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Article ; Online: l-Tryptophan-Induced Vasodilation Is Enhanced in Preeclampsia: Studies on Its Uptake and Metabolism in the Human Placenta.

Broekhuizen, Michelle / Klein, Theo / Hitzerd, Emilie / de Rijke, Yolanda B / Schoenmakers, Sam / Sedlmayr, Peter / Danser, A H Jan / Merkus, Daphne / Reiss, Irwin K M

Hypertension (Dallas, Tex. : 1979)

2020 Volume 76, Issue 1, Page(s) 184–194

Abstract: l-tryptophan induces IDO (indoleamine 2,3-dioxygenase) 1-dependent vasodilation. IDO1 is expressed ... to diminished placental perfusion, we studied l-tryptophan-induced vasodilation in healthy and early-onset ... this is due to enhanced l-tryptophan uptake, evidenced by increased l-tryptophan levels in preeclamptic ...

Abstract	l-tryptophan induces IDO (indoleamine 2,3-dioxygenase) 1-dependent vasodilation. IDO1 is expressed in placental endothelial cells and downregulated in preeclampsia. Hypothesizing that this may contribute to diminished placental perfusion, we studied l-tryptophan-induced vasodilation in healthy and early-onset preeclampsia placental arteries, focusing on placental kynurenine pathway alterations. Despite IDO1 downregulation, kynurenine pathway metabolite concentrations (measured with ultra-performance liquid chromatography-tandem mass spectrometry) were unaltered in preeclamptic versus healthy placentas. Most likely, this is due to enhanced l-tryptophan uptake, evidenced by increased l-tryptophan levels in preeclamptic placentas. Ex vivo perfused cotyledons from healthy and preeclamptic placentas released similar amounts of l-tryptophan and kynurenine pathway metabolites into the circulations. This release was not altered by adding l-tryptophan in the maternal circulation, suggesting that l-tryptophan metabolites act intracellularly. Maternally applied l-tryptophan did appear in the fetal circulation, confirming placental passage of this essential amino acid. After in vitro incubation of placental arteries with IDO1-upregulating cytokines interferon-γ and tumor necrosis factor-α, l-tryptophan induced vasodilation. This vasodilation was attenuated by both IDO1 and nitric oxide (NO) synthase inhibitors. Despite IDO1 downregulation, l-tryptophan-induced relaxation was enhanced in preeclamptic versus healthy placental arteries. However, cytokine stimulation additionally upregulated the LAT (l-type amino acid transporter) 1 in preeclamptic placental arteries only. Vasodilation to the lipophilic, transporter independent ethyl ester of l-tryptophan was reduced in preeclamptic versus healthy placental arteries, in agreement with reduced IDO1 expression. In conclusion, l-tryptophan induces IDO1- and NO-dependent relaxation in placental arteries, which is determined by l-tryptophan uptake rather than IDO1 expression. Increased l-tryptophan uptake might compensate for reduced IDO1 expression in preeclamptic placentas.
MeSH term(s)	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Adult ; Arteries/metabolism ; Carrier Proteins/biosynthesis ; Carrier Proteins/genetics ; Cytokines/pharmacology ; Enzyme Induction/drug effects ; Female ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/drug effects ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Kynurenine/metabolism ; Maternal-Fetal Exchange ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/antagonists & inhibitors ; Placenta/blood supply ; Placenta/drug effects ; Placenta/metabolism ; Pre-Eclampsia/enzymology ; Pre-Eclampsia/physiopathology ; Pregnancy ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Tryptophan/analogs & derivatives ; Tryptophan/pharmacology ; Vasodilation/drug effects
Chemical Substances	Carrier Proteins ; Cytokines ; IDO1 protein, human ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; RNA, Messenger ; Nitric Oxide (31C4KY9ESH) ; Kynurenine (343-65-7) ; tryptophan ethyl ester (6519-66-0) ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid (76898-47-0) ; Tryptophan (8DUH1N11BX) ; Nitric Oxide Synthase (EC 1.14.13.39)
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.120.14970
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Article ; Online: Optimally weighted L(2) distance for functional data.

Chen, Huaihou / Reiss, Philip T / Tarpey, Thaddeus

Biometrics

2014 Volume 70, Issue 3, Page(s) 516–525

Abstract: Many techniques of functional data analysis require choosing a measure of distance between functions, with the most common choice being L2 distance. In this article we show that using a weighted L2 distance, with a judiciously chosen weight function, can ...

Abstract	Many techniques of functional data analysis require choosing a measure of distance between functions, with the most common choice being L2 distance. In this article we show that using a weighted L2 distance, with a judiciously chosen weight function, can improve the performance of various statistical methods for functional data, including k-medoids clustering, nonparametric classification, and permutation testing. Assuming a quadratically penalized (e.g., spline) basis representation for the functional data, we consider three nontrivial weight functions: design density weights, inverse-variance weights, and a new weight function that minimizes the coefficient of variation of the resulting squared distance by means of an efficient iterative procedure. The benefits of weighting, in particular with the proposed weight function, are demonstrated both in simulation studies and in applications to the Berkeley growth data and a functional magnetic resonance imaging data set.
MeSH term(s)	Algorithms ; Computer Simulation ; Data Interpretation, Statistical ; Epidemiologic Methods ; Models, Statistical ; Sample Size
Language	English
Publishing date	2014-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	213543-7
ISSN	1541-0420 ; 0099-4987 ; 0006-341X
ISSN (online)	1541-0420
ISSN	0099-4987 ; 0006-341X
DOI	10.1111/biom.12161
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Article ; Online: Enhanced accumulation of harpagide and 8-O-acetyl-harpagide in Melittis melissophyllum L. agitated shoot cultures analyzed by UPLC-MS/MS.

Skrzypczak-Pietraszek, Ewa / Reiss, Katarzyna / Żmudzki, Paweł / Pietraszek, Jacek

PloS one

2018 Volume 13, Issue 8, Page(s) e0202556

Abstract: ... the effects of methyl jasmonate (MeJa, 50 μM), ethephon (Eth, 50 μM) and L-phenylalanine (L-Phe, 2.4 g/L ... with plant growth regulators: 6-benzylaminopurine 1.0 mg/L, α-naphthaleneacetic acid 0.5 mg/L, gibberellic acid 0.25 mg/L ... on the accumulation of harpagide and 8-O-acetyl-harpagide in Melittis melissophyllum L. agitated shoot cultures ...

Abstract	Harpagide and its derivatives have valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects. There is the demand for searching plant species containing these iridoids or developing biotechnological methods to obtain the compounds. The present study investigated the effects of methyl jasmonate (MeJa, 50 μM), ethephon (Eth, 50 μM) and L-phenylalanine (L-Phe, 2.4 g/L of medium), added to previously selected variant of Murashige and Skoog medium (supplemented with plant growth regulators: 6-benzylaminopurine 1.0 mg/L, α-naphthaleneacetic acid 0.5 mg/L, gibberellic acid 0.25 mg/L) on the accumulation of harpagide and 8-O-acetyl-harpagide in Melittis melissophyllum L. agitated shoot cultures. Plant material was harvested 2 and 8 days after the supplementation. Iridoids were quantitatively analyzed by the UPLC-MS/MS method in extracts from the biomass and the culture medium. It was found that all of the variants caused an increase in the accumulation of harpagide. In the biomass harvested after 2 days, the highest harpagide content of 247.3 mg/100 g DW was found for variant F (L-Phe and Eth), and the highest 8-O-acetyl-harpagide content of 138 mg/100 g DW for variant E (L-Phe and MeJa). After 8 days, in some variants, a portion of the metabolites was released into the culture medium. Considering the total amount of the compounds (in the biomass and medium), the highest accumulation of harpagide, amounting to 619 mg/100 g DW, was found in variant F, and the highest amount of 8-O-acetyl-harpagide, of 255.4 mg/100 g DW, was found in variant H (L-Phe, MeJa, Eth) when harvested on the 8th day. These amounts were, respectively, 24.7 and 4.8 times higher than in the control culture, and were, respectively, 15 and 6.7 times higher than in the leaves of the soil-grown plant. The total amount of the two iridoids was highest for variant F (0.78% DW) and variant H (0.68% DW) when harvested on the 8th day. The results indicate that the agitated shoot cultures of M. melissophyllum can be a rich source of harpagide and 8-O-acetyl-harpagide, having a potential practical application. To the best of our knowledge we present for the first time the results of the quantitative UPLC-MS/MS analysis of harpagide and 8-O-acetyl-harpagide in M. melissophyllum shoot cultures and the enhancement of their accumulation by means of medium supplementation with elicitors and precursor.
MeSH term(s)	Acetates/pharmacology ; Chromatography, High Pressure Liquid ; Culture Media ; Cyclopentanes/pharmacology ; Iridoid Glycosides/isolation & purification ; Iridoid Glycosides/metabolism ; Iridoids/pharmacology ; Lamiaceae/drug effects ; Lamiaceae/growth & development ; Lamiaceae/metabolism ; Mass Spectrometry ; Organophosphorus Compounds/pharmacology ; Oxylipins/pharmacology ; Phenylalanine/pharmacology ; Plant Leaves/drug effects ; Plant Leaves/growth & development ; Plant Leaves/metabolism ; Plant Shoots/drug effects ; Plant Shoots/growth & development ; Plant Shoots/metabolism ; Pyrans/isolation & purification ; Pyrans/metabolism
Chemical Substances	Acetates ; Culture Media ; Cyclopentanes ; Iridoid Glycosides ; Iridoids ; Organophosphorus Compounds ; Oxylipins ; Pyrans ; Phenylalanine (47E5O17Y3R) ; methyl jasmonate (900N171A0F) ; harpagide (OF59XHX7SR) ; ethephon (XU5R5VQ87S)
Language	English
Publishing date	2018-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0202556
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Article ; Online: Physiological changes in green stems of Vitis vinifera L. cv. Chardonnay in response to esca proper and apoplexy revealed by proteomic and transcriptomic analyses.

Spagnolo, Alessandro / Magnin-Robert, Maryline / Alayi, Tchilabalo Dilezitoko / Cilindre, Clara / Mercier, Laurence / Schaeffer-Reiss, Christine / Van Dorsselaer, Alain / Clément, Christophe / Fontaine, Florence

Journal of proteome research

2012 Volume 11, Issue 1, Page(s) 461–475

Abstract: Among grapevine trunk diseases, esca proper and apoplexy commonly represent a threat for viticulture worldwide. To retrieve further information about the mechanisms activated in apoplectic and esca proper-affected plants, a two-dimensional gel ... ...

Abstract	Among grapevine trunk diseases, esca proper and apoplexy commonly represent a threat for viticulture worldwide. To retrieve further information about the mechanisms activated in apoplectic and esca proper-affected plants, a two-dimensional gel electrophoresis (2-DE) based analysis was conducted on green stems from 26-year-old standing vines. Symptomatic and asymptomatic stems from both apoplectic (A) and esca proper-affected (E) plants compared to control (without visual symptom since 10 years) stems were studied. Thirty-three differentially expressed proteins were identified by nanoLC-MS/MS and included into three groups conceptually defined as proteins involved in (i) metabolism and energy, (ii) stress tolerance, and (iii) defense response. For nine of them, expression of the relative mRNA's was also monitored by qRT-PCR. Proteome variations were specifically related to apoplexy and esca proper but were more similar in asymptomatic stems than in the symptomatic ones. Remarkable quantitative differences were noted for several proteins in symptomatic stems according to the expressed form, A and E. Results further indicate that similar responses are likely activated in asymptomatic stems but a various quantitative expression is triggered upon onset of apoplexy or esca proper symptoms while both kind of plants are infected by the same pathogenic fungi.
MeSH term(s)	Electrophoresis, Gel, Two-Dimensional ; Energy Metabolism/genetics ; Fungi/isolation & purification ; Gene Expression Profiling ; Peptide Fragments/chemistry ; Peptide Mapping ; Plant Diseases/microbiology ; Plant Immunity/genetics ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Stems/genetics ; Plant Stems/metabolism ; Plant Stems/physiology ; Proteolysis ; Proteome/chemistry ; Proteome/genetics ; Proteome/metabolism ; Proteomics ; Real-Time Polymerase Chain Reaction ; Stress, Physiological ; Tandem Mass Spectrometry ; Transcriptome ; Vitis/genetics ; Vitis/metabolism ; Vitis/physiology
Chemical Substances	Peptide Fragments ; Plant Proteins ; Proteome
Language	English
Publishing date	2012-01-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/pr200892g
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Article ; Online: Enhanced accumulation of harpagide and 8-O-acetyl-harpagide in Melittis melissophyllum L. agitated shoot cultures analyzed by UPLC-MS/MS.

Ewa Skrzypczak-Pietraszek / Katarzyna Reiss / Paweł Żmudzki / Jacek Pietraszek

PLoS ONE, Vol 13, Iss 8, p e

2018 Volume 0202556

Abstract	Harpagide and its derivatives have valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects. There is the demand for searching plant species containing these iridoids or developing biotechnological methods to obtain the compounds. The present study investigated the effects of methyl jasmonate (MeJa, 50 μM), ethephon (Eth, 50 μM) and L-phenylalanine (L-Phe, 2.4 g/L of medium), added to previously selected variant of Murashige and Skoog medium (supplemented with plant growth regulators: 6-benzylaminopurine 1.0 mg/L, α-naphthaleneacetic acid 0.5 mg/L, gibberellic acid 0.25 mg/L) on the accumulation of harpagide and 8-O-acetyl-harpagide in Melittis melissophyllum L. agitated shoot cultures. Plant material was harvested 2 and 8 days after the supplementation. Iridoids were quantitatively analyzed by the UPLC-MS/MS method in extracts from the biomass and the culture medium. It was found that all of the variants caused an increase in the accumulation of harpagide. In the biomass harvested after 2 days, the highest harpagide content of 247.3 mg/100 g DW was found for variant F (L-Phe and Eth), and the highest 8-O-acetyl-harpagide content of 138 mg/100 g DW for variant E (L-Phe and MeJa). After 8 days, in some variants, a portion of the metabolites was released into the culture medium. Considering the total amount of the compounds (in the biomass and medium), the highest accumulation of harpagide, amounting to 619 mg/100 g DW, was found in variant F, and the highest amount of 8-O-acetyl-harpagide, of 255.4 mg/100 g DW, was found in variant H (L-Phe, MeJa, Eth) when harvested on the 8th day. These amounts were, respectively, 24.7 and 4.8 times higher than in the control culture, and were, respectively, 15 and 6.7 times higher than in the leaves of the soil-grown plant. The total amount of the two iridoids was highest for variant F (0.78% DW) and variant H (0.68% DW) when harvested on the 8th day. The results indicate that the agitated shoot cultures of M. melissophyllum can ...
Keywords	Medicine ; R ; Science ; Q
Subject code	580
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: R.E.N.A.L. Score Outperforms PADUA Score, C-Index and DAP Score for Outcome Prediction of Nephron Sparing Surgery in a Selected Cohort.

Borgmann, Hendrik / Reiss, Ann-Kathrin / Kurosch, Martin / Filmann, Natalie / Frees, Sebastian / Mager, Rene / Tsaur, Igor / Haferkamp, Axel

The Journal of urology

2016 Volume 196, Issue 3, Page(s) 664–671

Abstract: ... for patient, operative and tumor characteristics. Nephrometry scores, including R.E.N.A.L. (radius, exophytic ... and hospital stay were recorded as quantitative perioperative outcomes.: Results: The R.E.N.A.L ... score correlated best with MIC and quantitative perioperative outcomes. The continuously coded R.E.N.A.L ...

Abstract	Purpose: Several nephrometry scores have been proposed to predict perioperative outcomes in renal surgery. We evaluated which nephrometry score correlates best with the MIC (margin, ischemia and complications) score and quantitative perioperative outcomes in nephron sparing surgery. Materials and methods: Data on 188 patients undergoing nephron sparing surgery were retrospectively investigated for patient, operative and tumor characteristics. Nephrometry scores, including R.E.N.A.L. (radius, exophytic/endophytic properties, nearness of tumor to collecting system or sinus, anterior/posterior, hilar tumor touching the main renal artery or vein and location relative to polar lines), PADUA (preoperative aspects and dimensions used for an anatomical), C-index (concordance index) and DAP (diameter-axial-polar), were measured on preoperative computerized tomography or magnetic resonance imaging and coded continuously and categorically. Parameters pertaining to tumor margin, ischemia and complications were recorded as binary scores and classified as MIC achievement. Operative time, estimated blood loss, warm ischemia time and hospital stay were recorded as quantitative perioperative outcomes. Results: The R.E.N.A.L. score correlated best with MIC and quantitative perioperative outcomes. The continuously coded R.E.N.A.L. score was predictive of MIC on univariate analysis (OR 0.75, 95% CI 0.58-0.97, p = 0.03) and it had the best predictive value on multivariate logistic regression analysis (OR 0.31, 95% CI 0.18-0.82, p = 0.03). The C-index but not the PADUA or the DAP score was predictive of MIC on univariate and multivariate logistic regression analysis. MIC achievement rates were significantly higher for low than for high complexity tumors as assessed by categorically coded R.E.N.A.L. score, C-index and DAP scores. Continuously coded R.E.N.A.L. and PADUA scores positively correlated with operative time, warm ischemia time and hospital stay. The C-index and the DAP score correlated with warm ischemia time. Conclusions: Of 4 nephrometry scores the R.E.N.A.L. score correlated best with MIC achievement and quantitative perioperative outcomes of nephron sparing surgery.
MeSH term(s)	Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/physiopathology ; Carcinoma, Renal Cell/surgery ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Kidney/diagnostic imaging ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/physiopathology ; Kidney Neoplasms/surgery ; Laparoscopy/methods ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Staging ; Nephrectomy/methods ; Nephrons/pathology ; Nephrons/surgery ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed ; Tumor Burden
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2016.03.176
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Book ; Online ; Thesis: Einfluss von Defekten des Mismatch Reparatur Proteins MLH1 (Mut L Homolog 1) auf Fertilität und Tumorgenese im Mausmodell

Reiß, Cora

Impact of defects of the mismatch repair protein MLH1 (Mut L Homolog 1) on fertility and tumogenesis in mice

2010

Author's details	von Cora Reiß
Language	German
Size	Online-Ressource, Ill., graph. Darst
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Würzburg, 2010
Note	Zsfassung in dt. und engl. Sprache
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Online ; Thesis: Einfluss von Defekten des Mismatch-Reparatur-Proteins MLH1 (Mut L Homolog 1) auf Fertilität und Tumorgenese im Mausmodell

Reiß, Cora [Verfasser]

2010

Author's details	vorgelegt von Cora Reiß
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Language	German
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Book ; Thesis: The threatened brain

Reiß, Stefan

Psychological correlates of managing existential threats

2019

Abstract: ... DOI: 10.1371/journal.pone.0220732 (5) Reiss, S., Prentice, L., Schulte-Cloos, C. & Jonas, E. (2019 ... for future lines of research. - Contents: (1) Reiss, S. & Jonas, E. (2019). The cycle of intergroup conflict ... Reiss, S., Agroskin, D., Klackl, J., McGregor, I. & Jonas, E. (n. d.). The experiential nature ...

Title translation	Das bedrohte Gehirn: Psychologische Korrelate der Bewältigung existenzieller Bedrohungen
Abstract	Existential concerns such as the awareness of one's own mortality are ubiquitous in everyday life. Despite their influence on behavior, motivation, attitudes, and affect, humans have evolved to handle confrontations with these concerns in quick and efficient manners. The psychological processes associated with the immediate reactions to the experience of threat, however, are still fairly unknown. During my dissertation project, I aimed to investigate early and immediate responses to existential concerns and psychological threats. In this dissertation, I present five manuscripts with twelve experiments (total N = 1606). First, I discuss the importance of immediate activation of the behavioral inhibition system (BIS) in reaction to threat as motivationally fueling element for subsequent defense. The following empirical papers investigated the symptoms of BIS activation, with measures of affect, motivation, attention, and arousal. These experiments provided evidence for effects not only following mortality salience, but also other existential concerns such as uncontrollability, expectancy violations, and real-life situations such as the threatening aspects of organizational change. The research in this dissertation contributes to the literature by filling the literature gap regarding affective and motivational measures of BIS anxiety. It introduces a novel, experiential measure of BIS arousal in form of bodily sensation maps. Furthermore, the research investigates the interplay of BIS and approach system sensitivities with threat salience on attentional vigilance. In sum, this research enhances our understanding of threat experience, with many starting points for future lines of research. - Contents: (1) Reiss, S. & Jonas, E. (2019). The cycle of intergroup conflict: Terror management in the face of terrorism and war. In C. Routledge & M. Vess (Eds.), Handbook of terror management theory (pp. 449-484). Philadelphia, PA: Elsevier. DOI: 10.1016/B978-0-12-811844-3.00019-6 (2) Reiss, S., Agroskin, D., Klackl, J., McGregor, I. & Jonas, E. (n. d.). The experiential nature of immediate reactions to existential threat - Investigating the behavioral inhibition system. Manuscript submitted for publication. (3) Reiss, S., Klackl, J. & Jonas, E. (n. d.). The influence of dispositional approach/inhibition tendencies and threat salience on attentional bias - Insights from a dot probe paradigm. Manuscript in preparation. (4) Reiss, S., Klackl, J., Proulx, T. & Jonas, E. (2019). Strength of socio-political attitudes moderates electrophysiological responses to perceptual anomalies. PLoS ONE, 14:e0220732. DOI: 10.1371/journal.pone.0220732 (5) Reiss, S., Prentice, L., Schulte-Cloos, C. & Jonas, E. (2019). Organisationaler Wandel als Bedrohung - Von impliziter Angst zur Annäherung durch prozedurale Gerechtigkeit. Organizational change as threat - From implicit anxiety to approach through procedural justice. Gruppe. Interaktion. Organisation. Zeitschrift für Angewandte Organisationspsychologie (GIO), 50, 145-161. DOI: 10.1007/s11612-019-00469-x
Keywords	Attentional Bias ; Aufmerksamkeits-Bias ; Avoidance ; Behavioral Inhibition System ; Conflict Resolution ; Evoked Potentials ; Evozierte Potenziale ; Flüchtlinge ; Intergroup Dynamics ; Intergruppendynamik ; Konfliktlösung ; Physiological Arousal ; Physiologische Aktivierung ; Political Attitudes ; Politische Einstellungen ; Refugees ; Terror Management Theory ; Terror-Management-Theorie ; Uncertainty ; Ungewissheit ; Verhaltenshemmungssystem ; Vermeidung ; Vigilance ; Vigilanz
Language	English ; German
Size	35 S., 188 S. Anhang
Publisher	Universität, Natur- und Lebenswissenschaftliche Fakultät
Publishing place	Salzburg
Document type	Book ; Thesis
Note	Kumulative Dissertation
Database	PSYNDEX

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Article ; Online: Flowering as the most highly sensitive period of grapevine (Vitis vinifera L. cv Mourvèdre) to the Botryosphaeria dieback agents Neofusicoccum parvum and Diplodia seriata infection.

Spagnolo, Alessandro / Larignon, Philippe / Magnin-Robert, Maryline / Hovasse, Agnès / Cilindre, Clara / Van Dorsselaer, Alain / Clément, Christophe / Schaeffer-Reiss, Christine / Fontaine, Florence

International journal of molecular sciences

2014 Volume 15, Issue 6, Page(s) 9644–9669

Abstract: Botryosphaeria dieback is a fungal grapevine trunk disease that currently represents a threat for viticulture worldwide because of the important economical losses due to reduced yield of affected plants and their premature death. Neofusicoccum parvum and ...

Abstract	Botryosphaeria dieback is a fungal grapevine trunk disease that currently represents a threat for viticulture worldwide because of the important economical losses due to reduced yield of affected plants and their premature death. Neofusicoccum parvum and Diplodia seriata are among the causal agents. Vine green stems were artificially infected with N. parvum or D. seriata at the onset of three different phenological stages (G stage (separated clusters), flowering and veraison). Highest mean lesion lengths were recorded at flowering. Major proteome changes associated to artificial infections during the three different phenological stages were also reported using two dimensional gel electrophoresis (2D)-based analysis. Twenty (G stage), 15 (flowering) and 13 (veraison) differentially expressed protein spots were subjected to nanoLC-MS/MS and a total of 247, 54 and 25 proteins were respectively identified. At flowering, a weaker response to the infection was likely activated as compared to the other stages, and some defense-related proteins were even down regulated (e.g., superoxide dismutase, major latex-like protein, and pathogenesis related protein 10). Globally, the flowering period seemed to represent the period of highest sensitivity of grapevine to Botryosphaeria dieback agent infection, possibly being related to the high metabolic activity in the inflorescences.
MeSH term(s)	Ascomycota/physiology ; Electrophoresis, Gel, Two-Dimensional ; Plant Diseases/microbiology ; Plant Proteins/analysis ; Plant Proteins/metabolism ; Proteome/analysis ; Proteome/metabolism ; Proteomics ; Tandem Mass Spectrometry ; Vitis/growth & development ; Vitis/microbiology ; Vitis/physiology
Chemical Substances	Plant Proteins ; Proteome
Language	English
Publishing date	2014-05-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms15069644
Database	MEDical Literature Analysis and Retrieval System OnLINE

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