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Book ; Online: Differenz und Krise

Wischmann, Anke / Engel, Juliane / Demmer, Christine / Vehse, Paul

Krisenthematisierungen in der qualitativen Bildungs- und Biographieforschung

(Schriftenreihe der DGfE-Kommission Qualitative Bildungs- und Biographieforschung ; Band 11)

2024

Abstract: Was bedeutet es, Phänomene der Krise zum Gegenstand wissenschaftlicher Analysen zu machen? In der qualitativen Bildungs- und Biographieforschung werden Krisenphänomene und ihr Niederschlag in der alltäglichen Lebensführung häufig auf soziale ... ...

Author's details	Anke Wischmann, Juliane Engel, Christine Demmer, Paul Vehse (Hrsg.)
Series title	Schriftenreihe der DGfE-Kommission Qualitative Bildungs- und Biographieforschung ; Band 11
Collection
Abstract	Was bedeutet es, Phänomene der Krise zum Gegenstand wissenschaftlicher Analysen zu machen? In der qualitativen Bildungs- und Biographieforschung werden Krisenphänomene und ihr Niederschlag in der alltäglichen Lebensführung häufig auf soziale Differenzkategorien und strukturelle Ungleichheiten bezogen – Bezugspunkte, die sich wiederum im Kontext der Krise verändern. Der Band widmet sich erkenntnistheoretischen, methodischen und methodologischen Herausforderungen. What does it mean to make phenomena of crisis the object of scientific analysis? In qualitative educational and biographical research, phenomena of crisis and their reflection in everyday life are often related to social categories of difference and structural inequalities – points of reference that in turn change in the context of crisis. The volume is dedicated to epistemological, methodical and methodological challenges.
Keywords	crisis ; Qualitative Forschungsmethoden ; difference ; Methoden ; qualitative research ; Vulnerabilität ; education ; soziale Selektion ; Erziehungswissenschaft ; Krise ; Differenz ; Differenzkategorien ; Social research & statistics ; crisis;Qualitative Forschungsmethoden;difference;Methoden;qualitative research;Vulnerabilität;education;soziale Selektion;Erziehungswissenschaft;Krise;Differenz;Differenzkategorien ; Bildungsforschung ; Biografieforschung
Subject	Krisensituation ; Krisen ; Biographieforschung ; Biographiearbeit ; Biografiearbeit ; Lebenslaufanalyse ; Lebenslaufforschung ; Lebenslauf ; Biografisches Arbeiten ; Biographisches Arbeiten ; Biographische Forschung ; Biografische Forschung ; Biographieorientierte Intervention ; Biografieorientierte Intervention
Language	German
Size	1 Online-Ressource (271 Seiten)
Publisher	Verlag Barbara Budrich
Publishing place	Opladen ; Berlin ; Toronto
Publishing country	Germany ; Canada
Document type	Book ; Online
Note	German ; Literaturangaben
HBZ-ID	HT030721297
ISBN	978-3-8474-1922-8 ; 9783847427520 ; 3847427520 ; 3-8474-1922-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Thesis: Myokarditis und dendritische Zellen

Andreas, Elise / Schulze, Paul Christian / Heidecker, Bettina / Yilmaz, Atilla

eine Studie zur Charakterisierung und Beeinflussbarkeit der Krankheitsaktivität am Mausmodell (EAM)

2022

Title variant	experimentelle Autoimmunmyokarditis
Institution	Friedrich-Schiller-Universität Jena
Author's details	von Elise Andreas
Keywords	Myokarditis ; Dendritische Zelle ; Tiermodell ; Hochschulschrift ; Dissertation
Subject	Doktorarbeit ; Dissertationen ; Herzmuskelentzündung ; Myocarditis
Language	German
Size	IV, 50, xvii Blätter, Illustrationen, Diagramme, 29,5 cm
Publishing place	Jena
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Friedrich-Schiller-Universität Jena, 2022
Note	Tag der Verteidigung: 01.03.2022
HBZ-ID	HT021864494
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Perspectives on the future of occupational epidemiology in Canada.

Villeneuve, Paul J / Parent, Marie-Élise

Canadian journal of public health = Revue canadienne de sante publique

2021 Volume 112, Issue 5, Page(s) 787–790

Title translation	Perspectives sur l’avenir de l’épidémiologie du travail au Canada.
MeSH term(s)	Canada/epidemiology ; Forecasting ; Humans ; Occupational Diseases/epidemiology
Language	English
Publishing date	2021-10-12
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	417262-0
ISSN	1920-7476 ; 0008-4263
ISSN (online)	1920-7476
ISSN	0008-4263
DOI	10.17269/s41997-021-00573-w
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Article ; Online: Correction to: Guidelines: a structural topic modelling analysis of free-text data from 17,500 UK adults.

Wright, Liam / Paul, Elise / Steptoe, Andrew / Fancourt, Daisy

BMC public health

2022 Volume 22, Issue 1, Page(s) 581

Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-022-12614-1
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Article ; Online: The PCI domains are "winged" HEAT domains.

Eleanor Elise Paul / Assen Marintchev

PLoS ONE, Vol 17, Iss 9, p e

2022 Volume 0268664

Abstract: The HEAT domains are a family of helical hairpin repeat domains, composed of four or more hairpins. HEAT is derived from the names of four family members: huntingtin, eukaryotic translation elongation factor 3 (eEF3), protein phosphatase 2 regulatory A ... ...

Abstract	The HEAT domains are a family of helical hairpin repeat domains, composed of four or more hairpins. HEAT is derived from the names of four family members: huntingtin, eukaryotic translation elongation factor 3 (eEF3), protein phosphatase 2 regulatory A subunit (PP2A), and mechanistic target of rapamycin (mTOR). HEAT domain-containing proteins play roles in a wide range of cellular processes, such as protein synthesis, nuclear transport and metabolism, and cell signaling. The PCI domains are a related group of helical hairpin domains, with a "winged-helix" (WH) subdomain at their C-terminus, which is responsible for multi-subunit complex formation with other PCI domains. The name is derived from the complexes, where these domains are found: the 26S Proteasome "lid" regulatory subcomplex, the COP9 signalosome (CSN), and eukaryotic translation initiation factor 3 (eIF3). We noted that in structure similarity searches using HEAT domains, sometimes PCI domains appeared in the search results ahead of other HEAT domains, which indicated that the PCI domains could be members of the HEAT domain family, and not a related but separate group, as currently thought. Here, we report extensive structure similarity analysis of HEAT and PCI domains, both within and between the two groups of proteins. We present evidence that the PCI domains as a group have greater structural similarity with individual groups of HEAT domains than some of the HEAT domain groups have among each other. Therefore, our results indicate that the PCI domains have evolved from a HEAT domain that acquired a WH subdomain. The WH subdomain in turn mediated self-association into a multi-subunit complex, which eventually evolved into the common ancestor of the Proteasome lid/CSN/eIF3.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predictors of uncertainty and unwillingness to receive the COVID-19 booster vaccine

Elise Paul / Daisy Fancourt

The Lancet Regional Health. Europe, Vol 14, Iss , Pp 100317- (2022)

An observational study of 22,139 fully vaccinated adults in the UK

2022

Abstract: Summary: Background: The continued success of the COVID-19 vaccination programme in the UK will depend on widespread uptake of booster vaccines. However, there is evidence of hesitancy and unwillingness to receive the booster vaccine, even in fully ... ...

Abstract	Summary: Background: The continued success of the COVID-19 vaccination programme in the UK will depend on widespread uptake of booster vaccines. However, there is evidence of hesitancy and unwillingness to receive the booster vaccine, even in fully vaccinated adults. Identifying factors associated with COVID-19 booster vaccine intentions specifically in this population is therefore critical. Methods: We used data from 22,139 fully vaccinated adults who took part in the UCL COVID-19 Social Study. Multinomial logistic regression examined predictors of uncertainty and unwillingness (versus willingness) to receive a COVID-19 booster vaccine (measured 22 November 2021 to 6 December 2021), including (i) socio-demographic factors, (ii) COVID-19 related factors (e.g., having been infected with COVID-19), and (iii) initial intent to receive a COVID-19 vaccine in the four months following the announcement in the UK that the vaccines had been approved (2 December 2020 to 31 March 2021). Findings: 4% of the sample reported that they were uncertain about receiving a COVID-19 booster vaccine, and a further 4% unwilling. Initial uncertainty and unwillingness to accept the first COVID-19 vaccine in 2020-21 were each associated with over five times the risk of being uncertain about and unwilling to accept a booster vaccine. Healthy adults (those without a pre-existing physical health condition) were also more likely to be uncertain or unwilling to receive a booster vaccine. In addition, low levels of current stress about catching or becoming seriously ill from COVID-19, consistently low compliance with COVID-19 government guidelines during periods of strict restrictions (e.g., lockdowns), lower levels of educational qualification, lower socio-economic position, and age below 45 years were all associated with uncertainty and unwillingness. Interpretation: Our findings highlight that there are a range of factors that predict booster intentions, with the strongest predictor being previous uncertainty and unwillingness. Two other ...
Keywords	COVID-19 ; Booster vaccine ; Vaccine refusal ; Vaccine hesitancy ; Public aspects of medicine ; RA1-1270
Subject code	300
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The PCI domains are "winged" HEAT domains.

Paul, Eleanor Elise / Marintchev, Assen

PloS one

2022 Volume 17, Issue 9, Page(s) e0268664

Abstract	The HEAT domains are a family of helical hairpin repeat domains, composed of four or more hairpins. HEAT is derived from the names of four family members: huntingtin, eukaryotic translation elongation factor 3 (eEF3), protein phosphatase 2 regulatory A subunit (PP2A), and mechanistic target of rapamycin (mTOR). HEAT domain-containing proteins play roles in a wide range of cellular processes, such as protein synthesis, nuclear transport and metabolism, and cell signaling. The PCI domains are a related group of helical hairpin domains, with a "winged-helix" (WH) subdomain at their C-terminus, which is responsible for multi-subunit complex formation with other PCI domains. The name is derived from the complexes, where these domains are found: the 26S Proteasome "lid" regulatory subcomplex, the COP9 signalosome (CSN), and eukaryotic translation initiation factor 3 (eIF3). We noted that in structure similarity searches using HEAT domains, sometimes PCI domains appeared in the search results ahead of other HEAT domains, which indicated that the PCI domains could be members of the HEAT domain family, and not a related but separate group, as currently thought. Here, we report extensive structure similarity analysis of HEAT and PCI domains, both within and between the two groups of proteins. We present evidence that the PCI domains as a group have greater structural similarity with individual groups of HEAT domains than some of the HEAT domain groups have among each other. Therefore, our results indicate that the PCI domains have evolved from a HEAT domain that acquired a WH subdomain. The WH subdomain in turn mediated self-association into a multi-subunit complex, which eventually evolved into the common ancestor of the Proteasome lid/CSN/eIF3.
MeSH term(s)	COP9 Signalosome Complex ; Eukaryotic Initiation Factor-3/chemistry ; Hot Temperature ; Percutaneous Coronary Intervention ; Proteins
Chemical Substances	Eukaryotic Initiation Factor-3 ; Proteins ; COP9 Signalosome Complex (EC 3.4.19.12)
Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0268664
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health behaviours the month prior to COVID-19 infection and the development of self-reported long COVID and specific long COVID symptoms: a longitudinal analysis of 1581 UK adults.

Paul, Elise / Fancourt, Daisy

BMC public health

2022 Volume 22, Issue 1, Page(s) 1716

Abstract: Background: Demographic and infection-related characteristics have been identified as risk factors for long COVID, but research on the influence of health behaviours (e.g., exercise, smoking) immediately preceding the index infection is lacking. The aim ...

Abstract	Background: Demographic and infection-related characteristics have been identified as risk factors for long COVID, but research on the influence of health behaviours (e.g., exercise, smoking) immediately preceding the index infection is lacking. The aim of this study was to examine whether specific health behaviours in the month preceding infection with COVID-19 act as upstream risk factors for long COVID as well as well as three specific long COVID symptoms. Methods: One thousand five hundred eighty-one UK adults from the UCL COVID-19 Social Study and who had previously been infected with COVID-19 were analysed. Health behaviours in the month before infection were weekly exercise frequency, days of fresh air per week, sleep quality, smoking, consuming more than the number of recommended alcoholic drinks per week (> 14), and the number of mental health care behaviours (e.g., online mental health programme). Logistic regressions controlling for covariates (e.g., COVID-19 infection severity, socio-demographics, and pre-existing health conditions) examined the impact of health behaviours on long COVID and three long COVID symptoms (difficulty with mobility, cognition, and self-care). Results: In the month before infection with COVID-19, poor quality sleep increased the odds of long COVID (odds ratio [OR]: 3.53; (95% confidence interval [CI]: 2.01 to 6.21), as did average quality sleep (OR: 2.44; 95% CI: 1.44 to 4.12). Having smoked (OR: 8.39; 95% CI: 1.86 to 37.91) increased and meeting recommended weekly physical activity guidelines (3h hours) (OR: 0.05; 95% CI: 0.01 to 0.39) reduced the likelihood of difficulty with self-care (e.g., washing all over or dressing) amongst those with long COVID. Conclusions: Results point to the importance of sleep quality for long COVID, potentially helping to explain previously demonstrated links between stress and long COVID. Results also suggest that exercise and smoking may be modifiable risk factors for preventing the development of difficulty with self-care.
MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/epidemiology ; Health Behavior ; Humans ; Risk Factors ; Self Report ; United Kingdom/epidemiology
Language	English
Publishing date	2022-09-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-022-14123-7
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Article ; Online: Factors influencing self-harm thoughts and behaviours over the first year of the COVID-19 pandemic in the UK: longitudinal analysis of 49 324 adults.

Paul, Elise / Fancourt, Daisy

The British journal of psychiatry : the journal of mental science

2022 Volume 220, Issue 1, Page(s) 31–37

Abstract: Background: There is concern that the COVID-19 pandemic and its aftermath will result in excess suicides by increasing known risk factors such as self-harm, but evidence on how pandemic-related risk factors contribute to changes in these outcomes is ... ...

Abstract	Background: There is concern that the COVID-19 pandemic and its aftermath will result in excess suicides by increasing known risk factors such as self-harm, but evidence on how pandemic-related risk factors contribute to changes in these outcomes is lacking. Aims: To examine how different COVID-19-related experiences of and worries about adversity contribute to changes in self-harm thoughts and behaviours. Method: Data from 49 324 UK adults in the University College London COVID-19 Social Study were analysed (1 April 2020 to 17 May 2021). Fixed-effects regressions explored associations between weekly within-person variation in five categories of adversity experience and adversity worries with changes in self-harm thoughts and behaviours across age groups (18-29, 30-44, 45-59 and 60+ years). Results: In total, 26.1% and 7.9% of respondents reported self-harm thoughts and behaviours respectively at least once over the study period. The number of adverse experiences was more strongly related to outcomes than the number of worries. The largest specific adversity contributing to increases in both outcomes was having experienced physical or psychological abuse. Financial worries increased the likelihood of both outcomes in most age groups, and having had COVID-19 increased the likelihood of both outcomes in young (18-29 years) and middle-aged (45-59 years) adults. Conclusions: Findings suggest that a significant portion of UK adults may be at increased risk for self-harm thoughts and behaviours during the pandemic. Given the likelihood that the economic and social consequences of the pandemic will accumulate, policy makers can begin adapting evidence-based suicide prevention strategies and other social policies to help mitigate its consequences.
MeSH term(s)	Adolescent ; Adult ; COVID-19 ; Humans ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Self-Injurious Behavior/epidemiology ; Suicide ; United Kingdom/epidemiology ; Young Adult
Language	English
Publishing date	2022-01-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218103-4
ISSN	1472-1465 ; 0007-1250
ISSN (online)	1472-1465
ISSN	0007-1250
DOI	10.1192/bjp.2021.130
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Article ; Online: Proximally-occurring life events and the first transition from suicidal ideation to suicide attempt in adolescents.

Paul, Elise

Journal of affective disorders

2018 Volume 241, Page(s) 499–504

Abstract: Background: Informed by diathesis-stress models of suicide risk, this paper investigated the role of proximally-occurring stressful life events in the first transition from suicidal ideation to suicide attempt in adolescence. Interactions between ... ...

Abstract	Background: Informed by diathesis-stress models of suicide risk, this paper investigated the role of proximally-occurring stressful life events in the first transition from suicidal ideation to suicide attempt in adolescence. Interactions between stressful life events and psychiatric disorders in relation to this progression were also examined. Methods: Data are from a subsample (N = 928) of adolescents with lifetime suicidal ideation from the National Comorbidity Survey-Adolescent Supplement. Logistic regression analyses compared adolescents who had transitioned to a first suicide attempt (n = 81) in the year prior to the study to adolescents with suicidal ideation only (n = 847). Results: Multivariate logistic regressions implicated increased risk for progression from suicidal ideation to a first suicide attempt in the presence of a recent romantic break-up as well as more recent stressful life events. However, among adolescents with suicidal ideation and either a recent romantic break-up or above-average recent stressors, neither a disruptive behavior disorder, mood disorder, nor a substance use disorder intensified the risk for progressing to a first suicide attempt. Limitations: Analyses are cross-sectional and therefore limit causal inferences. Conclusions: Findings underscore the importance of comprehensive suicide risk evaluations that consider proximally-occurring interpersonal stressors which may influence the first transition from thinking about suicide to acting in adolescence.
MeSH term(s)	Adolescent ; Adolescent Behavior/psychology ; Attention Deficit and Disruptive Behavior Disorders/psychology ; Cross-Sectional Studies ; Female ; Humans ; Life Change Events ; Logistic Models ; Male ; Mood Disorders/psychology ; Risk Factors ; Substance-Related Disorders/psychology ; Suicidal Ideation ; Suicide, Attempted/psychology ; Violence
Language	English
Publishing date	2018-08-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2018.08.059
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