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Book ; Thesis: GRANULOCYTE-SPECIFIC ANTINUCLEAR ANTIBODIES

Wiik, Allan

POSSIBLE SIGNIFICANCE FOR THE PATHOGENESIS, CLINICAL FEATURES AND DIAGNOSIS OF RHEUMATOID ARTHRITIS

1980

Size	GETR. ZAEHLUNG
Publisher	FADL
Publishing place	KOEBENHAVN U.A
Document type	Book ; Thesis
Thesis / German Habilitation thesis	KOEBENHAVN, UNIV., DISS., 1980
HBZ-ID	HT002722651
ISBN	87-7437-789-2 ; 978-87-7437-789-4
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Clinical and pathophysiological significance of anti-neutrophil cytoplasmic autoantibodies in vasculitis syndromes.

Wiik, Allan

Modern rheumatology

2009 Volume 19, Issue 6, Page(s) 590–599

Abstract: Necrotizing vasculitis of small blood vessels is a rare condition, but when it affects important organs it can lead to life-threatening organ damage and death. Thus, recognizing these conditions at an early stage before they spread to become systemic is ... ...

Abstract	Necrotizing vasculitis of small blood vessels is a rare condition, but when it affects important organs it can lead to life-threatening organ damage and death. Thus, recognizing these conditions at an early stage before they spread to become systemic is a constant challenge to clinical medicine. The objectives of this review are: to give advice on clinical indications for ANCA diagnostics and laboratory procedures for highly specifically detecting the most important ANCA; to provide some data on the autoantigens involved in ANCA reactivity in small vessel vasculitides; and to discuss at the occurrence of ANCA in different vasculitic populations and at different stages of disease. One important task for the near future will be to standardize the assays used for ANCA detection/quantification and to harmonize the results given to clinicians by ensuring that international reference reagents are used by laboratories and the diagnostic industry. Finally, the author has attempted to summarize the role that ANCA are currently believed to play in the immuno-inflammatory events that take place in tissues and that affect small vessels in idiopathic vasculitis. The review concludes that the presence of ANCA is likely to become an important criterion for diagnosing idiopathic small vessel vasculitis.
MeSH term(s)	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Cytoplasm/immunology ; Humans ; Myeloblastin/immunology ; Neutrophils/immunology ; Pancreatic Elastase/immunology ; Peroxidase/immunology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Peroxidase (EC 1.11.1.7) ; Pancreatic Elastase (EC 3.4.21.36) ; Myeloblastin (EC 3.4.21.76)
Language	English
Publishing date	2009
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1007/s10165-009-0219-4
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Article: Drug-induced vasculitis.

Wiik, Allan

Current opinion in rheumatology

2008 Volume 20, Issue 1, Page(s) 35–39

Abstract: Purpose of review: This review aims to draw attention to the features that distinguish drug-induced vasculitis and drug-induced lupus-like disease from those of idiopathic autoimmune syndromes, first and foremost primary vasculitides and systemic lupus ... ...

Abstract	Purpose of review: This review aims to draw attention to the features that distinguish drug-induced vasculitis and drug-induced lupus-like disease from those of idiopathic autoimmune syndromes, first and foremost primary vasculitides and systemic lupus erythematosus. Drug-induced vasculitis and drug-induced lupus-like disease are seen in patients treated long term with a drug, and close to 100 drugs representing all pharmacologic classes have been assumed capable of inducing such syndromes. The clinical phenotypes vary from single tissue or organ involvement to severe systemic inflammatory disease dominated by vasculitis and sometimes organ failure. Recent findings: The recent discovery of antineutrophil cytoplasm antibodies in a large serological subset of drug-induced vasculitis/drug-induced lupus-like disease caused by long-term antithyroid drug treatment has opened new avenues for differential diagnostics. Antineutrophil cytoplasm antibodies with specificity to more than one lysosomal antigen, combined with presence of antibodies to histones and beta-2 glycoprotein 1 constitute a unique serological profile for drug-induced vasculitis/drug-induced lupus-like disease. Summary: Rational use of laboratory marker profiles is likely to aid in distinguishing drug-induced from idiopathic syndromes. Hence, the use of antineutrophil cytoplasm antibodies and other autoantibodies as biomarkers of different phenotypes of drug-induced vasculitis/drug-induced lupus-like disease is the main focus of this review.
MeSH term(s)	Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Antibodies, Antiphospholipid ; Antithyroid Agents/adverse effects ; Biomarkers ; Humans ; Lupus Erythematosus, Systemic/chemically induced ; Lupus Erythematosus, Systemic/immunology ; Vasculitis/chemically induced ; Vasculitis/immunology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Antibodies, Antiphospholipid ; Antithyroid Agents ; Biomarkers
Language	English
Publishing date	2008-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1045317-9
ISSN	1531-6963 ; 1040-8711
ISSN (online)	1531-6963
ISSN	1040-8711
DOI	10.1097/BOR.0b013e3282f1331f
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Article ; Online: Autoantibodies in ANCA-associated vasculitis.

Wiik, Allan S

Rheumatic diseases clinics of North America

2010 Volume 36, Issue 3, Page(s) 479–489

Abstract: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides are systemic or more limited conditions characterized by necrotizing destruction of small and medium-sized vessels (eg, capillaries, venules, and arterioles). ANCAs are the most ... ...

Abstract	Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides are systemic or more limited conditions characterized by necrotizing destruction of small and medium-sized vessels (eg, capillaries, venules, and arterioles). ANCAs are the most predominant autoantibodies in patients affected by vasculitis, but other autoantibodies may also occur, probably reflecting pathogenetic events in affected tissue. These autoantibodies are assumed to play a role in the initiation and propagation of chronic inflammation. ANCAs are valuable for clinical diagnosis, follow-up, and guidance in therapy.
MeSH term(s)	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Autoantibodies/immunology ; Endothelium, Vascular/immunology ; Humans ; Myeloblastin/immunology ; Peroxidase/immunology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Autoantibodies ; Peroxidase (EC 1.11.1.7) ; Myeloblastin (EC 3.4.21.76)
Language	English
Publishing date	2010-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	92118-x
ISSN	1558-3163 ; 0889-857X
ISSN (online)	1558-3163
ISSN	0889-857X
DOI	10.1016/j.rdc.2010.05.001
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Article: Guidelines for Antinuclear Antibody Testing.

Wiik, Allan S

EJIFCC

2006 Volume 17, Issue 3, Page(s) 134–140

Language	English
Publishing date	2006-10-01
Publishing country	Italy
Document type	Journal Article
ISSN	1650-3414
ISSN	1650-3414
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Article ; Online: Clinical and laboratory characteristics of drug-induced vasculitic syndromes.

Wiik, Allan

Arthritis research & therapy

2005 Volume 7, Issue 5, Page(s) 191–192

Abstract: Clinical recognition of drug-induced vasculitic and lupus-like syndromes is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary ... ...

Abstract	Clinical recognition of drug-induced vasculitic and lupus-like syndromes is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary haemorrhage). Withdrawal of the drug often leads to spontaneous recovery, meaning that immunosuppressive therapy can be avoided. The presence of myeloperoxidase-antineutrophil cytoplasmic antibodies, IgM anticardiolipin antibody, and antihistone antibodies in combination was found to be characteristic of drug-induced vasculitic syndromes caused by the antithyroid drugs propylthiouracil and methimazol. Clinically, skin vasculitis and arthralgias predominated and renal vasculitis was rare.
MeSH term(s)	Acute Kidney Injury/etiology ; Antibodies, Anticardiolipin/blood ; Antibodies, Antineutrophil Cytoplasmic/blood ; Antithyroid Agents/adverse effects ; Autoantibodies/blood ; Autoimmune Diseases/blood ; Autoimmune Diseases/chemically induced ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Churg-Strauss Syndrome/diagnosis ; Diagnosis, Differential ; Granulomatosis with Polyangiitis/diagnosis ; Humans ; Immunoglobulin M/blood ; Kidney/blood supply ; Lupus Erythematosus, Systemic/chemically induced ; Lupus Erythematosus, Systemic/diagnosis ; Methimazole/adverse effects ; Propylthiouracil/adverse effects ; Skin/blood supply ; Thrombophilia/etiology ; Vasculitis, Leukocytoclastic, Cutaneous/blood ; Vasculitis, Leukocytoclastic, Cutaneous/chemically induced ; Vasculitis, Leukocytoclastic, Cutaneous/complications ; Vasculitis, Leukocytoclastic, Cutaneous/diagnosis ; Vasculitis, Leukocytoclastic, Cutaneous/immunology
Chemical Substances	Antibodies, Anticardiolipin ; Antibodies, Antineutrophil Cytoplasmic ; Antithyroid Agents ; Autoantibodies ; Immunoglobulin M ; Methimazole (554Z48XN5E) ; Propylthiouracil (721M9407IY)
Language	English
Publishing date	2005
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/ar1805
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Article: The immune response to citrullinated proteins in patients with rheumatoid arthritis: genetic, clinical, technical, and epidemiological aspects.

Wiik, Allan S

Clinical reviews in allergy & immunology

2007 Volume 32, Issue 1, Page(s) 13–22

Abstract: This article reviews data concerning the applicability of anti-citrullinated peptide antibodies in the diagnosis, estimation of prognosis, and follow-up of patients with rheumatoid arthritis (RA). The production of anti-citrullinated peptide antibodies ... ...

Abstract	This article reviews data concerning the applicability of anti-citrullinated peptide antibodies in the diagnosis, estimation of prognosis, and follow-up of patients with rheumatoid arthritis (RA). The production of anti-citrullinated peptide antibodies is closely associated with the presence of the HLA-DRB1 shared epitope, a known risk factor for development of RA, and the production may be influenced by environmental factors such as tobacco smoking. Patients who harbor this antibody from the early stage of their disease develop more severe erosive disease than patients with RA who lack the antibody. The anti-citrullinated peptide antibody level may be a reflection of disease activity, at least in the early phase of the disease. The antibody can sometimes be found several years before the onset of clinical symptoms of RA, which may represent an open window for preventive measures to be taken.
MeSH term(s)	Animals ; Antibody Formation/immunology ; Antigens/immunology ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Biomarkers ; Epitopes/immunology ; Humans ; Peptides, Cyclic/immunology
Chemical Substances	Antigens ; Biomarkers ; Epitopes ; Peptides, Cyclic ; cyclic citrullinated peptide
Language	English
Publishing date	2007-04-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1239045-8
ISSN	1559-0267 ; 1080-0549
ISSN (online)	1559-0267
ISSN	1080-0549
DOI	10.1007/BF02686078
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Article ; Online: Autoantibodies in vasculitis.

Wiik, Allan

Arthritis research & therapy

2003 Volume 5, Issue 3, Page(s) 147–152

Abstract: Before the mid-1980s the only autoantibody widely used to assist in diagnosing vasculitic disease was IgG antibody to the alpha(3) domain of the noncollagenous part of type IV collagen (anti-glomerular basement membrane). Since that time, antineutrophil ... ...

Abstract	Before the mid-1980s the only autoantibody widely used to assist in diagnosing vasculitic disease was IgG antibody to the alpha(3) domain of the noncollagenous part of type IV collagen (anti-glomerular basement membrane). Since that time, antineutrophil cytoplasmic antibodies (ANCAs) directed at the azurophilic granule proteins proteinase-3 and myeloperoxidase have been established as clinically useful autoantibodies to support a diagnosis of Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and limited forms of these primary, small vessel necrotizing and often granulomatous vasculitides. The establishment of standardized methods for identifying those antibodies was needed before they could be used in clinical practice. The levels of both types of ANCAs tend to increase in parallel with the degree of clinical disease activity, and they decrease with successful immunosuppressive therapy. More than one assay may have to be used to discover imminent exacerbations in proteinase-3-ANCA associated syndromes. Although autoantibodies to endothelial cells may be important players in the pathogenesis of several vasculitic conditions, they have not gained clinical popularity because of lack of standardized detection methods.
MeSH term(s)	Antibodies, Antineutrophil Cytoplasmic/analysis ; Autoantibodies/analysis ; Autoantigens/immunology ; Humans ; Vasculitis/diagnosis ; Vasculitis/immunology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Autoantibodies ; Autoantigens
Language	English
Publishing date	2003-04-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/ar758
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Article: Neutrophil-specific autoantibodies in chronic inflammatory bowel diseases.

Wiik, Allan

Autoimmunity reviews

2003 Volume 1, Issue 1-2, Page(s) 67–72

Abstract: This review intends to highlight important differences between neutrophil-specific autoantibodies (NSA) typically found in chronic inflammatory bowel diseases (CIBD) and anti-neutrophil cytoplasm antibodies (ANCA) associated with primary systemic small ... ...

Abstract	This review intends to highlight important differences between neutrophil-specific autoantibodies (NSA) typically found in chronic inflammatory bowel diseases (CIBD) and anti-neutrophil cytoplasm antibodies (ANCA) associated with primary systemic small vessel vasculitides (SSVV). Indirect immunofluorescence (IF) techniques alone cannot distinguish NSA from ANCA and special measures must be taken to separate these two autoantibody populations. Many autoantigens originating in all cell compartments may be targeted by NSA in CIBD, several of these being constituents of neutrophil nuclei. Apart from the use of NSA in the differential diagnosis between Crohn's disease (CD) and ulcerative colitis (UC), very limited clinical significance is ascribed to these antibodies in CIBD. Laboratory reports on NSA-positivity must be clearly distinguishable from reports on ANCA to help avoid clinical misinterpretation.
MeSH term(s)	Animals ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Antibody Specificity ; Autoantibodies/immunology ; Humans ; Inflammatory Bowel Diseases/immunology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Autoantibodies
Language	English
Publishing date	2003-06-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1568-9972
ISSN	1568-9972
DOI	10.1016/s1568-9972(01)00007-6
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Article ; Online: A historical essay on detection of anti-neutrophil cytoplasmic antibodies.

Rasmussen, Niels / Wiik, Allan / Jayne, David R

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2015 Volume 30 Suppl 1, Page(s) i8–13

Abstract: In this essay we describe a number of the known and not so known experiences of the early anti-neutrophil cytoplasmic antibodies (ANCAs) days, explaining why and how we reached consensus on the standard indirect immunofluorescence (IIF) techniques, the ... ...

Abstract	In this essay we describe a number of the known and not so known experiences of the early anti-neutrophil cytoplasmic antibodies (ANCAs) days, explaining why and how we reached consensus on the standard indirect immunofluorescence (IIF) techniques, the naming of the two principal C- and P-ANCA patterns, why we chose to use IIF as the standard technique, how the solid phase assays have developed and where we stand today, the use of ANCA for diagnosis and the importance of using several techniques for that purpose, how ANCA titres are related to disease activity and the clinical impact of this, and finally the implications of ANCA being a natural, polyclonal antibody response against various epitopes in relation to diagnostics and disease patterns.
MeSH term(s)	Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Antineutrophil Cytoplasmic/history ; Autoantigens/history ; Autoantigens/immunology ; Biomarkers ; Fluorescent Antibody Technique, Indirect/history ; Fluorescent Antibody Technique, Indirect/standards ; Granulomatosis with Polyangiitis/history ; Granulomatosis with Polyangiitis/immunology ; History, 20th Century ; History, 21st Century ; Humans
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Autoantigens ; Biomarkers
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfv070
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