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Article ; Online: Why do people die from COVID-19?

Bastard, Paul

2022 Volume 375, Issue 6583, Page(s) 829–830

Abstract: Autoantibodies that neutralize type I interferons increase with age. ...

Abstract	Autoantibodies that neutralize type I interferons increase with age.
MeSH term(s)	Aging ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; COVID-19/complications ; COVID-19/immunology ; COVID-19/mortality ; Humans ; Interferon Type I/immunology ; Patient Acuity ; Polyendocrinopathies, Autoimmune/complications ; Polyendocrinopathies, Autoimmune/immunology ; Virus Diseases/immunology
Chemical Substances	Antibodies, Neutralizing ; Autoantibodies ; Interferon Type I
Language	English
Publishing date	2022-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abn9649
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: Le déficit en interférons de type I n’affecte pas la réponse immunitaire humorale au vaccin contre le SARS-CoV-2.

Sokal, Aurélien / Bastard, Paul / Casanova, Jean-Laurent / Weill, Jean-Claude / Chappert, Pascal / Mahévas, Matthieu

Medecine sciences : M/S

2024 Volume 40, Issue 1, Page(s) 99–101

Title translation	Type I interferon deficiency does not impair humoral immune response to SARS-CoV-2 vaccination.
MeSH term(s)	Humans ; Immunity, Humoral ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; Vaccination ; Antibodies, Viral
Chemical Substances	COVID-19 Vaccines ; Antibodies, Viral
Language	French
Publishing date	2024-02-01
Publishing country	France
Document type	Journal Article
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2023182
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Zs.B 2872: Show issues

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Article ; Online: Autoantibodies Neutralizing Type I INFs May Be Associated with Efficacy of Tocilizumab in COVID-19 Pneumonia.

Chauvineau-Grenier, Angélique / Bastard, Paul / Casanova, Jean-Laurent / Rossi, Benjamin

Journal of clinical immunology

2022 Volume 42, Issue 6, Page(s) 1107–1110

MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Autoantibodies ; Humans ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Monoclonal, Humanized ; Autoantibodies ; tocilizumab (I031V2H011)
Language	English
Publishing date	2022-06-08
Publishing country	Netherlands
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-022-01295-5
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Article ; Online: Human autoantibodies underlying infectious diseases.

Puel, Anne / Bastard, Paul / Bustamante, Jacinta / Casanova, Jean-Laurent

The Journal of experimental medicine

2022 Volume 219, Issue 4

Abstract: The vast interindividual clinical variability observed in any microbial infection-ranging from silent infection to lethal disease-is increasingly being explained by human genetic and immunological determinants. Autoantibodies neutralizing specific ... ...

Abstract	The vast interindividual clinical variability observed in any microbial infection-ranging from silent infection to lethal disease-is increasingly being explained by human genetic and immunological determinants. Autoantibodies neutralizing specific cytokines underlie the same infectious diseases as inborn errors of the corresponding cytokine or response pathway. Autoantibodies against type I IFNs underlie COVID-19 pneumonia and adverse reactions to the live attenuated yellow fever virus vaccine. Autoantibodies against type II IFN underlie severe disease caused by environmental or tuberculous mycobacteria, and other intra-macrophagic microbes. Autoantibodies against IL-17A/F and IL-6 are less common and underlie mucocutaneous candidiasis and staphylococcal diseases, respectively. Inborn errors of and autoantibodies against GM-CSF underlie pulmonary alveolar proteinosis; associated infections are less well characterized. In individual patients, autoantibodies against cytokines preexist infection with the pathogen concerned and underlie the infectious disease. Human antibody-driven autoimmunity can interfere with cytokines that are essential for protective immunity to specific infectious agents but that are otherwise redundant, thereby underlying specific infectious diseases.
MeSH term(s)	Autoantibodies ; COVID-19 ; Candidiasis, Chronic Mucocutaneous/genetics ; Communicable Diseases ; Humans ; Pulmonary Alveolar Proteinosis
Chemical Substances	Autoantibodies
Language	English
Publishing date	2022-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20211387
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

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Article ; Online: Human genetic and immunological determinants of critical COVID-19 pneumonia.

Zhang, Qian / Bastard, Paul / Cobat, Aurélie / Casanova, Jean-Laurent

Nature

2022 Volume 603, Issue 7902, Page(s) 587–598

Abstract: SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases. The ensuing risk of death (approximately 1% across age and gender) doubles ... ...

Abstract	SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases. The ensuing risk of death (approximately 1% across age and gender) doubles every five years from childhood onwards and is around 1.5 times greater in men than in women. Here we review the molecular and cellular determinants of critical COVID-19 pneumonia. Inborn errors of type I interferons (IFNs), including autosomal TLR3 and X-chromosome-linked TLR7 deficiencies, are found in around 1-5% of patients with critical pneumonia under 60 years old, and a lower proportion in older patients. Pre-existing auto-antibodies neutralizing IFNα, IFNβ and/or IFNω, which are more common in men than in women, are found in approximately 15-20% of patients with critical pneumonia over 70 years old, and a lower proportion in younger patients. Thus, at least 15% of cases of critical COVID-19 pneumonia can be explained. The TLR3- and TLR7-dependent production of type I IFNs by respiratory epithelial cells and plasmacytoid dendritic cells, respectively, is essential for host defence against SARS-CoV-2. In ways that can depend on age and sex, insufficient type I IFN immunity in the respiratory tract during the first few days of infection may account for the spread of the virus, leading to pulmonary and systemic inflammation.
MeSH term(s)	Age Distribution ; Autoantibodies/immunology ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/pathology ; Critical Illness ; Dendritic Cells/immunology ; Genome-Wide Association Study ; Humans ; Interferon Type I/genetics ; Interferon Type I/immunology ; Sex Distribution ; Toll-Like Receptor 3/deficiency ; Toll-Like Receptor 7/deficiency ; Toll-Like Receptor 7/genetics
Chemical Substances	Autoantibodies ; Interferon Type I ; TLR3 protein, human ; TLR7 protein, human ; Toll-Like Receptor 3 ; Toll-Like Receptor 7
Language	English
Publishing date	2022-01-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04447-0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article ; Online: Artificial Intelligence in Nephrology: Core Concepts, Clinical Applications, and Perspectives.

Niel, Olivier / Bastard, Paul

American journal of kidney diseases : the official journal of the National Kidney Foundation

2019 Volume 74, Issue 6, Page(s) 803–810

Abstract: Artificial intelligence is playing an increasingly important role in many fields of medicine, assisting physicians in most steps of patient management. In nephrology, artificial intelligence can already be used to improve clinical care, hemodialysis ... ...

Abstract	Artificial intelligence is playing an increasingly important role in many fields of medicine, assisting physicians in most steps of patient management. In nephrology, artificial intelligence can already be used to improve clinical care, hemodialysis prescriptions, and follow-up of transplant recipients. However, many nephrologists are still unfamiliar with the basic principles of medical artificial intelligence. This review seeks to provide an overview of medical artificial intelligence relevant to the practicing nephrologist, in all fields of nephrology. We define the core concepts of artificial intelligence and machine learning and cover the basics of the functioning of neural networks and deep learning. We also discuss the most recent clinical applications of artificial intelligence in nephrology and medicine; as an example, we describe how artificial intelligence can predict the occurrence of progressive immunoglobulin A nephropathy. Finally, we consider the future of artificial intelligence in clinical nephrology and its impact on medical practice, and conclude with a discussion of the ethical issues that the use of artificial intelligence raises in terms of clinical decision making, physician-patient relationship, patient privacy, and data collection.
MeSH term(s)	Algorithms ; Artificial Intelligence ; Female ; Forecasting ; Humans ; Machine Learning ; Male ; Nephrology/methods ; Nephrology/trends ; Quality Improvement
Language	English
Publishing date	2019-08-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2019.05.020
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 468: Show issues

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Article ; Online: Artificial intelligence improves estimation of tacrolimus area under the concentration over time curve in renal transplant recipients.

Niel, Olivier / Bastard, Paul

Transplant international : official journal of the European Society for Organ Transplantation

2018 Volume 31, Issue 8, Page(s) 940–941

MeSH term(s)	Area Under Curve ; Humans ; Immunosuppressive Agents/pharmacokinetics ; Kidney Transplantation ; Neural Networks (Computer) ; Tacrolimus/pharmacokinetics
Chemical Substances	Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2018-05-11
Publishing country	England
Document type	Letter
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.1111/tri.13271
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Zs.A 2358: Show issues

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Article ; Online: Low Lymphocytes and IFN-Neutralizing Autoantibodies as Biomarkers of COVID-19 Mortality.

Troya, Jesús / Bastard, Paul / Casanova, Jean-Laurent / Abel, Laurent / Pujol, Aurora

Journal of clinical immunology

2022 Volume 42, Issue 4, Page(s) 738–741

MeSH term(s)	Antibodies, Neutralizing ; Autoantibodies ; Biomarkers ; COVID-19 ; Humans ; Lymphocytes ; SARS-CoV-2
Chemical Substances	Antibodies, Neutralizing ; Autoantibodies ; Biomarkers
Language	English
Publishing date	2022-03-03
Publishing country	Netherlands
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-022-01241-5
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Article ; Online: Type I interferons and SARS-CoV-2: from cells to organisms.

Bastard, Paul / Zhang, Qian / Zhang, Shen-Ying / Jouanguy, Emmanuelle / Casanova, Jean-Laurent

Current opinion in immunology

2022 Volume 74, Page(s) 172–182

Abstract: Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro produce low levels of type I IFNs, and SARS-CoV-2 proteins can inhibit various ... ...

Abstract	Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro produce low levels of type I IFNs, and SARS-CoV-2 proteins can inhibit various steps in type I IFN production and response. Exogenous type I IFNs inhibit viral growth in vitro. In various animal species infected in vivo, type I IFN deficiencies underlie higher viral loads and more severe disease than in control animals. The early administration of exogenous type I IFNs improves infection control. In humans, inborn errors of, and auto-antibodies against type I IFNs underlie life-threatening COVID-19 pneumonia. Overall, type I IFNs are essential for host defense against SARS-CoV-2 in individual cells and whole organisms.
MeSH term(s)	Animals ; COVID-19/immunology ; Humans ; Interferon Type I/immunology ; SARS-CoV-2/immunology
Chemical Substances	Interferon Type I
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2022.01.003
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Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 13: Show issues

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Article ; Online: Impact of non-antibiotic drugs on the human intestinal microbiome.

Le Bastard, Quentin / Berthelot, Laureline / Soulillou, Jean-Paul / Montassier, Emmanuel

Expert review of molecular diagnostics

2021 Volume 21, Issue 9, Page(s) 911–924

Abstract: Introduction: The gut microbiota is composed of trillions of microbial cells and viruses that interact with hosts. The composition of the gut microbiota is influenced by several factors including age, diet, diseases, or medications. The impact of drugs ... ...

Abstract	Introduction: The gut microbiota is composed of trillions of microbial cells and viruses that interact with hosts. The composition of the gut microbiota is influenced by several factors including age, diet, diseases, or medications. The impact of drugs on the microbiota is not limited to antibiotics and many non-antibiotic molecules significantly alter the composition of the intestinal microbiota. Areas covered: This review focuses on the impact of four of the most widely prescribed non-antibiotic drugs in the world: Proton-pump inhibitors, metformin, statins, and non-steroidal anti-inflammatory. We conducted a systematic review by searching online databases including Medline, Web of science, and Scopus for indexed articles published in English until February 2021. We included studies assessing the intestinal microbiome alterations associated with proton pump inhibitors (PPIs), metformin, statins, and nonsteroidal anti-inflammatory drugs (NSAIDs). Only studies using culture-independent molecular techniques were included. Expert opinion: The taxonomical signature associated with non-antibiotic drugs are not yet fully described, especially in the field of metabolomic. The identification of taxonomic profiles associated a specific molecule provides information on its mechanism of action through interaction with the intestinal microbiota. Many side effects could be related to the dysbiosis induced by these molecules.
MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Dysbiosis/chemically induced ; Gastrointestinal Microbiome ; Humans ; Microbiota ; Proton Pump Inhibitors/adverse effects
Chemical Substances	Anti-Bacterial Agents ; Proton Pump Inhibitors
Language	English
Publishing date	2021-07-15
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	2112530-2
ISSN	1744-8352 ; 1473-7159
ISSN (online)	1744-8352
ISSN	1473-7159
DOI	10.1080/14737159.2021.1952075
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