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  1. Article ; Online: Application of AHP - GIS Model to Assess the Ecological Suitability of Codonopsis javanica in Kon Plong District, Kon Tum Province, Viet Nam

    Chu Luong Tri / Tran Anh Tuan / Truong Ngoc Kiem

    Journal of Ecological Engineering, Vol 23, Iss 7, Pp 276-

    2022  Volume 283

    Abstract: The Kon Plong district is located in the northeast area of the Kon Tum province, where ethnic ... Among the approaches to enhance the economical situation in the mountainous area like Kon Plong, the sustainable ... Hierarchy Process) integrated GIS, the influence of climate factors and soil features in the Kon Plong ...

    Abstract The Kon Plong district is located in the northeast area of the Kon Tum province, where ethnic people, such as Xo Dang and Hre, are dominant. With the portion of the poor families accounting for more than 50% of the total households, the improvement in the livelihood of ethnic is an emergency. Among the approaches to enhance the economical situation in the mountainous area like Kon Plong, the sustainable utilization of natural resources to produce valuable products is a possibility. The Codonopsis javanica (Blume) Hook.f. & Thomson (native name in the Vietnamese language is Dang Sam) is a precious medicinal plant with many benefits in pharmacological uses for human health. In nature, C. javanica is favorably distributed in the template climate and high mountain area. On the basis of the multi-criteria analysis using AHP (Analytic Hierarchy Process) integrated GIS, the influence of climate factors and soil features in the Kon Plong district on the growth of C. javanica was evaluated. Using AHP evaluation, the four classes of adaptation thresholds (very suitable, suitable, less suitable and not suitable) between the C. javanica growth and climate or soil factors were determined and expressed in weight values. These adaptation values (weight values) were then exported to ecological adaptation maps using the GIS mapping system. The results showed that the most suitable area ( called S1 and S2) for the cultivation of C. javanica could be an area of 77 ha, accounting for 55.8% of the study area. The area with high adaptability (S1) for growing C. javanica is mainly located in the Mang Den town and Mang But commune (the south area of the Kon Plong district). These study findings suggested that the growth of C. javanica is suitable in several places in Kon Plong and the production process of C. javanica probably promotes the exploitation of sustainable utilization of local medical plant biomass in the study area.
    Keywords ecological adaptation ; codonopsis javanica ; ahp - gis ; kon plong ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350
    Subject code 910
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Polish Society of Ecological Engineering (PTIE)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Identification of

    Lee, Seolah / Jang, Yoonhyuk / Moon, Jangsup / Chu, Kon

    Journal of clinical neurology (Seoul, Korea)

    2024  

    Language English
    Publishing date 2024-04-02
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2023.0300
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  3. Article: Autism-Like Presentation of Possible Autoimmune Encephalitis With Complete Recovery After Immunotherapy.

    Kim, Yongmoo / Jang, Yoonhyuk / Lee, Seolah / Chu, Kon

    Journal of clinical neurology (Seoul, Korea)

    2023  Volume 20, Issue 1, Page(s) 97–99

    Language English
    Publishing date 2023-12-20
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2023.0245
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  4. Article: Leptomeningeal Enhancement, a Phenotype of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With Caudate Nucleus Involvement: A Case Report and Literature Review.

    Kim, Seondeuk / Kim, Seoyeon / Jang, Yoonhyuk / Chu, Kon

    Journal of clinical neurology (Seoul, Korea)

    2023  Volume 19, Issue 2, Page(s) 210–213

    Language English
    Publishing date 2023-02-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2022.0307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Chronic social stress in early life can predispose mice to antisocial maltreating behavior.

    Jeon, Daejong / Kim, Sangwoo / Lee, Sang Kun / Chu, Kon

    Encephalitis (Seoul, Korea)

    2024  Volume 4, Issue 2, Page(s) 23–30

    Abstract: Purpose: In our previous study, we developed an assay system to evaluate antisocial maltreating behavior of conspecific mice using a perpetrator-victim paradigm. We also generated a mouse model for the maltreating behavior by mimicking child ... ...

    Abstract Purpose: In our previous study, we developed an assay system to evaluate antisocial maltreating behavior of conspecific mice using a perpetrator-victim paradigm. We also generated a mouse model for the maltreating behavior by mimicking child maltreatment or abuse. Here, we further investigate the antisocial behavior using anti-aggressive and antipsychotic drugs.
    Methods: Model mice sequentially subjected to maternal separation (MS), social defeat (SD), and social isolation (SI) in that order (MS/SD/SI model) were subjected to a maltreating behavioral task. The MS/SD/SI mice were treated with oxytocin (OXY), clozapine (CLZ), haloperidol (HAL), and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Western blotting and enzyme-linked immunosorbent assay were used for protein analysis.
    Results: A substantial portion of the MS/SD/SI model mice (46% of males and 40% of females) showed a higher number of nose pokes than the control. OXY or 8-OH-DPAT treatment reduced the high number of nose pokes by the MS/SD/SI mice, whereas HAL increased it. CLZ did not affect the number of nose pokes by the MS/SD/SI mice. Interestingly, although the OXY level in the MS/SD/SI mice was similar to that in the control, the amount of OXY receptor was lower in the MS/SD/SI mice. The amount of 5-HT1A receptor was also decreased in the MS/SD/SI mice.
    Conclusion: Chronic social stress in childhood might predispose a mouse to antisocial behavior. Our maltreating behavior assay system, including the MS/SD/SI model, is a good animal system for research on and drug screening for brain disorders associated with antisocial or psychotic behavior.
    Language English
    Publishing date 2024-03-06
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2734-1461
    ISSN (online) 2734-1461
    DOI 10.47936/encephalitis.2023.00199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Eosinophilic meningoencephalitis successfully treated with glucocorticoids and intravenous immunoglobulin: a case report.

    Ahn, Soo Hyun / Ahn, Seon-Jae / Kim, Seung Ae / Lee, Han Sang / Chu, Kon

    Encephalitis (Seoul, Korea)

    2024  Volume 4, Issue 2, Page(s) 40–46

    Abstract: Eosinophilic meningoencephalitis is a rare inflammatory condition of the central nervous system. As a limited number of cases has been reported, debate remains on the optimal treatment. We present a case of idiopathic eosinophilic meningoencephalitis ... ...

    Abstract Eosinophilic meningoencephalitis is a rare inflammatory condition of the central nervous system. As a limited number of cases has been reported, debate remains on the optimal treatment. We present a case of idiopathic eosinophilic meningoencephalitis successfully treated with glucocorticoids and intravenous immunoglobulin (IVIG). After extensive evaluation to rule out other possible causes, the patient was treated with intravenous (IV) dexamethasone and showed significant improvement within a few days. However, neurologic impairment persisted, and follow-up lumbar puncture results showed only a mild decrease in pleocytosis. Even after an additional 5 days of IV methylprednisolone, cerebrospinal fluid (CSF) pleocytosis persisted, and brain magnetic resonance imaging (MRI) showed an increase in enhanced lesions, implying persistent neuroinflammation. The patient was maintained on high-dose oral prednisolone for 2 months, and additional immune-modulatory effects were treated with IVIG. Follow-up MRI at 2 months showed a significant decrease in the extent of multiple enhanced lesions and a normalized CSF profile. The patient was maintained on regular maintenance doses of IVIG for an additional 6 months without any neurologic signs or symptoms. Inflammation is the key pathophysiology underlying neurological damage in eosinophilic meningoencephalitis. A literature review revealed that corticosteroid treatment is the only anti-inflammatory treatment used in cases of idiopathic meningoencephalitis, resulting in sufficient response in most patients but only partial response or death in a few cases. This is the first case report of IVIG use in idiopathic eosinophilic meningoencephalitis, suggesting the possibility of a new treatment modality for refractory cases.
    Language English
    Publishing date 2024-03-28
    Publishing country Korea (South)
    Document type Case Reports
    ISSN 2734-1461
    ISSN (online) 2734-1461
    DOI 10.47936/encephalitis.2024.00010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Autoimmune limbic encephalitis combined with leptomeningeal metastases of non-small cell lung cancer: treatment response to osimertinib, immunoglobulin, rituximab, and tocilizumab.

    Lee, Seolah / Ahn, Seon-Jae / Lee, Han Sang / Chu, Kon

    Encephalitis (Seoul, Korea)

    2023  Volume 3, Issue 1, Page(s) 34–38

    Abstract: When a patient with encephalopathy has an organic brain lesion, his symptom is easily and often mistakenly attributed to that brain lesion. However, a combination of different conditions is also possible. We present a case of autoimmune limbic ... ...

    Abstract When a patient with encephalopathy has an organic brain lesion, his symptom is easily and often mistakenly attributed to that brain lesion. However, a combination of different conditions is also possible. We present a case of autoimmune limbic encephalitis combined with leptomeningeal carcinomatosis. A 57-year-old female patient was transferred to our institute with a 1-month history of seizure and aggressive behavior. Subacute onset of psychosis with multifocal T2 high signal lesions suggested autoimmune encephalitis, and high-dose steroid pulse and immunoglobulin therapy were started. However, a cerebrospinal fluid study revealed metastatic adenocarcinoma of non-small cell lung cancer, of which she was in complete remission state. Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, was started targeting leptomeningeal metastases while maintaining immunotherapy of rituximab and tocilizumab. Her neurological symptoms showed improvement in response to immunotherapy which lasted approximately 1 month and then deteriorated again. We concluded that her symptoms were more attributable to autoimmune encephalitis than leptomeningeal carcinomatosis, and discontinued osimertinib.
    Language English
    Publishing date 2023-01-06
    Publishing country Korea (South)
    Document type Case Reports
    ISSN 2734-1461
    ISSN (online) 2734-1461
    DOI 10.47936/encephalitis.2022.00122
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  8. Article ; Online: Postvaccinal GABA-B receptor antibody encephalitis after ChAdOx1 nCoV-19 vaccination.

    Ahn, Seon-Jae / Lee, Soon-Tae / Chu, Kon

    Annals of clinical and translational neurology

    2022  Volume 9, Issue 10, Page(s) 1673–1678

    Abstract: Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV-19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic-clonic seizures, cognitive decline, and gait disturbance that occurred suddenly ... ...

    Abstract Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV-19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic-clonic seizures, cognitive decline, and gait disturbance that occurred suddenly after the second dose of the ChAdOx1 nCoV-19 vaccine. Clinical presentation and magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) test results were compatible with limbic encephalitis. Synaptic autoantibody tests confirmed serum and CSF GABA B receptor antibodies were present. The patient was treated with immunotherapy with intravenous immunoglobulin and rituximab. This GABA-B receptor antibody encephalitis case occurred presumably due to transient autoantibody production following vaccine administration.
    MeSH term(s) COVID-19/prevention & control ; ChAdOx1 nCoV-19/adverse effects ; Encephalitis/chemically induced ; Encephalomyelitis, Acute Disseminated ; Humans ; Immunoglobulins, Intravenous ; Male ; Receptors, GABA-B ; Rituximab ; Vaccination/adverse effects
    Chemical Substances Immunoglobulins, Intravenous ; Receptors, GABA-B ; Rituximab (4F4X42SYQ6) ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2740696-9
    ISSN 2328-9503 ; 2328-9503
    ISSN (online) 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.51659
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  9. Article ; Online: Talaromyces rugulosus ventriculitis diagnosed by nanopore amplicon sequencing, 2022.

    Lee, Yoonkyung / Kim, Narae / Kim, Seungae / Ha, Jiyeon / Moon, Jangsup / Chu, Kon

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2023  Volume 29, Issue 10, Page(s) 985–987

    Abstract: Ventriculitis has serious complications and a high mortality rate, so it is important to early identification of the pathogen for appropriate treatment. We report case of ventriculitis caused by Talaromyces rugulosus, a rare pathogen, in South Korea. ... ...

    Abstract Ventriculitis has serious complications and a high mortality rate, so it is important to early identification of the pathogen for appropriate treatment. We report case of ventriculitis caused by Talaromyces rugulosus, a rare pathogen, in South Korea. Affected patient was immunocompromised. Repeated cerebrospinal fluid culture tests were negative, but the pathogen was identified by fungal internal transcribed spacer amplicon nanopore sequencing. The pathogen was detected outside the endemic area of talaromycosis.
    MeSH term(s) Humans ; Nanopores ; Cerebral Ventriculitis/diagnosis ; Cerebral Ventriculitis/drug therapy ; Nanopore Sequencing ; Mycoses/diagnosis ; Mycoses/microbiology ; Myelitis
    Language English
    Publishing date 2023-06-04
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2023.05.021
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    Zs.A 5236: Show issues Location:
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  10. Article ; Online: ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease.

    Song, Shujuan / Su, Zhenyi / Kon, Ning / Chu, Bo / Li, Huan / Jiang, Xuejun / Luo, Jianyuan / Stockwell, Brent R / Gu, Wei

    Genes & development

    2023  Volume 37, Issue 5-6, Page(s) 204–217

    Abstract: Although it is well established that Huntington's disease (HD) is mainly caused by polyglutamine-expanded mutant huntingtin (mHTT), the molecular mechanism of mHTT-mediated actions is not fully understood. Here, we showed that expression of the N- ... ...

    Abstract Although it is well established that Huntington's disease (HD) is mainly caused by polyglutamine-expanded mutant huntingtin (mHTT), the molecular mechanism of mHTT-mediated actions is not fully understood. Here, we showed that expression of the N-terminal fragment containing the expanded polyglutamine (HTTQ94) of mHTT is able to promote both the ACSL4-dependent and the ACSL4-independent ferroptosis. Surprisingly, inactivation of the ACSL4-dependent ferroptosis fails to show any effect on the life span of Huntington's disease mice. Moreover, by using RNAi-mediated screening, we identified ALOX5 as a major factor required for the ACSL4-independent ferroptosis induced by HTTQ94. Although ALOX5 is not required for the ferroptotic responses triggered by common ferroptosis inducers such as erastin, loss of ALOX5 expression abolishes HTTQ94-mediated ferroptosis upon reactive oxygen species (ROS)-induced stress. Interestingly, ALOX5 is also required for HTTQ94-mediated ferroptosis in neuronal cells upon high levels of glutamate. Mechanistically, HTTQ94 activates ALOX5-mediated ferroptosis by stabilizing FLAP, an essential cofactor of ALOX5-mediated lipoxygenase activity. Notably, inactivation of the
    MeSH term(s) Animals ; Mice ; Disease Models, Animal ; Ferroptosis/genetics ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism ; Huntington Disease/genetics ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Neurons/metabolism ; Oxidative Stress/genetics ; Reactive Oxygen Species/metabolism
    Chemical Substances Huntingtin Protein ; Reactive Oxygen Species ; Alox5 protein, mouse (EC 1.3.11.34)
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.350211.122
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    Zs.A 2292: Show issues Location:
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