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Article ; Online: Early Lyme neuroborreliosis manifesting as brachial plexopathy and meningitis in Northwestern Ontario, Canada: A case report.

Gu, Kaien / Boodman, Carl / Orr, Pamela / Wuerz, Terence

2022 Volume 101, Issue 45, Page(s) e31576

Abstract: Rationale: Lyme disease is a tick-borne disease caused by the spirochete B. burgdorferi, and patients often present with symptoms comparable to a viral-like illness. The diagnosis can be challenging given its wide range of manifestations and diagnostic ... ...

Abstract	Rationale: Lyme disease is a tick-borne disease caused by the spirochete B. burgdorferi, and patients often present with symptoms comparable to a viral-like illness. The diagnosis can be challenging given its wide range of manifestations and diagnostic testing can take days or longer. Here, we present a case of Lyme disease presenting as brachial plexopathy and meningitis. Patient concerns: A 76-years-old male presented to a tertiary-care hospital with left arm weakness and neck pain. Diagnosis: Our patient was diagnosed with Lyme neuroborreliosis and had positive serology, including enzyme immunoassay and Western blot. Interventions: Our patient received 17 days of ceftriaxone (2g IV daily) followed by oral doxycycline (100mg bid). Outcomes: Over the subsequent year, our patient had eventual complete recovery in muscle strength and sensation, with slower improvement to the cervical neck and left arm pain. Lessons: Incidence of Lyme disease is increasing in North America, and the disease has a wide range of symptoms. Lyme neuroborreliosis (LNB) is 1 presentation and can present with early or late manifestations; clinicians should maintain a high index of suspicion and begin empiric treatment in individuals with a clinical syndrome consistent with LNB. Early LNB manifestations have onset within 6 months of infection and include cranial and peripheral neuropathy, radiculitis, and aseptic meningitis; late LNB encompasses a chronic encephalomyelitis.
MeSH term(s)	Humans ; Male ; Aged ; Lyme Neuroborreliosis/complications ; Lyme Neuroborreliosis/diagnosis ; Lyme Neuroborreliosis/drug therapy ; Ontario ; Doxycycline/therapeutic use ; Meningitis ; Brachial Plexus Neuropathies/diagnosis ; Brachial Plexus Neuropathies/etiology
Chemical Substances	Doxycycline (N12000U13O)
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031576
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Article ; Online: Dermatology and Basic Research: An Art Superimposed in Science.

Gu, Kaien / Silver, Shane

Journal of cutaneous medicine and surgery

2018 Volume 22, Issue 6, Page(s) 661

MeSH term(s)	Cholecalciferol ; Citric Acid ; Dermatology ; Humans ; Organometallic Compounds ; Pemphigus, Benign Familial
Chemical Substances	Organometallic Compounds ; Cholecalciferol (1C6V77QF41) ; Citric Acid (2968PHW8QP) ; magnesium citrate (RHO26O1T9V)
Language	English
Publishing date	2018-10-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1361720-5
ISSN	1615-7109 ; 1203-4754
ISSN (online)	1615-7109
ISSN	1203-4754
DOI	10.1177/1203475418798019
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Article ; Online: Polymorphic Ventricular Tachycardia Detected With a Smartwatch.

Gu, Kaien / Marshall, Kirsten / Robertson-Stovel, Quinn / Zieroth, Shelley

CJC open

2021 Volume 4, Issue 4, Page(s) 424–427

Abstract: Wearable" devices are a rapidly evolving technology that often can record and store personal healthcare data. We report the case of a 64-year-old woman who presented with a syncopal episode and subsequent cardiac arrest, ultimately requiring a dual- ... ...

Abstract	"Wearable" devices are a rapidly evolving technology that often can record and store personal healthcare data. We report the case of a 64-year-old woman who presented with a syncopal episode and subsequent cardiac arrest, ultimately requiring a dual-chamber implantable cardioverter defibrillator. Prior to hospitalization, she obtained electrocardiogram recordings using her Apple Watch, due to feeling unwell, and one showed nonsustained polymorphic ventricular tachycardia. Direct-to-consumer electrocardiogram monitors in "wearables" are increasing in popularity and may play a role in the work-up and diagnosis of patients' symptoms. However, they are not a replacement for healthcare expertise, and their misuse may result in undue anxiety and inappropriate healthcare utilization.
Language	English
Publishing date	2021-12-16
Publishing country	United States
Document type	Case Reports
ISSN	2589-790X
ISSN (online)	2589-790X
DOI	10.1016/j.cjco.2021.12.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Case of Hailey-Hailey Disease Managed With Oral Magnesium Citrate and High-Dose Vitamin D

Gu, Kaien / Silver, Shane

Journal of cutaneous medicine and surgery

2018 Volume 22, Issue 3, Page(s) 362–364

Abstract: Hailey-Hailey disease, or benign familial pemphigus, is a rare blistering disease originally described in 1939. The disease is due to an autosomal dominant mutation in the ATP2C1 gene on chromosome 3, which encodes for an adenosine triphosphate-dependent ...

Abstract	Hailey-Hailey disease, or benign familial pemphigus, is a rare blistering disease originally described in 1939. The disease is due to an autosomal dominant mutation in the ATP2C1 gene on chromosome 3, which encodes for an adenosine triphosphate-dependent calcium pump in the Golgi apparatus whose function is to maintain intercellular calcium homeostasis. Common treatments for Hailey-Hailey disease involve calcineurin inhibitors, topical corticosteroids, topical or systemic antibiotics, topical antifungals, ablative lasers, or botulin toxin. In this case report, we highlight a unique case of Hailey-Hailey disease that was resistant to many conventional therapies and ultimately managed with oral magnesium citrate and high-dose vitamin D
MeSH term(s)	Adult ; Cholecalciferol/therapeutic use ; Citric Acid/therapeutic use ; Female ; Humans ; Organometallic Compounds/therapeutic use ; Pemphigus, Benign Familial/diagnosis ; Pemphigus, Benign Familial/drug therapy ; Pemphigus, Benign Familial/pathology ; Torso/pathology
Chemical Substances	Organometallic Compounds ; Cholecalciferol (1C6V77QF41) ; Citric Acid (2968PHW8QP) ; magnesium citrate (RHO26O1T9V)
Language	English
Publishing date	2018-06-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1361720-5
ISSN	1615-7109 ; 1203-4754
ISSN (online)	1615-7109
ISSN	1203-4754
DOI	10.1177/1203475418756377
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Article ; Online: Congenital absence of the vas deferens: Cystic fibrosis transmembrane regulatory gene mutations.

Wong, Rachel / Gu, Kaien / Ko, Yool / Patel, Premal

Best practice & research. Clinical endocrinology & metabolism

2020 Volume 34, Issue 6, Page(s) 101476

Abstract: Congenital absence of the vas deferens (CAVD) is a rare genetic condition first discovered in the mid-18th century related to mutations in the cystic fibrosis transmembrane regulatory genes. The condition is typically found during work-up of male ... ...

Abstract	Congenital absence of the vas deferens (CAVD) is a rare genetic condition first discovered in the mid-18th century related to mutations in the cystic fibrosis transmembrane regulatory genes. The condition is typically found during work-up of male infertility, and the majority of cases can be diagnosed with complete history and physical examination and pertinent investigations. The condition can be separated into three subcategories, and genetic advances have led to a much better understanding behind the disease, its pathogenesis, and options for treatment. In this review, we discuss the genetics, pathogenesis, embryology, and diagnosis of treatment of CAVD. Future work in this area likely will aim to better understand the epigenetic factors that influence the development of the condition in order to identify potential upstream therapeutic targets.
MeSH term(s)	Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/embryology ; Infertility, Male/genetics ; Infertility, Male/therapy ; Male ; Mutation ; Urogenital Abnormalities/diagnosis ; Urogenital Abnormalities/embryology ; Urogenital Abnormalities/genetics ; Urogenital Abnormalities/therapy ; Vas Deferens/abnormalities ; Vas Deferens/diagnostic imaging ; Vas Deferens/embryology ; Vas Deferens/pathology
Chemical Substances	CFTR protein, human ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
Language	English
Publishing date	2020-12-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2052339-7
ISSN	1878-1594 ; 1532-1908 ; 1521-690X
ISSN (online)	1878-1594 ; 1532-1908
ISSN	1521-690X
DOI	10.1016/j.beem.2020.101476
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Article ; Online: Recurrent melanoma development in a Caucasian female with CDKN2A+ mutation and FAMMM syndrome

Kaien Gu / Rochelle Van De Velde / Marshall Pitz / Shane Silver

SAGE Open Medical Case Reports, Vol

A case report

2020 Volume 8

Abstract: Melanoma is a form of skin cancer originating from melanocytes that has an increasing incidence over the past few decades. From 1992 to 2010, the overall incidence of melanoma was 12.29 cases per 100,000 person-years in Canada. Approximately 10% of cases ...

Abstract	Melanoma is a form of skin cancer originating from melanocytes that has an increasing incidence over the past few decades. From 1992 to 2010, the overall incidence of melanoma was 12.29 cases per 100,000 person-years in Canada. Approximately 10% of cases are attributed to a hereditary component, with one of the most common being familial atypical multiple mole melanoma syndrome. In this case report, we highlight the atypical case of a middle-aged Caucasian female with familial atypical multiple mole melanoma syndrome, who has developed dozens of primary melanomas over the past decade. We highlight the management of her case, as well as the importance of monitoring by multiple other subspecialists given the propensity for the development of alternate malignancies.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Recurrent melanoma development in a Caucasian female with CDKN2A+ mutation and FAMMM syndrome: A case report.

Gu, Kaien / Velde, Rochelle Van De / Pitz, Marshall / Silver, Shane

SAGE open medical case reports

2020 Volume 8, Page(s) 2050313X20936034

Abstract	Melanoma is a form of skin cancer originating from melanocytes that has an increasing incidence over the past few decades. From 1992 to 2010, the overall incidence of melanoma was 12.29 cases per 100,000 person-years in Canada. Approximately 10% of cases are attributed to a hereditary component, with one of the most common being familial atypical multiple mole melanoma syndrome. In this case report, we highlight the atypical case of a middle-aged Caucasian female with familial atypical multiple mole melanoma syndrome, who has developed dozens of primary melanomas over the past decade. We highlight the management of her case, as well as the importance of monitoring by multiple other subspecialists given the propensity for the development of alternate malignancies.
Language	English
Publishing date	2020-09-02
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X20936034
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Article ; Online: Atypical pneumonia due to human bocavirus in an immunocompromised patient.

Gu, Kaien / Van Caeseele, Paul / Dust, Kerry / Ho, Julie

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2017 Volume 189, Issue 19, Page(s) E697–E699

MeSH term(s)	Female ; Human bocavirus ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Middle Aged ; Parvoviridae Infections/diagnosis ; Parvoviridae Infections/etiology ; Parvoviridae Infections/therapy ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/etiology ; Pneumonia, Viral/therapy ; Tacrolimus/therapeutic use
Chemical Substances	Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2017--15
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.161134
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Article: Hospitalizations in Patients with Systemic Lupus Erythematosus in an Academic Health Science Center.

Gu, Kaien / Gladman, Dafna D / Su, Jiandong / Urowitz, Murray B

The Journal of rheumatology

2017 Volume 44, Issue 8, Page(s) 1173–1178

Abstract: Objective: Hospitalization occurs in about 10% of patients with systemic lupus erythematosus (SLE) each year and accounts for most of the direct cost of SLE patient care. We aimed to determine the frequency of admissions of patients with SLE and ... ...

Abstract	Objective: Hospitalization occurs in about 10% of patients with systemic lupus erythematosus (SLE) each year and accounts for most of the direct cost of SLE patient care. We aimed to determine the frequency of admissions of patients with SLE and describe their causes and outcomes. Methods: We identified all hospitalizations at University Health Network in the periods 2011-2012 and 2013-2015 with an International Classification of Diseases, 10th ed. code of M32 (SLE). A retrospective chart review of these patients categorized them based on SLE care provider and cause of admission. Frequency of emergency room visits and duration of hospitalization were ascertained. Poisson and linear regressions were performed to determine factors associated with frequency and duration of hospitalizations. Results: There were 247 unique patients with SLE who were hospitalized a total of 491 times: 87.4% were women, average age of 43.9 ± 17.9 years, and disease duration 13.7 ± 12.3 years. Incidental causes were most common (35.6%); 21.4% and 22.4% of admissions were because of active SLE and infection, respectively. The patients with SLE averaged 1.6 hospitalizations lasting 8.5 days. Thirteen percent of hospitalizations resulted in intensive care unit admission, and 2.8% of hospitalizations resulted in death. Patient employment was associated with fewer hospitalizations during 2011-2015. Antimalarial use was associated with fewer hospitalizations as well as shorter length of stay during 2011-2012. The presence of damage correlated with increased hospitalizations. Higher educational level and antimalarial use correlated with shorter length of stay. Conclusion: Patients with SLE are frequently hospitalized, often because of active SLE or infection, and re-hospitalized within a short period of time.
MeSH term(s)	Adult ; Female ; Hospitalization/statistics & numerical data ; Humans ; Infection/etiology ; Infection/therapy ; Length of Stay ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/therapy ; Male ; Middle Aged ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2017-06-15
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.170072
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Article ; Online: Tunable Engineered Extracellular Matrix Materials: Polyelectrolyte Multilayers Promote Improved Neural Cell Growth and Survival.

Landry, Michael J / Gu, Kaien / Harris, Stephanie N / Al-Alwan, Laila / Gutsin, Laura / De Biasio, Daniele / Jiang, Bernie / Nakamura, Diane S / Corkery, T Christopher / Kennedy, Timothy E / Barrett, Christopher J

Macromolecular bioscience

2019 Volume 19, Issue 5, Page(s) e1900036

Abstract: Poly-d-lysine (PDL) and poly-l-lysine are standard surfaces for culturing neural cells; however, both are relatively unstable, costly, and the coated surface typically must be prepared immediately before use. Here, polyelectrolyte multilayers (PEMs) are ... ...

Abstract	Poly-d-lysine (PDL) and poly-l-lysine are standard surfaces for culturing neural cells; however, both are relatively unstable, costly, and the coated surface typically must be prepared immediately before use. Here, polyelectrolyte multilayers (PEMs) are employed as highly stable, relatively inexpensive, alternative substrates to support primary neural cell culture. Initial findings identify specific silk-based PEMs that significantly outperform the capacity of PDL to promote neuronal survival and process extension. Based on these results, a library of PEM variants, including commercial and bio-sourced polyelectrolytes, is generated and three silk-based PEMs that substantially outperform PDL as a substrate for primary neurons in cell culture are identified. Further, testing these PEM variants as substrates for primary oligodendrocyte progenitors demonstrates that one silk-based PEM functions significantly better than PDL. These findings reveal specificity of cellular responses, indicating that PEMs may be tuned to optimally support different neural cell types.
MeSH term(s)	Animals ; Cell Proliferation ; Cell Survival/drug effects ; Cells, Cultured ; Extracellular Matrix/chemistry ; Neurons/cytology ; Neurons/metabolism ; Polyelectrolytes/chemistry ; Polyelectrolytes/pharmacology ; Polylysine/chemistry ; Polylysine/pharmacology ; Rats ; Rats, Sprague-Dawley ; Surface Properties
Chemical Substances	Polyelectrolytes ; Polylysine (25104-18-1)
Language	English
Publishing date	2019-04-02
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.201900036
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