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  1. Book ; Thesis: Lokalisation, Quantifizierung und Charakterisierung von Antigen-präsentierenden Zellen der murinen Peyerschen Plaques während der postnatalen Entwicklungsphase

    Mingels, Clemens

    2020  

    Author's details vorgelegt von Clemens Mingels
    Language German
    Size 91 Seiten, Illustrationen, Diagramme
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2020
    HBZ-ID HT020618778
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: New thresholds in semi-quantitative [

    Knappe, Luisa / Bregenzer, Carola / Gözlügöl, Nasir / Mingels, Clemens / Alberts, Ian / Rominger, Axel / Caobelli, Federico

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 13, Page(s) 3890–3896

    Abstract: Aim: [: Methods: We retrospectively evaluated 100 patients (50 with LVV and 50 controls) who underwent [: Results: Of the 50 patients diagnosed with LVV, SA vessels were affected in 38 (76%), TA in 42 (84%) and IA vessels in 26 (52%). To-liver ... ...

    Abstract Aim: [
    Methods: We retrospectively evaluated 100 patients (50 with LVV and 50 controls) who underwent [
    Results: Of the 50 patients diagnosed with LVV, SA vessels were affected in 38 (76%), TA in 42 (84%) and IA vessels in 26 (52%). To-liver normalized values had higher diagnostic accuracy than non-normalized values (AUC always ≥ 0.90 vs. 0.74-0.89). For the SA vessels, best thresholds were 0.66 for SUV
    Conclusion: LAFOV [
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals ; Retrospective Studies ; Vasculitis/diagnostic imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-09-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06423-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: FDG imaging with long-axial field-of-view PET/CT in patients with high blood glucose-a matched pair analysis.

    Mingels, Clemens / Weissenrieder, Luis / Zeimpekis, Konstantinos / Sari, Hasan / Nardo, Lorenzo / Caobelli, Federico / Alberts, Ian / Rominger, Axel / Pyka, Thomas

    European journal of nuclear medicine and molecular imaging

    2024  

    Abstract: Purpose: High blood glucose (hBG) in patients undergoing [: Materials and methods: Oncologic patients with elevated blood glucose (≥ 8.0 mmol/l) and normal blood glucose (< 8.0 mmol/l, nBG) levels were matched for tumor entity, gender, age, and BMI. ... ...

    Abstract Purpose: High blood glucose (hBG) in patients undergoing [
    Materials and methods: Oncologic patients with elevated blood glucose (≥ 8.0 mmol/l) and normal blood glucose (< 8.0 mmol/l, nBG) levels were matched for tumor entity, gender, age, and BMI. hBG patients were further subdivided into two groups (BG 8-11 mmol/l and BG > 11 mmol/l). Tracer uptake in the liver, muscle, and tumor was evaluated. Furthermore, image quality was compared between long acquisitions (ultra-high sensitivity mode, 360 s) on a LAFOV PET/CT and routine acquisitions equivalent to a short-axial field-of-view scanner (simulated (sSAFOV), obtained with high sensitivity mode, 120 s). Tumor-to-background ratio (TBR) and contrast-to-noise ratio (CNR) were used as the main image quality criteria.
    Results: Thirty-one hBG patients met the inclusion criteria and were matched with 31 nBG patients. Overall, liver uptake was significantly higher in hBG patients (SUV
    Conclusion: While elevated blood glucose (> 11 mmol) negatively affected TBR and CNR in our cohort, the images from a LAFOV PET-scanner had comparable CNR to PET-images acquired from nBG patients using sSAFOV PET/CT. Therefore, we argue that oncologic patients with increased blood sugar levels might be imaged safely with LAFOV PET/CT when rescheduling is not feasible.
    Language English
    Publishing date 2024-02-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06646-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Internal dosimetry study of [

    Mercolli, Lorenzo / Bregenzer, Carola / Diemling, Markus / Mingels, Clemens / Rominger, Axel / Sari, Hasan / Seibel, Sigrid / Sohlberg, Antti / Viscione, Marco / Caobelli, Federico

    European journal of nuclear medicine and molecular imaging

    2024  

    Abstract: Purpose: Long axial field-of-view (LAFOV) positron emission tomography (PET) systems allow to image all major organs with one bed position, which is particularly useful for acquiring whole-body dynamic data using short-lived radioisotopes like : ... ...

    Abstract Purpose: Long axial field-of-view (LAFOV) positron emission tomography (PET) systems allow to image all major organs with one bed position, which is particularly useful for acquiring whole-body dynamic data using short-lived radioisotopes like
    Methods: We determined the absorbed dose in target organs of three subjects (29, 40, and 57 years old) using two different methods, i.e., MIRD and voxel dosimetry. The subjects were injected with 407.0 to 419.61 MBq of [
    Results: Using the MIRD formalism and voxel dosimetry, the absorbed dose ranged from 1.84 to 2.78 μGy/MBq (1.57 to 3.92 μGy/MBq for voxel dosimetry) for the heart wall, 2.76 to 5.73 μGy/MBq (3.22 to 5.37 μGy/MBq for voxel dosimetry) for the kidneys, and 0.94 to 1.88 μGy/MBq (0.98 to 1.92 μGy/MBq for voxel dosimetry) for the lungs. The total body effective dose lied between 0.50 and 0.76 μSv/MBq.
    Conclusion: Our study suggests that the radiation dose associated with [
    Language English
    Publishing date 2024-02-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06660-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Radiosynoviorthese des Daumensattelgelenks.

    Mingels, Clemens / Daneshvar, Keivan / Afshar-Oromieh, Ali

    Der Orthopade

    2021  Volume 51, Issue 1, Page(s) 9–12

    Abstract: Radiosynoviorthesis (RSO) is an established therapeutic method for the local treatment of pain in aseptic joint inflammation (e.g. arthritis, activated osteoarthritis, synovitis). RSO can be used for the treatment of synovial membrane inflammation of the ...

    Title translation Radiosynoviorthesis of the thumb's carpometacarpal joint.
    Abstract Radiosynoviorthesis (RSO) is an established therapeutic method for the local treatment of pain in aseptic joint inflammation (e.g. arthritis, activated osteoarthritis, synovitis). RSO can be used for the treatment of synovial membrane inflammation of the finger joints such as the thumb's carpometacarpal joint. The beta emitter Erbium-169 (Er-169) is injected into the joint space, which irradiates the inflamed synovialis, thereby leading to fibrosis and obliteration of the pain receptors of the synovial membrane. The chances of success in the treatment of the thumb's carpometacarpal joint by RSO are estimated to be 54-100% within 2-6 weeks after therapy.
    MeSH term(s) Arthritis, Rheumatoid ; Carpometacarpal Joints/diagnostic imaging ; Carpometacarpal Joints/surgery ; Humans ; Synovitis/diagnostic imaging ; Synovitis/radiotherapy ; Synovitis/surgery ; Thumb/diagnostic imaging ; Thumb/surgery ; Treatment Outcome
    Language German
    Publishing date 2021-12-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121792-6
    ISSN 1433-0431 ; 0085-4530
    ISSN (online) 1433-0431
    ISSN 0085-4530
    DOI 10.1007/s00132-021-04194-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dose Reduction in Pediatric Oncology Patients with Delayed Total-Body [

    Mingels, Clemens / Spencer, Benjamin A / Nalbant, Hande / Omidvari, Negar / Rokni, Mehrad / Rominger, Axel / Sen, Fatma / Cherry, Simon R / Badawi, Ramsey D / Abdelhafez, Yasser G / Nardo, Lorenzo

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  

    Abstract: Our aim was to define a lower limit of reduced injected activity in delayed [ ...

    Abstract Our aim was to define a lower limit of reduced injected activity in delayed [
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.124.267521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of the new ultra-high sensitivity mode in a long axial field-of-view PET/CT.

    Mingels, Clemens / Weidner, Sabine / Sari, Hasan / Buesser, Dorothee / Zeimpekis, Konstantinos / Shi, Kuangyu / Alberts, Ian / Rominger, Axel

    Annals of nuclear medicine

    2023  Volume 37, Issue 5, Page(s) 310–315

    Abstract: Objective: Long axial field-of-view (LAFOV) PET/CT showed improved performance resulting from higher sensitivity. The aim was to quantify the impact of using the full acceptance angle (UHS) in image reconstructions with the Biograph Vision Quadra LAFOV ... ...

    Abstract Objective: Long axial field-of-view (LAFOV) PET/CT showed improved performance resulting from higher sensitivity. The aim was to quantify the impact of using the full acceptance angle (UHS) in image reconstructions with the Biograph Vision Quadra LAFOV PET/CT (Siemens Healthineers) compared to the limited acceptance angle (high sensitivity mode, HS).
    Methods: 38 oncological patients examined on a LAFOV Biograph Vision Quadra PET/CT were analysed. 15 patients underwent [
    Results: The SNR was significantly higher for UHS compared to HS over all acquisition times (SNR UHS/HS [
    Conclusion: UHS showed significantly higher SNR opening the possibility of halving short acquisition times. This is of advantage in further reduction of whole-body PET/CT acquisition.
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Positron-Emission Tomography
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes
    Language English
    Publishing date 2023-03-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1146984-5
    ISSN 1864-6433 ; 0914-7187
    ISSN (online) 1864-6433
    ISSN 0914-7187
    DOI 10.1007/s12149-023-01827-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Diagnostic accuracy of [

    Mingels, Clemens / Bohn, Karl Peter / Rominger, Axel / Afshar-Oromieh, Ali / Alberts, Ian

    European journal of nuclear medicine and molecular imaging

    2022  Volume 49, Issue 7, Page(s) 2436–2444

    Abstract: Aim: Despite increasing use for the detection of biochemically recurrent prostate cancer (rPC), the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT) with [: Materials and methods: One hundred seventy-seven consecutive ... ...

    Abstract Aim: Despite increasing use for the detection of biochemically recurrent prostate cancer (rPC), the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT) with [
    Materials and methods: One hundred seventy-seven consecutive patients undergoing [
    Results: The overall PET-positivity rate was 91%. Conclusive follow-up for affirmation or refutation of a PSMA-positive lesion was available for 81/152 patients on a per region basis. In this subgroup, overall sensitivity, specificity, PPV, and NPV were 95% (CI: 0.90-0.98), 89% (CI: 0.83-0.93), 86% (0.80-0.90), and 96% (CI: 0.92-0.98), respectively. On a per region basis, PPV was 97% (CI: 0.83-0.99) for local recurrence, 93% (CI: 0.78-0.98) for pelvic LN, 87% (CI: 0.62-0.96) for retroperitoneal LN, 82% (CI: 0.52-0.95) for supradiaphragmatic LN, and 79% (0.65-0.89) for bone lesions. The number of solid organ metastases (n = 6) was too small for an accurate statistical analysis.
    Conclusion: The known high PET-positivity rate of [
    MeSH term(s) Gallium Radioisotopes ; Humans ; Male ; Niacinamide/analogs & derivatives ; Oligopeptides ; Positron Emission Tomography Computed Tomography/methods ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Tomography, X-Ray Computed
    Chemical Substances Gallium Radioisotopes ; Oligopeptides ; PSMA-1007 ; Niacinamide (25X51I8RD4) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2022-01-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-05693-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients.

    Alberts, Ian / Sari, Hasan / Mingels, Clemens / Afshar-Oromieh, Ali / Pyka, Thomas / Shi, Kuangyu / Rominger, Axel

    Cancer imaging : the official publication of the International Cancer Imaging Society

    2023  Volume 23, Issue 1, Page(s) 28

    Abstract: Recently introduced long-axial field-of-view (LAFOV) PET/CT systems represent one of the most significant advancements in nuclear medicine since the advent of multi-modality PET/CT imaging. The higher sensitivity exhibited by such systems allow for ... ...

    Abstract Recently introduced long-axial field-of-view (LAFOV) PET/CT systems represent one of the most significant advancements in nuclear medicine since the advent of multi-modality PET/CT imaging. The higher sensitivity exhibited by such systems allow for reductions in applied activity and short duration scans. However, we consider this to be just one small part of the story: Instead, the ability to image the body in its entirety in a single FOV affords insights which standard FOV systems cannot provide. For example, we now have the ability to capture a wider dynamic range of a tracer by imaging it over multiple half-lives without detrimental image noise, to leverage lower radiopharmaceutical doses by using dual-tracer techniques and with improved quantification. The potential for quantitative dynamic whole-body imaging using abbreviated protocols potentially makes these techniques viable for routine clinical use, transforming PET-reporting from a subjective analysis of semi-quantitative maps of radiopharmaceutical uptake at a single time-point to an accurate and quantitative, non-invasive tool to determine human function and physiology and to explore organ interactions and to perform whole-body systems analysis. This article will share the insights obtained from 2 years' of clinical operation of the first Biograph Vision Quadra (Siemens Healthineers) LAFOV system. It will also survey the current state-of-the-art in PET technology. Several technologies are poised to furnish systems with even greater sensitivity and resolution than current systems, potentially with orders of magnitude higher sensitivity. Current barriers which remain to be surmounted, such as data pipelines, patient throughput and the hindrances to implementing kinetic analysis for routine patient care will also be discussed.
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals ; Nuclear Medicine ; Kinetics ; Positron-Emission Tomography/methods
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2023-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2104862-9
    ISSN 1470-7330 ; 1470-7330
    ISSN (online) 1470-7330
    ISSN 1470-7330
    DOI 10.1186/s40644-023-00540-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Literature review: Imaging in prostate cancer.

    Mingels, Clemens / Loebelenz, Laura I / Huber, Adrian T / Alberts, Ian / Rominger, Axel / Afshar-Oromieh, Ali / Obmann, Verena C

    Current problems in cancer

    2023  Volume 47, Issue 2, Page(s) 100968

    Abstract: Imaging plays an increasingly important role in the detection and characterization of prostate cancer (PC). This review summarizes the key conventional and advanced imaging modalities including multiparametric magnetic resonance imaging (MRI) and ... ...

    Abstract Imaging plays an increasingly important role in the detection and characterization of prostate cancer (PC). This review summarizes the key conventional and advanced imaging modalities including multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging and tries to instruct clinicians in finding the best image modality depending on the patient`s PC-stage. We aim to give an overview of the different image modalities and their benefits and weaknesses in imaging PC. Emphasis is put on primary prostate cancer detection and staging as well as on recurrent and castration resistant prostate cancer. Results from studies using various imaging techniques are discussed and compared. For the different stages of PC, advantages and disadvantages of the different imaging modalities are discussed. Moreover, this review aims to give an outlook about upcoming, new imaging modalities and how they might be implemented in the future into clinical routine. Imaging patients suffering from PC should aim for exact diagnosis, accurate detection of PC lesions and should mirror the true tumor burden. Imaging should lead to the best patient treatment available in the current PC-stage and should avoid unnecessary therapeutic interventions. New image modalities such as long axial field of view PET/CT with photon-counting CT and radiopharmaceuticals like androgen receptor targeting radiopharmaceuticals open up new possibilities. In conclusion, PC imaging is growing and each image modality is aiming for improvement.
    MeSH term(s) Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Positron-Emission Tomography ; Magnetic Resonance Imaging/methods
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2023-06-04
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 441816-5
    ISSN 1535-6345 ; 0147-0272
    ISSN (online) 1535-6345
    ISSN 0147-0272
    DOI 10.1016/j.currproblcancer.2023.100968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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