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  1. Article: Orostachys japonicus exerts antipancreatic cancer activity through induction of apoptosis and cell cycle arrest in PANC‐1 cells

    Kim, Ji Hyun / Nam, Gi Suk / Kim, Sung Hyun / RYU, Deok-Seon / Lee, Dong Seok

    Food Science & Nutrition, 7(11):3549-3559

    2019  

    Abstract: Targeted therapy at the molecular level is important for pancreatic cancer treatment. This study looked over the anticancer activity of Orostachys japonicus in a human pancreatic cancer cell line, PANC‐1. An ethyl acetate fraction containing quercetin, ... ...

    Abstract Targeted therapy at the molecular level is important for pancreatic cancer treatment. This study looked over the anticancer activity of Orostachys japonicus in a human pancreatic cancer cell line, PANC‐1. An ethyl acetate fraction containing quercetin, kaempferol, and flavonol glycosides from O. japonicus (OJE) exhibited significant anticancer activity against the PANC‐1. OJE activated caspase‐3, caspase‐8, and caspase‐9, leading to the induction of both intrinsic and extrinsic apoptosis pathways. It also inhibited cyclin D1, cyclin B1, and cyclin‐dependent kinase 4, representing cell cycle arrest at both G1/S and G2/M phases. In addition, OJE phosphorylated MAPKs such as p38, JNK, and ERK, which are important upstream signaling factors in apoptosis and arrest of cell cycle inducing system. In conclusion, OJE effectively exerted antipancreatic cancer activity via induction of apoptosis directed by both intrinsic and extrinsic pathways and arrest of cell cycle regulated at both G1/S and G2/M stages, which is activated by MAPKs, p38, JNK, and ERK.
    Keywords Orostachys japonicus ; MAPK ; caspases ; cell cycle arrest ; apoptosis
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article ; Online: Antagonistic functions of CTL1 and SUH1 mediate cell wall assembly in

    Thuy, Nguyen Thi / Kim, Hyun-Jung / Hong, Suk-Whan

    Plant direct

    2024  Volume 8, Issue 3, Page(s) e580

    Abstract: Plant genomes contain numerous genes encoding chitinase-like (CTL) proteins, which have a similar protein structure to chitinase belonging to the glycoside hydrolase (GH) family but lack the chitinolytic activity to cleave ... ...

    Abstract Plant genomes contain numerous genes encoding chitinase-like (CTL) proteins, which have a similar protein structure to chitinase belonging to the glycoside hydrolase (GH) family but lack the chitinolytic activity to cleave the
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Journal Article
    ISSN 2475-4455
    ISSN (online) 2475-4455
    DOI 10.1002/pld3.580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Verrucous Carcinoma of the Palatine Tonsil With Neck Metastases.

    Chang, Suk Won / Kim, Hyun Jung / Kim, Jeong Hong

    Ear, nose, & throat journal

    2023  , Page(s) 1455613231199691

    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613231199691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
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  4. Article: Applying Sequential Pattern Mining to Investigate the Temporal Relationships between Commonly Occurring Internal Medicine Diseases and Intervals for the Risk of Concurrent Disease in Canine Patients.

    Lee, Suk-Jun / Kim, Jung-Hyun

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 21

    Abstract: Sequential pattern mining (SPM) is a data mining technique used for identifying common association rules in multiple sequential datasets and patterns in ordered events. In this study, we aimed to identify the relationships between commonly occurring ... ...

    Abstract Sequential pattern mining (SPM) is a data mining technique used for identifying common association rules in multiple sequential datasets and patterns in ordered events. In this study, we aimed to identify the relationships between commonly occurring internal medicine diseases in canine patients. We obtained medical records of dogs referred to the Konkuk University Veterinary Medicine Teaching Hospital. The data used for SPM included comorbidities and intervals between the diagnoses of internal medicine diseases. Additionally, we estimated the 3-year risk of developing an additional disease after the initial diagnosis of a commonly occurring veterinary internal medicine disease using logistic regression. We identified 547 canine patients diagnosed with ≥ 1 internal medicine disease. The SPM-based analysis assessed comorbidities and intervals for each of the five most common internal medical diseases, including hyperadrenocorticism, myxomatous mitral valve disease, canine atopic dermatitis, chronic kidney disease, and chronic pancreatitis. The highest values of the association rule were 3.01%, 6.02%, 3.9%, 4.1%, and 4.84%, and the shortest intervals were 1.64, 13.14, 5.37, 17.02, and 1.7 days, respectively. This study proposes that SPM is an effective technique for identifying common associations and temporal relationships between internal medicine diseases, and can be used to assess the probability of additional admission due to the development of the subsequent disease that may be diagnosed in canine patients. The results of this study will help veterinarians suggest appropriate preventive measures or other medical treatments for canine patients with medical conditions that have not yet been diagnosed, but are likely to develop in the short term.
    Language English
    Publishing date 2023-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13213359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Facial palsy reconstruction.

    Woo, Soo Hyun / Kim, Young Chul / Oh, Tae Suk

    Archives of craniofacial surgery

    2024  Volume 25, Issue 1, Page(s) 1–10

    Abstract: The facial nerve stimulates the muscles of facial expression and the parasympathetic nerves of the face. Consequently, facial nerve paralysis can lead to facial asymmetry, deformation, and functional impairment. Facial nerve palsy is most commonly ... ...

    Abstract The facial nerve stimulates the muscles of facial expression and the parasympathetic nerves of the face. Consequently, facial nerve paralysis can lead to facial asymmetry, deformation, and functional impairment. Facial nerve palsy is most commonly idiopathic, as with Bell palsy, but it can also result from a tumor or trauma. In this article, we discuss traumatic facial nerve injury. To identify the cause of the injury, it is important to first determine its location. The location and extent of the damage inform the treatment method, with options including primary repair, nerve graft, cross-face nerve graft, nerve crossover, and muscle transfer. Intracranial proximal facial nerve injuries present a challenge to surgical approaches due to the complexity of the temporal bone. Surgical intervention in these cases requires a collaborative approach between neurosurgery and otolaryngology, and nerve repair or grafting is difficult. This article describes the treatment of peripheral facial nerve injury. Primary repair generally offers the best prognosis. If primary repair is not feasible within 6 months of injury, nerve grafting should be attempted, and if more than 12 months have elapsed, functional muscle transfer should be performed. If the affected nerve cannot be utilized at that time, the contralateral facial nerve, ipsilateral masseter nerve, or hypoglossal nerve can serve as the donor nerve. Other accompanying symptoms, such as lagophthalmos or midface ptosis, must also be considered for the successful treatment of facial nerve injury.
    Language English
    Publishing date 2024-02-20
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2800630-6
    ISSN 2287-5603 ; 2287-1152
    ISSN (online) 2287-5603
    ISSN 2287-1152
    DOI 10.7181/acfs.2023.00528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Comparison of Nasal Dimensions According to the Facial and Nasal Indices Using Cone-Beam Computed Tomography.

    Lee, Jeong-Hyun / Kim, Hey-Suk / Park, Jong-Tae

    Journal of personalized medicine

    2024  Volume 14, Issue 4

    Abstract: The nasal cavity constitutes the foremost portion of the respiratory system, composed of the anterior nasal aperture, nostrils, and choanae. It has an intricate anatomical structure since it has various functions, such as heat exchange, humidification, ... ...

    Abstract The nasal cavity constitutes the foremost portion of the respiratory system, composed of the anterior nasal aperture, nostrils, and choanae. It has an intricate anatomical structure since it has various functions, such as heat exchange, humidification, and filtration. Accordingly, clinical symptoms related to the nose, such as nasal congestion, snoring, and nasal septal deviation, are closely linked to the complex anatomical structure of the nasal cavity. Thus, the nasal cavity stands as a paramount structure in both forensic and clinical contexts. The majority of relevant studies have performed comparisons between sexes, with studies making comparisons according to the FI and NI only and examining relative percentages. Furthermore, the nasal cavity was measured in 2D, and not 3D, in most cases. In this study, we conducted a 3D modeling and anthropometric assessment of the nasal cavity using a 3D analysis software. Furthermore, we aimed to investigate whether the size of the nasal cavity differs according to sex, facial index (FI), and nasal index (NI). We retrospectively reviewed the cone-beam computed tomography (CBCT) data of 100 participants (50 males, 50 females) aged 20-29 years who visited the dental hospital of Dankook University (IRB approval no. DKUDH IRB 2020-01-007). Our findings showed that nasal cavity sizes generally differed according to sex, FI, and NI. These findings provide implications for performing patient-tailored surgeries in clinical practice and conducting further research on the nasal cavity. Therefore, we believe that our study makes a significant contribution to the literature.
    Language English
    Publishing date 2024-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14040415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: All-Solid-State Synaptic Transistors with Lithium-Ion-Based Electrolytes for Linear Weight Mapping and Update in Neuromorphic Computing Systems.

    Park, Ji-Min / Hwang, Hwiho / Song, Min Suk / Jang, Seong Cheol / Kim, Jung Hyun / Kim, Hyungjin / Kim, Hyun-Suk

    ACS applied materials & interfaces

    2023  Volume 15, Issue 40, Page(s) 47229–47237

    Abstract: Neuromorphic computing, an innovative technology inspired by the human brain, has attracted increasing attention as a promising technology for the development of artificial intelligence systems. This study proposes synaptic transistors with a ... ...

    Abstract Neuromorphic computing, an innovative technology inspired by the human brain, has attracted increasing attention as a promising technology for the development of artificial intelligence systems. This study proposes synaptic transistors with a Li
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c09162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Applicability of Brassica juncea as a bioindicator for As contamination in soil near the abandoned mine area.

    Kim, Min-Suk / Chae, Eunji / Min, Hyun-Gi / Kim, Jeong-Gyu

    Journal of environmental management

    2024  Volume 358, Page(s) 120805

    Abstract: Soil monitoring in abandoned mine areas is important from the perspective of ecological and human health risk. Arsenic (As) is a predominant metalloid contaminant in abandoned mine area and its behavior has been influenced by various soil characteristics. ...

    Abstract Soil monitoring in abandoned mine areas is important from the perspective of ecological and human health risk. Arsenic (As) is a predominant metalloid contaminant in abandoned mine area and its behavior has been influenced by various soil characteristics. Bioindicator can be a useful tool in terms of testing the extent to which they are uptaken by plants bioavailability. Eighteen soils near the mine tailings dam were collected to investigate the effect of As contamination on As absorption by Brassica juncea. The pH range of the experimental soils was between 4.90 and 8.55, and the total As concentrations were between 34 mg kg
    MeSH term(s) Soil Pollutants/analysis ; Soil Pollutants/metabolism ; Mustard Plant/metabolism ; Soil/chemistry ; Mining ; Arsenic/analysis ; Arsenic/metabolism ; Environmental Monitoring/methods
    Chemical Substances Soil Pollutants ; Soil ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  9. Article ; Online: Nitrogen-Doped Activated Hollow Carbon Nanofibers with Controlled Hierarchical Pore Structures for High-Performance, Binder-Free, Flexible Supercapacitor Electrodes.

    Lim, TaeGyeong / Seo, Bong Hyun / Kim, Seo Ju / Han, Seungwoo / Lee, Wonyoung / Suk, Ji Won

    ACS omega

    2024  Volume 9, Issue 7, Page(s) 8247–8254

    Abstract: Carbon nanofibers (CNFs) are a fascinating electrode material for energy storage devices due to their one-dimensionality, interconnected networks, and chemical stability. However, a relatively low specific surface area of CNFs hinders their use as ... ...

    Abstract Carbon nanofibers (CNFs) are a fascinating electrode material for energy storage devices due to their one-dimensionality, interconnected networks, and chemical stability. However, a relatively low specific surface area of CNFs hinders their use as supercapacitor electrodes. Here, nitrogen-doped hollow CNFs with hierarchical pore structures are prepared via electrospinning of core-shell polymer nanofibers and subsequent carbonization and activation under an ammonia atmosphere. Hierarchical pore structures with micro-, meso-, and macropores are controlled by an ammonia etching effect during the carbonization of polymer nanofibers. In addition, a hollow structure in CNFs is obtained by thermal decomposition of the core polymer during the carbonization/activation. The nitrogen-doped activated hollow CNFs (ahCNFs) exhibited an exceptionally high specific surface area of 3618 m
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ventral Surface Midline Cavernous Hemangioma of Anterior Tongue in a Child.

    Kim, Hyun Jung / Kim, Min Bum / Chang, Suk Won

    Ear, nose, & throat journal

    2022  , Page(s) 1455613221080971

    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613221080971
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    In stock of ZB MED Cologne/Königswinter

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