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  1. Article ; Online: Author's reply.

    Lei, Shaoqing / Xia, Zhong-Yuan / Xia, Zhengyuan

    EClinicalMedicine

    2020  Volume 23, Page(s) 100386

    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100386
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  2. Article ; Online: Exploring adsorption capacity and mechanisms involved in cadmium removal from aqueous solutions by biochar derived from euhalophyte

    Shaoqing Ge / Shuai Zhao / Lei Wang / Zhenyong Zhao / Shoule Wang / Changyan Tian

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 11

    Abstract: Abstract Biochar has shown potential as a sorbent for reducing Cd levels in water. Euhalophytes, which thrive in saline-alkali soils containing high concentrations of metal ions and anions, present an intriguing opportunity for producing biochar with ... ...

    Abstract Abstract Biochar has shown potential as a sorbent for reducing Cd levels in water. Euhalophytes, which thrive in saline-alkali soils containing high concentrations of metal ions and anions, present an intriguing opportunity for producing biochar with inherent metal adsorption properties. This study focused on biochar derived from the euhalophyte Salicornia europaea and aimed to investigate its Cd adsorption capacity through adsorption kinetics and isotherm experiments. The results demonstrated that S. europaea biochar exhibited a high specific surface area, substantial base cation content, and a low negative surface charge, making it a highly effective adsorbent for Cd. The adsorption data fit well with the Langmuir isotherm model, revealing a maximum adsorption capacity of 108.54 mg g−1 at 25 °C. The adsorption process involved both surface adsorption and intraparticle diffusion. The Cd adsorption mechanism on the biochar encompassed precipitation, ion exchange, functional group complexation, and cation-π interactions. Notably, the precipitation of Cd2+ with CO3 2− in the biochar played a dominant role, accounting for 73.7% of the overall removal mechanism. These findings underscore the potential of euhalophytes such as S. europaea as a promising solution for remediating Cd contamination in aquatic environments.
    Keywords Medicine ; R ; Science ; Q
    Subject code 541
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Exploring adsorption capacity and mechanisms involved in cadmium removal from aqueous solutions by biochar derived from euhalophyte.

    Ge, Shaoqing / Zhao, Shuai / Wang, Lei / Zhao, Zhenyong / Wang, Shoule / Tian, Changyan

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 450

    Abstract: Biochar has shown potential as a sorbent for reducing Cd levels in water. Euhalophytes, which thrive in saline-alkali soils containing high concentrations of metal ions and anions, present an intriguing opportunity for producing biochar with inherent ... ...

    Abstract Biochar has shown potential as a sorbent for reducing Cd levels in water. Euhalophytes, which thrive in saline-alkali soils containing high concentrations of metal ions and anions, present an intriguing opportunity for producing biochar with inherent metal adsorption properties. This study focused on biochar derived from the euhalophyte Salicornia europaea and aimed to investigate its Cd adsorption capacity through adsorption kinetics and isotherm experiments. The results demonstrated that S. europaea biochar exhibited a high specific surface area, substantial base cation content, and a low negative surface charge, making it a highly effective adsorbent for Cd. The adsorption data fit well with the Langmuir isotherm model, revealing a maximum adsorption capacity of 108.54 mg g
    MeSH term(s) Cadmium/analysis ; Adsorption ; Water Purification/methods ; Water ; Charcoal ; Cations ; Kinetics ; Water Pollutants, Chemical/analysis
    Chemical Substances Cadmium (00BH33GNGH) ; biochar ; Water (059QF0KO0R) ; Charcoal (16291-96-6) ; Cations ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50525-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management

    Lei Peng / Yu Chen / Shaoqing Shi / Heling Wen

    Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-

    2022  Volume 19

    Abstract: Abstract Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent years, it remains the most common cause of end-stage renal disease. An early diagnosis and therapy may slow down the DN progression. Numerous potential ... ...

    Abstract Abstract Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent years, it remains the most common cause of end-stage renal disease. An early diagnosis and therapy may slow down the DN progression. Numerous potential biomarkers are currently being researched. Circulating levels of the kidney-released exosomes and biological molecules, which reflect the DN pathology including glomerular and tubular dysfunction as well as mesangial expansion and fibrosis, have shown the potential for predicting the occurrence and progression of DN. Moreover, many experimental therapies are currently being investigated, including stem cell therapy and medications targeting inflammatory, oxidant, or pro-fibrotic pathways activated during the DN progression. The therapeutic potential of stem cells is partly depending on their secretory capacity, particularly exosomal microRNAs (Exo-miRs). In recent years, a growing line of research has shown the participation of Exo-miRs in the pathophysiological processes of DN, which may provide effective therapeutic and biomarker tools for DN treatment. Methods A systematic literature search was performed in MEDLINE, Scopus, and Google Scholar to collect published findings regarding therapeutic stem cell-derived Exo-miRs for DN treatment as well as circulating Exo-miRs as potential DN-associated biomarkers. Findings Glomerular mesangial cells and podocytes are the most important culprits in the pathogenesis of DN and, thus, can be considered valuable therapeutic targets. Preclinical investigations have shown that stem cell-derived exosomes can exert beneficial effects in DN by transferring renoprotective miRs to the injured mesangial cells and podocytes. Of note, renoprotective Exo-miR-125a secreted by adipose-derived mesenchymal stem cells can improve the injured mesangial cells, while renoprotective Exo-miRs secreted by adipose-derived stem cells (Exo-miR-486 and Exo-miR-215-5p), human urine‐derived stem cells (Exo-miR-16-5p), and bone marrow-derived mesenchymal ...
    Keywords Biomarker ; Exosome ; Diabetic nephropathy ; microRNA ; Serum ; Stem cell ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
    Subject code 571
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: The complete mitochondrial genome of

    Fang, Jingping / Xu, Xiuming / Chen, Qinchang / Lin, Aiting / Lin, Shaoqing / Lei, Wen / Zhong, Cairong / Huang, Yongji / He, Yongjin

    Frontiers in microbiology

    2022  Volume 13, Page(s) 966219

    Abstract: ... The ... ...

    Abstract The haptophyte
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.966219
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  6. Article: Release characteristics of elemental mercury during low calorific value coal combustion.

    Gao, Libing / Liu, Kai / Guo, Shaoqing / Liang, Lei / Li, Hongyan

    Royal Society open science

    2022  Volume 9, Issue 5, Page(s) 211961

    Abstract: The dynamic release characteristics of ... ...

    Abstract The dynamic release characteristics of Hg
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.211961
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  7. Article ; Online: Author's reply - Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection.

    Lei, Shaoqing / Jiang, Fang / Xia, Zhong-Yuan / Xia, Zhengyuan

    EClinicalMedicine

    2020  Volume 22, Page(s) 100363

    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy.

    Zhou, Lu / Su, Wating / Wang, Yafeng / Zhang, Yuefu / Xia, Zhongyuan / Lei, Shaoqing

    Diabetes, obesity & metabolism

    2023  Volume 26, Issue 2, Page(s) 732–744

    Abstract: Aims: To investigate the role of FOXO1 in STAT3 activation and mitochondrial quality control in the diabetic heart.: Methods: Type 1 diabetes mellitus (T1DM) was induced in rats by a single intraperitoneal injection of 60 mg · kg: Results: Rats ... ...

    Abstract Aims: To investigate the role of FOXO1 in STAT3 activation and mitochondrial quality control in the diabetic heart.
    Methods: Type 1 diabetes mellitus (T1DM) was induced in rats by a single intraperitoneal injection of 60 mg · kg
    Results: Rats with T1DM or T2DM had excessive cardiac FOXO1 activation, accompanied by decreased STAT3 activation. Immunofluorescence and immunoprecipitation analysis showed colocalization and association of FOXO1 and STAT3 under basal conditions in isolated cardiomyocytes. Selective inhibition of FOXO1 activation by AS1842856 or FOXO1 siRNA transfection improved STAT3 activation, mitophagy and mitochondrial fusion, and decreased mitochondrial fission in isolated cardiomyocytes exposed to HG. Transfection with STAT3 siRNA further reduced mitophagy, mitochondrial fusion and increased mitochondrial fission in HG-treated cardiomyocytes. AS1842856 alleviated cardiac dysfunction, pathological damage and improved STAT3 activation, mitophagy and mitochondrial dynamics in diabetic db/db mice. Additionally, AS1842856 improved mitochondrial function indicated by increased mitochondrial membrane potential and adenosine triphosphate production and decreased mitochondrial reactive oxygen species production in isolated cardiomyocytes exposed to HG.
    Conclusions: Excessive FOXO1 activation during diabetes reduces STAT3 activation, with subsequent impairment of mitochondrial quality, ultimately promoting the development of diabetic cardiomyopathy.
    MeSH term(s) Animals ; Mice ; Rats ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Cardiomyopathies ; Glucose/metabolism ; Mitochondria ; Myocytes, Cardiac/metabolism ; RNA, Small Interfering/therapeutic use
    Chemical Substances Glucose (IY9XDZ35W2) ; RNA, Small Interfering ; Foxo1 protein, rat ; Foxo1 protein, mouse ; Stat3 protein, rat ; Stat3 protein, mouse
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15369
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Nobiletin alleviates myocardial ischemia-reperfusion injury via ferroptosis in rats with type-2 diabetes mellitus.

    Huang, Qin / Tian, Liqun / Zhang, Yi / Qiu, Zhen / Lei, Shaoqing / Xia, Zhong-Yuan

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 163, Page(s) 114795

    Abstract: Susceptibility to myocardial ischemia-reperfusion (IR) injury in type-2 diabetes (T2DM) remains disputed, although studies have reported that ferroptosis is associated with myocardial IR injury. Nobiletin, a flavonoid isolated from citrus peels, is an ... ...

    Abstract Susceptibility to myocardial ischemia-reperfusion (IR) injury in type-2 diabetes (T2DM) remains disputed, although studies have reported that ferroptosis is associated with myocardial IR injury. Nobiletin, a flavonoid isolated from citrus peels, is an antioxidant that possesses anti-inflammatory and anti-diabetic activities. However, it remains unknown whether nobiletin has any protective effects on susceptibility to myocardial IR injury during T2DM in rats via ferroptosis. To investigate the effects and underlying mechanisms of nobiletin on myocardial IR injury during T2DM, we induced myocardial IR model in rats at T2DM onset vs mature disease. We also established a high-fat high-glucose (HFHG) and hypoxia-reoxygenation (H/R) model in H9c2 cells to imitate abnormal glycolipid metabolism during T2DM. Myocardial injury, oxidative stress and ferroptosis towards myocardial IR in rats with mature T2DM but not at T2DM onset were increased. These changes were restored under treatment with ferrostain-1 or nobiletin. Both ferrostain-1 and nobiletin decreased the expression of ferroptosis-related proteins including Acyl-CoA synthetase long chain family member 4 (ACSL4) and nuclear receptor coactivator 4 (NCOA4) but not glutathione peroxidase 4 (GPX4) in rats with mature T2DM and cells with HFHG and H/R injury. Nobiletin strengthened the effect of si-ACSL4 on inhibiting ACSL4 expression, and also inhibited the effect of Erastin or oe-ACSL4 on increasing ACSL4 expression. Taken together, our data indicates that ferroptosis involves in susceptibility to myocardial IR injury in rats during T2DM. Nobiletin has therapeutic potential for alleviating myocardial IR injury associated with ACSL4- and NCOA4-related ferroptosis.
    MeSH term(s) Rats ; Animals ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/metabolism ; Ferroptosis ; Flavones/pharmacology ; Flavones/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Myocardial Ischemia/drug therapy ; Reperfusion Injury/metabolism
    Chemical Substances nobiletin (D65ILJ7WLY) ; Flavones
    Language English
    Publishing date 2023-05-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114795
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    Ud II Zs.198: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Pathogenicity and functional analysis of

    Yang, Shaoqing / Li, Ya / Yang, Lin / Guo, Qingge / You, Ya / Lei, Bo

    Frontiers in medicine

    2023  Volume 10, Page(s) 1216427

    Abstract: Background: Cone-rod dystrophy (CORD) caused by pathogenic variants in : Methods: A 6-year-old boy complained decreased vision for 1 year, underwent ocular examinations together with systemic X-ray check. Blood sample was taken for targeted next ... ...

    Abstract Background: Cone-rod dystrophy (CORD) caused by pathogenic variants in
    Methods: A 6-year-old boy complained decreased vision for 1 year, underwent ocular examinations together with systemic X-ray check. Blood sample was taken for targeted next generation sequencing (Tg-NGS). Pathogenicity of identified variants was determined by ACMG guideline. Mutated plasmids were constructed and transferred to HEK293T cells. Cell cycle, protein stability, and protein ubiquitination level was measured.
    Results: The best-corrected visual acuity of proband was 0.20 bilaterally. Fundus showed macular staphyloma and uneven granular pigment disorder in the periphery of the retina. SS-OCT showed thinning and atrophy of the outer retina, residual ellipsoid zone (EZ) in the fovea. Scotopic and photopic ERG responses severe reduced. Two heterozygous missense pathogenic variants, c.319 T > C (p.Tyr107His) and c.347 C > T (p.Pro116Leu) in exon 4 of the
    Conclusion: Compound heterozygous pathogenic variants c.319 T > C and c.347 C > T in
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1216427
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