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  1. Article ; Online: The International Consensus on ANA Patterns (ICAP): from conception to implementation.

    Damoiseaux, Jan

    Clinical chemistry and laboratory medicine

    2023  Volume 62, Issue 5, Page(s) 789–792

    MeSH term(s) Humans ; Consensus ; Autoimmune Diseases ; Antibodies, Antinuclear
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2023-11-17
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-1211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Autoantibodies in the criteria of autoimmune diseases: is it sufficient to know that the test is positive?

    Damoiseaux, Jan

    Journal of translational autoimmunity

    2022  Volume 5, Page(s) 100144

    Language English
    Publishing date 2022-01-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2022.100144
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  3. Article ; Online: Correspondence on "ACR/EULAR antiphospholipid syndrome classification criteria".

    Damoiseaux, Jan / van Beers, Joyce

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 3, Page(s) e6

    MeSH term(s) Humans ; Antiphospholipid Syndrome/diagnosis ; Sjogren's Syndrome ; Rheumatology
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-225067
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  4. Article ; Online: ANCA Testing in Clinical Practice: From Implementation to Quality Control and Harmonization.

    Damoiseaux, Jan

    Frontiers in immunology

    2021  Volume 12, Page(s) 656796

    Abstract: Analyses for the presence of anti-neutrophil cytoplasmic antibodies (ANCA) are important in the diagnostic work-up of patients with small vessel vasculitis. Since current immuno-assays are predominantly designed for diagnosis of patients with ANCA- ... ...

    Abstract Analyses for the presence of anti-neutrophil cytoplasmic antibodies (ANCA) are important in the diagnostic work-up of patients with small vessel vasculitis. Since current immuno-assays are predominantly designed for diagnosis of patients with ANCA-associated vasculitis (AAV), implementation in routine clinical practice, internal and external quality control, and harmonization are focused on this particular use. However, ANCA testing may also be relevant for monitoring therapy efficacy and for predicting a clinical relapse in AAV patients, and even for diagnostic purposes in other clinical situations. In the current review, the topics of implementation, quality control, and standardization vs. harmonization are discussed while taking into account the different applications of the ANCA assays in the context of AAV.
    MeSH term(s) Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Autoimmune Diseases/blood ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Biomarkers ; Clinical Decision-Making ; Disease Management ; Humans ; Immunoassay/methods ; Immunoassay/standards ; Prognosis ; Quality Control
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Biomarkers
    Language English
    Publishing date 2021-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.656796
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  5. Article: The perspective on standardisation and harmonisation: the viewpoint of the EASI president.

    Damoiseaux, Jan

    Auto- immunity highlights

    2020  Volume 11, Issue 1, Page(s) 4

    Abstract: Standardisation of immuno-assays for autoantibodies is a major challenge. Although multiple organisations participate in the generation of internationally accepted standards, adequate standardisation of assays has not yet been achieved. Harmonisation may ...

    Abstract Standardisation of immuno-assays for autoantibodies is a major challenge. Although multiple organisations participate in the generation of internationally accepted standards, adequate standardisation of assays has not yet been achieved. Harmonisation may offer an alternative approach to better align requesting, testing, reporting and interpretation of autoimmune diagnostics. The European Autoimmunity Standardisation Initiative (EASI) was founded to facilitate both standardisation as well as harmonisation of autoantibody tests, but over the years the focus has drifted away from standardisation in favour of harmonisation. In the current paper the options for harmonisation are highlighted.
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2563376-4
    ISSN 2038-3274 ; 2038-0305
    ISSN (online) 2038-3274
    ISSN 2038-0305
    DOI 10.1186/s13317-020-0127-3
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  6. Article ; Online: The IL-2 - IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor.

    Damoiseaux, Jan

    Clinical immunology (Orlando, Fla.)

    2020  Volume 218, Page(s) 108515

    Abstract: The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to ... ...

    Abstract The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is explored and the conflicting results on the function of sIL-2R are summarized. Finally, the added value of measuring sIL-2R in different types of diseases is being elaborated upon in terms of diagnosis, follow-up, and prognosis. Adequate interpretation of results is hampered by the apparent gap in our knowledge about the functional role of sIL-2R in immunity and tolerance.
    MeSH term(s) Animals ; Disease ; Health ; Humans ; Interleukin-2/immunology ; Receptors, Interleukin-2/immunology ; Signal Transduction
    Chemical Substances Interleukin-2 ; Receptors, Interleukin-2
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108515
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    Zs.A 880: Show issues Location:
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  7. Article ; Online: Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus.

    Damoiseaux, Jan / van Beers, Joyce

    Journal of translational autoimmunity

    2023  Volume 6, Page(s) 100191

    Abstract: Autoantibodies, in particular anti-dsDNA antibodies, are increasingly used for diagnosis, classification and follow-up of patients with SLE. Since standardization of autoantibody assays is a major challenge, more attention should be paid to harmonization ...

    Abstract Autoantibodies, in particular anti-dsDNA antibodies, are increasingly used for diagnosis, classification and follow-up of patients with SLE. Since standardization of autoantibody assays is a major challenge, more attention should be paid to harmonization initiatives and better definition of required test characteristics in classification criteria. For diagnosis and follow-up separate multi-center studies are required to establish test characteristics of distinct immuno-assays for both purposes. Finally, such studies should consider not to evaluate SLE as a single disease, but as a disease with distinct subtypes.
    Language English
    Publishing date 2023-01-21
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2023.100191
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  8. Article ; Online: Response to: 'Revised 2017 international consensus on ANCA testing in small vessel vasculitis: support from an external quality assessment' by Broeders

    Damoiseaux, Jan

    Annals of the rheumatic diseases

    2018  Volume 78, Issue 10, Page(s) e114–e111

    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ; Antibodies, Antineutrophil Cytoplasmic ; Consensus ; Fluorescent Antibody Technique, Indirect ; Humans ; Immunoassay
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2018-09-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2018-214243
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    Uh III Zs.114: Show issues Location:
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    Zs.MO 167: Show issues

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  9. Article ; Online: Are autoantibodies to RNA-polymerase III to be incorporated in routine diagnostic laboratory algorithms for systemic autoimmune rheumatic diseases?

    Damoiseaux, Jan

    Annals of the rheumatic diseases

    2014  Volume 73, Issue 5, Page(s) e29

    MeSH term(s) Diagnosis-Related Groups ; Humans ; Rheumatology ; Scleroderma, Systemic/classification ; Scleroderma, Systemic/diagnosis
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2014-205193
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  10. Article ; Online: The diagnosis and classification of the cryoglobulinemic syndrome.

    Damoiseaux, Jan

    Autoimmunity reviews

    2014  Volume 13, Issue 4-5, Page(s) 359–362

    Abstract: Cryoglobulinemia refers to the presence of reversible precipitation of immunoglobulins in the blood upon exposure to reduced (body) temperature. In clinical practice, the detection and typing of cryoglobulins appear to be poorly standardized. A consensus ...

    Abstract Cryoglobulinemia refers to the presence of reversible precipitation of immunoglobulins in the blood upon exposure to reduced (body) temperature. In clinical practice, the detection and typing of cryoglobulins appear to be poorly standardized. A consensus protocol for detection and typing of cryoglobulins, as extracted from the literature, is presented. Items that require further standardization are discussed. Cryoglobulins may cause clinical symptoms due to either obstruction of the small blood vessels, in particular in the extremities that are more exposed to the cold, or vascular inflammation due to the deposition of immune complexes. Only for the latter situation, i.e. cryoglobulinemic vasculitis in the presence of mixed-type cryoglobulinemia, preliminary classification criteria have been defined. Besides the presence of cryoglobulins, at least two of three items have to be present. These items include a restricted number of self-reported clinical history, typical clinical manifestations, and specified laboratory findings. These classification criteria await further validation in an independent patient cohort.
    MeSH term(s) Cryoglobulinemia/classification ; Cryoglobulinemia/diagnosis ; Cryoglobulinemia/immunology ; Cryoglobulins/immunology ; Diagnosis, Differential ; Humans ; Systemic Vasculitis/diagnosis
    Chemical Substances Cryoglobulins
    Language English
    Publishing date 2014-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2014.01.027
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