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  1. Article ; Online: The corruption of power: On the use and abuse of a pre-trial concept.

    Berg, Ronan M G / Christensen, Robin / Ried-Larsen, Mathias

    Experimental physiology

    2023  Volume 109, Issue 3, Page(s) 317–319

    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Editorial
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modelling.

    Windoloski, Kristen A / Janum, Susanne / Berg, Ronan M G / Olufsen, Mette S

    Experimental physiology

    2024  

    Abstract: Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion over multiple hours. Several studies hypothesize that the latter better ... ...

    Abstract Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion over multiple hours. Several studies hypothesize that the latter better represents the prolonged and pronounced inflammation observed in conditions like sepsis. Yet very few experimental studies have administered endotoxin using both strategies, leaving significant gaps in determining the underlying mechanisms responsible for their differing immune responses. We used mathematical modelling to analyse cytokine data from two studies administering a 2 ng kg
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A song of iron and oxygen: Hypoxic pulmonary vasoconstriction and gas exchange in chronic obstructive pulmonary disease.

    Hartmann, Jacob P / Bailey, Damian M / Berg, Ronan M G

    Experimental physiology

    2023  Volume 108, Issue 4, Page(s) 535–538

    MeSH term(s) Humans ; Oxygen ; Vasoconstriction ; Iron ; Hypoxia ; Pulmonary Disease, Chronic Obstructive ; Pulmonary Gas Exchange ; Pulmonary Circulation
    Chemical Substances Oxygen (S88TT14065) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Myths and methodologies: Assessment of dynamic cerebral autoregulation by the mean flow index.

    Olsen, Markus Harboe / Riberholt, Christian Gunge / Berg, Ronan M G / Møller, Kirsten

    Experimental physiology

    2024  Volume 109, Issue 4, Page(s) 614–623

    Abstract: The mean flow index-usually referred to as Mx-has been used for assessing dynamic cerebral autoregulation (dCA) for almost 30 years. However, concerns have arisen regarding methodological consistency, construct and criterion validity, and test-retest ... ...

    Abstract The mean flow index-usually referred to as Mx-has been used for assessing dynamic cerebral autoregulation (dCA) for almost 30 years. However, concerns have arisen regarding methodological consistency, construct and criterion validity, and test-retest reliability. Methodological nuances, such as choice of input (cerebral perfusion pressure, invasive or non-invasive arterial pressure), pre-processing approach and artefact handling, significantly influence mean flow index values, and previous studies correlating mean flow index with other established dCA metrics are confounded by inherent methodological flaws like heteroscedasticity, while the mean flow index also fails to discriminate individuals with presumed intact versus impaired dCA (discriminatory validity), and its prognostic performance (predictive validity) across various conditions remains inconsistent. The test-retest reliability, both within and between days, is generally poor. At present, no single approach for data collection or pre-processing has proven superior for obtaining the mean flow index, and caution is advised in the further use of mean flow index-based measures for assessing dCA, as current evidence does not support their clinical application.
    MeSH term(s) Humans ; Reproducibility of Results ; Arterial Pressure ; Homeostasis/physiology ; Cerebrovascular Circulation/physiology ; Blood Flow Velocity/physiology ; Ultrasonography, Doppler, Transcranial ; Blood Pressure/physiology
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Physiolometrics and the puzzle of methodical acumen.

    Hartmann, Jacob Peter / Olsen, Markus Harboe / Rose, George / Bailey, Damian M / Berg, Ronan M G

    Experimental physiology

    2023  Volume 108, Issue 9, Page(s) 1103–1105

    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Editorial
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sharpey-Schafer, Langley and Sherrington: 'swordsmen' of physiology. A historical look to the future.

    Bailey, Damian M / Berg, Ronan M G / Stewart, Alex / Adams, Josephine C / Kohl, Peter

    Experimental physiology

    2023  Volume 108, Issue 5, Page(s) 655–658

    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Editorial
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Test-retest reliability of transfer function analysis metrics for assessing dynamic cerebral autoregulation to spontaneous blood pressure oscillations.

    Olsen, Markus Harboe / Riberholt, Christian / Capion, Tenna / Plovsing, Ronni R / Møller, Kirsten / Berg, Ronan M G

    Experimental physiology

    2024  

    Abstract: Transfer function analysis (TFA) is a widely used method for assessing dynamic cerebral autoregulation in humans. In the present study, we assessed the test-retest reliability of established TFA metrics derived from spontaneous blood pressure ... ...

    Abstract Transfer function analysis (TFA) is a widely used method for assessing dynamic cerebral autoregulation in humans. In the present study, we assessed the test-retest reliability of established TFA metrics derived from spontaneous blood pressure oscillations and based on 5 min recordings. The TFA-based gain, phase and coherence in the low-frequency range (0.07-0.20 Hz) from 19 healthy volunteers, 37 patients with subarachnoid haemorrhage and 19 patients with sepsis were included. Reliability assessments included the smallest real difference (SRD) and the coefficient of variance for comparing consecutive 5 min recordings, temporally separated 5 min recordings and consecutive recordings with a minimal length of 10 min. In healthy volunteers, temporally separating the 5 min recordings led to a 0.38 (0.01-0.79) cm s
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pulmonary blood volume measured by

    Hartmann, Jacob Peter / Lassen, Martin Lyngby / Mohammad, Milan / Iepsen, Ulrik Winning / Mortensen, Jann / Hasbak, Philip / Berg, Ronan M G

    Journal of applied physiology (Bethesda, Md. : 1985)

    2024  

    Abstract: In patients with chronic obstructive pulmonary disease (COPD), pulmonary vascular dysfunction and destruction are observable before the onset of detectable emphysema, but it is unknown whether this is associated with central hypovolemia. We investigated ... ...

    Abstract In patients with chronic obstructive pulmonary disease (COPD), pulmonary vascular dysfunction and destruction are observable before the onset of detectable emphysema, but it is unknown whether this is associated with central hypovolemia. We investigated if COPD patients have reduced pulmonary blood volume (PBV) evaluated by
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00058.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.249: Show issues Location:
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  9. Article ; Online: Ventilation perfusion functional difference images in lung SPECT: A linear and symmetrical scale as an alternative to the ventilation perfusion ratio.

    de Nijs, Robin / Berg, Ronan M G / Lindskov Hansen, Sofie / Mortensen, Jann

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2024  Volume 119, Page(s) 103306

    Abstract: Purpose: Ventilation Perfusion SPECT is important in the diagnostics of e.g. pulmonary embolism ...

    Abstract Purpose: Ventilation Perfusion SPECT is important in the diagnostics of e.g. pulmonary embolism and chronic obstructive pulmonary disease. Classical and reverse mismatched defects can be identified by utilizing the ventilation-perfusion ratio. Unfortunately, this ratio is only linear in the ventilation, the scale is not symmetrical regarding classical and reversed mismatches and small perfusion values give rise to artifacts. The ventilation-perfusion (VQ) difference is developed as an alternative.
    Methods: For both VQ-ratio and VQ-difference a scaling factor for the perfusion is computed, so that voxels with matched ventilation and perfusion (on average) yield zero signal. The relative VQ-difference is calculated by scaling with the summed VQ-signal in each voxel. The scaled VQ-difference is calculated by scaling with the global maximum of this sum.
    Results: The relative and scaled differences have a scale from -1 (perfusion only) to + 1 (ventilation only). Image quality of relative VQ-difference and VQ-ratio images is hampered by artifacts from areas with both low perfusion and low ventilation. Ratio and differences have been investigated in ten patients and are shown for three patients (one without defects). Clinical thresholds for the difference images are derived resulting in color maps of relevant (reversed) mismatches with a (reciprocal) ratio larger than two.
    Conclusions: The relative ventilation-perfusion difference is a methodological improvement on the ventilation-perfusion ratio, because it has a symmetrical scale and is bound on a closed domain. A better diagnostic value is expected by utilizing the scaled difference, which represents functional difference instead of relative difference.
    MeSH term(s) Humans ; Ventilation-Perfusion Ratio ; Lung/diagnostic imaging ; Tomography, Emission-Computed, Single-Photon/methods ; Pulmonary Embolism/diagnostic imaging ; Perfusion
    Language English
    Publishing date 2024-02-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2024.103306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Vascular Inflammation as a Therapeutic Target in COVID-19 "Long Haulers": HIITing the Spot?

    Christensen, Regitse Højgaard / Berg, Ronan M G

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 643626

    Language English
    Publishing date 2021-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.643626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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