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  1. Article: Editorial: Non-cutaneous melanoma: new therapeutic insights.

    Rossi, Ernesto / Carvajal, Richard D

    Frontiers in oncology

    2024  Volume 13, Page(s) 1362238

    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1362238
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  2. Article: Considerations for adjuvant immunotherapy in stage II melanoma: KEYNOTE-716 and beyond.

    Chen, Lanyi Nora / Carvajal, Richard D

    Annals of translational medicine

    2023  Volume 11, Issue 10, Page(s) 368

    Language English
    Publishing date 2023-03-13
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-23-839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Updates in the Management of Uveal Melanoma.

    Barbi, Mali / Carvajal, Richard D / Devoe, Craig E

    Cancer journal (Sudbury, Mass.)

    2024  Volume 30, Issue 2, Page(s) 92–101

    Abstract: Abstract: Uveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and ... ...

    Abstract Abstract: Uveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and immunological subsets, plays a pivotal role in determining prognoses. The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies. Combined regional and systemic approaches, including immune checkpoint inhibitors and innovative liver-directed therapy, are also under investigation. Although recent progress has improved outcomes, ongoing research aims to address the unique challenges of UM and develop effective therapies, particularly for HLA-A*02:01-negative patients who represent a significant unmet medical need. This review comprehensively discusses the molecular characteristics of UM, risk stratification methods, and the current and future spectrum of regional and systemic therapeutic modalities.
    MeSH term(s) Humans ; Melanoma/therapy ; Melanoma/drug therapy ; Uveal Neoplasms/diagnosis ; Uveal Neoplasms/genetics ; Uveal Neoplasms/therapy ; Prognosis
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2018400-1
    ISSN 1540-336X ; 1528-9117 ; 1081-4442
    ISSN (online) 1540-336X
    ISSN 1528-9117 ; 1081-4442
    DOI 10.1097/PPO.0000000000000708
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  4. Article ; Online: Diversifying Eligibility to Enhance Real-World Results.

    Fayyaz, Fatima / Carvajal, Richard D / Devoe, Craig E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 23, Page(s) 3895–3898

    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00836
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  5. Article ; Online: Tebentafusp for the treatment of HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.

    Chen, Lanyi Nora / Carvajal, Richard D

    Expert review of anticancer therapy

    2022  Volume 22, Issue 10, Page(s) 1017–1027

    Abstract: Introduction: Metastatic uveal melanoma is associated with poor prognosis and few treatment options. Tebentafusp recently became the first FDA-approved agent for metastatic uveal melanoma.: Areas covered: In this review, we describe the mechanism of ... ...

    Abstract Introduction: Metastatic uveal melanoma is associated with poor prognosis and few treatment options. Tebentafusp recently became the first FDA-approved agent for metastatic uveal melanoma.
    Areas covered: In this review, we describe the mechanism of action of tebentafusp as well as preclinical data showing high tumor specificity of the drug. We also review promising early-phase trials in which tebentafusp demonstrated activity in metastatic uveal melanoma patients with an acceptable toxicity profile that included cytokine-mediated, dermatologic-related, and liver-related adverse events. Finally, we summarize findings from a pivotal phase III randomized trial in which tebentafusp demonstrated significant improvement in overall survival in comparison with investigator choice therapy.
    Expert opinion: Tebentafusp has transformed the treatment paradigm for metastatic uveal melanoma and should be the preferred frontline agent for most HLA-A*0201 positive patients. However, patients with rapidly progressing disease or high tumor benefit may not derive the same benefit. Areas of future study should focus on its role in the adjuvant setting as well as strategies to improve the efficacy of tebentafusp in the metastatic setting.
    MeSH term(s) Adult ; Cytokines ; HLA-A Antigens/therapeutic use ; Humans ; Immunoconjugates ; Melanoma ; Recombinant Fusion Proteins ; Uveal Neoplasms/drug therapy ; Uveal Neoplasms/pathology
    Chemical Substances Cytokines ; HLA-A Antigens ; Immunoconjugates ; Recombinant Fusion Proteins ; tebentafusp (N658GY6L3E)
    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2022.2124971
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    Zs.A 5907: Show issues Location:
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  6. Article ; Online: Human DNA polymerase θ does not harbor intrinsic nuclease activity.

    Carvajal-Maldonado, Denisse / Zahn, Karl / Jensen, Ryan / Wood, Richard D / Doublié, Sylvie

    Molecular cell

    2024  Volume 84, Issue 8, Page(s) 1394–1395

    MeSH term(s) Humans ; DNA Polymerase theta ; DNA-Directed DNA Polymerase/genetics ; Mutation
    Chemical Substances DNA Polymerase theta (EC 2.7.7.-) ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Letter
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2024.03.009
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    Zs.A 5055: Show issues Location:
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  7. Article ; Online: Dual Immunological Checkpoint Blockade for Uveal Melanoma.

    Khan, Shaheer / Carvajal, Richard D

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 6, Page(s) 554–556

    MeSH term(s) Humans ; Melanoma/drug therapy ; Uveal Neoplasms/drug therapy
    Language English
    Publishing date 2021-01-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.20.03274
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  8. Article ; Online: New targeted and epigenetic therapeutic strategies for the treatment of uveal melanoma.

    Wei, Alexander Z / Maniar, Ashray B / Carvajal, Richard D

    Cancer gene therapy

    2022  Volume 29, Issue 12, Page(s) 1819–1826

    Abstract: Uveal melanoma (UM) is a rare, genetically bland ocular malignancy with excellent local treatment options, but no disease-specific therapies are approved for use in the metastatic setting by the Food and Drug Administration. Metastatic UM (mUM) confers a ...

    Abstract Uveal melanoma (UM) is a rare, genetically bland ocular malignancy with excellent local treatment options, but no disease-specific therapies are approved for use in the metastatic setting by the Food and Drug Administration. Metastatic UM (mUM) confers a prognosis of ~15 months. Unlike cutaneous melanoma, UM is poorly responsive to checkpoint inhibitors and cytotoxic chemotherapy highlighting the importance of clarifying vulnerable disease-specific mechanisms, such as cell cycle or metabolic pathways necessary for tumor growth and survival. The elucidation of signaling pathways downstream of the frequently mutated GNA GTPase such as PKC/MAPK/ERK/MEK, PI3K/AKT, and YAP-Hippo have offered potential targets. Potentially druggable epigenetic targets due to BAP1-mutated UM have also been identified, including proteins involved with histone deacetylation and DNA splicing. This review describes the preclinical rationale for the development of targeted therapies and current strategies currently being studied in clinical trials or will be in the near future.
    MeSH term(s) United States ; Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Skin Neoplasms/genetics ; Epigenesis, Genetic
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1212513-1
    ISSN 1476-5500 ; 0929-1903
    ISSN (online) 1476-5500
    ISSN 0929-1903
    DOI 10.1038/s41417-022-00443-8
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  9. Article: Update on the treatment of uveal melanoma.

    Carvajal, Richard D

    Clinical advances in hematology & oncology : H&O

    2016  Volume 14, Issue 10, Page(s) 768–770

    MeSH term(s) Humans ; Melanoma/therapy ; Uveal Neoplasms/therapy
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
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  10. Article ; Online: Novel Approaches to the Systemic Management of Uveal Melanoma.

    Khan, Shaheer / Carvajal, Richard D

    Current oncology reports

    2020  Volume 22, Issue 10, Page(s) 104

    Abstract: Purpose of review: Uveal melanoma is a distinct subtype of melanoma characterized by a unique biology and divergent response to immune therapies. In this review, we will discuss our current understanding of the pathophysiology of uveal melanoma, ... ...

    Abstract Purpose of review: Uveal melanoma is a distinct subtype of melanoma characterized by a unique biology and divergent response to immune therapies. In this review, we will discuss our current understanding of the pathophysiology of uveal melanoma, systemic treatment options for advanced disease, and potential future therapeutic directions.
    Recent findings: Although treatment with single-agent checkpoint blockade has been generally disappointing, the results of combined checkpoint blockade are modestly more promising. Several alternative systemic therapeutic approaches have been or are currently being investigated, including two agents that have been taken into registration-intent clinical trials: tebentafusp, a T cell redirecting agent, and IDE196, an oral protein kinase C inhibitor. Treatment of advanced uveal melanoma remains challenging, however, encouraging results from novel agents offer hope for improvement in the near future.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Humans ; Immunotherapy ; Melanoma/diagnosis ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/physiopathology ; Melanoma/therapy ; Prognosis ; Risk Assessment ; Uveal Neoplasms/diagnosis ; Uveal Neoplasms/drug therapy ; Uveal Neoplasms/genetics ; Uveal Neoplasms/physiopathology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-020-00965-0
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