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Article ; Online: Chain-mediating effects of kinesiophobia and self-efficacy on pain catastrophizing and physical activity in haemophilia patients.

Zhang, Wenjing / Zhu, Tienan / Wang, Shujie / Zhang, Yanbin / Chen, Wenkun / Li, Kuixing

Haemophilia : the official journal of the World Federation of Hemophilia

2024 Volume 30, Issue 3, Page(s) 809–816

Abstract: Background: There is a lack of research on the relationship between pain catastrophizing, kinesiophobia, and physical activity (PA) in people with haemophilia (PWH), and the underlying mechanisms connecting these variables remain unclear.: Aim: The ... ...

Abstract	Background: There is a lack of research on the relationship between pain catastrophizing, kinesiophobia, and physical activity (PA) in people with haemophilia (PWH), and the underlying mechanisms connecting these variables remain unclear. Aim: The study's aim was to clarify the roles of kinesiophobia and self-efficacy in the relationship between pain catastrophizing and PA in PWH. Methods: This cross-sectional study included adult PWH at the Haemophilia Centre of a Tertiary hospital in Beijing, China. The following questionnaires were used to collect data: the general information, the International Physical Activity Short Questionnaire, the Pain Catastrophizing Scale, the Tampa Scale of Kinesiophobia Scale, and the Exercise Self-Efficacy Scale. Results: The study included a total of 187 PWH, including 154 having haemophilia A and 33 having haemophilia B. The median interquartile range of PA was 594 (198, 1554) MET-min/wk. There were significant differences in PA of patients based on age stage, treatment modality, highest pain score within the last seven days, and presence of haemophilic arthropathy (p < .05). It was showed that pain catastrophizing could directly predict PA (p < .001), accounting for 38.13% of the total effect. Pain catastrophizing also had indirect effects on PA through the mediating factors of kinesiophobia or self-efficacy, and through the chain-mediating effect of kinesiophobia and self-efficacy, accounting for 38.40%, 17.07%, and 6.40%, respectively. Conclusion: The study discovered that PWH have limited PA due to pain catastrophizing. This not only directly affects their activity but also indirectly influences it through kinesiophobia and self-efficacy.
MeSH term(s)	Humans ; Self Efficacy ; Hemophilia A/psychology ; Hemophilia A/complications ; Adult ; Exercise/psychology ; Male ; Cross-Sectional Studies ; Catastrophization/psychology ; Female ; Middle Aged ; Phobic Disorders/psychology ; Young Adult ; Surveys and Questionnaires ; Adolescent ; Kinesiophobia
Language	English
Publishing date	2024-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1229713-6
ISSN	1365-2516 ; 1351-8216 ; 1355-0691
ISSN (online)	1365-2516
ISSN	1351-8216 ; 1355-0691
DOI	10.1111/hae.15008
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Article: Composite Classical Hodgkin Lymphoma and Mantle Cell Lymphoma: A Case Report.

Kaur, Rajdeep / Zhang, Bingjun / Zhang, Kuixing / Eldaly, Mohamed / Clement, Jincy

Cureus

2023 Volume 15, Issue 9, Page(s) e45727

Abstract: Composite lymphoma implies the presence of two or more morphological and immunophenotypical subtypes of lymphoma in a single tissue or organ. Composite lymphoma with concurrent mantle cell lymphoma (MCL) and classical Hodgkin lymphoma is extremely rare. ... ...

Abstract	Composite lymphoma implies the presence of two or more morphological and immunophenotypical subtypes of lymphoma in a single tissue or organ. Composite lymphoma with concurrent mantle cell lymphoma (MCL) and classical Hodgkin lymphoma is extremely rare. In this case report, we present the case of a 70-year-old male who was diagnosed with a composite of MCL and classical Hodgkin lymphoma (cHL) and achieved near-complete resolution with chemoimmunotherapy. To the best of our knowledge, this is the first case of this kind demonstrating the effectiveness of a combination chemoimmunotherapy regimen leading to complete remission in composite lymphoma involving MCL and cHL. We report the history, imaging findings, and pathology and illustrate the challenges in therapeutic decision-making in managing composite lymphoma patients involving MCL and cHL. We also review the literature on this rare entity and discuss its clinical implications.
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45727
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Article ; Online: The global patent landscape of emerging infectious disease monkeypox.

Cai, Yuanqi / Zhang, Xiaoming / Zhang, Kuixing / Liang, Jingbo / Wang, Pingping / Cong, Jinyu / Xu, Xin / Li, Mengyao / Liu, Kunmeng / Wei, Benzheng

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 403

Abstract: Background: Monkeypox is an emerging infectious disease with confirmed cases and deaths in several parts of the world. In light of this crisis, this study aims to analyze the global knowledge pattern of monkeypox-related patents and explore current ... ...

Abstract	Background: Monkeypox is an emerging infectious disease with confirmed cases and deaths in several parts of the world. In light of this crisis, this study aims to analyze the global knowledge pattern of monkeypox-related patents and explore current trends and future technical directions in the medical development of monkeypox to inform research and policy. Methods: A comprehensive study of 1,791 monkeypox-related patents worldwide was conducted using the Derwent patent database by descriptive statistics, social network method and linear regression analysis. Results: Since the 21st century, the number of monkeypox-related patents has increased rapidly, accompanied by increases in collaboration between commercial and academic patentees. Enterprises contributed the most in patent quantity, whereas the initial milestone patent was filed by academia. The core developments of technology related to the monkeypox include biological and chemical medicine. The innovations of vaccines and virus testing lack sufficient patent support in portfolios. Conclusions: Monkeypox-related therapeutic innovation is geographically limited with strong international intellectual property right barriers though it has increased rapidly in recent years. The transparent licensing of patent knowledge is driven by the merger and acquisition model, and the venture capital, intellectual property and contract research organization model. Currently, the patent thicket phenomenon in the monkeypox field may slow the progress of efforts to combat monkeypox. Enterprises should pay more attention to the sharing of technical knowledge, make full use of drug repurposing strategies, and promote innovation of monkeypox-related technology in hotspots of antivirals (such as tecovirimat, cidofovir, brincidofovir), vaccines (JYNNEOS, ACAM2000), herbal medicine and gene therapy.
MeSH term(s)	Humans ; Communicable Diseases, Emerging/drug therapy ; Communicable Diseases, Emerging/epidemiology ; Mpox (monkeypox)/drug therapy ; Mpox (monkeypox)/epidemiology ; Technology ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-09252-w
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Article ; Online: Machine learning-based evaluation of application value of pulse wave parameter model in the diagnosis of hypertensive disorder in pregnancy.

Zhang, Xinyu / Meng, Yu / Jiang, Mei / Yang, Lin / Zhang, Kuixing / Lian, Cuiting / Li, Ziwei

Mathematical biosciences and engineering : MBE

2023 Volume 20, Issue 5, Page(s) 8308–8319

Abstract: Hypertensive disorder in pregnancy (HDP) remains a major health burden, and it is associated with systemic cardiovascular adaptation. The pulse wave is an important basis for evaluating the status of the human cardiovascular system. This research aims to ...

Abstract	Hypertensive disorder in pregnancy (HDP) remains a major health burden, and it is associated with systemic cardiovascular adaptation. The pulse wave is an important basis for evaluating the status of the human cardiovascular system. This research aims to evaluate the application value of pulse waves in the diagnosis of hypertensive disorder in pregnancy.This research a retrospective study of pregnant women who attended prenatal care and labored at Beijing Haidian District Maternal and Child Health Hospital. We extracted maternal hemodynamic factors and measured the pulse wave of the pregnant women. We developed an HDP predictive model by using support vector machine algorithms at five-gestational-week stages.At five-gestational-week stages, the area under the receiver operating characteristic curve (AUC) of the predictive model with pulse wave parameters was higher than that of the predictive model with hemodynamic factors. The AUC values of the predictive model with pulse wave parameters were 0.77 (95% CI 0.64 to 0.9), 0.83 (95% CI 0.77 to 0.9), 0.85 (95% CI 0.81 to 0.9), 0.93 (95% CI 0.9 to 0.96) and 0.88 (95% CI 0.8 to 0.95) at five-gestational-week stages, respectively. Compared to the predictive models with hemodynamic factors, the predictive model with pulse wave parameters had better prediction effects on HDP.Pulse waves had good predictive effects for HDP and provided appropriate guidance and a basis for non-invasive detection of HDP.
MeSH term(s)	Pregnancy ; Child ; Humans ; Female ; Retrospective Studies ; Heart Rate ; Algorithms ; Beijing ; Machine Learning
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2023363
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Article ; Online: Research on the classification of lymphoma pathological images based on deep residual neural network.

Zhang, Xiaoli / Zhang, Kuixing / Jiang, Mei / Yang, Lin

Technology and health care : official journal of the European Society for Engineering and Medicine

2021 Volume 29, Issue S1, Page(s) 335–344

Abstract: Background: Malignant lymphoma is a type of tumor that originated from the lymphohematopoietic system, with complex etiology, diverse pathological morphology, and classification. It takes a lot of time and energy for doctors to accurately determine the ... ...

Abstract	Background: Malignant lymphoma is a type of tumor that originated from the lymphohematopoietic system, with complex etiology, diverse pathological morphology, and classification. It takes a lot of time and energy for doctors to accurately determine the type of lymphoma by observing pathological images. Objective: At present, an automatic classification technology is urgently needed to assist doctors in analyzing the type of lymphoma. Methods: In this paper, by comparing the training results of the BP neural network and BP neural network optimized by genetic algorithm (GA-BP), adopts a deep residual neural network model (ResNet-50), with 374 lymphoma pathology images as the experimental data set. After preprocessing the dataset by image flipping, color transformation, and other data enhancement methods, the data set is input into the ResNet-50 network model, and finally classified by the softmax layer. Results: The training results showed that the classification accuracy was 98.63%. By comparing the classification effect of GA-BP and BP neural network, the accuracy of the network model proposed in this paper is improved. Conclusions: The network model can provide an objective basis for doctors to diagnose lymphoma types.
MeSH term(s)	Disease Progression ; Humans ; Lymphoma/diagnosis ; Neural Networks, Computer ; Physicians
Language	English
Publishing date	2021-03-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1159961-3
ISSN	1878-7401 ; 0928-7329
ISSN (online)	1878-7401
ISSN	0928-7329
DOI	10.3233/THC-218031
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Article: Ecological risk assessment for organophosphate esters in the surface water from the Bohai Sea of China using multimodal species sensitivity distributions

Qi, Yanjie / Yao, Ziwei / Ma, Xindong / Ding, Xiaolin / Shangguan, Kuixing / Zhang, Mingxing / Xu, Nan

Science of the total environment. 2022 May 10, v. 820

2022

Abstract: Organophosphate esters (OPEs) as the foremost substitutes of brominated flame retardants have been ubiquitously found in the aquatic environment around the world. However, the information on the community-level risks induced by OPEs to the marine ... ...

Abstract	Organophosphate esters (OPEs) as the foremost substitutes of brominated flame retardants have been ubiquitously found in the aquatic environment around the world. However, the information on the community-level risks induced by OPEs to the marine ecosystem remains scarce. This study adopted ten commonly used species sensitivity distribution (SSD) parametric statistical approaches coupled with the acute-to-chronic transformation for the toxicity data to fit the sensitivity distributions of different species to four major OPE congeners including triethyl phosphate (TEP), tri-n-butyl phosphate (TnBP), tri(2-chloroethyl) phosphate (TCEP), and tris(1-chloro-2-propyl) phosphate (TCPP) in the surface water of the Bohai Sea. All SSD models except Exponential for TnBP, TCEP, and TCPP fitted well the chronic toxicity data for the four OPE congeners. Discrepancies appeared among the best fitting models for different congeners, which also happened to the fitting results from the multiple SSD models for each congener. Based on the best fitting models, the hazard concentrations corresponding to the cumulative probability of 5% were 3.58 mg/L, 0.116 mg/L, 1.30 mg/L, and 1.44 mg/L for TEP, TnBP, TCEP, and TCPP, respectively. The risks induced by the four OPE congeners to the Bohai Sea ecosystem were negligible during the monitoring period because of both the risk quotients and the hazard indexes far <0.1. This study drew a clear picture of the joint ecological risks of TEP, TnBP, TCEP, and TCPP to the Bohai Sea environment. The application of multimodal SSD statistical methods will benefit the accurate derivation of water quality criteria and the community-level ecological risk assessment for pollutants.
Keywords	aquatic environment ; bromination ; chronic toxicity ; environmental assessment ; marine ecosystems ; organophosphorus compounds ; phosphates ; risk ; surface water ; water quality ; China ; Yellow Sea
Language	English
Dates of publication	2022-0510
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.153172
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Article ; Online: A Young Hemophilia Patient with Advanced Hemophilic Arthritis and HIV Infection

CAI Huacong / FENG Bin / CAO Wei / LIU Shufen / YUAN Tao / ZHANG Yan / LI Kuixing / ZHAO Yongqiang / WANG Shujie

罕见病研究, Vol 1, Iss 4, Pp 407-

2022 Volume 412

Abstract: A young male diagnosed with severe hemophilia A since childhood, was presented with recurrent joint and urinary bleeding. Annualized bleed rates dropped below five with low dose prophylactic medication.Bleeding in the right knee joint recently aggravated. ...

Abstract	A young male diagnosed with severe hemophilia A since childhood, was presented with recurrent joint and urinary bleeding. Annualized bleed rates dropped below five with low dose prophylactic medication.Bleeding in the right knee joint recently aggravated. Due to coexisting HIV infection and advanced hemophilic arthritis, the patient was managed by a multi-disciplinary team(MDT).Total knee arthroplasty was performed by an experienced surgeon using modern prosthesis design and intraoperative navigation technologies.Physical and rehabilitation therapy was provided during the postoperative period, and joint function improved. The MDT managed the young patient with HIV infection and advanced hemophilic arthritis. The patient was diagnosed with osteoporosis thought to have been caused by hemophilia, HIV infection and antiviral drugs; and he received treatment. The treatment of this patient reflects the importance of multidisciplinary cooperation in the management of difficult and rare diseases.
Keywords	hemophilia ; arthritis ; hiv ; osteoporosis ; Medicine ; R
Language	Chinese
Publishing date	2022-10-01T00:00:00Z
Publisher	Editorial Office of Journal of Rare Diseases
Document type	Article ; Online
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Article ; Online: SAMS-Net: Fusion of attention mechanism and multi-scale features network for tumor infiltrating lymphocytes segmentation.

Zhang, Xiaoli / Liu, Kunmeng / Zhang, Kuixing / Li, Xiang / Sun, Zhaocai / Wei, Benzheng

Mathematical biosciences and engineering : MBE

2022 Volume 20, Issue 2, Page(s) 2964–2979

Abstract: Automatic segmentation of tumor-infiltrating lymphocytes (TILs) from pathological images is essential for the prognosis and treatment of cancer. Deep learning technology has achieved great success in the segmentation task. It is still a challenge to ... ...

Abstract	Automatic segmentation of tumor-infiltrating lymphocytes (TILs) from pathological images is essential for the prognosis and treatment of cancer. Deep learning technology has achieved great success in the segmentation task. It is still a challenge to realize accurate segmentation of TILs due to the phenomenon of blurred edges and adhesion of cells. To alleviate these problems, a squeeze-and-attention and multi-scale feature fusion network (SAMS-Net) based on codec structure, namely SAMS-Net, is proposed for the segmentation of TILs. Specifically, SAMS-Net utilizes the squeeze-and-attention module with the residual structure to fuse local and global context features and boost the spatial relevance of TILs images. Besides, a multi-scale feature fusion module is designed to capture TILs with large size differences by combining context information. The residual structure module integrates feature maps from different resolutions to strengthen the spatial resolution and offset the loss of spatial details. SAMS-Net is evaluated on the public TILs dataset and achieved dice similarity coefficient (DSC) of 87.2% and Intersection of Union (IoU) of 77.5%, which improved by 2.5% and 3.8% compared with UNet. These results demonstrate the great potential of SAMS-Net in TILs analysis and can further provide important evidence for the prognosis and treatment of cancer.
MeSH term(s)	Lymphocytes, Tumor-Infiltrating ; Humans ; Computational Biology
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2023140
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Article ; Online: Enhanced antibody-defucosylation capability of α-L-fucosidase by proximity-based protein fusion.

Fan, Shuquan / Li, Wanzhen / Zhang, Kuixing / Zou, Xiangman / Shi, Wei / Liu, Zhi / Tang, Caihong / Huang, Wei / Tang, Feng

Biochemical and biophysical research communications

2023 Volume 645, Page(s) 40–46

Abstract: Up to date, the reported fucosidases generally show poor activities toward the IgG core-fucose, which limits the efficiency of ENGase-catalyzed glycoengineering process. However, EndoS or EndoS2 owns excellent activity and great selectivity towards the N- ...

Abstract	Up to date, the reported fucosidases generally show poor activities toward the IgG core-fucose, which limits the efficiency of ENGase-catalyzed glycoengineering process. However, EndoS or EndoS2 owns excellent activity and great selectivity towards the N-glycosylation of IgGs, and their non-catalytic domains are deduced to have specific interactions to IgG Fc domain that result in the great activity and selectivity. Herein, we constructed a series fusion protein of AlfC (an α-l-fucosidase from Lactobacillus casei BL23) with EndoS/S2 non-catalytic domain by replacing the catalytic GH (glycan hydrolase) domain of EndoS/S2 with the AlfC. We found that all these fused AlfCs showed significantly enhanced defucosylation activity toward the deglycosylated IgGs (Fucα1,6GlcNAc-IgG). We also performed the kinetic study of these fusion enzymes, and our results tend to tell that the EndoS-based fusion proteins have higher k
MeSH term(s)	alpha-L-Fucosidase/genetics ; alpha-L-Fucosidase/metabolism ; Polysaccharides/metabolism ; Antibodies, Monoclonal ; Immunoglobulin G/metabolism
Chemical Substances	alpha-L-Fucosidase (EC 3.2.1.51) ; Polysaccharides ; Antibodies, Monoclonal ; Immunoglobulin G
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.01.031
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Article ; Online: Ecological risk assessment for organophosphate esters in the surface water from the Bohai Sea of China using multimodal species sensitivity distributions.

Qi, Yanjie / Yao, Ziwei / Ma, Xindong / Ding, Xiaolin / Shangguan, Kuixing / Zhang, Mingxing / Xu, Nan

The Science of the total environment

2022 Volume 820, Page(s) 153172

Abstract	Organophosphate esters (OPEs) as the foremost substitutes of brominated flame retardants have been ubiquitously found in the aquatic environment around the world. However, the information on the community-level risks induced by OPEs to the marine ecosystem remains scarce. This study adopted ten commonly used species sensitivity distribution (SSD) parametric statistical approaches coupled with the acute-to-chronic transformation for the toxicity data to fit the sensitivity distributions of different species to four major OPE congeners including triethyl phosphate (TEP), tri-n-butyl phosphate (TnBP), tri(2-chloroethyl) phosphate (TCEP), and tris(1-chloro-2-propyl) phosphate (TCPP) in the surface water of the Bohai Sea. All SSD models except Exponential for TnBP, TCEP, and TCPP fitted well the chronic toxicity data for the four OPE congeners. Discrepancies appeared among the best fitting models for different congeners, which also happened to the fitting results from the multiple SSD models for each congener. Based on the best fitting models, the hazard concentrations corresponding to the cumulative probability of 5% were 3.58 mg/L, 0.116 mg/L, 1.30 mg/L, and 1.44 mg/L for TEP, TnBP, TCEP, and TCPP, respectively. The risks induced by the four OPE congeners to the Bohai Sea ecosystem were negligible during the monitoring period because of both the risk quotients and the hazard indexes far <0.1. This study drew a clear picture of the joint ecological risks of TEP, TnBP, TCEP, and TCPP to the Bohai Sea environment. The application of multimodal SSD statistical methods will benefit the accurate derivation of water quality criteria and the community-level ecological risk assessment for pollutants.
MeSH term(s)	China ; Ecosystem ; Environmental Monitoring ; Esters ; Flame Retardants/analysis ; Flame Retardants/toxicity ; Organophosphates/toxicity ; Risk Assessment
Chemical Substances	Esters ; Flame Retardants ; Organophosphates
Language	English
Publishing date	2022-01-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.153172
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