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Article ; Online: An Unusual Cause of Cardioplegia Failure Due to Coronary Origin From the Descending Thoracic Aorta.

Lefort, Bruno / Loardi, Claudia / Gouton, Marielle / Neville, Paul

2022 Volume 114, Issue 1, Page(s) e75

MeSH term(s)	Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Cardioplegic Solutions ; Heart ; Heart Arrest, Induced ; Humans
Chemical Substances	Cardioplegic Solutions
Language	English
Publishing date	2022-02-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2022.01.022
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Article ; Online: A Confined Youth? Lived Space and Shifting Boundaries in Beirut

Bruno Lefort

Middle East : Topics & Arguments, Vol

2017 Volume 9

Abstract: This article questions spatial experiences among students in Beirut. It mobilizes collaborative map interviews to explore the ways young people experiment with space and the social boundaries it incorporates. I argue that their perception of their lived ... ...

Abstract	This article questions spatial experiences among students in Beirut. It mobilizes collaborative map interviews to explore the ways young people experiment with space and the social boundaries it incorporates. I argue that their perception of their lived space underlines a crucial shift: whereas their parents experimented the city in terms of sectarian and political divisions, my interlocutors have integrated these boundaries not as ideological but as the result of daily practices of segregation born during the Lebanese wars (1975-1990). This evolution reveals renewed understandings of the Lebanese complex landscape and contributes to delineate youth as a social shifter.
Keywords	General Works ; A ; Social Sciences ; H
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Center for Near and Middle Eastern Studies
Document type	Article ; Online
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Article: Soignant en milieu d’exception : l’infirmier de bloc opératoire militaire en zone tropicale.

Petitjean, Mélodie / de La Villéon, Bruno / Lefort, Hugues / de Martène, Hugues / Caubère, Alexandre

Revue de l'infirmiere

2023 Volume 72, Issue 296, Page(s) 35–38

Abstract: The profession of operating theater nurse in the French Armed Forces Medical Corps is often little-known. Called upon to serve in mainland France, but also deployed on overseas operations, they provide medical and surgical support to the French armed ... ...

Title translation	Caregiving in an exceptional environment: the military operating theater nurse in a tropical zone.
Abstract	The profession of operating theater nurse in the French Armed Forces Medical Corps is often little-known. Called upon to serve in mainland France, but also deployed on overseas operations, they provide medical and surgical support to the French armed forces. Personal qualities - human, physical and technical - are essential to adapt to the environmental constraints of this isolated post.
MeSH term(s)	Humans ; Military Personnel ; France
Language	French
Publishing date	2023-11-29
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	632538-5
ISSN	1293-8505 ; 0397-7900
ISSN	1293-8505 ; 0397-7900
DOI	10.1016/j.revinf.2023.10.012
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Article ; Online: Eversion for Stabilization: A Standardized Technique for Pulmonary Autograft Inclusion.

El Arid, Jean-Marc / Dion, Fanny / Neville, Paul / Lefort, Bruno

The Annals of thoracic surgery

2022 Volume 114, Issue 3, Page(s) e217–e218

Abstract: We have developed a new technique avoiding autograft distortion and narrowing at inclusion during Ross procedure, in order to preserve the functional anatomy and the process of adaptation. ...

Abstract	We have developed a new technique avoiding autograft distortion and narrowing at inclusion during Ross procedure, in order to preserve the functional anatomy and the process of adaptation.
MeSH term(s)	Aortic Valve/surgery ; Aortic Valve Insufficiency/surgery ; Autografts ; Humans ; Pulmonary Valve/transplantation ; Reoperation/methods ; Transplantation, Autologous
Language	English
Publishing date	2022-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2021.12.027
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Article ; Online: Increased acylcarnitines in infant heart failure indicate fatty acid oxidation inhibition: towards therapeutic options?

Issa, Jean / Lodewyckx, Pierre / Blasco, Hélène / Benz-de-Bretagne, Isabelle / Labarthe, François / Lefort, Bruno

ESC heart failure

2023 Volume 10, Issue 5, Page(s) 3114–3122

Abstract: Aims: Heart failure in adults is characterized by reduction of long-chain fatty acid oxidation in favour of carbohydrate metabolism. This adaptive phenomenon becomes maladaptive because energy conversion decreases and lipid toxic derivatives known to ... ...

Abstract	Aims: Heart failure in adults is characterized by reduction of long-chain fatty acid oxidation in favour of carbohydrate metabolism. This adaptive phenomenon becomes maladaptive because energy conversion decreases and lipid toxic derivatives known to impair cardiac function are accumulating. No data are available concerning metabolic modification in heart failure in children. Methods and results: In order to evaluate the fatty acid oxidation in children suffering from heart failure, acylcarnitine profiles on dried blood spots were obtained from children under 16 years old with dilated cardiomyopathy and clinical heart failure (DCM-HF) and control children. Nine children were included in the DCM-HF group and eight in the control group. Acylcarnitine profiles revealed a significant 3.1-fold increase of total acylcarnitines (sum of C3 to C18 acylcarnitine species) in DCM-HF children compared with controls. This result persisted considering the sum of long-chain acylcarnitines (sum of C14 to C18 species), medium-chain acylcarnitines (sum of C8 to C12 species), and short-chain acylcarnitines (sum of C3 to C6 species), respectively, 2.0-, 2.6-, and 1.9-fold increase compared with the control group. A significant linear correlation was found between left ventricular dilatation or ejection fraction and acylcarnitines accumulation. Finally, acylcarnitine ratio C16OH/C16 and C18OH/C18 enhanced in the DCM-HF group, suggesting a diminution of the long-chain hydroxyl acyl-CoA dehydrogenase activity. Conclusions: Our results suggest down-regulation of fatty acid oxidation in children with heart failure. Such lipidomic alteration could worsen heart function and may suggest considering a metabolic treatment of heart failure in children.
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14449
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Article ; Online: Impact of the phenotypic expression of temocillin resistance in Escherichia coli on temocillin efficacy in a murine peritonitis model.

Mallart, Elise / Guerin, François / Amoura, Ariane / Le Scouarnec, Matthieu / Hamon, Antoine / El Meouche, Imane / Chau, Françoise / Lefort, Agnès / Fantin, Bruno / Cattoir, Vincent / de Lastours, Victoire

The Journal of antimicrobial chemotherapy

2024

Abstract: Background: Temocillin is a narrow spectrum β-lactam active against MDR Enterobacterales. Mechanisms of acquired resistance to temocillin are poorly understood. We analysed resistance mechanisms in clinical isolates of Escherichia coli and evaluated ... ...

Abstract	Background: Temocillin is a narrow spectrum β-lactam active against MDR Enterobacterales. Mechanisms of acquired resistance to temocillin are poorly understood. We analysed resistance mechanisms in clinical isolates of Escherichia coli and evaluated their impact on temocillin efficacy in vitro and in a murine peritonitis model. Methods: Two sets of isogenic clinical E. coli strains were studied: a susceptible isolate (MLTEM16S) and its resistant derivative, MLTEM16R (mutation in nmpC porin gene); and temocillin-resistant derivatives of E. coli CFT073: CFT-ΔnmpC (nmpC deletion), CFTbaeS-TP and CFTbaeS-AP (two different mutations in the baeS efflux-pump gene).Fitness cost, time-kill curves and phenotypic expression of resistance were determined. Temocillin efficacy was assessed in a murine peritonitis model. Results: MICs of temocillin were 16 and 64 mg/L for MLTEM16S and MLTEM16R, respectively, and 8, 128, 256 and 256 mg/L for E. coli-CFT073, CFT-ΔnmpC, CFTbaeS-TP and CFTbaeS-AP, respectively. No fitness cost of resistance was evidenced. All resistant strains showed heteroresistant profiles, except for CFTbaeS-AP, which displayed a homogeneous pattern. In vitro, temocillin was bactericidal against MLTEM16R, CFT-ΔnmpC, CFTbaeS-TP and CFTbaeS-AP at 128, 256, 512 and 512 mg/L, respectively. In vivo, temocillin was as effective as cefotaxime against MLTEM16R, CFT-ΔnmpC and CFTbaeS-TP, but inefficient against CFTbaeS-AP (100% mortality). Conclusions: Heteroresistant NmpC porin alteration and active efflux modification do not influence temocillin efficacy despite high MIC values, unfavourable pharmacokinetic/pharmacodynamic conditions and the absence of fitness cost, whereas homogeneously expressed BaeS efflux pump alteration yielding similar MICs leads to temocillin inefficacy. MIC as sole predictor of temocillin efficacy should be used with caution.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkae072
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Post-ligation cardiac syndrome after surgical versus transcatheter closure of patent ductus arteriosus in low body weight premature infants: a multicenter retrospective cohort study.

Duboue, Pierre-Marie / Padovani, Paul / Bouteiller, Xavier Paul / Martin-Kabore, Frédérique / Benbrik, Nadir / Gronier, Céline Grunenwald / Bouissou, Antoine / Garnier, Elodie / Mitanchez, Delphine / Flamant, Cyril / Rozé, Jean-Christophe / Baruteau, Alban-Elouen / Lefort, Bruno

European journal of pediatrics

2024 Volume 183, Issue 5, Page(s) 2193–2201

Abstract: Transcatheter patent ductus arteriosus (PDA) closure is a safe and effective alternative to surgical ligation in low-body-weight infants. Post-ligation cardiac syndrome (PLCS) is defined as severe hemodynamic and respiratory collapse within 24 h of PDA ... ...

Abstract	Transcatheter patent ductus arteriosus (PDA) closure is a safe and effective alternative to surgical ligation in low-body-weight infants. Post-ligation cardiac syndrome (PLCS) is defined as severe hemodynamic and respiratory collapse within 24 h of PDA closure, requiring initiation or an increase of an inotropic agent by > 20% of preligation dosing and an absolute increase of at least 20% in ventilation parameters compared with the preoperative value. Whilst PLCS is routinely observed after surgery, its incidence remains poorly described following transcatheter closure. This study aimed to compare the incidence of PLCS after surgical versus transcatheter closure of PDA in low-body-weight premature infants. Propensity scores were used to compare surgical (N = 78) and transcatheter (N = 76) groups of preterm infants who underwent PDA closure at a procedural weight less than 2000 g in two tertiary institutions between 2009 and 2021. The primary outcome was the incidence of PLCS. Secondary outcomes included overall mortality before discharge, risk factors for PLCS, and post-procedural complications. Procedural success was 100% in both groups. After matching, transcatheter group experienced no PLCS vs 15% in the surgical group (p = 0.012). Furthermore, overall mortality (2% vs 17%; p = 0.03) and major complications (2% vs 23%; p = 0.002) were higher in the surgical group. Surgery (100% vs 47%; p < 0.01), gestation age (25 ± 1 vs 26 ± 2 weeks, p < 0.05) and inotropic support before closure (90% vs 29%; p < 0.001) were associated with PLCS occurrence. Conclusion: Transcatheter PDA closure may be equally effective but safer than surgical PDA closure in low-body-weight premature infants. What is Known: • Post-ligation cardiac syndrome is a serious and common complication of surgical closure of the ductus arteriosus in preterm infants. • Transcatheter closure of preterm ductus arteriosus is a safe and effective technique that is becoming more and more common worldwide. What is New: • Device closure is safer than surgical ligation for patent ductus arteriosus closure in preterm infants and may be the first-line non-pharmacological therapeutic option in this indication in experienced teams. • Our findings should encourage neonatologists and pediatric cardiologists to start and/or strengthen a durable interventional program for transcatheter PDA closure in premature infants.
MeSH term(s)	Humans ; Ductus Arteriosus, Patent/surgery ; Retrospective Studies ; Infant, Newborn ; Female ; Ligation/methods ; Ligation/adverse effects ; Male ; Cardiac Catheterization/methods ; Cardiac Catheterization/adverse effects ; Infant, Premature ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Infant, Low Birth Weight ; Incidence ; Cardiac Surgical Procedures/adverse effects ; Cardiac Surgical Procedures/methods ; Syndrome ; Propensity Score ; Septal Occluder Device ; Risk Factors ; Infant, Premature, Diseases/surgery ; Infant, Premature, Diseases/etiology ; Infant, Premature, Diseases/therapy ; Infant, Premature, Diseases/epidemiology
Language	English
Publishing date	2024-02-21
Publishing country	Germany
Document type	Journal Article ; Multicenter Study ; Comparative Study
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-024-05481-y
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Article ; Online: Reconstruction of the aortic valve leaflet with autologous pulmonary artery wall.

El Arid, Jean-Marc / Neville, Paul / Soulé, Nathalie / Lefort, Bruno

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2020 Volume 59, Issue 1, Page(s) 269–270

Abstract: Leaflet reconstruction outcomes in young patients can be compromised by treated autologous pericardium utilization. We present a new and simple unicuspid/unicommissural aortic valve repair technique with an autologous pulmonary artery wall graft. With ... ...

Abstract	Leaflet reconstruction outcomes in young patients can be compromised by treated autologous pericardium utilization. We present a new and simple unicuspid/unicommissural aortic valve repair technique with an autologous pulmonary artery wall graft. With comparative and longitudinal follow-up studies, this technique could constitute a living reconstruction of the aortic valve that does not preclude a future Ross procedure.
MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/surgery ; Aortic Valve Stenosis ; Heart Valve Diseases ; Humans ; Pericardium/transplantation ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/surgery ; Transplantation, Autologous
Language	English
Publishing date	2020-09-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezaa246
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Article ; Online: Large retrospective study analysing predictive factors of primary treatment failure, recurrence and death in pyogenic liver abscesses.

Rossi, Geoffrey / Nguyen, Yann / Lafont, Emmanuel / Rossi, Benjamin / Canouï, Etienne / Roux, Olivier / Dokmak, Safi / Bert, Frédéric / Fantin, Bruno / Lefort, Agnès

Infection

2022 Volume 50, Issue 5, Page(s) 1205–1215

Abstract: Purpose: Pyogenic liver abscess (PLA) is a severe disease, which unfavourable evolution remains frequent. Our objective was to assess predictive factors of unfavourable outcome in patients with PLA.: Methods: We conducted a retrospective study in a ... ...

Abstract	Purpose: Pyogenic liver abscess (PLA) is a severe disease, which unfavourable evolution remains frequent. Our objective was to assess predictive factors of unfavourable outcome in patients with PLA. Methods: We conducted a retrospective study in a French tertiary care centre. All patients admitted for PLA between 2010 and 2018 were included. Unfavourable course was defined as the occurrence of a primary treatment failure (PTF), recurrence of PLA after an initial cure, or death within 3 months after diagnosis. Hazard ratios (95% CI) were calculated with multivariable Cox proportional hazard models. Results: 302 patients were included among which 91 (30.1%) patients had an unfavourable outcome because of PTF, recurrence or death in 55 (18.2%), 28 (9.2%) and 32 (10.6%) patients, respectively. Hepatic metastases (HR 2.08; 95% CI 1.04-4.15), a nosocomial infection (2.25; 1.14-4.42), portal thrombosis (2.12; 1.14-3.93), and the isolation of Enterococcus spp. (2.18; 1.22- 3.90) were independently associated with PTF. Ischemic cholangitis (6.30; 2.70-14.70) and the isolation of Streptococcus spp. (3.72; 1.36-10.16) were associated with the risk of recurrence. Charlson comorbidity index (HR 1.30 per one point; 95% CI 1.15-1.46; p < 0.001), portal thrombosis (3.53; 1.65-7.56) and the presence of multi-drug-resistant organisms (3.81; 1.73-8.40) were associated with mortality within 3 months following PLA diagnosis. PLA drainage was the only factor associated with a lower mortality (0.14; 0.06-0.34). Conclusion: Identification of specific risk factors may help to improve the management of PLA and to elaborate targeted recommendations according to patient's and disease's characteristics.
MeSH term(s)	Cholangitis/complications ; Enterococcus ; Humans ; Liver Abscess, Pyogenic/diagnosis ; Liver Abscess, Pyogenic/etiology ; Liver Abscess, Pyogenic/therapy ; Retrospective Studies ; Risk Factors ; Thrombosis/complications ; Treatment Failure
Language	English
Publishing date	2022-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-022-01793-z
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinical utility of periodic reinterpretation of CNVs of uncertain significance: an 8-year retrospective study.

Ravel, Jean-Marie / Renaud, Mathilde / Muller, Jean / Becker, Aurélie / Renard, Émeline / Remen, Thomas / Lefort, Geneviève / Dexheimer, Mylène / Jonveaux, Philippe / Leheup, Bruno / Bonnet, Céline / Lambert, Laëtitia

Genome medicine

2023 Volume 15, Issue 1, Page(s) 39

Abstract: Background: Array-CGH is the first-tier genetic test both in pre- and postnatal developmental disorders worldwide. Variants of uncertain significance (VUS) represent around 10~15% of reported copy number variants (CNVs). Even though VUS reanalysis has ... ...

Abstract	Background: Array-CGH is the first-tier genetic test both in pre- and postnatal developmental disorders worldwide. Variants of uncertain significance (VUS) represent around 10~15% of reported copy number variants (CNVs). Even though VUS reanalysis has become usual in practice, no long-term study regarding CNV reinterpretation has been reported. Methods: This retrospective study examined 1641 CGH arrays performed over 8 years (2010-2017) to demonstrate the contribution of periodically re-analyzing CNVs of uncertain significance. CNVs were classified using AnnotSV on the one hand and manually curated on the other hand. The classification was based on the 2020 American College of Medical Genetics (ACMG) criteria. Results: Of the 1641 array-CGH analyzed, 259 (15.7%) showed at least one CNV initially reported as of uncertain significance. After reinterpretation, 106 of the 259 patients (40.9%) changed categories, and 12 of 259 (4.6%) had a VUS reclassified to likely pathogenic or pathogenic. Six were predisposing factors for neurodevelopmental disorder/autism spectrum disorder (ASD). CNV type (gain or loss) does not seem to impact the reclassification rate, unlike the length of the CNV: 75% of CNVs downgraded to benign or likely benign are less than 500 kb in size. Conclusions: This study's high rate of reinterpretation suggests that CNV interpretation has rapidly evolved since 2010, thanks to the continuous enrichment of available databases. The reinterpreted CNV explained the phenotype for ten patients, leading to optimal genetic counseling. These findings suggest that CNVs should be reinterpreted at least every 2 years.
MeSH term(s)	DNA Copy Number Variations ; Retrospective Studies ; Autism Spectrum Disorder/genetics ; Neurodevelopmental Disorders/genetics ; Humans
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2484394-5
ISSN	1756-994X ; 1756-994X
ISSN (online)	1756-994X
ISSN	1756-994X
DOI	10.1186/s13073-023-01191-6
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