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Article ; Online: In vitro susceptibility testing of tetracycline-class antibiotics against slowly growing non-tuberculous mycobacteria.

Li, Anqi / Tan, Zhili / He, Siyuan / Chu, Haiqing

Clinical and experimental pharmacology & physiology

2023 Volume 50, Issue 7, Page(s) 604–609

Abstract: Non-tuberculous mycobacterial infections are gradually increasing worldwide, with slow-growing mycobacteria such as Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium kansasii accounting for the majority of cases. The use of ... ...

Abstract	Non-tuberculous mycobacterial infections are gradually increasing worldwide, with slow-growing mycobacteria such as Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium kansasii accounting for the majority of cases. The use of tetracyclines has received renewed attention in recent years, and this study was designed to investigate the antibacterial activity of omadacycline, eravacycline, tigecycline, sarecycline, minocycline and doxycycline against M. avium, M. intracellulare and M. kansasii. Susceptibility testing of six tetracyclines was conducted against M. avium, M. intracellulare and M. kansasii isolates, and all the clinical isolates were collected from January 2012 to December 2018. All six agents exhibited poor antibacterial activity against slowly growing mycobacteria (SGM) isolates of three subspecies with MIC
MeSH term(s)	Nontuberculous Mycobacteria ; Tetracycline/pharmacology ; Anti-Bacterial Agents/pharmacology ; Minocycline
Chemical Substances	omadacycline (090IP5RV8F) ; Tetracycline (F8VB5M810T) ; Anti-Bacterial Agents ; Minocycline (FYY3R43WGO)
Language	English
Publishing date	2023-04-22
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189277-0
ISSN	1440-1681 ; 0305-1870 ; 0143-9294
ISSN (online)	1440-1681
ISSN	0305-1870 ; 0143-9294
DOI	10.1111/1440-1681.13777
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Article ; Online: Candida auris

Bing, Jian / Du, Han / Guo, Penghao / Hu, Tianren / Xiao, Meng / Lu, Sha / Nobile, Clarissa J / Chu, Haiqing / Huang, Guanghua

Emerging microbes & infections

2024 Volume 13, Issue 1, Page(s) 2302843

Abstract: The emerging human fungal ... ...

Abstract	The emerging human fungal pathogen
MeSH term(s)	Humans ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida ; Candidiasis/microbiology ; Candida auris ; Disease Outbreaks ; China/epidemiology ; Microbial Sensitivity Tests
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2024.2302843
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Article ; Online: sRNA21, a novel small RNA, protects Mycobacterium abscessus against oxidative stress.

Tan, Zhili / Fan, Junsheng / He, Siyuan / Zhang, Zhemin / Chu, Haiqing

The journal of gene medicine

2023 Volume 25, Issue 6, Page(s) e3492

Abstract: Background: During infection, Mycobacterium abscessus encounters numerous environmental changes and adapts to them using a variety of complex mechanisms. Non-coding small RNAs (sRNAs) have been shown in other bacteria to be involved in post- ... ...

Abstract	Background: During infection, Mycobacterium abscessus encounters numerous environmental changes and adapts to them using a variety of complex mechanisms. Non-coding small RNAs (sRNAs) have been shown in other bacteria to be involved in post-transcriptional regulatory pathways, including environmental stress adaptation. However, the potential role of sRNAs in the resistance to oxidative stress in M. abscessus was not clearly described. Methods: In the present study, we analyzed putative sRNAs identified by RNA-sequencing (RNA-seq) experiments in M. abscessus ATCC_19977 under oxidative stress, and the transcription profiles of sRNAs with differential expression were verified by quantitative reverse transcription-PCR (qRT-PCR). Six sRNA overexpression strains were constructed, and the differences in growth curves between these strains and the control strain were verified. An upregulated sRNA under oxidative stress was selected and named sRNA21. The survival ability of the sRNA21 overexpression strain was assessed, and computer-based approaches were used to predict the targets and pathways regulated by sRNA21. The total ATP production and NAD Results: In total, 14 putative sRNAs were identified under oxidative stress, and the qRT-PCR analysis of six sRNAs showed comparable results to RNA-seq assays. Overexpression of sRNA21 in M. abscessus increased cell growth rate and intracellular ATP level before and after peroxide exposure. The expression of genes encoding alkyl hydroperoxidase and superoxide dismutase was significantly increased, and superoxide dismutase activity was enhanced in the sRNA21 overexpression strain. Meanwhile, after sRNA21 overexpression, the intracellular NAD Conclusions: Our findings show that sRNA21 is an oxidative stress-induced sRNA that increases M. abscessus survival and promotes the expression of antioxidant enzymes under oxidative stress. These findings may provide new insights into the adaptive transcriptional response of M. abscessus to oxidative stress.
MeSH term(s)	Mycobacterium abscessus/genetics ; Mycobacterium abscessus/metabolism ; NAD/metabolism ; RNA, Bacterial/genetics ; RNA, Bacterial/metabolism ; RNA, Small Untranslated/genetics ; RNA, Small Untranslated/metabolism ; Oxidative Stress/genetics ; Adenosine Triphosphate/metabolism
Chemical Substances	NAD (0U46U6E8UK) ; RNA, Bacterial ; RNA, Small Untranslated ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2023-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1458024-x
ISSN	1521-2254 ; 1099-498X
ISSN (online)	1521-2254
ISSN	1099-498X
DOI	10.1002/jgm.3492
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Zs.A 5423: Show issues

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Article: The ambulatory transoral endoscopic thyroidectomy vestibular approach is safe and economical for patients with thyroid nodules.

Sun, Haiqing / Chu, Yongli / Zhang, Guojun / Zheng, Guibin / Zheng, Haitao

Frontiers in endocrinology

2023 Volume 14, Page(s) 1116280

Abstract: Background: Ambulatory thyroid surgery has been increasingly performed in recent years. However, the feasibility of the ambulatory transoral endoscopic thyroidectomy vestibular approach (TOETVA) has not been evaluated. We aimed to evaluate the safety, ... ...

Abstract	Background: Ambulatory thyroid surgery has been increasingly performed in recent years. However, the feasibility of the ambulatory transoral endoscopic thyroidectomy vestibular approach (TOETVA) has not been evaluated. We aimed to evaluate the safety, economy, and mental health outcomes of ambulatory TOETVA. Methods: We retrospectively reviewed the data of patients who underwent TOETVA between March 2019 and August 2022. The procedure was performed by a skilled surgical team from the Department of Thyroid Surgery of the affiliated Yantai Yuhuangding Hospital of Qingdao University. Patients were enrolled in the ambulatory (n=166) and conventional (n=290) groups, based on their chosen procedure. We analyzed patients' clinical characteristics, surgical outcomes, Hamilton Anxiety Rating Scale (HAM-A) scores, and hospitalization costs. Results: Of 456 patients, 166 underwent ambulatory TOETVA and 290 underwent conventional TOETVA. No significant differences were found in clinical and surgical characteristics between the groups, including sex (P=0.363), age (P=0.077), body mass index (P=0.351), presence of internal diseases (P=0.613), presence of Hashimoto's thyroiditis (P=0.429), pathology (P=0.362), maximum tumor diameter (P=0.520), scope of surgery (P=0.850), or operative time (P=0.351). There were no significant differences in maximum tumor diameter (P=0.349), extrathyroidal tissue invasion (P=0.516), number of retrieved central lymph nodes (P=0.069), or metastatic central lymph nodes (P=0.897) between the groups. No significant differences were found in complications, including transient hypoparathyroidism (P=0.438), transient vocal cord palsy (P=0.876), transient mental nerve injury (P=0.749), permanent mental nerve injury (P=0.926), and other complications (P=1.000). Ambulatory patients had shorter hospital stays (P<0.001) and reduced hospitalization costs (P<0.001). There was no significant difference in HAM-A scores between the groups (P=0.056). Conclusions: Ambulatory TOETVA is a safe, feasible, and cost-effective procedure for selected patients. This procedure resulted in shorter hospital stays, decreased medical costs, and did not increase patient anxiety. To ensure patient safety, surgical teams must inform patients of the indications, when to seek help, and how to receive the fastest medical attention.
MeSH term(s)	Humans ; Thyroidectomy/adverse effects ; Thyroidectomy/methods ; Thyroid Nodule/surgery ; Thyroid Nodule/etiology ; Retrospective Studies ; Mandibular Nerve Injuries/etiology ; Natural Orifice Endoscopic Surgery/adverse effects ; Natural Orifice Endoscopic Surgery/methods
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1116280
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Article ; Online: Selective depletion of CD11b-positive monocytes/macrophages potently suppresses bleomycin-induced pulmonary fibrosis.

Wan, Xiaoyu / Xiao, Yongtao / Tian, Xinbei / Lu, Ying / Chu, Haiqing

International immunopharmacology

2022 Volume 114, Page(s) 109570

Abstract: The understanding of pathogenesis underlying idiopathic pulmonary fibrosis (IPF) is still limited presently. Monocytes or macrophages are involved in progression of the pulmonary injury and repair. The aim of this study is to investigate the roles of ... ...

Abstract	The understanding of pathogenesis underlying idiopathic pulmonary fibrosis (IPF) is still limited presently. Monocytes or macrophages are involved in progression of the pulmonary injury and repair. The aim of this study is to investigate the roles of CD11b
MeSH term(s)	Animals ; Mice ; Bleomycin/adverse effects ; Idiopathic Pulmonary Fibrosis/genetics ; Lung/pathology ; Macrophages ; Mice, Inbred C57BL ; Monocytes/metabolism
Chemical Substances	Bleomycin (11056-06-7) ; Itgam protein, mouse
Language	English
Publishing date	2022-12-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.109570
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Zs.A 5408: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Omadacycline, Eravacycline, and Tigecycline Express Anti-Mycobacterium abscessus Activity

Li, Anqi / He, Siyuan / Li, Jingren / Zhang, Zhemin / Li, Bing / Chu, Haiqing

Microbiology spectrum

2023 Volume 11, Issue 3, Page(s) e0071823

Abstract: Mycobacterium abscessus infections are increasing worldwide necessitating the development of new antibiotics and treatment regimens. The utility of third-generation tetracycline antibiotics was reestablished; their anti-M. abscessus activity needs ... ...

Abstract	Mycobacterium abscessus infections are increasing worldwide necessitating the development of new antibiotics and treatment regimens. The utility of third-generation tetracycline antibiotics was reestablished; their anti-M. abscessus activity needs further study. The activities of omadacycline (OMC), eravacycline (ERC), tigecycline (TGC), and sarecycline (SAC) were tested against two reference strains and 193 clinical M. abscessus isolates at different temperatures (30°C and 37°C). The minimum bactericidal concentrations (MBCs) of the four drugs were determined to distinguish between their bactericidal and bacteriostatic activities. The MICs of OMC, ERC, and TGC for the reference strains and clinical isolates were summarized and compared. OMC, ERC, and TGC exhibited a high level of bacteriostatic activity against M. abscessus. The MICs of OMC and ERC for
MeSH term(s)	Tigecycline/pharmacology ; Mycobacterium abscessus ; Tetracyclines/pharmacology ; Anti-Bacterial Agents/pharmacology
Chemical Substances	sarecycline (94O110CX2E) ; Tigecycline (70JE2N95KR) ; omadacycline (090IP5RV8F) ; eravacycline (07896928ZC) ; Tetracyclines ; Anti-Bacterial Agents
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00718-23
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Article ; Online: Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection.

Bing, Jian / Guan, Zhangyue / Zheng, Tianhong / Ennis, Craig L / Nobile, Clarissa J / Chen, Changbin / Chu, Haiqing / Huang, Guanghua

Nature communications

2024 Volume 15, Issue 1, Page(s) 2381

Abstract: Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in ... ...

Abstract	Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in the murine host during systemic infection. C. auris aggregative cells accumulate in the brain and exhibit obvious advantages over the single-celled yeast-form cells during systemic infection. Genetic mutations, specifically de novo point mutations in genes associated with cell division or budding processes, underlie the rapid evolution of this aggregative phenotype. Most mutated C. auris genes are associated with the regulation of cell wall integrity, cytokinesis, cytoskeletal properties, and cellular polarization. Moreover, the multicellular aggregates are notably more recalcitrant to the host antimicrobial peptides LL-37 and PACAP relative to the single-celled yeast-form cells. Overall, to survive in the host, C. auris can rapidly evolve a multicellular aggregative morphology via genetic mutations.
MeSH term(s)	Animals ; Mice ; Candida/genetics ; Candidiasis/microbiology ; Candida auris ; Saccharomyces cerevisiae ; Phenotype ; Sepsis ; Antifungal Agents ; Microbial Sensitivity Tests ; Mammals
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46786-8
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Article: Sitafloxacin Expresses Potent Anti-

He, Siyuan / Guo, Qi / Zhao, Lan / Xu, Liyun / Fan, Junsheng / Wu, Wenye / Zhang, Zhemin / Li, Bing / Chu, Haiqing

Frontiers in microbiology

2022 Volume 12, Page(s) 779531

Abstract: Therapeutic options for ... ...

Abstract	Therapeutic options for treating
Language	English
Publishing date	2022-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.779531
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Article: The role of ferroptosis in intervertebral disc degeneration.

Fan, Chunyang / Chu, Genglei / Yu, Zilin / Ji, Zhongwei / Kong, Fanchen / Yao, Lingye / Wang, Jiale / Geng, Dechun / Wu, Xiexing / Mao, Haiqing

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1219840

Abstract: Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of the most widespread health issues worldwide, intervertebral disc ... ...

Abstract	Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of the most widespread health issues worldwide, intervertebral disc degeneration (IVDD) is recognized as a key contributor to back and neck discomfort. A number of degenerative disorders have a strong correlation with ferroptosis, a recently identified novel regulated cell death (RCD) characterized by an iron-dependent mechanism and a buildup of lipid reactive oxygen species (ROS). There is growing interest in the part ferroptosis plays in IVDD pathophysiology. Inhibiting ferroptosis has been shown to control IVDD development. Several studies have demonstrated that in TBHP-induced oxidative stress models, changes in ferroptosis marker protein levels and increased lipid peroxidation lead to the degeneration of intervertebral disc cells, which subsequently aggravates IVDD. Similarly, IVDD is significantly relieved with the use of ferroptosis inhibitors. The purpose of this review was threefold: 1) to discuss the occurrence of ferroptosis in IVDD; 2) to understand the mechanism of ferroptosis and its role in IVDD pathophysiology; and 3) to investigate the feasibility and prospect of ferroptosis in IVDD treatment.
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1219840
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Article ; Online: 3 × 1 fiber signal combiner with high beam quality Gaussian-like beam for a 10kW-level fiber laser.

Zhou, Yanyan / Yang, Aibi / Yang, Guanghua / Qiu, Qiang / Zhang, Xu / Zhang, Zhilun / Xing, Yinbin / Peng, Jinggang / Li, HaiQing / Chu, Yingbo / Li, Jinyan / Dai, Nengli

Optics express

2023 Volume 31, Issue 2, Page(s) 2780–2791

Abstract: We present the design and fabrication of a 3 × 1 signal combiner with high beam quality based on supermode theory. For improving beam quality, the fiber with core diameter of 34 µm and numerical aperture of 0.11 is first chosen as the output fiber. An 8 ... ...

Abstract	We present the design and fabrication of a 3 × 1 signal combiner with high beam quality based on supermode theory. For improving beam quality, the fiber with core diameter of 34 µm and numerical aperture of 0.11 is first chosen as the output fiber. An 8.89 kW output laser with a power transmission efficiency of 97.2% and a low temperature rise coefficient of 3.5 °C/ kW at >8 kW is obtained when the combiner launched by three Yb-doped fiber lasers. In addition, the energy density distribution of the output beam is Gaussian-like and M
Language	English
Publishing date	2023-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.475281
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