmann, S / Bachmayer, M / Back, J J / Bailly-Reyre, A / Baladron Rodriguez, P / Balagura, V / Baldini, W / Baptista de Souza Leite, J / Barbetti, M / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Basels, J M / Bassi, G / Batsukh, B / Battig, A / Bay, A / Beck, A / Becker, M / Bedeschi, F / Bediaga, I B / Beiter, A / Belin, S / Bellee, V / Belous, K / Belov, I / Belyaev, I / Benane, G / Bencivenni, G / Ben-Haim, E / Berezhnoy, A / Bernet, R / Bernet Andres, S / Berninghoff, D / Bernstein, H C / Bertella, C / Bertolin, A / Betancourt, C / Betti, F / Bezshyiko, Ia / Bhom, J / Bian, L / Bieker, M S / Biesuz, N V / Billoir, P / Biolchini, A / Birch, M / Bishop, F C R / Bitadze, A / Bizzeti, A / Blago, M P / Blake, T / Blanc, F / Blank, J E / Blusk, S / Bobulska, D / Boelhauve, J A / Boente Garcia, O / Boettcher, T / Boldyrev, A / Bolognani, C S / Bolzonella, R / Bondar, N / Borgato, F / Borghi, S / Borsato, M / Borsuk, J T / Bouchiba, S A / Bowcock, T J V / Boyer, A / Bozzi, C / Bradley, M J / Braun, S / Brea Rodriguez, A / Brodzicka, J / Brossa Gonzalo, A / Brown, J / Brundu, D / Buonaura, A / Buonincontri, L / Burke, A T / Burr, C / Bursche, A / Butkevich, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Calefice, L / Cali, S / Calvi, M / Calvo Gomez, M / Campana, P / Campora Perez, D H / Campoverde Quezada, A F / Capelli, S / Capriotti, L / Carbone, A / Cardinale, R / Cardini, A / Carniti, P / Carus, L / Casais Vidal, A / Caspary, R / Casse, G / Cattaneo, M / Cavallero, G / Cavallini, V / Celani, S / Cerasoli, J / Cervenkov, D / Chadwick, A J / Chahrour, I / Chapman, M G / Charles, M / Charpentier, Ph / Chavez Barajas, C A / Chefdeville, M / Chen, C / Chen, S / Chernov, A / Chernyshenko, S / Chobanova, V / Cholak, S / Chrzaszcz, M / Chubykin, A / Chulikov, V / Ciambrone, P / Cicala, M F / Cid Vidal, X / Ciezarek, G / Cifra, P / Ciullo, G / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Cobbledick, J L / Coco, V / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Congedo, L / Contu, A / Cooke, N / Corredoira, I / Corti, G / Couturier, B / Craik, D C / Cruz Torres, M / Currie, R / Da Silva, C L / Dadabaev, S / Dai, L / Dai, X / Dall'Occo, E / Dalseno, J / D'Ambrosio, C / Daniel, J / Danilina, A / d'Argent, P / Davies, J E / Davis, A / De Aguiar Francisco, O / de Boer, J / De Bruyn, K / De Capua, S / De Cian, M / De Freitas Carneiro Da Graca, U / De Lucia, E / De Miranda, J M / De Paula, L / De Serio, M / De Simone, D / De Simone, P / De Vellis, F / de Vries, J A / Dean, C T / Debernardis, F / Decamp, D / Dedu, V / Del Buono, L / Delaney, B / Dembinski, H-P / Denysenko, V / Deschamps, O / Dettori, F / Dey, B / Di Nezza, P / Diachkov, I / Didenko, S / Dieste Maronas, L / Ding, S / Dobishuk, V / Dolmatov, A / Dong, C / Donohoe, A M / Dordei, F / Dos Reis, A C / Douglas, L / Downes, A G / Duda, P / Dudek, M W / Dufour, L / Duk, V / Durante, P / Duras, M M / Durham, J M / Dutta, D / Dziurda, A / Dzyuba, A / Easo, S / Egede, U / Egorychev, V / Eirea Orro, C / Eisenhardt, S / Ejopu, E / Ek-In, S / Eklund, L / Elashri, M E / Ellbracht, J / Ely, S / Ene, A / Epple, E / Escher, S / Eschle, J / Esen, S / Evans, T / Fabiano, F / Falcao, L N / Fan, Y / Fang, B / Fantini, L / Faria, M / Farry, S / Fazzini, D / Felkowski, L F / Feo, M / Fernandez Gomez, M / Fernez, A D / Ferrari, F / Ferreira Lopes, L / Ferreira Rodrigues, F / Ferreres Sole, S / Ferrillo, M / Ferro-Luzzi, M / Filippov, S / Fini, R A / Fiorini, M / Firlej, M / Fischer, K M / Fitzgerald, D S / Fitzpatrick, C / Fiutowski, T / Fleuret, F / Fontana, M / Fontanelli, F / Forty, R / Foulds-Holt, D / Franco Lima, V / Franco Sevilla, M / Frank, M / Franzoso, E / Frau, G / Frei, C / Friday, D A / Frontini, L / Fu, J / Fuehring, Q / Fulghesu, T / Gabriel, E / Galati, G / Galati, M D / Gallas Torreira, A / Galli, D / Gambetta, S / Gandelman, M / Gandini, P / Gao, H G / Gao, Y / Garau, M / Garcia Martin, L M / Garcia Moreno, P / García Pardiñas, J / Garcia Plana, B / Garcia Rosales, F A / Garrido, L / Gaspar, C / Geertsema, R E / Gerick, D / Gerken, L L / Gersabeck, E / Gersabeck, M / Gershon, T / Giambastiani, L / Gibson, V / Giemza, H K / Gilman, A L / Giovannetti, M / Gioventù, A / Gironella Gironell, P / Giugliano, C / Giza, M A / Gizdov, K / Gkougkousis, E L / Gligorov, V V / Göbel, C / Golobardes, E / Golubkov, D / Golutvin, A / Gomes, A / Gomez Fernandez, S / Goncalves Abrantes, F / Goncerz, M / Gong, G / Gorelov, I V / Gotti, C / Grabowski, J P / Grammatico, T / Granado Cardoso, L A / Graugés, E / Graverini, E / Graziani, G / Grecu, A T / Greeven, L M / Grieser, N A / Grillo, L / Gromov, S / Gruberg Cazon, B R / Gu, C / Guarise, M / Guittiere, M / Günther, P A / Gushchin, E / Guth, A / Guz, Y / Gys, T / Hadavizadeh, T / Hadjivasiliou, C / Haefeli, G / Haen, C / Haimberger, J / Haines, S C / Halewood-Leagas, T / Halvorsen, M M / Hamilton, P M / Hammerich, J / Han, Q / Han, X / Hansmann-Menzemer, S / Hao, L / Harnew, N / Harrison, T / Hasse, C / Hatch, M / He, J / Heijhoff, K / Hemmer, F H / Henderson, C / Henderson, R D L / Hennequin, A M / Hennessy, K / Henry, L / Herd, J / Heuel, J / Hicheur, A / Hill, D / Hilton, M / Hollitt, S E / Horswill, J / Hou, R / Hou, Y / Hu, J / Hu, W / Hu, X / Huang, W / Huang, X / Hulsbergen, W / Hunter, R J / Hushchyn, M / Hutchcroft, D / Ibis, P / Idzik, M / Ilin, D / Ilten, P / Inglessi, A / Iniukhin, A / Ishteev, A / Ivshin, K / Jacobsson, R / Jage, H / Jaimes Elles, S J / Jakobsen, S / Jans, E / Jashal, B K / Jawahery, A / Jevtic, V / Jiang, E / Jiang, X / Jiang, Y / John, M / Johnson, D / Jones, C R / Jones, T P / Joshi, S J / Jost, B / Jurik, N / Juszczak, I / Kandybei, S / Kang, Y / Karacson, M / Karpenkov, D / Karpov, M / Kautz, J W / Keizer, F / Keller, D M / Kenzie, M / Ketel, T / Khanji, B / Kharisova, A / Kholodenko, S / Khreich, G / Kirn, T / Kirsebom, V S / Kitouni, O / Klaver, S / Kleijne, N / Klimaszewski, K / Kmiec, M R / Koliiev, S / Kolk, L / Kondybayeva, A / Konoplyannikov, A / Kopciewicz, P / Kopecna, R / Koppenburg, P / Korolev, M / Kostiuk, I / Kot, O / Kotriakhova, S / Kozachuk, A / Kravchenko, P / Kravchuk, L / Krawczyk, R D / Kreps, M / Kretzschmar, S / Krokovny, P / Krupa, W / Krzemien, W / Kubat, J / Kubis, S / Kucewicz, W / Kucharczyk, M / Kudryavtsev, V / Kulikova, E K / Kupsc, A / Lacarrere, D / Lafferty, G / Lai, A / Lampis, A / Lancierini, D / Landesa Gomez, C / Lane, J J / Lane, R / Langenbruch, C / Langer, J / Lantwin, O / Latham, T / Lazzari, F / Lazzaroni, M / Lazzeroni, C / Le Gac, R / Lee, S H / Lefèvre, R / Leflat, A / Legotin, S / Lenisa, P / Leroy, O / Lesiak, T / Leverington, B / Li, A / Li, H / Li, K / Li, P / Li, P-R / Li, S / Li, T / Li, Y / Li, Z / Liang, X / Lin, C / Lin, T / Lindner, R / Lisovskyi, V / Litvinov, R / Liu, G / Liu, H / Liu, K / Liu, Q / Liu, S / Lobo Salvia, A / Loi, A / Lollini, R / Lomba Castro, J / Longstaff, I / Lopes, J H / Lopez Huertas, A / López Soliño, S / Lovell, G H / Lu, Y / Lucarelli, C / Lucchesi, D / Luchuk, S / Lucio Martinez, M / Lukashenko, V / Luo, Y / Lupato, A / Luppi, E / Lusiani, A / Lynch, K / Lyu, X-R / Ma, R / Maccolini, S / Machefert, F / Maciuc, F / Mackay, I / Macko, V / Madhan Mohan, L R / Maevskiy, A / Maisuzenko, D / Majewski, M W / Malczewski, J J / Malde, S / Malecki, B / Malinin, A / Maltsev, T / Manca, G / Mancinelli, G / Mancuso, C / Manera Escalero, R / Manuzzi, D / Manzari, C A / Marangotto, D / Marchand, J F / Marconi, U / Mariani, S / Marin Benito, C / Marks, J / Marshall, A M / Marshall, P J / Martelli, G / Martellotti, G / Martinazzoli, L / Martinelli, M / Martinez Santos, D / Martinez Vidal, F / Massafferri, A / Materok, M / Matev, R / Mathad, A / Matiunin, V / Matteuzzi, C / Mattioli, K R / Mauri, A / Maurice, E / Mauricio, J / Mazurek, M / McCann, M / Mcconnell, L / McGrath, T H / McHugh, N T / McNab, A / McNulty, R / Meadows, B / Meier, G / Melnychuk, D / Meloni, S / Merk, M / Merli, A / Meyer Garcia, L / Miao, D / Mikhasenko, M / Milanes, D A / Millard, E / Milovanovic, M / Minard, M-N / Minotti, A / Miralles, T / Mitchell, S E / Mitreska, B / Mitzel, D S / Modak, A / Mödden, A / Mohammed, R A / Moise, R D / Mokhnenko, S / Mombächer, T / Monk, M / Monroy, I A / Monteil, S / Morello, G / Morello, M J / Morgenthaler, M P / Moron, J / Morris, A B / Morris, A G / Mountain, R / Mu, H / Muhammad, E / Muheim, F / Mulder, M / Müller, K / Murphy, C H / Murray, D / Murta, R / Muzzetto, P / Naik, P / Nakada, T / Nandakumar, R / Nanut, T / Nasteva, I / Needham, M / Neri, N / Neubert, S / Neufeld, N / Neustroev, P / Newcombe, R / Nicolini, J / Nicotra, D / Niel, E M / Nieswand, S / Nikitin, N / Nolte, N S / Normand, C / Novoa Fernandez, J / Nowak, G N / Nunez, C / Oblakowska-Mucha, A / Obraztsov, V / Oeser, T / Okamura, S / Oldeman, R / Oliva, F / Onderwater, C J G / O'Neil, R H / Otalora Goicochea, J M / Ovsiannikova, T / Owen, P / Oyanguren, A / Ozcelik, O / Padeken, K O / Pagare, B / Pais, P R / Pajero, T / Palano, A / Palutan, M / Panshin, G / Paolucci, L / Papanestis, A / Pappagallo, M / Pappalardo, L L / Pappenheimer, C / Parker, W / Parkes, C / Passalacqua, B / Passaleva, G / Pastore, A / Patel, M / Patrignani, C / Pawley, C J / Pellegrino, A / Pepe Altarelli, M / Perazzini, S / Pereima, D / Pereiro Castro, A / Perret, P / Petridis, K / Petrolini, A / Petrucci, S / Petruzzo, M / Pham, H / Philippov, A / Piandani, R / Pica, L / Piccini, M / Pietrzyk, B / Pietrzyk, G / Pili, M / Pinci, D / Pisani, F / Pizzichemi, M / Placinta, V / Plews, J / Plo Casasus, M / Polci, F / Poli Lener, M / Poluektov, A / Polukhina, N / Polyakov, I / Polycarpo, E / Ponce, S / Popov, D / Poslavskii, S / Prasanth, K / Promberger, L / Prouve, C / Pugatch, V / Puill, V / Punzi, G / Qi, H R / Qian, W / Qin, N / Qu, S / Quagliani, R / Raab, N V / Rachwal, B / Rademacker, J H / Rajagopalan, R / Rama, M / Ramos Pernas, M / Rangel, M S / Ratnikov, F / Raven, G / Rebollo De Miguel, M / Redi, F / Reich, J / Reiss, F / Remon Alepuz, C / Ren, Z / Resmi, P K / Ribatti, R / Ricci, A M / Ricciardi, S / Richardson, K / Richardson-Slipper, M / Rinnert, K / Robbe, P / Robertson, G / Rodrigues, E / Rodriguez Fernandez, E / Rodriguez Lopez, J A / Rodriguez Rodriguez, E / Rolf, D L / Rollings, A / Roloff, P / Romanovskiy, V / Romero Lamas, M / Romero Vidal, A / Roth, J D / Rotondo, M / Rudolph, M S / Ruf, T / Ruiz Fernandez, R A / Ruiz Vidal, J / Ryzhikov, A / Ryzka, J / Saborido Silva, J J / Sagidova, N / Sahoo, N / Saitta, B / Salomoni, M / Sanchez Gras, C / Sanderswood, I / Santacesaria, R / Santamarina Rios, C / Santimaria, M / Santovetti, E / Saranin, D / Sarpis, G / Sarpis, M / Sarti, A / Satriano, C / Satta, A / Saur, M / Savrina, D / Sazak, H / Scantlebury Smead, L G / Scarabotto, A / Schael, S / Scherl, S / Schiller, M / Schindler, H / Schmelling, M / Schmidt, B / Schmitt, S / Schneider, O / Schopper, A / Schubiger, M / Schulte, S / Schune, M H / Schwemmer, R / Sciascia, B / Sciuccati, A / Sellam, S / Semennikov, A / Senghi Soares, M / Sergi, A / Serra, N / Sestini, L / Seuthe, A / Shang, Y / Shangase, D M / Shapkin, M / Shchemerov, I / Shchutska, L / Shears, T / Shekhtman, L / Shen, Z / Sheng, S / Shevchenko, V / Shi, B / Shields, E B / Shimizu, Y / Shmanin, E / Shorkin, R / Shupperd, J D / Siddi, B G / Silva Coutinho, R / Simi, G / Simone, S / Singla, M / Skidmore, N / Skuza, R / Skwarnicki, T / Slater, M W / Smallwood, J C / Smeaton, J G / Smith, E / Smith, K / Smith, M / Snoch, A / Soares Lavra, L / Sokoloff, M D / Soler, F J P / Solomin, A / Solovev, A / Solovyev, I / Song, R / Souza De Almeida, F L / Souza De Paula, B / Spaan, B / Spadaro Norella, E / Spedicato, E / Spiridenkov, E / Spradlin, P / Sriskaran, V / Stagni, F / Stahl, M / Stahl, S / Stanislaus, S / Stein, E N / Steinkamp, O / Stenyakin, O / Stevens, H / Strekalina, D / Su, Y S / Suljik, F / Sun, J / Sun, L / Sun, Y / Swallow, P N / Swientek, K / Szabelski, A / Szumlak, T / Szymanski, M / Tan, Y / Taneja, S / Tat, M D / Terentev, A / Teubert, F / Thomas, E / Thompson, D J D / Thomson, K A / Tilquin, H / Tisserand, V / T'Jampens, S / Tobin, M / Tomassetti, L / Tonani, G / Tong, X / Torres Machado, D / Tou, D Y / Trippl, C / Tuci, G / Tuning, N / Ukleja, A / Unverzagt, D J / Usachov, A / Ustyuzhanin, A / Uwer, U / Vagner, A / Vagnoni, V / Valassi, A / Valenti, G / Valls Canudas, N / Van Dijk, M / Van Hecke, H / van Herwijnen, E / Van Hulse, C B / van Veghel, M / Vazquez Gomez, R / Vazquez Regueiro, P / Vázquez Sierra, C / Vecchi, S / Velthuis, J J / Veltri, M / Venkateswaran, A / Veronesi, M / Vesterinen, M / Vieira, D / Vieites Diaz, M / Vilasis-Cardona, X / Vilella Figueras, E / Villa, A / Vincent, P / Volle, F C / Vom Bruch, D / Vorobyev, A / Vorobyev, V / Voropaev, N / Vos, K / Vrahas, C / Walsh, J / Walton, E J / Wan, G / Wang, C / Wang, G / Wang, J / Wang, M / Wang, R / Wang, X / Wang, Y / Wang, Z / Ward, J A / Watson, N K / Websdale, D / Wei, Y / Westhenry, B D C / White, D J / Whitehead, M / Wiederhold, A R / Wiedner, D / Wilkinson, G / Wilkinson, M K / Williams, I / Williams, M / Williams, M R J / Williams, R / Wilson, F F / Wislicki, W / Witek, M / Witola, L / Wong, C P / Wormser, G / Wotton, S A / Wu, H / Wu, J / Wyllie, K / Xiang, Z / Xie, Y / Xu, A / Xu, J / Xu, L / Xu, M / Xu, Q / Xu, Z / Yang, D / Yang, S / Yang, X / Yang, Y / Yang, Z / Yeomans, L E / Yeroshenko, V / Yeung, H / Yin, H / Yu, J / Yuan, X / Zaffaroni, E / Zavertyaev, M / Zdybal, M / Zeng, M / Zhang, C / Zhang, D / Zhang, L / Zhang, S / Zhang, Y / Zhao, Y / Zharkova, A / Zhelezov, A / Zheng, Y / Zhou, T / Zhou, X / Zhou, Y / Zhovkovska, V / Zhu, X / Zhu, Z / Zhukov, V / Zou, Q / Zucchelli, S / Zuliani, D / Zunica, G

Physical review letters

2023 Volume 131, Issue 13, Page(s) 131902

Abstract: Two new excited states, Ω_{c}(3185)^{0} and Ω_{c}(3327)^{0}, are observed in the Ξ_{c}^{+}K^ ... to an integrated luminosity of 9 fb^{-1}. Five previously observed excited Ω_{c}^{0} states are confirmed, namely ... Ω_{c}(3000)^{0}, Ω_{c}(3050)^{0}, Ω_{c}(3065)^{0}, Ω_{c}(3090)^{0}, and Ω_{c}(3119)^{0}. The masses ...

Abstract	Two new excited states, Ω_{c}(3185)^{0} and Ω_{c}(3327)^{0}, are observed in the Ξ_{c}^{+}K^{-} invariant-mass spectrum using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of 9 fb^{-1}. Five previously observed excited Ω_{c}^{0} states are confirmed, namely Ω_{c}(3000)^{0}, Ω_{c}(3050)^{0}, Ω_{c}(3065)^{0}, Ω_{c}(3090)^{0}, and Ω_{c}(3119)^{0}. The masses and widths of these seven states are measured with the highest precision to date.
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.131902
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Article ; Online: Identification of the novel HLA-C*03:648 allele by next generation sequencing.

Du, Zeying / Williams, Charles / Robinson, Terrence / Hardage, Brittney / Elrefaei, Mohamed

HLA

2023 Volume 103, Issue 1, Page(s) e15324

Abstract: HLA-C*03:648 differs from HLA-C*03:04:02 by one nucleotide substitution at Codon -23 (CGG > CTG ...

Abstract	HLA-C03:648 differs from HLA-C03:04:02 by one nucleotide substitution at Codon -23 (CGG > CTG) in exon 1.
MeSH term(s)	Humans ; HLA-C Antigens/genetics ; High-Throughput Nucleotide Sequencing ; Alleles ; Genes, MHC Class I ; Exons/genetics
Chemical Substances	HLA-C Antigens
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15324
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Article ; Online: C-C Bond Activation and Demethylenation of Epoxides by Amine Radical Dications.

Holt, Eric / Garrison, Nathaniel G / Rowshanpour, Rozhin / Kim, Justin Jeeyoung / Henriquez, Nicolas / Lam, Winson / Kiame, Neil / Williams, Jack / Zhao, Sherrie / Dudding, Travis / Lectka, Thomas

The Journal of organic chemistry

2023 Volume 88, Issue 11, Page(s) 7597–7600

Abstract: In this note, we explore a unique reactivity pattern that involves a rare radical-based C-C bond ...

Abstract	In this note, we explore a unique reactivity pattern that involves a rare radical-based C-C bond scission of epoxides followed by demethylenation. The reaction is accomplished by Selecfluor and its radical dication working in tandem; a mechanism supported by experiment and DFT calculations is proposed that involves the generation and identification of a key reactive intermediate. The reaction seems to be fairly general for 1,1-disubstituted epoxides.
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c00605
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Article ; Online: Slicing through silos: Development and evaluation of a hospital-based telehealth hepatitis C virus treatment program.

Babiarz, J / Ryu, H / Williams, C / Ham, Y / Rivera Sarti, J / Levander, X A

The International journal on drug policy

2024 Volume 127, Page(s) 104396

Abstract: Background: There exist many barriers to hepatitis C virus (HCV) treatment ...

Abstract	Background: There exist many barriers to hepatitis C virus (HCV) treatment for those with substance use disorder (SUD) or who lack access to routine medical care. A hospital-based telehealth program was developed to provide treatment opportunities for hospitalized patients living with HCV. Methods: This single site prospective cohort study conducted from July 2022 to March 2023 aimed to measure linkage to care with an HCV clinician and initiation of HCV treatment in hospitalized patients. Patients were assessed in-person by a social worker then seen via telehealth by a clinician who prescribed either glecaprevir/pibrentasvir or sofosbuvir/velpatasvir. Treatment was initiated with pharmacist assistance. The team conducted in-person and/or telephonic outreach during and after hospitalization. Cure was confirmed by sustained virologic response at 12 weeks (SVR12) post-treatment. Results: A total of 25 patients were enrolled and completed telehealth visits. All patients had a history of SUD and 18 (72 %) were unstably housed. Nineteen patients (76 %) initiated treatment, and 14 (56 %) successfully completed treatment. Twelve patients (48 %) completed post-treatment labs, including two who prematurely discontinued treatment. Eleven patients (44 %) achieved confirmed cure with SVR12. Conclusion: A hospital-based, multidisciplinary telehealth program can be an innovative care model to successfully treat HCV in a difficult-to-treat patient populations.
Language	English
Publishing date	2024-04-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2010000-0
ISSN	1873-4758 ; 0955-3959
ISSN (online)	1873-4758
ISSN	0955-3959
DOI	10.1016/j.drugpo.2024.104396
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Article: Hyperextended telomeres promote C-circle formation in telomerase positive human cells.

Jones, Celina Y / Williams, Christopher L / Moreno, Sara P / Morris, Danna K / Mondello, Chiara / Karlseder, Jan / Bertuch, Alison A

bioRxiv : the preprint server for biology

2023

Abstract: ... The primary ALT biomarker is the C-circle, a type of circular DNA with extrachromosomal telomere repeats ... cECTRs). How C-circles form is not well characterized. To investigate C-circle formation in telomerase+ ...

Abstract	Telomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). The primary ALT biomarker is the C-circle, a type of circular DNA with extrachromosomal telomere repeats (cECTRs). How C-circles form is not well characterized. To investigate C-circle formation in telomerase+ cells, we studied the human cen3tel cell line, in which telomeres progressively hyper-elongated post
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.26.525615
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Article ; Online: Revisiting the potential-energy surface of C

Inostroza, Diego / Vásquez-Espinal, Alejandro / Leyva-Parra, Luis / García-Argote, Williams / Cerón, María Luisa / Yañez, Osvaldo / Tiznado, William

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 30, Page(s) 20235–20240

Abstract: Using various exploration strategies, in this study, we investigated the potential energy surfaces (PES) of ... ...

Abstract	Using various exploration strategies, in this study, we investigated the potential energy surfaces (PES) of CBe
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp02056h
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Article ; Online: Development of Negative Controls for Fc-C-Type Lectin Receptor Probes.

Hatinguais, Rémi / Kay, Madalaine / Salazar, Fabián / Conn, Daniel P / Williams, David L / Cook, Peter C / Willment, Janet A / Brown, Gordon D

Microbiology spectrum

2023 Volume 11, Issue 3, Page(s) e0113523

Abstract: Fc-C-type lectin receptor (Fc-CTLRs) probes are soluble chimeric proteins constituted ...

Abstract	Fc-C-type lectin receptor (Fc-CTLRs) probes are soluble chimeric proteins constituted of the extracellular domain of a CTLR fused with the constant fraction (Fc) of the human IgG. These probes are useful tools to study the interaction of CTLRs with their ligands, with applications similar to those of antibodies, often in combination with widely available fluorescent antibodies targeting the Fc fragment (anti-hFc). In particular, Fc-Dectin-1 has been extensively used to study the accessibility of β-glucans at the surface of pathogenic fungi. However, there is no universal negative control for Fc-CTLRs, making the distinction of specific versus nonspecific binding difficult. We describe here 2 negative controls for Fc-CTLRs: a Fc-control constituting of only the Fc portion, and a Fc-Dectin-1 mutant predicted to be unable to bind β-glucans. Using these new probes, we found that while Fc-CTLRs exhibit virtually no nonspecific binding to Candida albicans yeasts, Aspergillus fumigatus resting spores strongly bind Fc-CTLRs in a nonspecific manner. Nevertheless, using the controls we describe here, we were able to demonstrate that A. fumigatus spores expose a low amount of β-glucan. Our data highlight the necessity of appropriate negative controls for experiments involving Fc-CTLRs probes.
MeSH term(s)	Humans ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; Ligands ; Aspergillus fumigatus/genetics ; Aspergillus fumigatus/metabolism ; Fungi/metabolism ; Yeasts ; Spores, Fungal/metabolism ; beta-Glucans/metabolism
Chemical Substances	Lectins, C-Type ; Ligands ; beta-Glucans
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01135-23
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