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Article ; Online: Author's Response to Ferreira:

Camacho, Angela Domínguez

Photobiomodulation, photomedicine, and laser surgery

2020 Volume 38, Issue 6, Page(s) 328–331

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Letter ; Comment
ISSN	2578-5478
ISSN (online)	2578-5478
DOI	10.1089/photob.2020.4899
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Author's Response to Ferreira: Can Transdermal Photobiomodulation Help Us at the Time of COVID-19? An Update

Camacho, Angela Domínguez

Photobiomodul Photomed Laser Surg

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #613726
Database	COVID19

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Article ; Online: Author's Response to Ferreira

Camacho, Angela Domínguez

Photobiomodulation, Photomedicine, and Laser Surgery

Can Transdermal Photobiomodulation Help Us at the Time of COVID-19? An Update

2020 Volume 38, Issue 6, Page(s) 328–331

Keywords	covid19
Language	English
Publisher	Mary Ann Liebert Inc
Publishing country	us
Document type	Article ; Online
ISSN	2578-5478
DOI	10.1089/photob.2020.4899
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effective Wavelength Range in Photobiomodulation for Tooth Movement Acceleration in Orthodontics: A Systematic Review.

Domínguez Camacho, Angela / Montoya Guzmán, Diana / Velásquez Cujar, Sergio Andrés

Photobiomodulation, photomedicine, and laser surgery

2020 Volume 38, Issue 10, Page(s) 581–590

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Acceleration ; Low-Level Light Therapy ; Orthodontics ; Tooth Movement Techniques
Keywords	covid19
Language	English
Publishing date	2020-06-30
Publishing country	United States
Document type	Journal Article ; Systematic Review
ISSN	2578-5478
ISSN (online)	2578-5478
DOI	10.1089/photob.2020.4814
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A systematic review of the effective laser wavelength range in delivering photobiomodulation for pain relief in active orthodontic treatment.

Domínguez Camacho, Angela / Bravo Reyes, Mateo / Velasquez Cujar, Sergio Andrés

International orthodontics

2020 Volume 18, Issue 4, Page(s) 684–695

Abstract: Objective: This systematic review aimed to establish an effective wavelength range for PhotoBioModulation (PBM) to relieve pain in orthodontic treatments.: Material and methods: The electronic literature search was carried out in the following ... ...

Abstract	Objective: This systematic review aimed to establish an effective wavelength range for PhotoBioModulation (PBM) to relieve pain in orthodontic treatments. Material and methods: The electronic literature search was carried out in the following databases: PubMed, ISI Web of Science, Scopus, and Cochrane. In the initial search, 255 papers were obtained. Deleting duplicates in the search left 180 items. One manually searched study was included for a total of 181 studies. According to PRISMA guidelines and a thorough analysis of their methodology, the final sample was composed of 13 RCTs. The final statistical analysis was performed in 11 studies. The statistical analysis sought to strengthen the collected data, determining the correlation coefficient (r) for the same time interval (24h) using a scale equivalent to the standard value (0-10cm). Aiming to reduce the effect of heterogeneity, the difference in cm between control group (GC) and experimental group (EG) averages was considered the outcome. This difference was correlated with the wavelength in nm, calculating the Pearson linear correlation coefficient, and calculating a logarithmic correlation. Results: The dispersion of the data obtained in the experimental groups at each given wavelength showed that the most significant number of studies were in the ranges of 780-830nm. The correlation between the wavelength and the difference between the control and experimental group averages, either linear (R2=0.0564, r=0.237) or logarithmic (R2=0.0688, r=0.262) was not significant (P>0.90). Therefore, pain reduction after 24h is not significantly dependent of wavelength. Conclusion: The majority of RCTs related to pain relief in orthodontic treatment showed 780-830nm as the most effective photobiomodulation wavelength range for orthodontic pain relief. However, pain reduction after 24h is not significantly dependent of wavelength. The protocol was registered in PROSPERO (CRD42019119799).
MeSH term(s)	Databases, Factual ; Humans ; Laser Therapy ; Lasers ; Orthodontics ; Pain/radiotherapy ; Pain Measurement ; Tooth Movement Techniques/adverse effects ; Tooth Movement Techniques/methods
Language	English
Publishing date	2020-10-12
Publishing country	France
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	1879-680X
ISSN (online)	1879-680X
DOI	10.1016/j.ortho.2020.08.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effective Wavelength Range in Photobiomodulation for Tooth Movement Acceleration in Orthodontics: A Systematic Review

Domínguez Camacho, Angela / Montoya Guzmán, Diana / Velásquez Cujar, Sergio Andrés

Photobiomodul Photomed Laser Surg

Abstract: Objective: The present systematic review aims to establish an effective range of low-level laser therapy wavelengths to accelerate tooth movement in orthodontic treatments. Materials and methods: The electronic literature search was carried out in the ... ...

Abstract	Objective: The present systematic review aims to establish an effective range of low-level laser therapy wavelengths to accelerate tooth movement in orthodontic treatments. Materials and methods: The electronic literature search was carried out in the following databases: PubMed, ISI Web of Science, Scopus, and Cochrane randomized controlled trials (RCTs). The protocol (CRD42019117648) was registered in PROSPERO. Results: According to PRISMA guidelines and after applying the inclusion criteria, nine RCTs were included. Three blind reviewers independently assessed the methodological quality and evidence level of selected articles. Evidence level classification was established according to the recommendations of SIGN 50 (Scottish Intercollegiate Guidelines Network 2012) and was high quality being ++, acceptable +, low quality -, unacceptable -, reject 0. Conclusions: The majority of RCTs related to accelerating the tooth movement in orthodontic treatments are ideally between 780 and 830 nm wavelengths. The average increase in speed movement calculated as a percentage of the control group in nine studies is 24%. Further studies are necessary to establish the exact dosimeter in photobiomodulation during orthodontic movement.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32609566
Database	COVID19

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Article ; Online: Photobiomodulation as oedema adjuvant in post-orthognathic surgery patients: A randomized clinical trial.

Domínguez Camacho, Angela / Velásquez, Sergio Andrés / Benjumea Marulanda, Neftalí Joaquín / Moreno, Mauricio

International orthodontics

2019 Volume 18, Issue 1, Page(s) 69–78

Abstract: Objective: Photobiomodulation therapy (PBMT) has been used in multiple applications in general medicine as powerful anti-inflammatory, analgesic and reducing oedema in different parts of the body. The aim of this study is to compare the effect on post- ... ...

Abstract	Objective: Photobiomodulation therapy (PBMT) has been used in multiple applications in general medicine as powerful anti-inflammatory, analgesic and reducing oedema in different parts of the body. The aim of this study is to compare the effect on post-surgical oedema after mandibular orthognathic surgery, between two different laser power densities and oral medication with non-steroidal anti-inflammatory. Materials and methods: In a randomized clinical trial, on 60 patients who were subject to mandibular orthognathic surgery were divided into three groups. All groups received sodium naproxen 250mg every 8hours for 6days. Two groups were irradiated with two different laser application protocols and the other was a control group. In G1 group the irradiation parameters three times per week for two weeks were: 940nm, in continuous mode, 2.5W, 120s, 85.71J/cm Results: All differences between T1 and T6 were significant for the three groups, (paired T, P<0.05). The differences between the groups were generally not significant (P>0.05) except for commissure - right and left gonion when compared G1 vs CG (P<0.05) and G2 vs CG (P<0.05). Initial changes (T1-T2) between groups were significantly different except for the measurement from commissure to right tragus G1 vs CG (P=0.411) and from commissure to left tragus G2 vs CG (P=0.94). The faster resolution of the oedema occurred in G2 group. PTBM with an energy density of 68.33J/cm
MeSH term(s)	Adolescent ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Edema/drug therapy ; Edema/prevention & control ; Edema/radiotherapy ; Female ; Humans ; Low-Level Light Therapy ; Male ; Mandible/surgery ; Naproxen/therapeutic use ; Orthognathic Surgical Procedures/adverse effects ; Pain, Postoperative/prevention & control ; Postoperative Complications/drug therapy ; Postoperative Complications/prevention & control ; Postoperative Complications/radiotherapy ; Radiotherapy, Adjuvant ; Young Adult
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Naproxen (57Y76R9ATQ)
Language	English
Publishing date	2019-10-31
Publishing country	France
Document type	Journal Article ; Randomized Controlled Trial
ISSN	1879-680X
ISSN (online)	1879-680X
DOI	10.1016/j.ortho.2019.09.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dental movement acceleration: Literature review by an alternative scientific evidence method.

Camacho, Angela Domínguez / Velásquez Cujar, Sergio Andres

World journal of methodology

2014 Volume 4, Issue 3, Page(s) 151–162

Abstract: The aim of this study was to analyze the majority of publications using effective methods to speed up orthodontic treatment and determine which publications carry high evidence-based value. The literature published in Pubmed from 1984 to 2013 was ... ...

Abstract	The aim of this study was to analyze the majority of publications using effective methods to speed up orthodontic treatment and determine which publications carry high evidence-based value. The literature published in Pubmed from 1984 to 2013 was reviewed, in addition to well-known reports that were not classified under this database. To facilitate evidence-based decision making, guidelines such as the Consolidation Standards of Reporting Trials, Preferred Reporting items for systematic Reviews and Meta-analyses, and Transparent Reporting of Evaluations with Non-randomized Designs check list were used. The studies were initially divided into three groups: local application of cell mediators, physical stimuli, and techniques that took advantage of the regional acceleration phenomena. The articles were classified according to their level of evidence using an alternative method for orthodontic scientific article classification. 1a: Systematic Reviews (SR) of randomized clinical trials (RCTs), 1b: Individual RCT, 2a: SR of cohort studies, 2b: Individual cohort study, controlled clinical trials and low quality RCT, 3a: SR of case-control studies, 3b: Individual case-control study, low quality cohort study and short time following split mouth designs. 4: Case-series, low quality case-control study and non-systematic review, and 5: Expert opinion. The highest level of evidence for each group was: (1) local application of cell mediators: the highest level of evidence corresponds to a 3B level in Prostaglandins and Vitamin D; (2) physical stimuli: vibratory forces and low level laser irradiation have evidence level 2b, Electrical current is classified as 3b evidence-based level, Pulsed Electromagnetic Field is placed on the 4(th) level on the evidence scale; and (3) regional acceleration phenomena related techniques: for corticotomy the majority of the reports belong to level 4. Piezocision, dentoalveolar distraction, alveocentesis, monocortical tooth dislocation and ligament distraction technique, only had case series or single report cases (4(th) level of evidence). Surgery first and periodontal distraction have 1 study at level 2b and corticision one report at level 5. Multiple orthodontic acceleration reports on humans were identified by an alternative evidence level scale, which is a simple and accurate way of determining which techniques are better and have a higher rate of effectiveness. The highest level of evidence for a specific procedure to accelerate orthodontic dental movement up to October 2013 was surgery first followed by low level laser application, corticotomy and periodontal distraction located on level 2, recommendation grade b from this proposed scientific evidence-based scale.
Language	English
Publishing date	2014-09-26
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2222-0682
ISSN	2222-0682
DOI	10.5662/wjm.v4.i3.151
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.

Block, Jana / Rashkova, Christina / Castanon, Irinka / Zoghi, Samaneh / Platon, Jessica / Ardy, Rico C / Fujiwara, Mitsuhiro / Chaves, Beatriz / Schoppmeyer, Rouven / van der Made, Caspar I / Jimenez Heredia, Raul / Harms, Frederike L / Alavi, Samin / Alsina, Laia / Sanchez Moreno, Paula / Ávila Polo, Rainiero / Cabrera-Pérez, Rocío / Kostel Bal, Sevgi / Pfajfer, Laurène /

Ransmayr, Bernhard / Mautner, Anna-Katharina / Kondo, Ryohei / Tinnacher, Anna / Caldera, Michael / Schuster, Michael / Domínguez Conde, Cecilia / Platzer, René / Salzer, Elisabeth / Boyer, Thomas / Brunner, Han G / Nooitgedagt-Frons, Judith E / Iglesias, Estíbaliz / Deyà-Martinez, Angela / Camacho-Lovillo, Marisol / Menche, Jörg / Bock, Christoph / Huppa, Johannes B / Pickl, Winfried F / Distel, Martin / Yoder, Jeffrey A / Traver, David / Engelhardt, Karin R / Linden, Tobias / Kager, Leo / Hannich, J Thomas / Hoischen, Alexander / Hambleton, Sophie / Illsinger, Sabine / Da Costa, Lydie / Kutsche, Kerstin / Chavoshzadeh, Zahra / van Buul, Jaap D / Antón, Jordi / Calzada-Hernández, Joan / Neth, Olaf / Viaud, Julien / Nishikimi, Akihiko / Dupré, Loïc / Boztug, Kaan

The New England journal of medicine

2023 Volume 389, Issue 6, Page(s) 527–539

Abstract: Background: Increasing evidence links genetic defects affecting actin-regulatory proteins to diseases with severe autoimmunity and autoinflammation, yet the underlying molecular mechanisms are poorly understood. Dedicator of cytokinesis 11 (DOCK11) ... ...

Abstract	Background: Increasing evidence links genetic defects affecting actin-regulatory proteins to diseases with severe autoimmunity and autoinflammation, yet the underlying molecular mechanisms are poorly understood. Dedicator of cytokinesis 11 (DOCK11) activates the small Rho guanosine triphosphatase (GTPase) cell division cycle 42 (CDC42), a central regulator of actin cytoskeleton dynamics. The role of DOCK11 in human immune-cell function and disease remains unknown. Methods: We conducted genetic, immunologic, and molecular assays in four patients from four unrelated families who presented with infections, early-onset severe immune dysregulation, normocytic anemia of variable severity associated with anisopoikilocytosis, and developmental delay. Functional assays were performed in patient-derived cells, as well as in mouse and zebrafish models. Results: We identified rare, X-linked germline mutations in Conclusions: Germline hemizygous loss-of-function mutations affecting the actin regulator DOCK11 were shown to cause a previously unknown inborn error of hematopoiesis and immunity characterized by severe immune dysregulation and systemic inflammation, recurrent infections, and anemia. (Funded by the European Research Council and others.).
MeSH term(s)	Animals ; Humans ; Mice ; Actins/genetics ; Actins/metabolism ; Anemia/etiology ; Anemia/genetics ; Disease Models, Animal ; Guanine Nucleotide Exchange Factors/deficiency ; Guanine Nucleotide Exchange Factors/genetics ; Hematopoiesis ; Inflammation/etiology ; Inflammation/genetics ; Zebrafish/genetics ; Zebrafish/metabolism
Chemical Substances	Actins ; CDC42 protein, human (EC 3.6.5.2) ; Cdc42 protein, mouse ; Guanine Nucleotide Exchange Factors
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMoa2210054
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Article ; Online: Management and outcomes of patients with left atrial appendage thrombus prior to percutaneous closure.

Marroquin, Luis / Tirado-Conte, Gabriela / Pracoń, Radosław / Streb, Witold / Gutierrez, Hipolito / Boccuzzi, Giacomo / Arzamendi-Aizpurua, Dabit / Cruz-González, Ignacio / Ruiz-Nodar, Juan Miguel / Kim, Jung-Sun / Freixa, Xavier / Lopez-Minguez, Jose Ramon / De Backer, Ole / Ruiz-Salmeron, Rafael / Dominguez, Antonio / McInerney, Angela / Peral, Vicente / Estevez-Loureiro, Rodrigo / Fernandez-Nofrerias, Eduard /

Heart (British Cardiac Society)

2022 Volume 108, Issue 14, Page(s) 1098–1106

Abstract: Objective: Left atrial appendage (LAA) thrombus has heretofore been considered a contraindication to percutaneous LAA closure (LAAC). Data regarding its management are very limited. The aim of this study was to analyse the medical and invasive treatment ...

Abstract	Objective: Left atrial appendage (LAA) thrombus has heretofore been considered a contraindication to percutaneous LAA closure (LAAC). Data regarding its management are very limited. The aim of this study was to analyse the medical and invasive treatment of patients referred for LAAC in the presence of LAA thrombus. Methods: This multicentre observational registry included 126 consecutive patients referred for LAAC with LAA thrombus on preprocedural imaging. Treatment strategies included intensification of antithrombotic therapy (IAT) or direct LAAC. The primary and secondary endpoints were a composite of bleeding, stroke and death at 18 months, and procedural success, respectively. Results: IAT was the preferred strategy in 57.9% of patients, with total thrombus resolution observed in 60.3% and 75.3% after initial and subsequent IAT, respectively. Bleeding complications and stroke during IAT occurred in 9.6% and 2.9%, respectively, compared with 3.8% bleeding and no embolic events in the direct LAAC group before the procedure. Procedural success was 90.5% (96.2% vs 86.3% in direct LAAC and IAT group, respectively, p=0.072), without cases of in-hospital thromboembolic complications. The primary endpoint occurred in 29.3% and device-related thrombosis was found in 12.8%, without significant difference according to treatment strategy. Bleeding complications at 18 months occurred in 22.5% vs 10.5% in the IAT and direct LAAC group, respectively (p=0.102). Conclusion: In the presence of LAA thrombus, IAT was the initial management strategy in half of our cohort, with initial thrombus resolution in 60% of these, but with a relatively high bleeding rate (~10%). Direct LAAC was feasible, with high procedural success and absence of periprocedural embolic complications. However, a high rate of device-related thrombosis was detected during follow-up.
MeSH term(s)	Atrial Appendage/diagnostic imaging ; Atrial Fibrillation/complications ; Atrial Fibrillation/therapy ; Cardiac Catheterization/adverse effects ; Heart Diseases/diagnostic imaging ; Heart Diseases/etiology ; Heart Diseases/therapy ; Hemorrhage/etiology ; Humans ; Stroke/complications ; Stroke/prevention & control ; Thrombosis/complications ; Thrombosis/prevention & control ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2021-319811
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