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  1. Article ; Online: PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity

    Fanghang Zhou / Qianya Wan / Ying Chen / Sheng Chen / Ming-liang He

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    2021  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  2. Article ; Online: PIM1 kinase facilitates Zika virus replication by suppressing host cells' natural immunity.

    Zhou, Fanghang / Wan, Qianya / Chen, Ying / Chen, Sheng / He, Ming-Liang

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 207

    MeSH term(s) A549 Cells ; Humans ; Immunity, Innate ; Proto-Oncogene Proteins c-pim-1/immunology ; Virus Replication/immunology ; Zika Virus/physiology ; Zika Virus Infection/immunology
    Chemical Substances PIM1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-pim-1 (EC 2.7.11.1)
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00539-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Attenuating innate immunity and facilitating β-coronavirus infection by NSP1 of SARS-CoV-2 through specific redistributing hnRNP A2/B1 cellular localization.

    Zhou, Fanghang / Wan, Qianya / Chen, Sheng / Chen, Ying / Wang, Pui-Hui / Yao, Xi / He, Ming-Liang

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 371

    MeSH term(s) COVID-19 ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B ; Humans ; Immunity, Innate ; SARS-CoV-2
    Chemical Substances Heterogeneous-Nuclear Ribonucleoprotein Group A-B ; hnRNP A2
    Language English
    Publishing date 2021-10-26
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00786-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Attenuating innate immunity and facilitating β-coronavirus infection by NSP1 of SARS-CoV-2 through specific redistributing hnRNP A2/B1 cellular localization

    Fanghang Zhou / Qianya Wan / Sheng Chen / Ying Chen / Pui-Hui Wang / Xi Yao / Ming-liang He

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    2021  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Emergent charge order in pressurized kagome superconductor CsV

    Zheng, Lixuan / Wu, Zhimian / Yang, Ye / Nie, Linpeng / Shan, Min / Sun, Kuanglv / Song, Dianwu / Yu, Fanghang / Li, Jian / Zhao, Dan / Li, Shunjiao / Kang, Baolei / Zhou, Yanbing / Liu, Kai / Xiang, Ziji / Ying, Jianjun / Wang, Zhenyu / Wu, Tao / Chen, Xianhui

    Nature

    2022  Volume 611, Issue 7937, Page(s) 682–687

    Abstract: The discovery of several electronic orders in kagome superconductors ... ...

    Abstract The discovery of several electronic orders in kagome superconductors AV
    Language English
    Publishing date 2022-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-05351-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  6. Article ; Online: Pim1 Impacts Enterovirus A71 Replication and Represents a Potential Target in Antiviral Therapy.

    Zhou, Fanghang / Wan, Qianya / Lu, Jing / Chen, Ying / Lu, Gui / He, Ming-Liang

    iScience

    2019  Volume 19, Page(s) 715–727

    Abstract: Enterovirus A71 (EV-A71) infection causes hand-foot-and-mouth disease (HFMD) and fatal neurological diseases, and there are no effective treatments. Host factors play key roles in establishing viral infection and determining the disease progression and ... ...

    Abstract Enterovirus A71 (EV-A71) infection causes hand-foot-and-mouth disease (HFMD) and fatal neurological diseases, and there are no effective treatments. Host factors play key roles in establishing viral infection and determining the disease progression and outcome of antiviral therapies. In this study, we found that the expression of Pim1 was significantly upregulated in EV-A71 infection. Ectopic expression or silencing of Pim1 promoted or inhibited EV-A71 replication through two distinct mechanisms. Pim1 enhanced viral IRES activity by increasing viral 2A protease-mediated eIF4G cleavage and blocked AUF1, a suppressor of IRES, translocation from the nucleus to cytosol. More importantly, we discovered that Pim1 inhibitors (SGI-1776, AZD-1208, and CX-6258) reduced EV-A71 reproduction. Particularly, CX-6258 remarkably reduced EV-A71 reproduction more than 1,000 times, providing a potential therapeutic agent for EV-A71 treatment.
    Language English
    Publishing date 2019-08-08
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2019.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Charge-density-wave-driven electronic nematicity in a kagome superconductor.

    Nie, Linpeng / Sun, Kuanglv / Ma, Wanru / Song, Dianwu / Zheng, Lixuan / Liang, Zuowei / Wu, Ping / Yu, Fanghang / Li, Jian / Shan, Min / Zhao, Dan / Li, Shunjiao / Kang, Baolei / Wu, Zhimian / Zhou, Yanbing / Liu, Kai / Xiang, Ziji / Ying, Jianjun / Wang, Zhenyu /
    Wu, Tao / Chen, Xianhui

    Nature

    2022  Volume 604, Issue 7904, Page(s) 59–64

    Abstract: Electronic nematicity, in which rotational symmetry is spontaneously broken by electronic degrees of freedom, has been demonstrated as a ubiquitous phenomenon in correlated quantum fluids including high-temperature superconductors and quantum Hall ... ...

    Abstract Electronic nematicity, in which rotational symmetry is spontaneously broken by electronic degrees of freedom, has been demonstrated as a ubiquitous phenomenon in correlated quantum fluids including high-temperature superconductors and quantum Hall systems
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04493-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Pim1 Impacts Enterovirus A71 Replication and Represents a Potential Target in Antiviral Therapy

    Fanghang Zhou / Qianya Wan / Jing Lu / Ying Chen / Gui Lu / Ming-Liang He

    iScience, Vol 19, Iss , Pp 715-

    2019  Volume 727

    Abstract: Summary: Enterovirus A71 (EV-A71) infection causes hand-foot-and-mouth disease (HFMD) and fatal neurological diseases, and there are no effective treatments. Host factors play key roles in establishing viral infection and determining the disease ... ...

    Abstract Summary: Enterovirus A71 (EV-A71) infection causes hand-foot-and-mouth disease (HFMD) and fatal neurological diseases, and there are no effective treatments. Host factors play key roles in establishing viral infection and determining the disease progression and outcome of antiviral therapies. In this study, we found that the expression of Pim1 was significantly upregulated in EV-A71 infection. Ectopic expression or silencing of Pim1 promoted or inhibited EV-A71 replication through two distinct mechanisms. Pim1 enhanced viral IRES activity by increasing viral 2A protease-mediated eIF4G cleavage and blocked AUF1, a suppressor of IRES, translocation from the nucleus to cytosol. More importantly, we discovered that Pim1 inhibitors (SGI-1776, AZD-1208, and CX-6258) reduced EV-A71 reproduction. Particularly, CX-6258 remarkably reduced EV-A71 reproduction more than 1,000 times, providing a potential therapeutic agent for EV-A71 treatment. : Biological Sciences; Biochemistry; Microbiology; Virology; Viral Microbiology; Molecular Microbiology; Cell Biology Subject Areas: Biological Sciences, Biochemistry, Microbiology, Virology, Viral Microbiology, Molecular Microbiology, Cell Biology
    Keywords Science ; Q
    Subject code 570
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Targeting m6A modification inhibits herpes virus 1 infection

    Zhuoying Feng / Fanghang Zhou / Miaomiao Tan / Tingting Wang / Ying Chen / Wenwen Xu / Bin Li / Xin Wang / Xin Deng / Ming-Liang He

    Genes and Diseases, Vol 9, Iss 4, Pp 1114-

    2022  Volume 1128

    Abstract: The latent infection by herpes virus type 1 (HSV-1) may be lifelong in trigeminal ganglia and a suspected cause of Alzheimer's Disease (AD) and Amyotrophic lateral sclerosis (ALS). Whether and how N6-methyladenosine (m6A) modification of viral RNAs ... ...

    Abstract The latent infection by herpes virus type 1 (HSV-1) may be lifelong in trigeminal ganglia and a suspected cause of Alzheimer's Disease (AD) and Amyotrophic lateral sclerosis (ALS). Whether and how N6-methyladenosine (m6A) modification of viral RNAs affects virus infection are poorly understood. Here, we report that HSV-1 infection enhanced the expression of m6A writers (METTL3, METTL14) and readers (YTHDF1/2/3) at the early infection stage and decreased their expression later on, while suppressed the erasers' (FTO, ALBKH5) expression immediately upon infection to facilitate viral replication. Inhibiting m6A modification by 3-deazaadenosine (DAA) significantly decreased viral replication and reduced viral reproduction over 1000 folds. More interestingly, depleting the writers and readers by siRNAs inhibited virus replication and reproduction; whereas depleting the erasers promoted viral replication and reproduction. Silencing YTHDF3 strikingly decreased viral replication by up to 90%, leading to reduction of up to 10-fold viral replication and over 100-fold virus reproduction, respectively. Depletion of m6A initiator METTL3 (by 60%–70%) by siRNA correlatedly decreased viral replication 60%–70%, and reduced virus yield over 30-fold. Consistently, ectopic expression of METTL3 largely increased virus yield. METTL3 knockdown suppressed the HSV-1 intermediate early and early genes (ICP0, ICP8 and UL23) and late genes (VP16, UL44, UL49 and ICP47); while ectopic expression of METTL3 upregulated these gene expression. Results from our study shed the lights on the importance for m6A modification to initiate HSV-1 early replication. The components of m6A modification machinery, particularly m6A initiator METTL3 and reader YTHDF3, would be potential important targets for combating HSV-1 infections.
    Keywords Gene silencing ; HSV-1 infection ; m6A modification ; Virus replication ; Virus reproduction ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Subject code 570
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  10. Article ; Online: Targeting m6A modification inhibits herpes virus 1 infection.

    Feng, Zhuoying / Zhou, Fanghang / Tan, Miaomiao / Wang, Tingting / Chen, Ying / Xu, Wenwen / Li, Bin / Wang, Xin / Deng, Xin / He, Ming-Liang

    Genes & diseases

    2021  Volume 9, Issue 4, Page(s) 1114–1128

    Abstract: The latent infection by herpes virus type 1 (HSV-1) may be lifelong in trigeminal ganglia and a suspected cause of Alzheimer's Disease (AD) and Amyotrophic lateral sclerosis (ALS). Whether and how N6-methyladenosine (m6A) modification of viral RNAs ... ...

    Abstract The latent infection by herpes virus type 1 (HSV-1) may be lifelong in trigeminal ganglia and a suspected cause of Alzheimer's Disease (AD) and Amyotrophic lateral sclerosis (ALS). Whether and how N6-methyladenosine (m6A) modification of viral RNAs affects virus infection are poorly understood. Here, we report that HSV-1 infection enhanced the expression of m6A writers (METTL3, METTL14) and readers (YTHDF1/2/3) at the early infection stage and decreased their expression later on, while suppressed the erasers' (FTO, ALBKH5) expression immediately upon infection to facilitate viral replication. Inhibiting m6A modification by 3-deazaadenosine (DAA) significantly decreased viral replication and reduced viral reproduction over 1000 folds. More interestingly, depleting the writers and readers by siRNAs inhibited virus replication and reproduction; whereas depleting the erasers promoted viral replication and reproduction. Silencing YTHDF3 strikingly decreased viral replication by up to 90%, leading to reduction of up to 10-fold viral replication and over 100-fold virus reproduction, respectively. Depletion of m6A initiator METTL3 (by 60%-70%) by siRNA correlatedly decreased viral replication 60%-70%, and reduced virus yield over 30-fold. Consistently, ectopic expression of METTL3 largely increased virus yield. METTL3 knockdown suppressed the HSV-1 intermediate early and early genes (ICP0, ICP8 and UL23) and late genes (VP16, UL44, UL49 and ICP47); while ectopic expression of METTL3 upregulated these gene expression. Results from our study shed the lights on the importance for m6A modification to initiate HSV-1 early replication. The components of m6A modification machinery, particularly m6A initiator METTL3 and reader YTHDF3, would be potential important targets for combating HSV-1 infections.
    Language English
    Publishing date 2021-02-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2021.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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