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  1. Article: Victor Harold Turnbull, M.B., B.Ch. (Rand), R.C.P. (Lond.), R.C.S. (Eng.).

    Bernstein, H

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    1971  Volume 45, Issue 34, Page(s) 955

    MeSH term(s) History, 20th Century ; Occupational Medicine ; South Africa
    Language English
    Publishing date 1971-08-28
    Publishing country South Africa
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0256-9574 ; 0038-2469
    ISSN (online) 2078-5135
    ISSN 0256-9574 ; 0038-2469
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.406: Show issues Location:
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    Zs.MO 645: Show issues

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  2. Article: Comparison of pooled semen insemination and single colony insemination as sustainable honeybee breeding strategies.

    Du, Manuel / Bernstein, Richard / Hoppe, Andreas

    Royal Society open science

    2024  Volume 11, Issue 1, Page(s) 231556

    Abstract: Instrumental insemination of honeybees allows for two opposing breeding strategies. In single colony insemination (SCI), all drones to inseminate a queen are taken from one colony. In pooled semen insemination (PSI), sperm of many genetically diverse ... ...

    Abstract Instrumental insemination of honeybees allows for two opposing breeding strategies. In single colony insemination (SCI), all drones to inseminate a queen are taken from one colony. In pooled semen insemination (PSI), sperm of many genetically diverse drones is mixed and queens are fertilized from the resulting drone pool. While SCI allows for maximum pedigree control, proponents of PSI claim to reduce inbreeding and maintain genetic variance. Using stochastic simulation studies, we compared genetic progress and inbreeding rates in small honeybee populations under SCI and PSI. Four different selection criteria were covered: estimated breeding values (EBV), phenotypes, true breeding values (TBV) and random selection. Under EBV-based truncation selection, SCI yielded 9.0% to 44.4% higher genetic gain than PSI, but had vastly increased inbreeding rates. Under phenotypical or TBV selection, the gap between SCI and PSI in terms of genetic progress narrowed. Throughout, PSI yielded lower inbreeding rates than SCI, but the differences were only substantial under EBV truncation selection. As a result, PSI did not appear as a viable breeding strategy owing to its incompatibility with modern methods of genetic evaluation. Instead, SCI is to be preferred but instead of strict truncation selection, strategies to avoid inbreeding need to be installed.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.231556
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  3. Article ; Online: Addressing myths related to racism and unconscious bias in the recruitment and hiring of academic dental faculty.

    Burgette, Jacqueline M / Bernstein, Eric R / Frazier-Bowers, Sylvia A

    Journal of the American Dental Association (1939)

    2023  Volume 154, Issue 10, Page(s) 871–873

    MeSH term(s) Humans ; Racism ; Bias, Implicit ; Faculty, Dental
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Editorial
    ZDB-ID 220622-5
    ISSN 1943-4723 ; 0002-8177 ; 1048-6364
    ISSN (online) 1943-4723
    ISSN 0002-8177 ; 1048-6364
    DOI 10.1016/j.adaj.2023.02.010
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Microbial hydrolysis of atrazine in contaminated groundwater.

    Arar, Mohammad / Bakkour, Rani / Elsner, Martin / Bernstein, Anat

    Chemosphere

    2023  Volume 322, Page(s) 138226

    Abstract: Degradation of the widespread herbicide atrazine has been intensively studied in soils, while its degradation in groundwater has received less attention. This work studied atrazine degradation in contaminated groundwater adjacent to its production plant. ...

    Abstract Degradation of the widespread herbicide atrazine has been intensively studied in soils, while its degradation in groundwater has received less attention. This work studied atrazine degradation in contaminated groundwater adjacent to its production plant. The degradation potential was first explored in groundwater enrichment cultures. A broad potential for microbial atrazine degradation was observed when atrazine served as the sole nitrogen source, even when incubated with nitrate. Hydroxyatrazine was formed by the cultures, while desethylatrazine and desisopropylatrazine were not detected. Both the atzA and the trzN genes were identified by quantitative PCR analysis, with a clear dominance of atzA. Carbon isotope enrichments throughout the degradation process varied between the different cultures, with ε values ranging from -0.6 to -5.5‰. This implies corresponding uncertainties when using compound-specific isotope analysis to estimate degradation extents. In the field samples, in-situ degradation was reflected by a high percentage of metabolites, with hydroxyatrazine accounting for >95% of the metabolites in most wells. Both atzA and trzN were detected in the groundwater at quantities of ≈10
    MeSH term(s) Atrazine/analysis ; Hydrolysis ; Herbicides/analysis ; Carbon Isotopes/analysis ; Groundwater ; Biodegradation, Environmental
    Chemical Substances Atrazine (QJA9M5H4IM) ; Herbicides ; Carbon Isotopes
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.138226
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  5. Article ; Online: The Potential of Instrumental Insemination for Sustainable Honeybee Breeding.

    Du, Manuel / Bernstein, Richard / Hoppe, Andreas

    Genes

    2023  Volume 14, Issue 9

    Abstract: Mating control is crucial in honeybee breeding and commonly guaranteed by bringing virgin queens to isolated mating stations (IMS) for their nuptial flights. However, most breeding programs struggle to provide sufficiently many IMS. Research institutions ...

    Abstract Mating control is crucial in honeybee breeding and commonly guaranteed by bringing virgin queens to isolated mating stations (IMS) for their nuptial flights. However, most breeding programs struggle to provide sufficiently many IMS. Research institutions routinely perform instrumental insemination of honeybees, but its potential to substitute IMS in breeding programs has not been sufficiently studied. We performed stochastic simulations to compare instrumental insemination strategies and mating on IMS in terms of genetic progress and inbreeding development. We focused on the role of paternal generation intervals, which can be shortened to two years with instrumental insemination in comparison to three years when using IMS. After 70 years, instrumental insemination yielded up to 42% higher genetic gain than IMS strategies-particularly with few available mating sites. Inbreeding rates with instrumental insemination and IMS were comparable. When the paternal generation interval in instrumental insemination was stretched to three years, the number of drone producers required for sustainable breeding was reduced substantially. In contrast, when shortening the interval to two years, it yielded the highest generational inbreeding rates (up to 2.28%). Overall, instrumental insemination with drones from a single colony appears as a viable strategy for honeybee breeding and a promising alternative to IMS.
    MeSH term(s) Bees/genetics ; Animals ; Reproduction/genetics ; Inbreeding ; Cell Communication ; Insemination
    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14091799
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  6. Article ; Online: Active querying approach to epidemic source detection on contact networks.

    Sterchi, Martin / Hilfiker, Lorenz / Grütter, Rolf / Bernstein, Abraham

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11363

    Abstract: The problem of identifying the source of an epidemic (also called patient zero) given a network of contacts and a set of infected individuals has attracted interest from a broad range of research communities. The successful and timely identification of ... ...

    Abstract The problem of identifying the source of an epidemic (also called patient zero) given a network of contacts and a set of infected individuals has attracted interest from a broad range of research communities. The successful and timely identification of the source can prevent a lot of harm as the number of possible infection routes can be narrowed down and potentially infected individuals can be isolated. Previous research on this topic often assumes that it is possible to observe the state of a substantial fraction of individuals in the network before attempting to identify the source. We, on the contrary, assume that observing the state of individuals in the network is costly or difficult and, hence, only the state of one or few individuals is initially observed. Moreover, we presume that not only the source is unknown, but also the duration for which the epidemic has evolved. From this more general problem setting a need to query the state of other (so far unobserved) individuals arises. In analogy with active learning, this leads us to formulate the active querying problem. In the active querying problem, we alternate between a source inference step and a querying step. For the source inference step, we rely on existing work but take a Bayesian perspective by putting a prior on the duration of the epidemic. In the querying step, we aim to query the states of individuals that provide the most information about the source of the epidemic, and to this end, we propose strategies inspired by the active learning literature. Our results are strongly in favor of a querying strategy that selects individuals for whom the disagreement between individual predictions, made by all possible sources separately, and a consensus prediction is maximal. Our approach is flexible and, in particular, can be applied to static as well as temporal networks. To demonstrate our approach's practical importance, we experiment with three empirical (temporal) contact networks: a network of pig movements, a network of sexual contacts, and a network of face-to-face contacts between residents of a village in Malawi. The results show that active querying strategies can lead to substantially improved source inference results as compared to baseline heuristics. In fact, querying only a small fraction of nodes in a network is often enough to achieve a source inference performance comparable to a situation where the infection states of all nodes are known.
    MeSH term(s) Animals ; Swine ; Bayes Theorem ; Epidemics/prevention & control ; Malawi
    Language English
    Publishing date 2023-07-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38282-8
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  7. Article ; Online: Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies.

    Seebald, Leah M / Haratipour, Pouya / Jacobs, Michaela R / Bernstein, Hannah M / Kashemirov, Boris A / McKenna, Charles E / Imperiali, Barbara

    Journal of the American Chemical Society

    2024  Volume 146, Issue 5, Page(s) 3220–3229

    Abstract: Complex bacterial glycoconjugates drive interactions between pathogens, symbionts, and their human hosts. Glycoconjugate biosynthesis is initiated at the membrane interface by phosphoglycosyl transferases (PGTs), which catalyze the transfer of a ... ...

    Abstract Complex bacterial glycoconjugates drive interactions between pathogens, symbionts, and their human hosts. Glycoconjugate biosynthesis is initiated at the membrane interface by phosphoglycosyl transferases (PGTs), which catalyze the transfer of a phosphosugar from a soluble uridine diphosphosugar (UDP-sugar) substrate to a membrane-bound polyprenol-phosphate (Pren-P). The two distinct superfamilies of PGT enzymes (polytopic and monotopic) show striking differences in their structure and mechanism. We designed and synthesized a series of uridine bisphosphonates (UBPs), wherein the diphosphate of the UDP and UDP-sugar is replaced by a substituted methylene bisphosphonate (CXY-BPs; X/Y = F/F, Cl/Cl, (
    MeSH term(s) Humans ; Transferases/chemistry ; Uridine ; Diphosphates ; Glycoconjugates/chemistry ; Diphosphonates ; Sugars ; Uridine Diphosphate
    Chemical Substances Transferases (EC 2.-) ; Uridine (WHI7HQ7H85) ; Diphosphates ; Glycoconjugates ; Diphosphonates ; Sugars ; Uridine Diphosphate (58-98-0)
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c11402
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    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  8. Article ; Online: Prevención de Incendios en la Sala de Operaciones: Vídeo en Anestesia Clínica.

    Bernstein, Wendy / Norris, Mark / Chase, Abbie / Hayes, Rebecca / Binda, Dhanesh / Ortega, Rafael

    Anesthesia and analgesia

    2024  Volume 138, Issue 4, Page(s) 913–917

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006788
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    Zs.MO 149: Show issues

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  9. Article ; Online: Operating Room Fire Prevention: Video in Clinical Anesthesia.

    Bernstein, Wendy / Norris, Mark / Chase, Abbie / Hayes, Rebecca / Binda, Dhanesh D / Ortega, Rafael

    Anesthesia and analgesia

    2024  Volume 138, Issue 4, Page(s) 909–912

    MeSH term(s) Operating Rooms ; Fires/prevention & control ; Anesthesia/adverse effects ; Anesthesiology
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006787
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  10. Article ; Online: sEMG Biofeedback for Episodic Migraines: A Pilot Randomized Clinical Trial.

    Lazaridou, Asimina / Paschali, Myrella / Bernstein, Carolyn / Curiel, Marie / Moore, Sara / Edwards, Robert R

    Applied psychophysiology and biofeedback

    2024  

    Abstract: The aim of this study was to assess the feasibility and potential effectiveness of a 6-week virtual sEMG biofeedback intervention for patients with episodic migraines. Patients with episodic migraines were randomized to treatment with a novel surface EMG ...

    Abstract The aim of this study was to assess the feasibility and potential effectiveness of a 6-week virtual sEMG biofeedback intervention for patients with episodic migraines. Patients with episodic migraines were randomized to treatment with a novel surface EMG (sEMG) at-home biofeedback device or a treatment as usual control group; they completed validated baseline and post-intervention assessments of migraine related disability (migraine-specific quality of life, anxiety and depression). Participants also underwent a series of Quantitative Sensory Testing (QST) procedures referring to several different tests that quantitatively assess responses to mechanical stimuli during two separate visits (baseline and post intervention). No adverse events were reported during the study. Compared to the treatment as usual comparison group, patients in the sEMG biofeedback group reported lower migraine disability (p < 0.05). Compared to baseline, participants in the sEMG biofeedback group demonstrated statistically significant reductions in anxiety (p < 0.01), and significant increases in quality of life (p < 0.001), and significant decreases in temporal summation (p < 0.05) assessed by QST. No significant changes were observed in any of the outcomes in the control comparison group (p > 0.05). No significant changes were observed in migraine frequency in either of the two groups (p > 0.05). In addition, mediation analyses revealed that changes in migraine related quality of life mediated group effects on changes in migraine disability. Virtual sEMG biofeedback shows promise as a potential therapy for reducing disability, anxiety and depression and improving quality of life in individuals with episodic migraines. These results demonstrate the feasibility of a digital intervention for migraines and set the basis for conducting a future, larger scale randomized controlled trial to confirm these preliminary findings.
    Language English
    Publishing date 2024-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1390949-6
    ISSN 1573-3270 ; 1090-0586
    ISSN (online) 1573-3270
    ISSN 1090-0586
    DOI 10.1007/s10484-023-09615-0
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