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  1. Article: Musculoskeletal Injuries and Risk Factors in Spanish CrossFit

    Lastra-Rodríguez, Lucas / Llamas-Ramos, Inés / Rodríguez-Pérez, Vicente / Llamas-Ramos, Rocío / López-Rodríguez, Ana F

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 9

    Abstract: ... ...

    Abstract CrossFit
    Language English
    Publishing date 2023-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11091346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The role of the brain renin-angiotensin system in Parkinson´s disease.

    Labandeira-Garcia, Jose Luis / Labandeira, Carmen M / Guerra, Maria J / Rodriguez-Perez, Ana I

    Translational neurodegeneration

    2024  Volume 13, Issue 1, Page(s) 22

    Abstract: The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS. Mutual regulation between the dopaminergic ... ...

    Abstract The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS. Mutual regulation between the dopaminergic system and RAS has been observed in several tissues. Dysregulation of these interactions leads to renal and cardiovascular diseases, as well as progression of dopaminergic neuron degeneration in a major brain center of dopamine/angiotensin interaction such as the nigrostriatal system. A decrease in the dopaminergic function induces upregulation of the angiotensin type-1 (AT1) receptor activity, leading to recovery of dopamine levels. However, AT1 receptor overactivity in dopaminergic neurons and microglial cells upregulates the cellular NADPH-oxidase-superoxide axis and Ca
    MeSH term(s) Animals ; Humans ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensins/metabolism ; Blood Pressure ; Brain/metabolism ; Dopamine ; Parkinson Disease/pathology ; Receptor, Angiotensin, Type 1/metabolism ; Renin-Angiotensin System/physiology
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensins ; Dopamine (VTD58H1Z2X) ; Receptor, Angiotensin, Type 1
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2653701-1
    ISSN 2047-9158
    ISSN 2047-9158
    DOI 10.1186/s40035-024-00410-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Therapeutic Exercise Intervention Using Vibration Platforms for Glycemic Control in Type 2 Diabetes: A Pilot Study.

    Fabregat-Fernández, Juan / Rodríguez-Pérez, Vicente / Llamas-Ramos, Rocío / López-Rodríguez, Ana Felicitas / Seco-Calvo, Jesús / Llamas-Ramos, Inés

    Journal of clinical medicine

    2023  Volume 12, Issue 20

    Abstract: Diabetes generates a great impact on society, as well as a concern for health professionals due to its high and increasing prevalence; there are several studies that demonstrate the effectiveness of vibration platforms and their benefits at a ... ...

    Abstract Diabetes generates a great impact on society, as well as a concern for health professionals due to its high and increasing prevalence; there are several studies that demonstrate the effectiveness of vibration platforms and their benefits at a physiological level. The aim of this study will be to analyze the decrease in glycosylated hemoglobin and glycemia levels after the use of whole-body vibration platforms and the possible inclusion of this therapeutic option within the usual treatments. This is a double-blind, randomized controlled trial with parallel group design in a 1:1 ratio. The sample will be composed of people diagnosed with type 2 diabetes mellitus in in the Plasencia area (Cáceres, Extremadura). Participants will be randomly assigned to the intervention or control group using a randomization list and will follow the inclusion criteria: type 2 diabetics between 50 and 60 years of age and not taking diabetes medication. All participants will undergo a determination of glycosylated hemoglobin, blood pressure, lipid profile, weight and height, and different functional tests such as Time Up and Go, 10 Meters Walk Test, and 5 Sit To Stand. The experimental group will perform a whole-body vibration intervention on an oscillating platform for 12 weeks with a weekly frequency of three nonconsecutive days and a duration of 12 min. The exercises will consist of 60 s of work and 60 s with rest. The control group will carry out their normal life insisting on the importance of glycemic controls before and after their daily physical exercise. This study has been registered at clinical.trial.org, ID: NCT05968222. Whole-body vibration platforms have demonstrated their effectiveness in different pathologies such as stroke, fibromyalgia, sclerosis multiple, or Parkinson's. For that reason, an improvement in glycemic and lipid values and body composition are expected in people with diabetes after a whole-body vibration intervention for 12 weeks' duration. In addition, whole-body vibration platforms could be postulated as an alternative to usual treatments.
    Language English
    Publishing date 2023-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12206518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lymphocyte transformation test in the diagnosis of adult fish-induced enterocolitis syndrome.

    Entrala, Ana / Domínguez-Ortega, Javier / Pulido Lucas, Elisa / Losantos, Itsaso / Lluch-Bernal, Magdalena / Quirce, Santiago / Rodríguez-Perez, Rosa

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 9, Page(s) 2945–2947

    MeSH term(s) Animals ; Humans ; Lymphocyte Activation ; Fishes ; Food Hypersensitivity/diagnosis ; Enterocolitis/diagnosis ; Dietary Proteins
    Chemical Substances Dietary Proteins
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Immediate Effects of Whole-Body versus Local Dynamic Electrostimulation of the Abdominal Muscles in Healthy People Assessed by Ultrasound: A Randomized Controlled Trial.

    Álvarez-Barrio, Lorena / Rodríguez-Pérez, Vicente / Calvo-Lobo, César / Leirós-Rodríguez, Raquel / Alba-Pérez, Eduardo / López-Rodríguez, Ana Felicitas

    Biology

    2023  Volume 12, Issue 3

    Abstract: Dynamic electrostimulation consists of the application of local or global electrostimulation together with physical exercise. This study aimed to investigate the immediate effects of a dynamic electrostimulation session on the thickness of the abdominal ... ...

    Abstract Dynamic electrostimulation consists of the application of local or global electrostimulation together with physical exercise. This study aimed to investigate the immediate effects of a dynamic electrostimulation session on the thickness of the abdominal musculature, inter-rectus distance, heart rate, blood pressure, and body temperature, and to identify possible differences in its form of application. A total of 120 healthy participants were divided into three groups: the whole-body electrostimulation group, the local electrostimulation group, and the control group without electrical stimulation. All groups performed a single session with the same dynamic exercise protocol. Muscle thickness and inter-rectus distance were evaluated ultrasonographically using the Rehabilitative Ultrasound Imaging technique both at rest and in muscle contraction (the active straight leg raise test) to find the post-intervention differences. The results showed significant differences in immediate post-intervention heart rate, with a smaller increase in the local electrostimulation group compared to the control and whole-body electrostimulation groups. No significant differences were identified between the groups after the interventions in the rest of the variables analyzed. Therefore, a local application, with the same effects as a global application on the abdominal musculature, has fewer contraindications, which makes its use more advisable, especially in populations with cardiorespiratory disorders, for which more research is needed.
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12030454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission.

    Lage, Lucia / Rodriguez-Perez, Ana I / Villar-Cheda, Begoña / Labandeira-Garcia, Jose L / Dominguez-Meijide, Antonio

    NPJ Parkinson's disease

    2024  Volume 10, Issue 1, Page(s) 37

    Abstract: The brain renin-angiotensin system (RAS) has been related to dopaminergic degeneration, and high expression of the angiotensin II (AngII) type 1 receptor (AT1) gene is a marker of the most vulnerable neurons in humans. However, it is unknown whether ... ...

    Abstract The brain renin-angiotensin system (RAS) has been related to dopaminergic degeneration, and high expression of the angiotensin II (AngII) type 1 receptor (AT1) gene is a marker of the most vulnerable neurons in humans. However, it is unknown whether AngII/AT1 overactivation affects α-synuclein aggregation and transmission. In vitro, AngII/AT1 activation increased α-synuclein aggregation in dopaminergic neurons and microglial cells, which was related to AngII-induced NADPH-oxidase activation and intracellular calcium raising. In mice, AngII/AT1 activation was involved in MPTP-induced increase in α-synuclein expression and aggregation, as they significantly decreased in mice treated with the AT1 blocker telmisartan and AT1 knockout mice. Cell co-cultures (transwells) revealed strong transmission of α-synuclein from dopaminergic neurons to astrocytes and microglia. AngII induced a higher α-synuclein uptake by microglial cells and an increase in the transfer of α-synuclein among astroglial cells. However, AngII did not increase the release of α-synuclein by neurons. The results further support brain RAS dysregulation as a major mechanism for the progression of Parkinson's disease, and AT1 inhibition and RAS modulation as therapeutic targets.
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/s41531-024-00650-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Boolean analysis shows a high proportion of dopamine D

    Rivas-Santisteban, Rafael / Rico, Alberto José / Muñoz, Ana / Rodríguez-Pérez, Ana I / Reyes-Resina, Irene / Navarro, Gemma / Labandeira-García, José Luis / Lanciego, José Luis / Franco, Rafael

    Neurobiology of disease

    2023  Volume 188, Page(s) 106341

    Abstract: The antagonistic effect of adenosine on dopaminergic transmission in the basal ganglia indirect motor control pathway is mediated by dopamine ... ...

    Abstract The antagonistic effect of adenosine on dopaminergic transmission in the basal ganglia indirect motor control pathway is mediated by dopamine D
    MeSH term(s) Rats ; Animals ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Dopamine/metabolism ; Medium Spiny Neurons ; Adenosine/metabolism ; Reproducibility of Results ; Corpus Striatum/metabolism ; Receptors, Dopamine/metabolism ; Primates/metabolism ; Receptors, Purinergic P1/metabolism ; Receptor, Adenosine A2A/metabolism ; Receptors, Dopamine D1/metabolism
    Chemical Substances Dopamine (VTD58H1Z2X) ; Adenosine (K72T3FS567) ; Receptors, Dopamine ; Receptors, Purinergic P1 ; Receptor, Adenosine A2A ; Receptors, Dopamine D1
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2023.106341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4444: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The cannabinoid CB

    Rivas-Santisteban, Rafael / Lillo, Jaume / Raïch, Iu / Muñoz, Ana / Lillo, Alejandro / Rodríguez-Pérez, Ana I / Labandeira-García, José L / Navarro, Gemma / Franco, Rafael

    Experimental neurology

    2023  Volume 362, Page(s) 114319

    Abstract: It is of particular interest the potential of cannabinoid and angiotensin receptors as targets in the therapy of Parkinson's disease (PD). While endocannabinoids are neuromodulators that act through the ... ...

    Abstract It is of particular interest the potential of cannabinoid and angiotensin receptors as targets in the therapy of Parkinson's disease (PD). While endocannabinoids are neuromodulators that act through the CB
    MeSH term(s) Rats ; Animals ; Receptors, Cannabinoid/metabolism ; Levodopa ; Oxidopamine ; Corpus Striatum/metabolism ; Parkinson Disease/metabolism ; Cannabinoids ; Receptors, Angiotensin ; Angiotensins/metabolism ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism
    Chemical Substances Receptors, Cannabinoid ; Levodopa (46627O600J) ; Oxidopamine (8HW4YBZ748) ; Cannabinoids ; Receptors, Angiotensin ; Angiotensins ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Fungal Pathogens Associated with Aerial Symptoms of Avocado (

    Hernández, David / García-Pérez, Omar / Perera, Santiago / González-Carracedo, Mario A / Rodríguez-Pérez, Ana / Siverio, Felipe

    Microorganisms

    2023  Volume 11, Issue 3

    Abstract: Fungi of the family Botryosphaeriaceae are considered responsible for various symptoms in avocado such as dieback, external necrosis of branches and inflorescences, cankers on branches and trunks, or stem-end rot of fruits. In recent years, these ... ...

    Abstract Fungi of the family Botryosphaeriaceae are considered responsible for various symptoms in avocado such as dieback, external necrosis of branches and inflorescences, cankers on branches and trunks, or stem-end rot of fruits. In recent years, these problems are becoming more frequent in avocado orchards in the Canary Islands (Spain). This work includes the characterization of fungal species involved in these diseases, which were isolated from avocado crops in Tenerife Island between 2018 and 2022. A total of 158 vegetal samples were collected, from which 297 fungal isolates were culture-isolated. Fifty-two of them were selected according to their morphological features as representative isolates of Botryosphaeriaceae, and their molecular characterization was carried out, sequencing the ITS1-2 region as well as the
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11030585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Angiotensin System Autoantibodies Correlate With Routine Prognostic Indicators for COVID-19 Severity.

    Labandeira, Carmen M / Pedrosa, Maria A / Suarez-Quintanilla, Juan A / Cortes-Ayaso, María / Labandeira-García, José Luis / Rodríguez-Pérez, Ana I

    Frontiers in medicine

    2022  Volume 9, Page(s) 840662

    Abstract: Objective: We previously showed that angiotensin type-1 receptor and ACE2 autoantibodies (AT1-AA, ACE2-AA) are associated with COVID-19 severity. Our aim is to find correlations of these autoantibodies with routine biochemical parameters that allow an ... ...

    Abstract Objective: We previously showed that angiotensin type-1 receptor and ACE2 autoantibodies (AT1-AA, ACE2-AA) are associated with COVID-19 severity. Our aim is to find correlations of these autoantibodies with routine biochemical parameters that allow an initial classification of patients.
    Methods: In an initial cohort of 119 COVID-19 patients, serum AT1-AA and ACE2-AA concentrations were obtained within 24 h after diagnosis. In 50 patients with a complete set of routine biochemical parameters, clinical data and disease outcome information, a Random Forest algorithm was used to select prognostic indicators, and the Spearman coefficient was used to analyze correlations with AT1-AA, ACE2-AA.
    Results: Hemoglobin, lactate dehydrogenase and procalcitonin were selected. A decrease in one unit of hemoglobin, an increase in 0.25 units of procalcitonin, or an increase in 100 units of lactate dehydrogenase increased the severity of the disease by 35.27, 69.25, and 3.2%, respectively. Our binary logistic regression model had a predictive capability to differentiate between mild and moderate/severe disease of 84%, and between mild/moderate and severe disease of 76%. Furthermore, the selected parameters showed strong correlations with AT1-AA or ACE2-AA, particularly in men.
    Conclusion: Hemoglobin, lactate dehydrogenase and procalcitonin can be used for initial classification of COVID-19 patients in the admission day. Subsequent determination of more complex or late arrival biomarkers may provide further data on severity, mechanisms, and therapeutic options.
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.840662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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