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  1. Article ; Online: Interferons α and β in cancer: therapeutic opportunities from new insights.

    Borden, Ernest C

    Nature reviews. Drug discovery

    2019  Volume 18, Issue 3, Page(s) 219–234

    Abstract: Over the past decade, preclinical and clinical research have confirmed the essential role of interferons for effective host immunological responses to malignant cells. Type I interferons (IFNα and IFNβ) directly regulate transcription of >100 downstream ... ...

    Abstract Over the past decade, preclinical and clinical research have confirmed the essential role of interferons for effective host immunological responses to malignant cells. Type I interferons (IFNα and IFNβ) directly regulate transcription of >100 downstream genes, which results in a myriad of direct (on cancer cells) and indirect (through immune effector cells and vasculature) effects on the tumour. New insights into endogenous and exogenous activation of type I interferons in the tumour and its microenvironment have given impetus to drug discovery and patient evaluation of interferon-directed strategies. When combined with prior observations or with other effective modalities for cancer treatment, modulation of the interferon system could contribute to further reductions in cancer morbidity and mortality. This Review discusses new interferon-directed therapeutic opportunities, ranging from cyclic dinucleotides to genome methylation inhibitors, angiogenesis inhibitors, chemoradiation, complexes with neoantigen-targeted monoclonal antibodies, combinations with other emerging therapeutic interventions and associations of interferon-stimulated gene expression with patient prognosis - all of which are strategies that have or will soon enter translational clinical evaluation.
    MeSH term(s) Animals ; Antibodies, Monoclonal/therapeutic use ; Humans ; Immunologic Factors/therapeutic use ; Interferon-alpha/therapeutic use ; Interferon-beta/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/immunology ; Tumor Microenvironment/drug effects
    Chemical Substances Antibodies, Monoclonal ; Immunologic Factors ; Interferon-alpha ; Interferon-beta (77238-31-4)
    Language English
    Publishing date 2019-01-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-018-0011-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Melanoma

    Borden, Ernest C.

    biologically targeted therapeutics

    2002  

    Author's details ed. by Ernest C. Borden
    Keywords Melanoma / therapy ; Biological Therapy ; Gene Therapy ; Melanom ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Malignes Melanom ; Melanocytoblastom ; Melanozytoblastom ; Melanosarkom ; Melanoma maligna
    Language English
    Size XVI, 389 S. : Ill.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013482309
    ISBN 0-89603-876-9 ; 978-0-89603-876-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 A 302 order for loan Magazin

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  3. Book: Side effects of interferon-alpha

    Borden, Ernest C.

    possible clinical causes and intervention strategies

    (Seminars in oncology ; 25, Suppl. 1)

    1998  

    Title variant interferon alpha
    Author's details Ernest C. Borden ..., guest ed
    Series title Seminars in oncology ; 25, Suppl. 1
    Collection
    Keywords Interferon-alpha / therapeutic use ; Interferon-alpha / adverse effects
    Language English
    Size 81 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT008353828
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1348 -25,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  4. Book: Recombinant alfa interferons from naturally occurring genes

    Borden, Ernest C. / Pestka, Sidney

    (Seminars in oncology ; 24, Suppl. 9)

    1997  

    Title variant alfa-interferons
    Author's details Sidney Pestka ..., guest ed. Contrib. Ernest C. Borden
    Series title Seminars in oncology ; 24, Suppl. 9
    Collection
    Keywords Interferon Alfa, Recombinant
    Language English
    Size S9-104 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT007603386
    Database Catalogue ZB MED Medicine, Health

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  5. Book ; Conference proceedings: The metastatic cascade

    Borden, Ernest C.

    scope for intervention

    (Therapeutic strategies in oncology ; 3)

    1991  

    Event/congress Round Table The Metastatic Cascade, Scope for Intervention (1990, Hamburg) ; International Cancer Congress (15, 1990, Hamburg)
    Author's details [Round Table the Metastatic Cascade: Scope for Intervention] held at the 15th International Cancer Congress, hamburg, Federal Republic of Germany, 16 - 22 August 1990. Series ed and ed. of this issue: Ernest C. Borden
    Series title Therapeutic strategies in oncology ; 3
    Collection
    Keywords Neoplasm Metastasis / congresses
    Size IV, 92 S. : Ill., graph. Darst.
    Publisher Mediscript
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT004200815
    ISBN 1-87121-180-8 ; 978-1-87121-180-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 B 905 order for loan Magazin

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  6. Book ; Conference proceedings: Molecular diagnosis and monitoring of leukaemia and lymphoma

    Borden, Ernest C.

    [proceedings of the International Symposium on "Molecular Diagnosis and Monitoring of Leukaemia and Lymphoma" held in Perugia, Italy on April 15 - 17, 1993]

    (Challenges of modern medicine ; 2 ; Ares-Serono symposia publications)

    1994  

    Event/congress International Symposium on Molecular Diagnosis and Monitoring of Leukaemia and Lymphoma (1993, Perugia)
    Author's details ed. Ernest C. Borden
    Series title Challenges of modern medicine ; 2
    Ares-Serono symposia publications
    Collection
    Keywords Leukemia / diagnosis / congresses ; Leukemia / genetics / congresses ; Lymphoma / diagnosis / congresses ; Lymphoma / genetics / congresses ; Leukämie ; Diagnose ; Molekularbiologie ; Lymphom ; Überwachung
    Subject Lymphknotenvergrößerung ; Lymphknotentumor ; Lymphsystem ; Blutkrebs ; Ärztliche Diagnose ; Molekulare Biologie ; Überwachungstätigkeit ; Beobachtung
    Language English
    Size XII, 242 S. : Ill., graph. Darst.
    Publisher Ares-Serono Symposia Publ
    Publishing place Rome
    Publishing country Italy
    Document type Book ; Conference proceedings
    HBZ-ID HT006451473
    ISBN 88-85974-11-2 ; 978-88-85974-11-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 5150 order for loan Magazin

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  7. Book ; Conference proceedings: Immunomodulation in cancer

    Borden, Ernest C.

    critical issues for therapeutic design

    (Therapeutic strategies in oncology ; 7)

    1991  

    Event/congress Round Table Immunomodulation in Cancer: Critical Issues for Therapeutic Design (1991, HoustonTex.)
    Author's details Round Table [Immunomodulation in Cancer: Critical Issues for Therapeutic Design] ... Houston, USA, 16 May 1991. Ed. of this issue Ernest C. Borden
    Series title Therapeutic strategies in oncology ; 7
    Collection
    Keywords Adjuvants, Immunologic / congresses ; Neoplasms / therapy / congresses ; Combined Modality Therapy / congresses ; Immunotherapy / congresses
    Size VI, 103 S. : Ill., graph. Darst.
    Publisher Mediscript
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT004269427
    ISBN 1-871211-06-9 ; 978-1-871211-06-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 B 1411 order for loan Magazin

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  8. Article: Melanoma 2007: current state and preview of the future.

    Borden, Ernest C

    Seminars in oncology

    2007  Volume 34, Issue 6, Page(s) 449–451

    MeSH term(s) Humans ; Medical Oncology/trends ; Melanoma/pathology ; Melanoma/secondary ; Melanoma/therapy ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy
    Language English
    Publishing date 2007-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 189220-4
    ISSN 1532-8708 ; 0093-7754
    ISSN (online) 1532-8708
    ISSN 0093-7754
    DOI 10.1053/j.seminoncol.2007.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1348: Show issues Location:
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  9. Article: Adult sarcomas: a missed opportunity for sustained cooperative group translational and clinical research.

    Borden, Ernest C

    Oncology (Williston Park, N.Y.)

    2007  Volume 21, Issue 2, Page(s) 247–249

    Abstract: Preclinical advances offer an opportunity to further reduce morbidity and mortality from sarcomas over the next decade. Since no single institution or North American cooperative oncology group has the expertise or patient resources for histology-specific ...

    Abstract Preclinical advances offer an opportunity to further reduce morbidity and mortality from sarcomas over the next decade. Since no single institution or North American cooperative oncology group has the expertise or patient resources for histology-specific clinical and translational research on adult sarcomas, efforts have been made to develop funding from the National Cancer Institute (NCI). One such initiative was the Intergroup Coalition Against Sarcomas (ICAS), which, building upon the strengths of the multimodality cooperative oncology groups, provided an infrastructure for broad participation by investigators from all treatment disciplines in protocol development and patient entry. However, despite an excellent evaluation in formal peer review, the Division of Cancer Treatment of NCI has ended this initiative claiming insufficient available funds--to the detriment of adult sarcoma patients now and in the future.
    MeSH term(s) Adult ; Clinical Trials as Topic ; Gastrointestinal Stromal Tumors/epidemiology ; Gastrointestinal Stromal Tumors/therapy ; Health Care Coalitions ; Humans ; Medical Oncology ; National Institutes of Health (U.S.) ; Research Support as Topic ; Sarcoma/epidemiology ; Sarcoma/therapy ; United States
    Language English
    Publishing date 2007-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3168: Show issues Location:
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    Zs.MO 372: Show issues

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  10. Article ; Online: Phase I trials of targeted anticancer drugs: a need to refocus.

    Borden, Ernest C / Dowlati, Afshin

    Nature reviews. Drug discovery

    2012  Volume 11, Issue 12, Page(s) 889–890

    Abstract: As cancer therapy progresses through the development of molecularly targeted drugs, the focus of Phase I trials needs to shift towards investigating end points that could guide more effective trial design, dosing and choice of tumour setting for Phase II ...

    Abstract As cancer therapy progresses through the development of molecularly targeted drugs, the focus of Phase I trials needs to shift towards investigating end points that could guide more effective trial design, dosing and choice of tumour setting for Phase II studies.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Clinical Trials, Phase I as Topic ; Humans ; Neoplasms/drug therapy ; Research Design
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2012-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/nrd3909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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