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Article ; Online: Three new species of Neotropical Ceraleurodicus Hempel (Hemiptera: Aleyrodidae) found in the Natural History Museum (London) collection, with notes and a puparial key to species.

Canty, Roy J / Martini, Biancamaria / Wanke, Dominic

Zootaxa

2023 Volume 5277, Issue 2, Page(s) 313–338

Abstract: ... Museum, London (NHMUK): Ceraleurodicus boteh Canty sp. nov., Ceraleurodicus brianeno Canty sp. nov., and ... Ceraleurodicus wire Canty sp. nov. Also included is a key to puparia of the ten known species in the genus, and ...

Abstract	In this study, three new species of whitefly in the neotropical genus Ceraleurodicus Hempel are described and illustrated based on specimens discovered in the aleyrodid collection of the Natural History Museum, London (NHMUK): Ceraleurodicus boteh Canty sp. nov., Ceraleurodicus brianeno Canty sp. nov., and Ceraleurodicus wire Canty sp. nov. Also included is a key to puparia of the ten known species in the genus, and brief descriptions and illustrations of the known puparia and adults within the genus.
MeSH term(s)	Animals ; Hemiptera ; London ; Museums
Language	English
Publishing date	2023-05-02
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5277.2.4
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Article ; Online: Deep-NCA: A deep learning methodology for performing noncompartmental analysis of pharmacokinetic data.

Liu, Gengbo / Brooks, Logan / Canty, John / Lu, Dan / Jin, Jin Y / Lu, James

CPT: pharmacometrics & systems pharmacology

2024

Abstract: Noncompartmental analysis (NCA) is a model-independent approach for assessing pharmacokinetics (PKs). Although the existing NCA algorithms are very well-established and widely utilized, they suffer from low accuracies in the setting of sparse PK samples. ...

Abstract	Noncompartmental analysis (NCA) is a model-independent approach for assessing pharmacokinetics (PKs). Although the existing NCA algorithms are very well-established and widely utilized, they suffer from low accuracies in the setting of sparse PK samples. In response, we developed Deep-NCA, a deep learning (DL) model to improve the prediction of key noncompartmental PK parameters. Our methodology utilizes synthetic PK data for model training and uses an innovative patient-specific normalization method for data preprocessing. Deep-NCA demonstrated adequate performance across six previously unseen simulated drugs under multiple dosing, showcasing effective generalization. Compared to traditional NCA, Deep-NCA exhibited superior performance for sparse PK data. This study advances the application of DL to PK studies and introduces an effective method for handling sparse PK data. With further validation and refinement, Deep-NCA could significantly enhance the efficiency of drug development by providing more accurate NCA estimates while requiring fewer PK samples.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2697010-7
ISSN	2163-8306 ; 2163-8306
ISSN (online)	2163-8306
ISSN	2163-8306
DOI	10.1002/psp4.13124
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Article ; Online: An evaluation of pediatric dermatology curbside consultations in an academic center: A prospective cohort study.

Puar, Neha K / Canty, Kristi M / Newell, Brandon D / Nopper, Amy J / Reynolds, Sean / Horii, Kimberly A

Journal of the American Academy of Dermatology

2024

Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.12.069
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Article: Evidence of batch effects masking treatment effect in GAW20 methylation data.

Canty, Angelo J / Paterson, Andrew D

BMC proceedings

2018 Volume 12, Issue Suppl 9, Page(s) 32

Abstract: Using the real data set from GAW20, we examined changes in the distribution of DNA methylation before and after treatment. Paired analysis of differences in both mean and variance had grossly inflated type 1 error, suggesting either a very large number ... ...

Abstract	Using the real data set from GAW20, we examined changes in the distribution of DNA methylation before and after treatment. Paired analysis of differences in both mean and variance had grossly inflated type 1 error, suggesting either a very large number of changes across the entire epigenome or major non-biological issues, such as batch effects. Separate analysis of Infinium I and II probes indicated differences in the paired
Language	English
Publishing date	2018-09-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2411867-9
ISSN	1753-6561
ISSN	1753-6561
DOI	10.1186/s12919-018-0129-6
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Article ; Online: Obstructive sleep apnea, chronic obstructive pulmonary disease and hypertensive microvascular disease: a cross-sectional observational cohort study.

Chew, Sky / Colville, Deb / Hutchinson, Anastasia / Canty, Piers / Hodgson, Lauren / Savige, Judy

Scientific reports

2022 Volume 12, Issue 1, Page(s) 13350

Abstract: Hypertensive microvascular disease is associated with an increased risk of diastolic heart failure, vascular dementia and progressive renal impairment. This study examined whether individuals with obstructive sleep apnoea (OSA) had more retinal ... ...

Abstract	Hypertensive microvascular disease is associated with an increased risk of diastolic heart failure, vascular dementia and progressive renal impairment. This study examined whether individuals with obstructive sleep apnoea (OSA) had more retinal hypertensive microvascular disease than those with chronic obstructive pulmonary disease (COPD) and hospital controls. This was a single-centre, cross-sectional, observational study of participants recruited consecutively from a general respiratory clinic and a general medical clinic. OSA was diagnosed on overnight polysomnography study (apnoea:hypopnoea index ≥ 5), and controls with COPD had a forced expiratory volume/forced vital capacity (forced expiratory ratio) < 70%. Individuals with both OSA and COPD were excluded. Hospital controls had no COPD on respiratory function testing and no OSA on specialist physician questioning. Study participants completed a medical questionnaire, and underwent resting BP measurement, and retinal photography with a non-mydriatic camera. Images were deidentified and graded for microvascular retinopathy (Wong and Mitchell classification), and arteriole and venular calibre using a semiautomated method at a grading centre. Individuals with OSA (n = 79) demonstrated a trend to a higher mean arterial pressure than other hospital patients (n = 143) (89.2 ± 8.9 mmHg, p = 0.02), and more microvascular retinopathy (p < 0.001), and narrower retinal arterioles (134.2 ± 15.9 μm and 148.0 ± 16.2 μm respectively, p < 0.01). Microvascular retinopathy and arteriolar narrowing were still more common in OSA than hospital controls, after adjusting for age, BMI, mean arterial pressure, smoking history and dyslipidaemia (p < 0.01, p < 0.01, respectively). Individuals with OSA demonstrated a trend to a higher mean arterial pressure than those with COPD (n = 132, 93.2 ± 12.2 mmHg and 89.7 ± 12.8 mmHg respectively, p = 0.07), and more microvascular retinopathy (p = 0.0001) and narrower arterioles (134.2 ± 15.9 and 152.3 ± 16.8, p < 0.01). Individuals with OSA alone had more systemic microvascular disease than those with COPD alone or other hospital patients without OSA and COPD, despite being younger in age.
MeSH term(s)	Cohort Studies ; Cross-Sectional Studies ; Humans ; Hypertensive Retinopathy/epidemiology ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Sleep Apnea, Obstructive/epidemiology
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-17481-9
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Article ; Online: Experimental laboratory models as tools for understanding modifiable dementia risk.

Sinclair, Duncan / Canty, Alison J / Ziebell, Jenna M / Woodhouse, Adele / Collins, Jessica M / Perry, Sharn / Roccati, Eddy / Kuruvilla, Maneesh / Leung, Jacqueline / Atkinson, Rachel / Vickers, James C / Cook, Anthony L / King, Anna E

Alzheimer's & dementia : the journal of the Alzheimer's Association

2024

Abstract: Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to ... ...

Abstract	Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to technological constraints and confounds. Therefore, controlled laboratory experiments in models such as transgenic rodents, invertebrates and in vitro cultured cells are increasingly used to investigate dementia risk factors and test strategies which target them to prevent dementia. This review provides an overview of experimental research into 15 established and putative modifiable dementia risk factors: less early-life education, hearing loss, depression, social isolation, life stress, hypertension, obesity, diabetes, physical inactivity, heavy alcohol use, smoking, air pollution, anesthetic exposure, traumatic brain injury, and disordered sleep. It explores how experimental models have been, and can be, used to address questions about modifiable dementia risk and prevention that cannot readily be addressed in human studies. HIGHLIGHTS: Modifiable dementia risk factors are promising targets for dementia prevention. Interrogation of mechanisms underlying dementia risk is difficult in human populations. Studies using diverse experimental models are revealing modifiable dementia risk mechanisms. We review experimental research into 15 modifiable dementia risk factors. Laboratory science can contribute uniquely to dementia prevention.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13834
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Zs.A 6316: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes.

Roshandel, Delnaz / Chen, Zhuo / Canty, Angelo J / Bull, Shelley B / Natarajan, Rama / Paterson, Andrew D

Clinical epigenetics

2020 Volume 12, Issue 1, Page(s) 52

Abstract: Background: Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-tissue and Skin & Blood try to ... ...

Abstract	Background: Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-tissue and Skin & Blood try to estimate chronological age in the normal population whereas PhenoAge and GrimAge use surrogate markers associated with mortality to estimate biological age and its departure from chronological age. Here, we applied Horvath's four methods to calculate and compare DNAm age in 499 subjects with type 1 diabetes (T1D) from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study using DNAm data measured by Illumina EPIC array in the whole blood. Association of the four DNAm ages with development of diabetic complications including cardiovascular diseases (CVD), nephropathy, retinopathy, and neuropathy, and their risk factors were investigated. Results: Pan-tissue and GrimAge were higher whereas Skin & Blood and PhenoAge were lower than chronological age (p < 0.0001). DNAm age was not associated with the risk of CVD or retinopathy over 18-20 years after DNAm measurement. However, higher PhenoAge (β = 0.023, p = 0.007) and GrimAge (β = 0.029, p = 0.002) were associated with higher albumin excretion rate (AER), an indicator of diabetic renal disease, measured over time. GrimAge was also associated with development of both diabetic peripheral neuropathy (OR = 1.07, p = 9.24E-3) and cardiovascular autonomic neuropathy (OR = 1.06, p = 0.011). Both HbA1c (β = 0.38, p = 0.026) and T1D duration (β = 0.01, p = 0.043) were associated with higher PhenoAge. Employment (β = - 1.99, p = 0.045) and leisure time (β = - 0.81, p = 0.022) physical activity were associated with lower Pan-tissue and Skin & Blood, respectively. BMI (β = 0.09, p = 0.048) and current smoking (β = 7.13, p = 9.03E-50) were positively associated with Skin & Blood and GrimAge, respectively. Blood pressure, lipid levels, pulse rate, and alcohol consumption were not associated with DNAm age regardless of the method used. Conclusions: Various methods of measuring DNAm age are sub-optimal in detecting people at higher risk of developing diabetic complications although some work better than the others.
MeSH term(s)	Adolescent ; Adult ; Albumins/metabolism ; CpG Islands ; DNA Methylation ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Diabetic Neuropathies/genetics ; Diabetic Neuropathies/metabolism ; Epigenesis, Genetic ; Female ; Genome-Wide Association Study/methods ; Humans ; Male ; Oligonucleotide Array Sequence Analysis ; Young Adult
Chemical Substances	Albumins
Language	English
Publishing date	2020-04-05
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553921-8
ISSN	1868-7083 ; 1868-7075
ISSN (online)	1868-7083
ISSN	1868-7075
DOI	10.1186/s13148-020-00840-6
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Article ; Online: Intrafascicular chondroid-like bodies in the ageing equine superficial digital flexor tendon comprise glycosaminoglycans and type II collagen.

Ali, Othman J / Ehrle, Anna / Comerford, Eithne J / Canty-Laird, Elizabeth G / Mead, Ashleigh / Clegg, Peter D / Maddox, Thomas W

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2021 Volume 39, Issue 12, Page(s) 2755–2766

Abstract: The superficial digital flexor tendon (SDFT) is considered functionally equivalent to the human Achilles tendon. Circular chondroid depositions scattered amongst the fascicles of the equine SDFT are rarely reported. The purpose of this study was the ... ...

Abstract	The superficial digital flexor tendon (SDFT) is considered functionally equivalent to the human Achilles tendon. Circular chondroid depositions scattered amongst the fascicles of the equine SDFT are rarely reported. The purpose of this study was the detailed characterization of intrafascicular chondroid-like bodies (ICBs) in the equine SDFT, and the assessment of the effect of ageing on the presence and distribution of these structures. Ultrahigh field magnetic resonance imaging (9.4T) series of SDFT samples of young (1-9 years) and aged (17-25 years) horses were obtained, and three-dimensional reconstruction of ICBs was performed. Morphological evaluation of the ICBs included histology, immunohistochemistry and transmission electron microscopy. The number, size, and position of ICBs was determined and compared between age groups. There was a significant difference (p = .008) in the ICB count between young and old horses with ICBs present in varying number (13-467; median = 47, mean = 132.6), size and distribution in the SDFT of aged horses only. There were significantly more ICBs in the tendon periphery when compared with the tendon core region (p = .010). Histological characterization identified distinctive cells associated with increased glycosaminoglycan and type II collagen extracellular matrix content. Ageing and repetitive strain frequently cause tendon micro-damage before the development of clinical tendinopathy. Documentation of the presence and distribution of ICBs is a first step towards improving our understanding of the impact of these structures on the viscoelastic properties, and ultimately their effect on the risk of age-related tendinopathy in energy-storing tendons.
MeSH term(s)	Aging ; Animals ; Collagen Type II ; Glycosaminoglycans ; Horses ; Tendinopathy/diagnostic imaging ; Tendinopathy/pathology ; Tendinopathy/veterinary ; Tendons/pathology
Chemical Substances	Collagen Type II ; Glycosaminoglycans
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.25002
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Article ; Online: Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.

Allaith, S / Tew, S R / Hughes, C E / Clegg, P D / Canty-Laird, E G / Comerford, E J

Veterinary journal (London, England : 1997)

2021 Volume 272, Page(s) 105657

Abstract: Cranial cruciate ligament disease and rupture (CCLD/R) is one of the most common orthopaedic conditions in dogs, eventually leading to osteoarthritis of the stifle joint. Certain dog breeds such as the Staffordshire bull terrier have an increased risk of ...

Abstract	Cranial cruciate ligament disease and rupture (CCLD/R) is one of the most common orthopaedic conditions in dogs, eventually leading to osteoarthritis of the stifle joint. Certain dog breeds such as the Staffordshire bull terrier have an increased risk of developing CCLD/R. Previous studies into CCLD/R have found that glycosaminoglycan levels were elevated in cranial cruciate ligament (CCL) tissue from high-risk breeds when compared to the CCL from a low-risk breed to CCLD/R. Our objective was to determine specific proteoglycans/glycosaminoglycans in the CCL and to see whether their content was altered in dog breeds with differing predispositions to CCLD/R. Disease-free CCLs from Staffordshire bull terriers (moderate/high-risk to CCLD/R) and Greyhounds (low-risk to CCLD/R) were collected and key proteoglycan/glycosaminoglycans were determined by semi-quantitative Western blotting, quantitative biochemistry, quantitative reverse transcription polymerase chain reaction, and immunohistochemistry. Gene expression of fibromodulin (P = 0.03), aggrecan (P = 0.0003), and chondroitin-6-sulphate stubs (P = 0.01) were significantly increased, and for fibromodulin this correlated with an increase in protein content in Staffordshire bull terriers compared to Greyhound CCLs (P = 0.02). Decorin (P = 0.03) and ADAMTS-4 (P = 0.04) gene expression were significantly increased in Greyhounds compared to Staffordshire bull terrier CCLs. The increase of specific proteoglycans and glycosaminoglycans within the Staffordshire bull terrier CCLs may indicate a response to higher compressive loads, potentially altering their risk to traumatic injury. The higher decorin content in the Greyhound CCLs is essential for maintaining collagen fibril strength, while the increase of ADAMTS-4 indicates a higher rate of turnover helping to regulate normal CCL homeostasis in Greyhounds.
MeSH term(s)	ADAMTS4 Protein/analysis ; ADAMTS4 Protein/genetics ; Aggrecans/analysis ; Aggrecans/genetics ; Animals ; Anterior Cruciate Ligament/chemistry ; Chondroitin Sulfates/analysis ; Chondroitin Sulfates/genetics ; Dog Diseases/genetics ; Dogs ; Fibromodulin/analysis ; Fibromodulin/genetics ; Gene Expression ; Genetic Predisposition to Disease/genetics ; Joint Diseases/genetics ; Joint Diseases/veterinary ; Proteoglycans/analysis ; Proteoglycans/genetics ; Rupture, Spontaneous/genetics ; Rupture, Spontaneous/veterinary ; Species Specificity ; Stifle
Chemical Substances	Aggrecans ; Proteoglycans ; Fibromodulin (126468-95-9) ; Chondroitin Sulfates (9007-28-7) ; ADAMTS4 Protein (EC 3.4.24.82)
Language	English
Publishing date	2021-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	428614-5
ISSN	1532-2971 ; 0372-5545 ; 1090-0233
ISSN (online)	1532-2971
ISSN	0372-5545 ; 1090-0233
DOI	10.1016/j.tvjl.2021.105657
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Article ; Online: Automatic deep learning-based pleural effusion segmentation in lung ultrasound images.

Vukovic, Damjan / Wang, Andrew / Antico, Maria / Steffens, Marian / Ruvinov, Igor / van Sloun, Ruud Jg / Canty, David / Royse, Alistair / Royse, Colin / Haji, Kavi / Dowling, Jason / Chetty, Girija / Fontanarosa, Davide

BMC medical informatics and decision making

2023 Volume 23, Issue 1, Page(s) 274

Abstract: Background: Point-of-care lung ultrasound (LUS) allows real-time patient scanning to help diagnose pleural effusion (PE) and plan further investigation and treatment. LUS typically requires training and experience from the clinician to accurately ... ...

Abstract	Background: Point-of-care lung ultrasound (LUS) allows real-time patient scanning to help diagnose pleural effusion (PE) and plan further investigation and treatment. LUS typically requires training and experience from the clinician to accurately interpret the images. To address this limitation, we previously demonstrated a deep-learning model capable of detecting the presence of PE on LUS at an accuracy greater than 90%, when compared to an experienced LUS operator. Methods: This follow-up study aimed to develop a deep-learning model to provide segmentations for PE in LUS. Three thousand and forty-one LUS images from twenty-four patients diagnosed with PE were selected for this study. Two LUS experts provided the ground truth for training by reviewing and segmenting the images. The algorithm was then trained using ten-fold cross-validation. Once training was completed, the algorithm segmented a separate subset of patients. Results: Comparing the segmentations, we demonstrated an average Dice Similarity Coefficient (DSC) of 0.70 between the algorithm and experts. In contrast, an average DSC of 0.61 was observed between the experts. Conclusion: In summary, we showed that the trained algorithm achieved a comparable average DSC at PE segmentation. This represents a promising step toward developing a computational tool for accurately augmenting PE diagnosis and treatment.
MeSH term(s)	Humans ; Deep Learning ; Follow-Up Studies ; Algorithms ; Lung/diagnostic imaging ; Pleural Effusion/diagnostic imaging
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2046490-3
ISSN	1472-6947 ; 1472-6947
ISSN (online)	1472-6947
ISSN	1472-6947
DOI	10.1186/s12911-023-02362-6
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