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  1. Article ; Online: Mucormycosis, past and present: a comprehensive review.

    Gupta, Ishita / Baranwal, Pritika / Singh, Gagandeep / Gupta, Vandana

    Future microbiology

    2023  Volume 18, Page(s) 217–234

    Abstract: Mucormycosis is an emerging opportunistic angioinvasive fungal infection. Predisposing factors such as diabetes, neutropenia, long-term corticosteroid therapy, solid organ transplantation and immunosuppression contribute to its occurrence. This disease ... ...

    Abstract Mucormycosis is an emerging opportunistic angioinvasive fungal infection. Predisposing factors such as diabetes, neutropenia, long-term corticosteroid therapy, solid organ transplantation and immunosuppression contribute to its occurrence. This disease was not of significant concern prior to the COVID-19 pandemic, but gained prominence due to infections in COVID-19 patients. Mucormycosis needs special attention and coordinated efforts of the scientific community and medical professionals to reduce morbidity and mortality. Here we present an overview of the epidemiology and prevalence of mucormycosis in the pre- and post-COVID-19 eras, the factors that contributed to the abrupt increase in COVID-19-associated mucormycosis (CAM), the actions taken by the regulatory agencies (including Code Mucor and CAM registry), the existing diagnostic tools and CAM management strategies.
    MeSH term(s) Humans ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Mucormycosis/epidemiology ; Pandemics ; COVID-19 ; Immunosuppression Therapy ; Neutropenia ; Opportunistic Infections
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2022-0141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Upstaging of Tuberculosis in the Post-COVID-19 Era: A Case Series.

    Malik, Neeru / Sidhar, Meenakshi / Sehgal, Nidhi Prabha / Gupta, Anurag / Gupta, Ishita

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54687

    Abstract: The COVID-19 pandemic has significantly impacted the global health system as well as the social and economic impact on tuberculosis (TB) treatment and diagnostic services. A high volume of patients diagnosed and treated for TB were impacted by the ... ...

    Abstract The COVID-19 pandemic has significantly impacted the global health system as well as the social and economic impact on tuberculosis (TB) treatment and diagnostic services. A high volume of patients diagnosed and treated for TB were impacted by the pandemic restrictions, particularly reduced access to TB services provided by the National Tuberculosis Elimination Programme in India; this in turn increased the number of deaths due to TB. The Indian healthcare system has been struggling with the eradication of TB, and this additional worldwide health crisis caused by SARS-CoV-2 has put the Indian healthcare system under severe stress. Both COVID-19 and TB are infectious diseases that primarily affect the lungs and have similar symptoms such as cough, fever, and difficulty breathing. The need of the hour is to take proper actions to mitigate and reverse these impacts urgently. The immediate priority is to aggressively step up the provision of essential TB services so that the levels of TB case detection and treatment return to at least pre-COVID-19 levels. The diagnosis of genital TB especially needs a high index of suspicion, as most of the cases are asymptomatic and diagnosed by chance in young women being evaluated for fertility. Here, we present a series of advanced genital TB cases that required intensive care and could have been detected and treated at an early stage.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of E2F transcription factor in oral cancer: Recent insight and advancements.

    Kassab, Amal / Gupta, Ishita / Moustafa, Ala-Eddin Al

    Seminars in cancer biology

    2023  Volume 92, Page(s) 28–41

    Abstract: The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to cell proliferation, apoptosis and ... ...

    Abstract The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to cell proliferation, apoptosis and differentiation, mainly in a cell cycle-dependent manner. E2F activity is frequently controlled via the retinoblastoma protein (pRb), cyclins, p53 and the ubiquitin-proteasome pathway. Additionally, genetic or epigenetic changes result in the deregulation of E2F family genes expression altering S phase entry and apoptosis, an important hallmark for the onset and development of cancer. Although studies reveal E2Fs to be involved in several human malignancies, the mechanisms underlying the role of E2Fs in oral cancer lies nascent and needs further investigations. This review focuses on the role of E2Fs in oral cancer and the etiological factors regulating E2Fs activity, which in turn transcriptionally control the expression of their target genes, thus contributing to cell proliferation, metastasis, and drug/therapy resistance. Further, we will discuss therapeutic strategies for E2Fs, which may prevent oral tumor growth, metastasis, and drug resistance.
    MeSH term(s) Animals ; Humans ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism ; Transcription Factors/genetics ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Mouth Neoplasms/genetics ; Mammals/metabolism
    Chemical Substances E2F Transcription Factors ; Transcription Factors ; Cell Cycle Proteins
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2023.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Helicobacter pylori

    Jamal Eddin, Tala M / Nasr, Shahd M O / Gupta, Ishita / Zayed, Hatem / Al Moustafa, Ala-Eddin

    Heliyon

    2023  Volume 9, Issue 8, Page(s) e18945

    Abstract: Gastric cancer, a multifactorial disease, is considered one of the most common malignancies worldwide. In addition to genetic and environmental risk factors, infectious agents, such as Epstein-Barr virus (EBV) ... ...

    Abstract Gastric cancer, a multifactorial disease, is considered one of the most common malignancies worldwide. In addition to genetic and environmental risk factors, infectious agents, such as Epstein-Barr virus (EBV) and
    Language English
    Publishing date 2023-08-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e18945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The recognition of proteasomal receptors by Plasmodium falciparum DSK2.

    Gupta, Ishita / Khan, Sameena

    Molecular and biochemical parasitology

    2020  Volume 236, Page(s) 111266

    Abstract: One of the pathways by which proteins are targeted for degradation by the proteasome involve transport by shuttle proteins to proteasomal receptors. The malaria parasite Plasmodium falciparum has recently been found to possess a similar pathway, with the ...

    Abstract One of the pathways by which proteins are targeted for degradation by the proteasome involve transport by shuttle proteins to proteasomal receptors. The malaria parasite Plasmodium falciparum has recently been found to possess a similar pathway, with the shuttle protein PfDsk2 being the major player. In this study, we have demonstrated how PfDsk2 and its recognition by proteasomal receptors differ from the mammalian system. Our crystal structure of unbound PfDsk2 UBL domain at 1.30 Å revealed an additional 3
    MeSH term(s) Cell Cycle Proteins ; DNA-Binding Proteins/metabolism ; Models, Molecular ; Molecular Conformation ; Plasmodium falciparum/metabolism ; Proteasome Endopeptidase Complex/chemistry ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; Saccharomyces cerevisiae Proteins ; Ubiquitin/chemistry ; Ubiquitin/metabolism ; Ubiquitins
    Chemical Substances Cell Cycle Proteins ; DNA-Binding Proteins ; DSK2 protein, S cerevisiae ; Saccharomyces cerevisiae Proteins ; Ubiquitin ; Ubiquitins ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2020-02-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 756166-0
    ISSN 1872-9428 ; 0166-6851
    ISSN (online) 1872-9428
    ISSN 0166-6851
    DOI 10.1016/j.molbiopara.2020.111266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2437: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways.

    Kheraldine, Hadeel / Gupta, Ishita / Cyprian, Farhan Sachal / Vranic, Semir / Al-Farsi, Halema F / Merhi, Maysaloun / Dermime, Said / Al Moustafa, Ala-Eddin

    Cancer cell international

    2024  Volume 24, Issue 1, Page(s) 94

    Abstract: Background: Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast cancer. Nevertheless, ... ...

    Abstract Background: Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast cancer. Nevertheless, the outcome of the combination of these inhibitors on HER2-positive breast cancer is not explored yet.
    Methods: Herein, we investigated the impact of DA and PD-L1 inhibitor (BMS-202) combination on HER2-positive breast cancer cell lines, SKBR3 and ZR75.
    Results: Our data reveal that the combination significantly inhibits cell viability of both cancer cell lines as compared to monotreatment. Moreover, the combination inhibits epithelial-mesenchymal transition (EMT) progression and reduces cancer cell invasion by restoring E-cadherin and β-catenin expressions and loss of vimentin, major biomarkers of EMT. Additionally, the combination reduces the colony formation of both cell lines in comparison with their matched control. Also, the combination considerably inhibits the angiogenesis of the chorioallantoic membrane model compared with monotreatment. Molecular pathway analysis of treated cells shows that this combination blocks HER2, AKT, β-catenin, and JNK1/2/3 activities.
    Conclusion: Our findings implicate that a combination of DA and BMS-202 could have a significant impact on the management of HER2-positive breast cancer.
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-023-03195-z
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  7. Article ; Online: A comparison of end-of-shift reports to an incident reporting system for reporting incidents in the intensive care unit.

    Gupta, Ishita / Cheung, Winston / Saxena, Manoj / Kol, Mark / Shah, Asim / Wagh, Atul / Hunt, Rhiannon / Skylas, Katina / Brannelly, Alison / Brennan, Kathleen

    International journal for quality in health care : journal of the International Society for Quality in Health Care

    2023  Volume 35, Issue 3

    MeSH term(s) Humans ; Intensive Care Units ; Shift Work Schedule ; Medical Errors
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1194150-9
    ISSN 1464-3677 ; 1353-4505
    ISSN (online) 1464-3677
    ISSN 1353-4505
    DOI 10.1093/intqhc/mzad064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3052: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Trends in Data Monitoring Committees, Randomization, and Blinding in Cardiovascular Disease Studies on ClinicalTrials.gov from 2012 to 2021.

    Rawlley, Bharat / Bansal, Kannu / Dayal, Utkarsh / Julka, Dhawani / Salooja, Ishita / Sanchez, Andres Cordova / Gupta, Kartik / Kumar, Sandeep / Chaudhuri, Debanik

    The American journal of cardiology

    2023  Volume 205, Page(s) 10–11

    MeSH term(s) Humans ; Clinical Trials Data Monitoring Committees ; Cardiovascular Diseases/epidemiology ; Random Allocation ; COVID-19 ; SARS-CoV-2
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.07.128
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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.73: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Elaeagnus angustifolia

    Fouzat, Arij / Hussein, Ola Jihad / Gupta, Ishita / Al-Farsi, Halema F / Khalil, Ashraf / Al Moustafa, Ala-Eddin

    Frontiers in nutrition

    2022  Volume 9, Page(s) 871667

    Abstract: Elaeagnus ... ...

    Abstract Elaeagnus angustifolia
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.871667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Implications of Gut Microbiota in Epithelial-Mesenchymal Transition and Cancer Progression: A Concise Review.

    Gupta, Ishita / Pedersen, Shona / Vranic, Semir / Al Moustafa, Ala-Eddin

    Cancers

    2022  Volume 14, Issue 12

    Abstract: Advancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial-mesenchymal transition (EMT) event. EMT is essential for embryogenesis, ...

    Abstract Advancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial-mesenchymal transition (EMT) event. EMT is essential for embryogenesis, wound repair, and organ development; meanwhile, during carcinogenesis, initiation of the EMT can promote cancer progression and metastasis. Recent studies have reported that interactions between the host and dysbiotic microbiota in different tissues and organs, such as the oral and nasal cavities, esophagus, stomach, gut, skin, and the reproductive tract, may provoke EMT. On the other hand, it is revealed that certain microorganisms display a protective role against cancer growth, indicative of possible therapeutic function. In this review, we summarize recent findings elucidating the underlying mechanisms of pathogenic microorganisms, especially the microbiota, in eliciting crucial regulator genes that induce EMT. Such an approach may help explain cancer progression and pave the way for developing novel preventive and therapeutic strategies.
    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14122964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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