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  1. Book ; Conference proceedings: Peripheral T-cell lymphomas

    Foss, Francine M.

    challenges in diagnosis and treatment ; [based on the friday satellite symposium ... preceding the 51st annual meeting of the American Society of Hematology, December 4, 2009, in New Orleans, Louisiana]

    (Seminars in hematology ; 47,2, Suppl. 1)

    2010  

    Author's details Francine M. Foss, guest ed
    Series title Seminars in hematology ; 47,2, Suppl. 1
    Collection
    Language English
    Size S22 S.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016365148
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 328 -47,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Book ; Conference proceedings: Advances in the treatment of T-cell lymphomas

    Foss, Francine M.

    review of presentations at American Society of Clinical Oncology annual meeting, May 29 - June 2, 2009, Orlando, Florida, Pan Pacific Lymphoma Conference, June 22 - 26, 2009, Kohala Coast, Hawaii

    (Clinical advances in hematology & oncology ; 7,10, Suppl. 18)

    2009  

    Institution American Society of Clinical Oncology
    Event/congress Pan Pacific Lymphoma Conference (2009)
    Author's details with expert commentary by: Francine Foss
    Series title Clinical advances in hematology & oncology ; 7,10, Suppl. 18
    Collection
    Language English
    Size 13 S. : graph. Darst.
    Publisher Millennium Med. Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016158451
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6505 -7,Suppl.18- verfügbar in Königswinter Königswinter

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  3. Book: Purine analogues in the treatment of lymphoid malignancies

    Foss, Francine M.

    [based on presentations made during educational symposia held in 2005 during the Lymphoma Meeting in Lugano, Switzerland and the Pan Pacific Meeting in Hawaii]

    (Seminars in hematology ; 43,2, Suppl. 2)

    2006  

    Author's details Francine Foss ..., guest ed
    Series title Seminars in hematology ; 43,2, Suppl. 2
    Collection
    Language English
    Size S54 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT014737313
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 328 -43,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  4. Book: Cutaneous lymphomas

    Foss, Francine M.

    (Hematology oncology clinics of North America ; 17,6)

    2003  

    Author's details Francine M. Foss ... guest ed
    Series title Hematology oncology clinics of North America ; 17,6
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size XIV S., S. 1277 - 1543 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013903985
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1077 -17,6- verfügbar in Königswinter Königswinter

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  5. Book: Past, present, and future developments in cutaneous T-cell lymphomas (CTCL)

    Bagot, Martine / Foss, Francine M.

    (Seminars in oncology ; 33,1, Suppl. 3)

    2006  

    Author's details Francine Foss ..., guest ed. Contributors Martine Bagot
    Series title Seminars in oncology ; 33,1, Suppl. 3
    Collection
    Language English
    Size S36 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT014701397
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 1348 -33,1,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  6. Book: T-cell lymphoma

    Armitage, James O. / Hsi, Eric D. / Foss, Francine M.

    therapeutic overview and disease state awareness

    (Clinical advances in hematology & oncology ; 8,12, Suppl. 22)

    2010  

    Author's details discussants James O. Armitage ; Eric D. Hsi ; Francine M. Foss
    Series title Clinical advances in hematology & oncology ; 8,12, Suppl. 22
    Collection
    Language English
    Size 15 S. : Ill.
    Publisher Millennium Med. Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016742046
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6505 -8,Suppl.22- verfügbar in Königswinter Königswinter

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  7. Article ; Online: Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy.

    Ren, Jingjing / Liao, Xiaofeng / Lewis, Julia M / Chang, Jungsoo / Qu, Rihao / Carlson, Kacie R / Foss, Francine / Girardi, Michael

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 519

    Abstract: Current treatments for T cell malignancies encounter issues of disease relapse and off-target toxicity. Using T cell receptor (TCR)Vβ2 as a model, here we demonstrate the rapid generation of an off-the-shelf allogeneic chimeric antigen receptor (CAR)-T ... ...

    Abstract Current treatments for T cell malignancies encounter issues of disease relapse and off-target toxicity. Using T cell receptor (TCR)Vβ2 as a model, here we demonstrate the rapid generation of an off-the-shelf allogeneic chimeric antigen receptor (CAR)-T platform targeting the clone-specific TCR Vβ chain for malignant T cell killing while limiting normal cell destruction. Healthy donor T cells undergo CRISPR-induced TRAC, B2M and CIITA knockout to eliminate T cell-dependent graft-versus-host and host-versus-graft reactivity. Second generation 4-1BB/CD3zeta CAR containing high affinity humanized anti-Vβ scFv is expressed efficiently on donor T cells via both lentivirus and adeno-associated virus transduction with limited detectable pre-existing immunoreactivity. Our optimized CAR-T cells demonstrate specific and persistent killing of Vβ2+ Jurkat cells and Vβ2+ patient derived malignant T cells, in vitro and in vivo, without affecting normal T cells. In parallel, we generate humanized anti-Vβ2 antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC) by Fc-engineering for NK cell ADCC therapy.
    MeSH term(s) Humans ; Receptors, Antigen, T-Cell/genetics ; Jurkat Cells ; Immunotherapy, Adoptive ; Receptors, Chimeric Antigen/genetics ; Clone Cells
    Chemical Substances Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44786-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Necrotic papulonodules on the legs.

    Zhou, Amanda / Damsky, William / Girardi, Michael / Foss, Francine M / Vesely, Matthew D

    JAAD case reports

    2021  Volume 11, Page(s) 10–12

    Language English
    Publishing date 2021-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2021.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mycosis Fungoides and Sezary Syndrome.

    Foss, Francine M / Girardi, Michael

    Hematology/oncology clinics of North America

    2017  Volume 31, Issue 2, Page(s) 297–315

    Abstract: Mycosis fungoides and the Sezary syndrome (SS) are rare lymphomas of ... ...

    Abstract Mycosis fungoides and the Sezary syndrome (SS) are rare lymphomas of CD4
    MeSH term(s) Allografts ; Humans ; Immunologic Factors/therapeutic use ; Mycosis Fungoides/metabolism ; Mycosis Fungoides/pathology ; Mycosis Fungoides/therapy ; Sezary Syndrome/metabolism ; Sezary Syndrome/pathology ; Sezary Syndrome/therapy ; Stem Cell Transplantation ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/pathology
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2016.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Se 1077: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Treatment strategies for peripheral T-cell lymphomas.

    Foss, Francine M

    Best practice & research. Clinical haematology

    2013  Volume 26, Issue 1, Page(s) 43–56

    Abstract: Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of clinically aggressive diseases historically associated with inferior outcomes using conventional lymphoma therapies. Aggressive first line therapy and consolidation with autologous stem cell ...

    Abstract Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of clinically aggressive diseases historically associated with inferior outcomes using conventional lymphoma therapies. Aggressive first line therapy and consolidation with autologous stem cell transplantation has led to improved survival, but the majority of patients either fails to respond to therapy or are not transplant candidates. Novel approaches have included new classes of drug and biological agents, including antifolates, immunoconjugates, histone deacetylase (HDAC) inhibitors, monoclonal antibodies, and signal transduction inhibitors. Molecular profiling has led to identification of relevant pathways for future novel approaches.
    MeSH term(s) Anthracyclines/administration & dosage ; Antibodies, Monoclonal/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols ; Clinical Trials as Topic ; Folic Acid Antagonists/administration & dosage ; Histone Deacetylase Inhibitors/administration & dosage ; Humans ; Immunoconjugates/administration & dosage ; Lymphoma, T-Cell, Peripheral/diagnosis ; Lymphoma, T-Cell, Peripheral/drug therapy ; Lymphoma, T-Cell, Peripheral/pathology ; T-Lymphocytes/drug effects ; T-Lymphocytes/pathology
    Chemical Substances Anthracyclines ; Antibodies, Monoclonal ; Folic Acid Antagonists ; Histone Deacetylase Inhibitors ; Immunoconjugates
    Language English
    Publishing date 2013-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2013.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 1029: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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