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  1. Article ; Online: Toward a Paradigm to Distinguish Distinct Functions of FOXP3

    Weinberg, Samuel E / Singer, Benjamin D

    ImmunoHorizons

    2021  Volume 5, Issue 12, Page(s) 944–952

    Abstract: ... ...

    Abstract FOXP3
    MeSH term(s) Acute Lung Injury/immunology ; Acute Lung Injury/metabolism ; Animals ; Forkhead Transcription Factors/immunology ; Forkhead Transcription Factors/metabolism ; Homeostasis/immunology ; Humans ; Immune Tolerance ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Forkhead Transcription Factors
    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2100046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeting Bacteria within Us to Diminish Infection and Autoimmunity.

    Weinberg, Samuel E / Chandel, Navdeep S

    Immunity

    2019  Volume 54, Issue 1, Page(s) 1–3

    Abstract: Antibiotics improve clinical outcomes independent of their antibacterial effects. In this issue of Immunity, Almeida et al. and Colaço et al. demonstrate that antibiotic impairment of mitochondrial ribosomes modulates both T-cell-dependent inflammation ... ...

    Abstract Antibiotics improve clinical outcomes independent of their antibacterial effects. In this issue of Immunity, Almeida et al. and Colaço et al. demonstrate that antibiotic impairment of mitochondrial ribosomes modulates both T-cell-dependent inflammation and host tolerance to infection.
    MeSH term(s) Autoimmunity ; Bacteria ; T-Lymphocytes
    Language English
    Publishing date 2019-06-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2020.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  3. Article: Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes.

    Lyman, Kyle A / Han, Ye / Robinson, Andrew P / Weinberg, Samuel E / Fisher, Daniel W / Heuermann, Robert J / Lyman, Reagan E / Kim, Dong Kyu / Ludwig, Andreas / Chandel, Navdeep S / Does, Mark D / Miller, Stephen D / Chetkovich, Dane M

    Frontiers in cellular neuroscience

    2024  Volume 18, Page(s) 1321682

    Abstract: Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. ... ...

    Abstract Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their respective current (I
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2024.1321682
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  4. Article ; Online: Atypical lymphocytes in peripheral blood of patients with COVID-19.

    Weinberg, Samuel E / Behdad, Amir / Ji, Peng

    British journal of haematology

    2020  Volume 190, Issue 1, Page(s) 36–39

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/immunology ; Betacoronavirus/metabolism ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Female ; Humans ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Lymphocytes/pathology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country England
    Document type Case Reports ; Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16848
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    Uh III Zs.182: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: IFN-Induced Protein with Tetratricopeptide Repeats 2 Limits Autoimmune Inflammation by Regulating Myeloid Cell Activation and Metabolic Activity.

    Kim, Dongkyun / Rai, Nagendra Kumar / Burrows, Amy / Kim, Sohee / Tripathi, Ajai / Weinberg, Samuel E / Dutta, Ranjan / Sen, Ganes C / Min, Booki

    Journal of immunology (Baltimore, Md. : 1950)

    2023  Volume 210, Issue 6, Page(s) 721–731

    Abstract: Besides antiviral functions, type I IFN expresses potent anti-inflammatory properties and is being widely used to treat certain autoimmune conditions, such as multiple sclerosis. In a murine model of multiple sclerosis, experimental autoimmune ... ...

    Abstract Besides antiviral functions, type I IFN expresses potent anti-inflammatory properties and is being widely used to treat certain autoimmune conditions, such as multiple sclerosis. In a murine model of multiple sclerosis, experimental autoimmune encephalomyelitis, administration of IFN-β effectively attenuates the disease development. However, the precise mechanisms underlying IFN-β-mediated treatment remain elusive. In this study, we report that IFN-induced protein with tetratricopeptide repeats 2 (Ifit2), a type I and type III IFN-stimulated gene, plays a previously unrecognized immune-regulatory role during autoimmune neuroinflammation. Mice deficient in Ifit2 displayed greater susceptibility to experimental autoimmune encephalomyelitis and escalated immune cell infiltration in the CNS. Ifit2 deficiency was also associated with microglial activation and increased myeloid cell infiltration. We also observed that myelin debris clearance and the subsequent remyelination were substantially impaired in Ifit2-/- CNS tissues. Clearing myelin debris is an important function of the reparative-type myeloid cell subset to promote remyelination. Indeed, we observed that bone marrow-derived macrophages, CNS-infiltrating myeloid cells, and microglia from Ifit2-/- mice express cytokine and metabolic genes associated with proinflammatory-type myeloid cell subsets. Taken together, our findings uncover a novel regulatory function of Ifit2 in autoimmune inflammation in part by modulating myeloid cell function and metabolic activity.
    MeSH term(s) Animals ; Mice ; Encephalomyelitis, Autoimmune, Experimental ; Inflammation ; Mice, Inbred C57BL ; Microglia ; Multiple Sclerosis ; Myeloid Cells ; Tetratricopeptide Repeat ; Interferons/pharmacology
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  7. Article: [WITHDRAWN] Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction.

    Tatekoshi, Yuki / Shapiro, Jason S / Liu, Mingyang / Bianco, George M / Tatekoshi, Ayumi / De Jesus, Adam / Koleini, Navid / Wasserstrom, J Andrew / Dillmann, Wolfgang H / Weinberg, Samuel E / Ardehali, Hossein

    Research square

    2023  

    Abstract: The authors have requested that this preprint be removed from Research Square. ...

    Abstract The authors have requested that this preprint be removed from Research Square.
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2448086/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Atypical lymphocytes in peripheral blood of patients with COVID‐19

    Weinberg, Samuel E. / Behdad, Amir / Ji, Peng

    British Journal of Haematology

    2020  Volume 190, Issue 1, Page(s) 36–39

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16848
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Optimized protocol to isolate primary mouse peritoneal macrophage metabolites.

    De Jesus, Adam / Pusec, Carolina M / Nguyen, Tivoli / Keyhani-Nejad, Farnaz / Gao, Peng / Weinberg, Samuel E / Ardehali, Hossein

    STAR protocols

    2022  Volume 3, Issue 4, Page(s) 101668

    Abstract: Peritoneal macrophages (PMs) have been shown to have higher stability compared to other macrophage subtypes. However, obtaining enough PMs from a single mouse is often a limitation for metabolomics analysis. Here, we describe a protocol to isolate ... ...

    Abstract Peritoneal macrophages (PMs) have been shown to have higher stability compared to other macrophage subtypes. However, obtaining enough PMs from a single mouse is often a limitation for metabolomics analysis. Here, we describe a protocol to isolate metabolites from a small number of mouse primary PMs for 13C-stable glucose tracing and metabolomics. Our protocol uses X for metabolite extraction instead of methanol. Our protocol can consistently extract metabolites from low cell number samples with fewer steps than methanol-based approaches. For complete details on the use and execution of this protocol, please refer to De Jesus et al., (2022).
    MeSH term(s) Animals ; Mice ; Methanol ; Macrophages, Peritoneal ; Metabolomics/methods ; Glucose
    Chemical Substances Methanol (Y4S76JWI15) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.

    Chaudhuri, Shuvam M / Weinberg, Samuel E / Wang, Dongmei / Yalom, Lenore K / Montauti, Elena / Iyer, Radhika / Tang, Amy Y / Torres Acosta, Manuel A / Shen, Jian / Mani, Nikita L / Wang, Shengnan / Liu, Kun / Lu, Weiyuan / Bui, Triet M / Manzanares, Laura D / Dehghani, Zeinab / Wai, Ching Man / Gao, Beixue / Wei, Juncheng /
    Yue, Feng / Cui, Weiguo / Singer, Benjamin D / Sumagin, Ronen / Zhang, Yana / Fang, Deyu

    Cell reports. Medicine

    2024  Volume 5, Issue 3, Page(s) 101441

    Abstract: While immunotherapy has revolutionized cancer treatment, its safety has been hampered by immunotherapy-related adverse events. Unexpectedly, we show that Mediator complex subunit 1 (MED1) is required for T regulatory ( ... ...

    Abstract While immunotherapy has revolutionized cancer treatment, its safety has been hampered by immunotherapy-related adverse events. Unexpectedly, we show that Mediator complex subunit 1 (MED1) is required for T regulatory (T
    MeSH term(s) Humans ; Animals ; Mice ; T-Lymphocytes, Regulatory ; Mediator Complex Subunit 1/metabolism ; Forkhead Transcription Factors ; Neoplasms/pathology ; Inflammation/metabolism ; Tumor Microenvironment
    Chemical Substances Mediator Complex Subunit 1 ; Forkhead Transcription Factors
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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