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Article: Exercise-mediated adaptations in vascular function and structure: Beneficial effects in coronary artery disease.

Sakellariou, Xenofon M / Papafaklis, Michail I / Domouzoglou, Eleni M / Katsouras, Christos S / Michalis, Lampros K / Naka, Katerina K

World journal of cardiology

2021 Volume 13, Issue 9, Page(s) 399–415

Abstract: Exercise exerts direct effects on the ... ...

Abstract	Exercise exerts direct effects on the vasculature
Language	English
Publishing date	2021-09-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573665-6
ISSN	1949-8462
ISSN	1949-8462
DOI	10.4330/wjc.v13.i9.399
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Role of FGF21 and Leptin for the Diagnosis of Metabolic Health in Children with and without Obesity.

Domouzoglou, Eleni M / Vlahos, Antonios P / Papafaklis, Michail I / Cholevas, Vasileios K / Chaliasos, Nikolaos / Siomou, Ekaterini / Michalis, Lampros K / Tsatsoulis, Agathocles / Naka, Katerina K

Journal of personalized medicine

2023 Volume 13, Issue 12

Abstract: Obesity and unfavorable metabolic profiles increase the risk for cardiovascular complications in adults. Although it is important to distinguish different metabolic health states at an early stage, there are limited data on the related value of ... ...

Abstract	Obesity and unfavorable metabolic profiles increase the risk for cardiovascular complications in adults. Although it is important to distinguish different metabolic health states at an early stage, there are limited data on the related value of biomarkers in childhood. We aimed to identify biomarkers for the detection of different metabolic health states in children with and without obesity. The serum levels of metabolic regulators (fibroblast growth factor 21 [FGF21], leptin, adiponectin and insulin-like growth factor binding protein 1) and vascular indices (flow-mediated dilation [FMD] and carotid intima-media thickness) were assessed in 78 children. Differences between the metabolically healthy and unhealthy state within children with normal weight (MHN vs. MUN), and within children with overweight/obesity (MHO vs. MUO) were investigated; the discriminatory power of the biomarkers was studied. Both MUN and MUO groups expressed altered lipid and glucose homeostasis compared to their healthy counterparts. The metabolic unhealthy state in children with normal weight was linked to higher FGF21 levels which had good discriminatory ability (area under the curve [AUC]: 0.71, 95% CI: 0.54-0.88;
Language	English
Publishing date	2023-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13121680
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Article ; Online: A rare case of hypereosinophilic obliterative bronchiolitis in an adolescent girl.

Zioga, Aikaterini / Fouzas, Sotirios / Kostara, Maria / Domouzoglou, Eleni / Giantsouli, Anastasia / Siomou, Ekaterini / Tsabouri, Sophia

Pediatric pulmonology

2022 Volume 57, Issue 12, Page(s) 3180–3182

MeSH term(s)	Female ; Adolescent ; Humans ; Bronchiolitis Obliterans/diagnostic imaging ; Bronchiolitis Obliterans/etiology ; Lung Transplantation ; Eosinophilia
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26130
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Article ; Online: Atypical HCoV-NL63 Infection in an Infant During the SARS-CoV-2 Pandemic.

Domouzoglou, Eleni M / Tsabouri, Sophia / Vlahos, Antonios P / Kittas, Christos / Gartzonika, Konstantina / Siomou, Ekaterini / Makis, Alexandros

Indian journal of pediatrics

2020 Volume 88, Issue 4, Page(s) 386–387

MeSH term(s)	COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus NL63, Human ; Humans ; Infant ; Male ; Pandemics ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/virology
Language	English
Publishing date	2020-11-27
Publishing country	India
Document type	Case Reports ; Letter
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-020-03580-w
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Article ; Online: Role of FGF21 and Leptin for the Diagnosis of Metabolic Health in Children with and without Obesity

Eleni M. Domouzoglou / Antonios P. Vlahos / Michail I. Papafaklis / Vasileios K. Cholevas / Nikolaos Chaliasos / Ekaterini Siomou / Lampros K. Michalis / Agathocles Tsatsoulis / Katerina K. Naka

Journal of Personalized Medicine, Vol 13, Iss 12, p

2023 Volume 1680

Abstract	Obesity and unfavorable metabolic profiles increase the risk for cardiovascular complications in adults. Although it is important to distinguish different metabolic health states at an early stage, there are limited data on the related value of biomarkers in childhood. We aimed to identify biomarkers for the detection of different metabolic health states in children with and without obesity. The serum levels of metabolic regulators (fibroblast growth factor 21 [FGF21], leptin, adiponectin and insulin-like growth factor binding protein 1) and vascular indices (flow-mediated dilation [FMD] and carotid intima-media thickness) were assessed in 78 children. Differences between the metabolically healthy and unhealthy state within children with normal weight (MHN vs. MUN), and within children with overweight/obesity (MHO vs. MUO) were investigated; the discriminatory power of the biomarkers was studied. Both MUN and MUO groups expressed altered lipid and glucose homeostasis compared to their healthy counterparts. The metabolic unhealthy state in children with normal weight was linked to higher FGF21 levels which had good discriminatory ability (area under the curve [AUC]: 0.71, 95% CI: 0.54–0.88; p = 0.044). In overweight/obese children, leptin was increased in the metabolically unhealthy subgroup (AUC: 0.81, 95% CI: 0.68–0.95; p = 0.01). There was a decrease in FMD indicating worse endothelial function in overweight/obese children versus those with normal weight. Distinct states of metabolic health exist in both children with normal weight and overweight/obese children. FGF21 and leptin may help to identify the metabolic unhealthy state in children with normal weight and in overweight/obese children, respectively, early in life.
Keywords	obesity ; overweight ; fibroblast growth factor 21 ; leptin ; metabolism ; adiponectin ; Medicine ; R
Subject code	360
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The evolution of comprehensive genetic analysis in neurology: Implications for precision medicine.

Papadopoulou, Eirini / Pepe, Georgia / Konitsiotis, Spiridon / Chondrogiorgi, Maria / Grigoriadis, Nikolaos / Kimiskidis, Vasilios K / Tsivgoulis, Georgios / Mitsikostas, Dimos D / Chroni, Elisabeth / Domouzoglou, Eleni / Tsaousis, Georgios / Nasioulas, Georgios

Journal of the neurological sciences

2023 Volume 447, Page(s) 120609

Abstract: Technological advancements have facilitated the availability of reliable and thorough genetic analysis in many medical fields, including neurology. In this review, we focus on the importance of selecting the appropriate genetic test to aid in the ... ...

Abstract	Technological advancements have facilitated the availability of reliable and thorough genetic analysis in many medical fields, including neurology. In this review, we focus on the importance of selecting the appropriate genetic test to aid in the accurate identification of disease utilizing currently employed technologies for analyzing monogenic neurological disorders. Moreover, the applicability of comprehensive analysis via NGS for various genetically heterogeneous neurological disorders is reviewed, revealing its efficiency in clarifying a frequently cloudy diagnostic picture and delivering a conclusive and solid diagnosis that is essential for the proper management of the patient. The feasibility and effectiveness of medical genetics in neurology require interdisciplinary cooperation among several medical specialties and geneticists, to select and perform the most relevant test according to each patient's medical history, using the most appropriate technological tools. The prerequisites for a comprehensive genetic analysis are discussed, highlighting the utility of appropriate gene selection, variant annotation, and classification. Moreover, genetic counseling and interdisciplinary collaboration could improve diagnostic yield further. Additionally, a sub-analysis is conducted on the 1,502,769 variation records with submitted interpretations in the Clinical Variation (ClinVar) database, with a focus on neurology-related genes, to clarify the value of suitable variant categorization. Finally, we review the current applications of genetic analysis in the diagnosis and personalized management of neurological patients and the advances in the research and scientific knowledge of hereditary neurological disorders that are evolving the utility of genetic analysis towards the individualization of the treatment strategy.
MeSH term(s)	Humans ; Precision Medicine ; Genetic Testing ; Neurology ; Nervous System Diseases/diagnosis ; Nervous System Diseases/genetics ; Nervous System Diseases/therapy ; Databases, Factual ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2023-03-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2023.120609
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Article: Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers.

Domouzoglou, Eleni M / Vlahos, Antonios P / Cholevas, Vasileios K / Papafaklis, Michail I / Chaliasos, Nikolaos / Siomou, Ekaterini / Michalis, Lampros K / Tsatsoulis, Agathocles / Naka, Katerina K

Annals of pediatric endocrinology & metabolism

2021 Volume 26, Issue 4, Page(s) 242–251

Abstract: Purpose: Metabolic and cardiovascular disease prevention starting in childhood is critical for reducing morbidity later in life. In the present study, the association of novel biomarkers with metabolic syndrome (MS) and vascular function/structure ... ...

Abstract	Purpose: Metabolic and cardiovascular disease prevention starting in childhood is critical for reducing morbidity later in life. In the present study, the association of novel biomarkers with metabolic syndrome (MS) and vascular function/structure indices of early atherosclerosis in children was investigated. Methods: This was a prospective study of 78 children (8-16 years of age) grouped based on the presence or absence of MS. The serum biomarkers investigated included fibroblast growth factor 21 (FGF21), leptin, adiponectin, and insulinlike growth factor binding protein-1 (IGFBP1). Endothelial function and carotid atherosclerosis were assessed based on brachial artery flow-mediated dilation (FMD) and carotid intima-media thickness, respectively. Results: Children with MS (n=12) had higher levels of FGF21 (median [interquartile range]: 128 [76-189] pg/mL vs. 60 [20-98] pg/mL, P=0.003) and leptin (18.1 [11-34.8] pg/mL vs. 7.5 [1.9-16.5] ng/mL, P=0.003), and lower levels of IGFBP1 (1.5 [1.2-2.1] ng/mL vs. 2.3 [1.5-6] ng/mL, P=0.028) compared with children without MS. FMD inversely correlated with FGF21 (Spearman rho= -0.24, P=0.035) and leptin (rho= -0.24, P=0.002) in all children. The best cutoff value of FGF21 levels for MS diagnosis was above 121.3 pg/mL (sensitivity/specificity, 58/86%). Only FGF21 was significantly associated with the presence of MS after adjustment for body mass index, age, and sex (odds ratio per 10 pg/mL increase: 1.10 [95% confidence interval, 1.01-1.22]; P=0.043). Conclusion: Increased FGF21 levels were associated with the presence of MS and worse endothelial function in children. Larger studies are needed to evaluate the potential value of FGF21 as a biomarker that could predict future metabolic/cardiovascular disease at an early stage.
Language	English
Publishing date	2021-05-17
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2800460-7
ISSN	2287-1292 ; 2287-1012
ISSN (online)	2287-1292
ISSN	2287-1012
DOI	10.6065/apem.2040258.129
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Article ; Online: Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis.

Domouzoglou, Eleni M / Maratos-Flier, Eleftheria

The American journal of clinical nutrition

2011 Volume 93, Issue 4, Page(s) 901S–5

Abstract: Fibroblast growth factor 21 (FGF21) was originally identified as a member of the FGF family in homology studies and is a member of the endocrine FGF subfamily that lacks heparin binding domains and is released into the circulation. A potential role as a ... ...

Abstract	Fibroblast growth factor 21 (FGF21) was originally identified as a member of the FGF family in homology studies and is a member of the endocrine FGF subfamily that lacks heparin binding domains and is released into the circulation. A potential role as a metabolic regulator emerged when FGF21 was shown to increase glucose uptake in adipocytes. Subsequently, marked elevations in FGF21 expression were observed in mice that ate a ketogenic diet and when fasting, which suggests that FGF21 expression plays a role in the adaptation to metabolic states that require increased fatty acid oxidation. Consistent with this evidence, FGF21 knockout mice were not able to respond appropriately to consumption of a ketogenic diet. FGF21 expression is downstream of peroxisome proliferator-activated receptor (PPAR) α in the liver and PPARγ in adipose tissue. FGF21 concentrations are higher in both rodent and human obesity, and recent data suggest that obesity may be an FGF21-resistant state. Recent data increasingly suggest that FGF21 is an important metabolic regulator that may have potential clinical implications.
MeSH term(s)	Adaptation, Physiological ; Adipose Tissue/cytology ; Adipose Tissue/metabolism ; Animals ; Diet, Ketogenic ; Fasting ; Fatty Acids/metabolism ; Fibroblast Growth Factors/metabolism ; Glucose/metabolism ; Humans ; Ketosis/metabolism ; Liver/metabolism ; Mice ; Mice, Knockout ; Obesity/metabolism ; Oxidation-Reduction ; PPAR alpha/metabolism ; PPAR gamma/metabolism
Chemical Substances	Fatty Acids ; PPAR alpha ; PPAR gamma ; fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2011-02-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.3945/ajcn.110.001941
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Article: Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis

Domouzoglou, Eleni M / Maratos-Flier, Eleftheria

American journal of clinical nutrition. 2011 Apr., v. 93, no. 4

2011

Abstract	Fibroblast growth factor 21 (FGF21) was originally identified as a member of the FGF family in homology studies and is a member of the endocrine FGF subfamily that lacks heparin binding domains and is released into the circulation. A potential role as a metabolic regulator emerged when FGF21 was shown to increase glucose uptake in adipocytes. Subsequently, marked elevations in FGF21 expression were observed in mice that ate a ketogenic diet and when fasting, which suggests that FGF21 expression plays a role in the adaptation to metabolic states that require increased fatty acid oxidation. Consistent with this evidence, FGF21 knockout mice were not able to respond appropriately to consumption of a ketogenic diet. FGF21 expression is downstream of peroxisome proliferator-activated receptor (PPAR) α in the liver and PPARγ in adipose tissue. FGF21 concentrations are higher in both rodent and human obesity, and recent data suggest that obesity may be an FGF21-resistant state. Recent data increasingly suggest that FGF21 is an important metabolic regulator that may have potential clinical implications.
Keywords	adipocytes ; fatty acids ; diet ; liver ; fibroblast growth factors ; humans ; glucose ; adipose tissue ; ketosis ; fasting ; mice ; heparin ; family studies ; obesity ; oxidation ; receptors ; ingestion
Language	English
Dates of publication	2011-04
Size	p. 901S-905S.
Publishing place	American Society for Clinical Nutrition
Document type	Article
Note	Includes references ; 2019-12-06
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.3945/ajcn.110.001941
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21.

Domouzoglou, Eleni M / Naka, Katerina K / Vlahos, Antonios P / Papafaklis, Michail I / Michalis, Lampros K / Tsatsoulis, Agathoklis / Maratos-Flier, Eleftheria

American journal of physiology. Heart and circulatory physiology

2015 Volume 309, Issue 6, Page(s) H1029–38

Abstract: Early detection of risk factors for enhanced primary prevention and novel therapies for treating the chronic consequences of cardiovascular disease are of the utmost importance for reducing morbidity. Recently, fibroblast growth factors (FGFs) have been ... ...

Abstract	Early detection of risk factors for enhanced primary prevention and novel therapies for treating the chronic consequences of cardiovascular disease are of the utmost importance for reducing morbidity. Recently, fibroblast growth factors (FGFs) have been intensively studied as potential new molecules in the prevention and treatment of cardiovascular disease mainly attributable to metabolic effects and angiogenic actions. Members of the endocrine FGF family have been shown to increase metabolic rate, decrease adiposity, and restore glucose homeostasis, suggesting a multiple metabolic role. Serum levels of FGFs have been associated with established cardiovascular risk factors as well as with the severity and extent of coronary artery disease and could be useful for prediction of cardiovascular death. Furthermore, preclinical investigations and clinical trials have tested FGF administration for therapeutic angiogenesis in ischemic vascular disease, demonstrating a potential role in improving angina and limb function. FGF21 has lately emerged as a potent metabolic regulator with multiple effects that ultimately improve the lipoprotein profile. Early studies show that FGF21 is associated with the presence of atherosclerosis and may play a protective role against plaque formation by improving endothelial function. The present review highlights recent investigations suggesting that FGFs, in particular FGF21, may be useful as markers of cardiovascular risk and may also serve as protective/therapeutic agents in cardiovascular disease.
MeSH term(s)	Atherosclerosis/metabolism ; Cardiovascular Diseases/metabolism ; Coronary Artery Disease/metabolism ; Endothelium, Vascular/metabolism ; Fibroblast Growth Factors/metabolism ; Humans ; Neovascularization, Physiologic ; Plaque, Atherosclerotic/metabolism
Chemical Substances	fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3)
Language	English
Publishing date	2015-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00527.2015
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