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Article ; Online: Attività ginnico-sportiva: i benefici sulla salute in periodo di emergenza CoViD-19. Come organizzare una rapida ripresa.

Regis, Guido

2020 Volume 111, Issue 5, Page(s) 297–301

Abstract: Regular physical activity grants significant health effects and lowers the risk of premature death for all causes, in particular cardiovascular ones in asymptomatic subjects. Physical activity is useful in the primary and secondary prevention of ... ...

Title translation	Gymnastics-sports activities: health benefits in emergency period CoViD-19. How to organize a quick shot.
Abstract	Regular physical activity grants significant health effects and lowers the risk of premature death for all causes, in particular cardiovascular ones in asymptomatic subjects. Physical activity is useful in the primary and secondary prevention of cardiovascular and lung diseases, metabolic diseases, musculoskeletal diseases, cancer and depression. Recent studies correlate inactivity with chronic low-grade inflammation and obesity, at the origin of chronic non-communicable diseases. The evidence must be taken seriously into consideration in this particular CoViD-19 emergency period and long-term effects of prolonged limitation of sports activity must not be overlooked. Contagion in open places is very difficult and the absolute prohibition of sports activities in open places and the closure of parks are creating discomfort and confusion. Institutions and media are generating the wrong message that active people must be looked at with disapproval. Instead, this habit should be encouraged, in order to protect citizens' and community health, lightening the welfare load for society.
MeSH term(s)	COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Exercise/physiology ; Gymnastics ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Sports/physiology ; Time Factors
Keywords	covid19
Language	Italian
Publishing date	2020-04-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	138266-4
ISSN	2038-1840 ; 0034-1193
ISSN (online)	2038-1840
ISSN	0034-1193
DOI	10.1701/3366.33411
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Article: [Gymnastics-sports activities: health benefits in emergency period CoViD-19. How to organize a quick shot.]

Regis, Guido

Recenti Prog Med

Abstract: Regular physical activity grants significant health effects and lowers the risk of premature death for all causes, in particular cardiovascular ones in asymptomatic subjects Physical activity is useful in the primary and secondary prevention of ... ...

Abstract	Regular physical activity grants significant health effects and lowers the risk of premature death for all causes, in particular cardiovascular ones in asymptomatic subjects Physical activity is useful in the primary and secondary prevention of cardiovascular and lung diseases, metabolic diseases, musculoskeletal diseases, cancer and depression Recent studies correlate inactivity with chronic low-grade inflammation and obesity, at the origin of chronic non-communicable diseases The evidence must be taken seriously into consideration in this particular CoViD-19 emergency period and long-term effects of prolonged limitation of sports activity must not be overlooked Contagion in open places is very difficult and the absolute prohibition of sports activities in open places and the closure of parks are creating discomfort and confusion Institutions and media are generating the wrong message that active people must be looked at with disapproval Instead, this habit should be encouraged, in order to protect citizens' and community health, lightening the welfare load for society
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #375481
Database	COVID19

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Article: Attività ginnico-sportiva: i benefici sulla salute in periodo di emergenza CoViD-19. Come organizzare una rapida ripresa./ [Gymnastics-sports activities: health benefits in emergency period CoViD-19. How to organize a quick shot.]

Regis, Guido

Recenti Prog Med

Abstract	Regular physical activity grants significant health effects and lowers the risk of premature death for all causes, in particular cardiovascular ones in asymptomatic subjects. Physical activity is useful in the primary and secondary prevention of cardiovascular and lung diseases, metabolic diseases, musculoskeletal diseases, cancer and depression. Recent studies correlate inactivity with chronic low-grade inflammation and obesity, at the origin of chronic non-communicable diseases. The evidence must be taken seriously into consideration in this particular CoViD-19 emergency period and long-term effects of prolonged limitation of sports activity must not be overlooked. Contagion in open places is very difficult and the absolute prohibition of sports activities in open places and the closure of parks are creating discomfort and confusion. Institutions and media are generating the wrong message that active people must be looked at with disapproval. Instead, this habit should be encouraged, in order to protect citizens' and community health, lightening the welfare load for society.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32448880
Database	COVID19

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Article ; Online: Systemic benefits of periodontal therapy in patients with obesity and periodontitis: a systematic review.

Menezes, Cláudia Callegaro de / Barbirato, Davi da Silva / Fogacci, Mariana Fampa / Marañón-Vásquez, Guido Artemio / Carneiro, João Régis Ivar / Maia, Lucianne Copple / Barros, Maria Cynésia Medeiros de

Brazilian oral research

2024 Volume 38, Page(s) e031

Abstract: This systematic review aimed to answer the focused question: "What are the benefits of subgingival periodontal therapy on blood hematological and biochemical index, biomarkers of inflammation and oxidative stress, quality of life, and periodontal ... ...

Abstract	This systematic review aimed to answer the focused question: "What are the benefits of subgingival periodontal therapy on blood hematological and biochemical index, biomarkers of inflammation and oxidative stress, quality of life, and periodontal pathogen counts in patients with obesity and periodontitis?". A systematic literature search was performed in six databases: PubMed, Embase, LILACS, Web of Science, Cochrane and SCOPUS and other sources, and a manual search was conducted as well. Inclusion criteria were randomized and non-randomized clinical trials, and before-and-after studies on patients with obesity subjected to periodontal therapy. The results were synthesized qualitatively. Risk of bias within studies was assessed using RoB 2 and ROBINS-I tools. The certainty of evidence was evaluated following the GRADE approach. Three randomized controlled trials and 15 before-and-after studies were included. Randomized controlled trials were considered to have a low risk of bias, as compared to before-and-after studies assessed as having low, serious, and critical risks of bias. Non-surgical periodontal therapy plus azithromycin, chlorhexidine, and cetylpyridinium chloride reduced blood pressure and decreased serum levels of HbA1c, hsCRP, IL-1β, and TNF-α. Salivary resistin level also decreased in patients with obesity and periodontitis after therapy and chlorhexidine mouth rinse. Before-and-after data suggest an improvement in total cholesterol, LDL, triglycerides, insulin resistance, C3, GCF levels of TNF-α, chemerin, vaspin, omentin-1, visfatin, 8-OHdG, and periodontal pathogen counts after therapy.
MeSH term(s)	Humans ; Chlorhexidine ; Tumor Necrosis Factor-alpha ; Quality of Life ; Periodontitis/complications ; Periodontitis/therapy ; Obesity/complications ; Obesity/therapy ; Chronic Periodontitis/therapy ; Randomized Controlled Trials as Topic
Chemical Substances	Chlorhexidine (R4KO0DY52L) ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2024-04-05
Publishing country	Brazil
Document type	Systematic Review ; Journal Article
ZDB-ID	2179332-3
ISSN	1807-3107 ; 1806-8324 ; 1517-7491
ISSN (online)	1807-3107
ISSN	1806-8324 ; 1517-7491
DOI	10.1590/1807-3107bor-2024.vol38.0031
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Article: Evaluating the risks in the construction wood product system through a criticality assessment framework

Ioannidou, Dimitra / Régis Pommier / Guillaume Habert / Guido Sonnemann

Resources, conservation, and recycling. 2019 July, v. 146

2019

Abstract: The increasing use of wood in product eco-design focuses on the environmental merits of wood. Nevertheless, forest cover loss and other threats may hamper the supply of certain wood species, hence significantly impacting the economic sector. Supply risk ... ...

Abstract	The increasing use of wood in product eco-design focuses on the environmental merits of wood. Nevertheless, forest cover loss and other threats may hamper the supply of certain wood species, hence significantly impacting the economic sector. Supply risk has been intensively studied in the field of mineral resources; this has led to the emergence of the criticality concept, which evaluates the supply risks and main impacts of limited accessibility. In the case of biotic, renewable resources, lack of sustainable management can result in supply shortage. We developed here a criticality framework for wood to assess the risk of supply shortage of different wood species in different regions. Our motivation to look at wood is that it is the biotic resource most used in construction. The indicators used in the framework express all factors that can disturb the forest growth, such as fire and diseases, the sustainable supply of harvested wood, such as trade barriers and country governance, as well as the impacts of the aforementioned factors on the construction wood product system. The value of the framework and of the observations that can be derived thereof is shown through application to four different wood species. Such a criticality assessment can help define points of intervention at different geographic scales.
Keywords	design for environment ; economic sectors ; forest growth ; forests ; governance ; mineral resources ; motivation ; product system ; renewable resources ; risk ; trade barriers ; wood
Language	English
Dates of publication	2019-07
Size	p. 68-76.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1498716-8
ISSN	0921-3449
ISSN	0921-3449
DOI	10.1016/j.resconrec.2019.03.021
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Material Flow Analysis to Evaluate Supply Chain Evolution and Management

Rory J. Layton / Rachel Horta Arduin / Haji Yazdeen / Regis Pommier / Guido Sonnemann

Sustainability, Vol 13, Iss 4378, p

An Example Focused on Maritime Pine in the Landes de Gascogne Forest, France

2021 Volume 4378

Abstract: The Landes de Gascogne forest, located in southwestern France, spans nearly 10,000 km 2 and consists largely of maritime pine ( Pinus pinaster ). This forest in unique to Europe because it is almost entirely created and managed by man for specific ... ...

Abstract	The Landes de Gascogne forest, located in southwestern France, spans nearly 10,000 km 2 and consists largely of maritime pine ( Pinus pinaster ). This forest in unique to Europe because it is almost entirely created and managed by man for specific industries. On the basis of a material flow analysis, we assessed the upstream supply chain of maritime pine from 2013 to 2019, using a cradle-to-gate approach. The assessment is based on data provided by Alliance Forêts Bois, an important stakeholder of the region and leader in the production of forest resources in France. For various reasons, the harvest totals decreased 10% in the last years. We identified a clear orientation to specific industries—in 2019, 45% was used as pulpwood. This is due to the overall design of the current territory, species of tree, and market values of the pulp and paper industry. The current design provides a limited supply of old growth trees, which produce high-quality logs for construction-based products, and are also more resistant to climate variability. A future shift or balance in raw material flows could be a crucial step in protecting the long-term economic viability of the region. This article aims to contribute to new attempts in providing comprehensive views of stocks and flows in the French forest-wood supply chain.
Keywords	material flow analysis ; wood ; production ; raw materials supply ; sustainable regional development ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo

Sönmezer, Can / Kleinendorst, Rozemarijn / Imanci, Dilek / Barzaghi, Guido / Villacorta, Laura / Schübeler, Dirk / Benes, Vladimir / Molina, Nacho / Krebs, Arnaud Regis

Molecular cell. 2021 Jan. 21, v. 81, no. 2

2021

Abstract: Gene activation requires the cooperative activity of multiple transcription factors at cis-regulatory elements (CREs). Yet, most transcription factors have short residence time, questioning the requirement of their physical co-occupancy on DNA to achieve ...

Abstract	Gene activation requires the cooperative activity of multiple transcription factors at cis-regulatory elements (CREs). Yet, most transcription factors have short residence time, questioning the requirement of their physical co-occupancy on DNA to achieve cooperativity. Here, we present a DNA footprinting method that detects individual molecular interactions of transcription factors and nucleosomes with DNA in vivo. We apply this strategy to quantify the simultaneous binding of multiple transcription factors on single DNA molecules at mouse CREs. Analysis of the binary occupancy patterns at thousands of motif combinations reveals that high DNA co-occupancy occurs for most types of transcription factors, in the absence of direct physical interaction, at sites of competition with nucleosomes. Perturbation of pairwise interactions demonstrates the function of molecular co-occupancy in binding cooperativity. Our results reveal the interactions regulating CREs at molecular resolution and identify DNA co-occupancy as a widespread cooperativity mechanism used by transcription factors to remodel chromatin.
Keywords	DNA ; DNA footprinting ; gene activation ; mice ; nucleosomes ; regulatory sequences ; transcription factors
Language	English
Dates of publication	2021-0121
Size	p. 255-267.e6.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2020.11.015
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo.

Sönmezer, Can / Kleinendorst, Rozemarijn / Imanci, Dilek / Barzaghi, Guido / Villacorta, Laura / Schübeler, Dirk / Benes, Vladimir / Molina, Nacho / Krebs, Arnaud Regis

Molecular cell

2020 Volume 81, Issue 2, Page(s) 255–267.e6

Abstract	Gene activation requires the cooperative activity of multiple transcription factors at cis-regulatory elements (CREs). Yet, most transcription factors have short residence time, questioning the requirement of their physical co-occupancy on DNA to achieve cooperativity. Here, we present a DNA footprinting method that detects individual molecular interactions of transcription factors and nucleosomes with DNA in vivo. We apply this strategy to quantify the simultaneous binding of multiple transcription factors on single DNA molecules at mouse CREs. Analysis of the binary occupancy patterns at thousands of motif combinations reveals that high DNA co-occupancy occurs for most types of transcription factors, in the absence of direct physical interaction, at sites of competition with nucleosomes. Perturbation of pairwise interactions demonstrates the function of molecular co-occupancy in binding cooperativity. Our results reveal the interactions regulating CREs at molecular resolution and identify DNA co-occupancy as a widespread cooperativity mechanism used by transcription factors to remodel chromatin.
MeSH term(s)	Animals ; Binding Sites ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; DNA Footprinting/methods ; Male ; Mice ; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/metabolism ; Nucleosomes/chemistry ; Nucleosomes/metabolism ; Protein Binding ; Regulatory Elements, Transcriptional ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic
Chemical Substances	Nucleosomes ; Transcription Factors ; DNA (9007-49-2)
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2020.11.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: LCA (Life Cycle Assessment) of EVP – engineering veneer product: plywood glued using a vacuum moulding technology from green veneers

Pommier, Régis / Guido Sonnemann / Guilhem Grimaud / Marion Prinçaud / Nicolas Perry

Journal of cleaner production. 2016 June 15, v. 124

2016

Abstract: The production of plywood represents a major proportion of engineered wood products. The traditional manufacturing process requires very thorough drying of the wood before gluing. Gluing green wood is a new technology which can be applied to plywood ... ...

Abstract	The production of plywood represents a major proportion of engineered wood products. The traditional manufacturing process requires very thorough drying of the wood before gluing. Gluing green wood is a new technology which can be applied to plywood vacuum moulding. Gluing wood when it is in a green state can be done, because it can be dried by the vacuum at the same time that pressure is applied for the gluing. The main interest of this method is that it reduces considerably the number of steps in its manufacture. The aim of this paper is to propose a Life Cycle Assessment (LCA) in order to validate the use of the vacuum process with green veneers. The types of glue, the gluing techniques (by vacuum or traditional methods) and the wood varieties have been compared. The functional analysis focused on 4 traditional plywood in order to compare it with our product. The 5 products meet the quality requirements of plywood EN 13986 (2004). The environmental modelling was carried out according to the ISO 14040, standard of life cycle assessment, principles and framework, starting from existing databases and from measurements taken on manufacturing sites and during the testing. The model shows that there is a significant interest in the technology of gluing green wood with a vacuum process compared to the conventional approach. For an industrial use, the disadvantage of this new technology is the use of consumables but that could be reduced considerably in industrial production by using reusable consumables.
Keywords	databases ; drying ; engineered wood products ; engineering ; environmental models ; life cycle assessment ; manufacturing ; plywood ; vacuum processing ; wood
Language	English
Dates of publication	2016-0615
Size	p. 383-394.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2016.02.130
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues.

Castriconi, Roberta / Carrega, Paolo / Dondero, Alessandra / Bellora, Francesca / Casu, Beatrice / Regis, Stefano / Ferlazzo, Guido / Bottino, Cristina

Frontiers in immunology

2018 Volume 9, Page(s) 2324

Abstract: A large body of data shows that Natural Killer (NK) cells are immune effectors exerting a potent cytolytic activity against tumors and virus infected cells. The discovery and characterization of several inhibitory and activating receptors unveiled most ... ...

Abstract	A large body of data shows that Natural Killer (NK) cells are immune effectors exerting a potent cytolytic activity against tumors and virus infected cells. The discovery and characterization of several inhibitory and activating receptors unveiled most of the mechanisms allowing NK cells to spare healthy cells while selectively attacking abnormal tissues. Nevertheless, the mechanisms ruling NK cell subset recirculation among the different compartments of human body have only lately started to be investigated. This is particularly true for pathological settings such as tumors or infected tissues but also for para-physiological condition like pregnant human uterine mucosa. It is becoming evident that the microenvironment associated to a particular clinical condition can deeply influence the migratory capabilities of NK cells. In this review we describe the main mechanisms and stimuli known to regulate the expression of chemokine receptors and other molecules involved in NK cell homing to either normal or pathological/inflamed tissues, including tumors or organs such as lung and liver. We will also discuss the role played by the chemokine/chemokine receptor axes in the orchestration of physiological events such as NK cell differentiation, lymphoid organ retention/egress and recruitment to decidua during pregnancy.
MeSH term(s)	Animals ; Cell Movement/genetics ; Cell Movement/immunology ; Cytokines/metabolism ; Cytotoxicity, Immunologic ; Female ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; Organ Specificity/immunology ; Pregnancy
Chemical Substances	Cytokines
Language	English
Publishing date	2018-10-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02324
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