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  1. Article: Spotted fever group rickettsiae and

    Kosak, Leonie / Satz, Norbert / Jutzi, Markus / Dobec, Marinko / Schlagenhauf, Patricia

    New microbes and new infections

    2023  Volume 53, Page(s) 101139

    Abstract: Background: The : Methods: Indirect fluorescent antibody tests for SFG rickettsiae and : Results: Out of 121 : Conclusion: Infections with SFG rickettsiae ... ...

    Abstract Background: The
    Methods: Indirect fluorescent antibody tests for SFG rickettsiae and
    Results: Out of 121
    Conclusion: Infections with SFG rickettsiae and
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2023.101139
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  2. Article ; Online: Hadrosynthesis and Quark Confinement

    Satz Helmut

    EPJ Web of Conferences, Vol 71, p

    2014  Volume 00119

    Abstract: Multihadron production in high energy collisions, from e+e− annihilation to heavy ion interactions, shows remarkable thermal behaviour, specified by a universal “Hagedorn” temperature. We argue that this hadronic radiation is formed by tunnelling through ...

    Abstract Multihadron production in high energy collisions, from e+e− annihilation to heavy ion interactions, shows remarkable thermal behaviour, specified by a universal “Hagedorn” temperature. We argue that this hadronic radiation is formed by tunnelling through the event horizon of colour confinement, i.e., that it is the QCD counterpart of Hawking-Unruh radiation from black holes. It is shown to be emitted at a universal temperature TH ≃ (σ/2π)1/2, where σ denotes the string tension. Since the event horizon does not allow information transfer, the radiation is thermal “at birth”.
    Keywords Physics ; QC1-999 ; Science ; Q
    Language English
    Publishing date 2014-04-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Quarkonium Analysis of the QGP

    Satz Helmut

    EPJ Web of Conferences, Vol 71, p

    2014  Volume 00118

    Abstract: Quarkonium production has been considered as a tool to study the medium formed in high energy nuclear collisions, assuming that the formation of a hot and dense environment modifies the production pattern observed in elementary collisions. The basic ... ...

    Abstract Quarkonium production has been considered as a tool to study the medium formed in high energy nuclear collisions, assuming that the formation of a hot and dense environment modifies the production pattern observed in elementary collisions. The basic features measured there are the relative fractions of hidden to open heavy flavor and the relative fractions of the different hidden heavy flavor states. Hence the essential question is if and how these quantities are modified in nuclear collisions. We show how the relevant data must be calibrated, i.e., what reference has to be used, in order to determine this in a model-independent way.
    Keywords Physics ; QC1-999 ; Science ; Q
    Language English
    Publishing date 2014-04-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Laterality tests: an inferential problem.

    Satz, P

    Cortex; a journal devoted to the study of the nervous system and behavior

    2005  Volume 13, Issue 2, Page(s) 208–212

    Abstract: A Baysean analysis is used to examine some of the inductive inferences about hemispheric "dominance" based on various laterality measures (e.g., dichotic listening). The results reveal some glaring errors of induction that may occur when inferences are ... ...

    Abstract A Baysean analysis is used to examine some of the inductive inferences about hemispheric "dominance" based on various laterality measures (e.g., dichotic listening). The results reveal some glaring errors of induction that may occur when inferences are made on constructs that have a low probability of occurrence in the population (i.e., right brain speech). The problem of measurement error and test validity is also discussed.
    MeSH term(s) Adult ; Bayes Theorem ; Child ; Data Interpretation, Statistical ; Functional Laterality/physiology ; Hearing/physiology ; Humans ; Sensation/physiology ; Speech/physiology
    Language English
    Publishing date 2005-11-08
    Publishing country Italy
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 280622-8
    ISSN 1973-8102 ; 0010-9452
    ISSN (online) 1973-8102
    ISSN 0010-9452
    DOI 10.1016/s0010-9452(77)80010-5
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  5. Article ; Online: The interaction between depression diagnosis and BMI is related to altered activation pattern in the right inferior frontal gyrus and anterior cingulate cortex during food anticipation.

    Manelis, A / Halchenko, Y O / Satz, S / Ragozzino, R / Iyengar, S / Swartz, H A / Levine, M D

    Brain and behavior

    2022  Volume 12, Issue 9, Page(s) e2695

    Abstract: ... anterior cingulate cortex (ACC) during food versus nonfood anticipation (p < .0125). Brain activation ...

    Abstract Background: Depression and overweight/obesity often cooccur but the underlying neural mechanisms for this bidirectional link are not well understood.
    Methods: In this functional magnetic resonance imaging study, we scanned 54 individuals diagnosed with depressive disorders (DD) and 48 healthy controls (HC) to examine how diagnostic status moderates the relationship between body mass index (BMI) and brain activation during anticipation and pleasantness rating of food versus nonfood stimuli.
    Results: We found a significant BMI-by-diagnosis interaction effect on activation in the right inferior frontal gyrus (RIFG) and anterior cingulate cortex (ACC) during food versus nonfood anticipation (p < .0125). Brain activation in these regions was greater in HC with higher BMI than in HC with lower BMI. Individuals with DD showed an opposite pattern of activation. Structural equation modeling revealed that the relationship between BMI, activation in the RIFG and ACC, and participants' desire to eat food items shown in the experiment depended on the diagnostic status.
    Conclusions: Considering that food anticipation is an important component of appetitive behavior and that the RIFG and ACC are involved in emotion regulation, response inhibition and conflict monitoring necessary to control this behavior, we propose that future clinical trials targeting weight loss in DD should investigate whether adequate mental preparation positively affects subsequent food consumption behaviors in these individuals.
    MeSH term(s) Body Mass Index ; Brain/physiology ; Brain Mapping ; Depression/diagnostic imaging ; Gyrus Cinguli/diagnostic imaging ; Humans ; Magnetic Resonance Imaging/methods ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/physiology
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.2695
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  6. Article: DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2-p53 Inhibitor.

    Silvestri, Anthony P / Zhang, Qi / Ping, Yan / Muir, Erik W / Zhao, Jingsi / Chakka, Sai Kumar / Wang, Gaonan / Bray, Walter M / Chen, Wenhua / Fribourgh, Jennifer L / Tripathi, Sarvind / He, Yunyun / Rubin, Seth M / Satz, Alexander L / Pye, Cameron R / Kuai, Letian / Su, Wenji / Schwochert, Joshua A

    ACS medicinal chemistry letters

    2023  Volume 14, Issue 6, Page(s) 820–826

    Abstract: Synthetic macrocyclic peptides are an emerging molecular class for both targeting intracellular protein-protein interactions (PPIs) and providing an oral modality for drug targets typically addressed by biologics. Display technologies, such as mRNA and ... ...

    Abstract Synthetic macrocyclic peptides are an emerging molecular class for both targeting intracellular protein-protein interactions (PPIs) and providing an oral modality for drug targets typically addressed by biologics. Display technologies, such as mRNA and phage display, often yield peptides that are too large and too polar to achieve passive permeability or oral bioavailability without substantial off-platform medicinal chemistry. Herein, we use DNA-encoded cyclic peptide libraries to discover a neutral nonapeptide, UNP-6457, that inhibits MDM2-p53 interaction with an IC
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.3c00117
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  7. Article ; Online: Aberrant levels of cortical myelin distinguish individuals with depressive disorders from healthy controls.

    Baranger, David A A / Halchenko, Yaroslav O / Satz, Skye / Ragozzino, Rachel / Iyengar, Satish / Swartz, Holly A / Manelis, Anna

    NeuroImage. Clinical

    2021  Volume 32, Page(s) 102790

    Abstract: ... T2w ratio distinguished patients from HC with 68% accuracy (p < 0.001; sensitivity = 63.8 ...

    Abstract The association between depressive disorders and measures reflecting myelin content is underexplored, despite growing evidence of associations with white matter tract integrity. We characterized the T1w/T2w ratio using the Glasser atlas in 39 UD and 47 HC participants (ages = 19-44, 75% female). A logistic elastic net regularized regression with nested cross-validation and a subsequent linear discriminant analysis conducted on held-out samples were used to select brain regions and classify patients vs. healthy controls (HC). True-label model performance was compared against permuted-label model performance. The T1w/T2w ratio distinguished patients from HC with 68% accuracy (p < 0.001; sensitivity = 63.8%, specificity = 71.5%). Brain regions contributing to this classification performance were located in the orbitofrontal cortex, anterior cingulate, extended visual, and auditory cortices, and showed statistically significant differences in the T1w/T2w ratio for patients vs. HC. As the T1w/T2w ratio is thought to characterize cortical myelin, patterns of cortical myelin in these regions may be a biomarker distinguishing individuals with depressive disorders from HC.
    MeSH term(s) Adult ; Brain ; Depressive Disorder ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Myelin Sheath ; White Matter/diagnostic imaging ; Young Adult
    Language English
    Publishing date 2021-08-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2021.102790
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  8. Article ; Online: Hawking-Unruh hadronization and strangeness production in high energy collisions

    Castorina Paolo / Satz Helmut

    EPJ Web of Conferences, Vol 97, p

    2015  Volume 00009

    Abstract: The interpretation of quark (q)- antiquark (q̄) pairs production and the sequential string breaking as tunneling through the event horizon of colour confinement leads to a thermal hadronic spectrum with a universal Unruh temperature, T ≃ 165 Mev, related ...

    Abstract The interpretation of quark (q)- antiquark (q̄) pairs production and the sequential string breaking as tunneling through the event horizon of colour confinement leads to a thermal hadronic spectrum with a universal Unruh temperature, T ≃ 165 Mev, related to the quark acceleration, a, by T = a/2π. The resulting temperature depends on the quark mass and then on the content of the produced hadrons, causing a deviation from full equilibrium and hence a suppression of strange particle production in elementary collisions. In nucleus-nucleus collisions, where the quark density is much bigger, one has to introduce an average temperature (acceleration) which dilutes the quark mass effect and the strangeness suppression almost disappears.
    Keywords Science ; Q ; Physics ; QC1-999
    Publishing date 2015-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Low levels of serum vitamin D in clozapine-treated schizophrenia patients are associated with high levels of the proinflammatory cytokine IL-6.

    Krivoy, Amir / Satz, Joshua / Hornfeld, Shay H / Bar, Lior / Gaughran, Fiona / Shoval, Gal / Hochman, Eldar / Weizman, Abraham / Taler, Michal

    International clinical psychopharmacology

    2020  Volume 35, Issue 4, Page(s) 208–213

    Abstract: ... Pearson's r = -0.38, P < 0.05). Vitamin D levels correlated with the severity of positive symptoms (r = 0.39 ... P < 0.05). These results suggest that within clozapine-treated schizophrenia patients, high levels ...

    Abstract Low levels of vitamin D are prevalent among patients with schizophrenia and have been linked to the risk and outcome of the disorder. Vitamin D has a regulatory effect on the inflammatory system, which is dysfunctional in schizophrenia. We investigated the association between serum vitamin D levels, inflammatory status, and severity of schizophrenia symptoms. A total of 39 clozapine-treated schizophrenia patients were recruited to the study. Blood samples for biochemical analysis were collected from all participants. Serum levels of vitamin D and cytokines (IL-4, IL-6, IL-10, and TNF-α) were analyzed and the association between biochemical and clinical measures was assessed. Most of the sample (82%) had insufficient levels of vitamin D. There was a significant inverse correlation between serum vitamin D and IL-6 levels (Pearson's r = -0.38, P < 0.05). Vitamin D levels correlated with the severity of positive symptoms (r = 0.39, P < 0.05). These results suggest that within clozapine-treated schizophrenia patients, high levels of vitamin D are associated with lower serum levels of the proinflammatory cytokine IL-6. This relationship may indicate an immunomodulatory effect of vitamin D in treatment-resistant patients with schizophrenia maintained on clozapine.
    MeSH term(s) Adult ; Clozapine/therapeutic use ; Cytokines/blood ; Female ; Humans ; Interleukin-6/blood ; Male ; Schizophrenia/blood ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Vitamin D/blood ; Young Adult
    Chemical Substances Cytokines ; Interleukin-6 ; Vitamin D (1406-16-2) ; Clozapine (J60AR2IKIC)
    Language English
    Publishing date 2020-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 632837-4
    ISSN 1473-5857 ; 0268-1315
    ISSN (online) 1473-5857
    ISSN 0268-1315
    DOI 10.1097/YIC.0000000000000303
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    Zs.A 2162: Show issues Location:
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  10. Article ; Online: Impact of a shelter-in-place order during the COVID-19 pandemic on the incidence of opioid overdoses.

    Rosenbaum, Jennifer / Lucas, Nicole / Zandrow, Gregory / Satz, Wayne A / Isenberg, Derek / D'Orazio, Joseph / Gentile, Nina T / Schreyer, Kraftin E

    The American journal of emergency medicine

    2020  Volume 41, Page(s) 51–54

    Abstract: ... the Pre-SIP period, consistent with a 6.8% decline. A Fisher's Exact Test demonstrated a p < 0.0001 ...

    Abstract Introduction: Since the beginning of the novel coronavirus (COVID-19) pandemic in the United States, there have been concerns about the potential impact of the pandemic on persons with opioid use disorder. Shelter-in-place (SIP) orders, which aimed to reduce the spread and scope of the virus, likely also impacted this patient population. This study aims to assess the role of the COVID-19 pandemic on the incidence of opioid overdose before and after a SIP order.
    Methods: A retrospective review of the incidence of opioid overdoses in an urban three-hospital system was conducted. Comparisons were made between the first 100 days of a city-wide SIP order during the COVID-19 pandemic and the 100 days during the COVID-19 pandemic preceding the SIP order (Pre-SIP). Differences in observed incidence and expected incidence during the SIP period were evaluated using a Fisher's Exact test.
    Results: Total patient visits decreased 22% from 46,078 during the Pre-SIP period to 35,971 during the SIP period. A total of 1551 opioid overdoses were evaluated during the SIP period, compared to 1665 opioid overdoses during the Pre-SIP period, consistent with a 6.8% decline. A Fisher's Exact Test demonstrated a p < 0.0001, with a corresponding Odds Ratio of 1.20 with a 95% confidence interval (1.12;1.29).
    Conclusion: The COVID-19 pandemic and the associated SIP order were associated with a statistically and clinically significant increase in the proportion of opioid overdoses in relation to the overall change in total ED visits.
    MeSH term(s) COVID-19/epidemiology ; Emergency Service, Hospital/statistics & numerical data ; Facilities and Services Utilization ; Humans ; Incidence ; Opiate Overdose/epidemiology ; Opiate Overdose/mortality ; Pandemics ; Philadelphia/epidemiology ; Physical Distancing ; Quarantine ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2020-12-30
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2020.12.047
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