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Article ; Online: A survey of current anticoagulation patient education practices and development.

Jones, Aubrey E / Saunders, John / Vazquez, Sara R / Fagerlin, Angela / Witt, Daniel M

2021 Volume 208, Page(s) 11–13

MeSH term(s)	Anticoagulants/therapeutic use ; Blood Coagulation ; Humans ; Patient Education as Topic ; Surveys and Questionnaires
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2021.10.003
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Zs.A 863: Show issues

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Article ; Online: Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.

Cazzaro, Sara / Woo, Jung-A A / Wang, Xinming / Liu, Tian / Rego, Shanon / Kee, Teresa R / Koh, Yeojung / Vázquez-Rosa, Edwin / Pieper, Andrew A / Kang, David E

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 30, Page(s) e2217128120

Abstract: Oxidative damage in the brain is one of the earliest drivers of pathology in Alzheimer's disease (AD) and related dementias, both preceding and exacerbating clinical symptoms. In response to oxidative stress, nuclear factor erythroid 2-related factor 2 ( ... ...

Abstract	Oxidative damage in the brain is one of the earliest drivers of pathology in Alzheimer's disease (AD) and related dementias, both preceding and exacerbating clinical symptoms. In response to oxidative stress, nuclear factor erythroid 2-related factor 2 (Nrf2) is normally activated to protect the brain from oxidative damage. However, Nrf2-mediated defense against oxidative stress declines in AD, rendering the brain increasingly vulnerable to oxidative damage. Although this phenomenon has long been recognized, its mechanistic basis has been a mystery. Here, we demonstrate through in vitro and in vivo models, as well as human AD brain tissue, that Slingshot homolog-1 (SSH1) drives this effect by acting as a counterweight to neuroprotective Nrf2 in response to oxidative stress and disease. Specifically, oxidative stress-activated SSH1 suppresses nuclear Nrf2 signaling by sequestering Nrf2 complexes on actin filaments and augmenting Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 interaction, independently of SSH1 phosphatase activity. We also show that
MeSH term(s)	Animals ; Humans ; Mice ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Neuroprotection ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/physiology
Chemical Substances	Amyloid beta-Peptides ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; SSH1 protein, human (EC 3.1.3.16)
Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2217128120
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Zs.A 1148: Show issues

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Article ; Online: A microphysiological system for handling graphene related materials under flow conditions.

Lacueva-Aparicio, Alodia / González, Viviana Jehová / Remacha, Ana Rosa / Woods, Daniel / Prado, Eduardo / Ochoa, Ignacio / Oliván, Sara / Vázquez, Ester

Nanoscale horizons

2024

Abstract: The field of nanotechnology has developed rapidly in recent decades due to its broad applications in many industrial and biomedical fields. Notably, 2D materials such as graphene-related materials (GRMs) have been extensively explored and, as such, their ...

Abstract	The field of nanotechnology has developed rapidly in recent decades due to its broad applications in many industrial and biomedical fields. Notably, 2D materials such as graphene-related materials (GRMs) have been extensively explored and, as such, their safety needs to be assessed. However, GRMs tend to deposit quickly, present low stability in aqueous solutions, and adsorb to plastic materials. Consequently, traditional approaches based on static assays facilitate their deposition and adsorption and fail to recreate human physiological conditions. Organ-on-a-chip (OOC) technology could, however, solve these drawbacks and lead to the development of microphysiological systems (MPSs) that mimic the microenvironment present in human tissues. In light of the above, in the present study a microfluidic system under flow conditions has been optimised to minimise graphene oxide (GO) and few-layer graphene (FLG) adsorption and deposition. For that purpose, a kidney-on-a-chip was developed and optimised to evaluate the effects of exposure to GO and FLG flakes at a sublethal dose under fluid flow conditions. In summary, MPSs are an innovative and precise tool for evaluating the effects of exposure to GRMs and other type of nanomaterials.
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ISSN	2055-6764
ISSN (online)	2055-6764
DOI	10.1039/d4nh00064a
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Article ; Online: Youth's energy intake during a laboratory-based loss-of-control eating paradigm: Associations with reported current dieting.

Parker, Megan N / Moursi, Nasreen A / Adekola, Praise E / Bloomer, Bess F / Te-Vazquez, Jennifer / Nwosu, Ejike E / Lazareva, Julia / Jones, Jeremiah L / Yang, Shanna B / Turner, Sara A / Brady, Sheila M / Chen, Kong Y / Tanofsky-Kraff, Marian / Yanovski, Jack A

Eating behaviors

2024 Volume 53, Page(s) 101877

Abstract: Dieting is theorized as a risk factor for loss-of-control (LOC)-eating (i.e., feeling a sense ... style meal and instructed to "Let yourself go and eat as much as you want." Current dieting (i.e ...

Abstract	Dieting is theorized as a risk factor for loss-of-control (LOC)-eating (i.e., feeling a sense of lack of control while eating). Support for this association has largely relied on retrospective self-report data, which does not always correlate with objectively assessed eating behavior in youth. We hypothesized that during a laboratory-based LOC-eating paradigm, children and adolescents who reported current (at the time of the visit) dieting would consume meals consistent with LOC-eating (greater caloric intake, and intake of carbohydrates and fats, but less intake of protein). Participants were presented with a buffet-style meal and instructed to "Let yourself go and eat as much as you want." Current dieting (i.e., any deliberate change to the amount or type of food eaten to influence shape or weight, regardless of how effective the changes are) was assessed via interview. General linear models were adjusted for fat mass (%), lean mass (kg), height, sex, protocol, race and ethnicity, pre-meal hunger and minutes since consumption of a breakfast shake. Of 337 participants (M
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2073366-5
ISSN	1873-7358 ; 1471-0153
ISSN (online)	1873-7358
ISSN	1471-0153
DOI	10.1016/j.eatbeh.2024.101877
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Zs.A 6208: Show issues

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Article ; Online: Revalorization of Microalgae Biomass for Synergistic Interaction and Sustainable Applications: Bioplastic Generation.

López-Pacheco, Itzel Y / Rodas-Zuluaga, Laura Isabel / Cuellar-Bermudez, Sara P / Hidalgo-Vázquez, Enrique / Molina-Vazquez, Abraham / Araújo, Rafael G / Martínez-Ruiz, Manuel / Varjani, Sunita / Barceló, Damià / Iqbal, Hafiz M N / Parra-Saldívar, Roberto

Marine drugs

2022 Volume 20, Issue 10

Abstract: ... for bioplastic production while not competing with food sources (e.g., corn, wheat, and soy protein ...

Abstract	Microalgae and cyanobacteria are photosynthetic microorganisms' sources of renewable biomass that can be used for bioplastic production. These microorganisms have high growth rates, and contrary to other feedstocks, such as land crops, they do not require arable land. In addition, they can be used as feedstock for bioplastic production while not competing with food sources (e.g., corn, wheat, and soy protein). In this study, we review the macromolecules from microalgae and cyanobacteria that can serve for the production of bioplastics, including starch and glycogen, polyhydroxyalkanoates (PHAs), cellulose, polylactic acid (PLA), and triacylglycerols (TAGs). In addition, we focus on the cultivation of microalgae and cyanobacteria for wastewater treatment. This approach would allow reducing nutrient supply for biomass production while treating wastewater. Thus, the combination of wastewater treatment and the production of biomass that can serve as feedstock for bioplastic production is discussed. The comprehensive information provided in this communication would expand the scope of interdisciplinary and translational research.
MeSH term(s)	Microalgae/metabolism ; Biomass ; Waste Water ; Polyhydroxyalkanoates ; Soybean Proteins/metabolism ; Cyanobacteria/metabolism ; Cellulose ; Starch/metabolism ; Triglycerides/metabolism ; Glycogen/metabolism ; Biofuels
Chemical Substances	Waste Water ; Polyhydroxyalkanoates ; Soybean Proteins ; Cellulose (9004-34-6) ; Starch (9005-25-8) ; Triglycerides ; Glycogen (9005-79-2) ; Biofuels
Language	English
Publishing date	2022-09-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md20100601
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Article ; Online: Direct oral anticoagulant plus antiplatelet therapy: prescribing practices and bleeding outcomes.

Tinkham, Tyler T / Vazquez, Sara R / Jones, Aubrey E / Witt, Daniel M

Journal of thrombosis and thrombolysis

2020 Volume 49, Issue 3, Page(s) 492–496

Abstract: Concurrent antiplatelet therapy (APT) is common during warfarin therapy but is less well-documented during direct oral anticoagulant (DOAC) therapy. Combined anticoagulant and APT use has been associated with increased bleeding risk without providing ... ...

Abstract	Concurrent antiplatelet therapy (APT) is common during warfarin therapy but is less well-documented during direct oral anticoagulant (DOAC) therapy. Combined anticoagulant and APT use has been associated with increased bleeding risk without providing additional protection against thrombosis. This study aimed to describe single-center prescribing rates of DOAC + APT as well as compare bleeding rates between DOAC monotherapy and DOAC + APT cohorts. Patients receiving DOAC therapy were evaluated for APT use at the time of hospital discharge. Patients were categorized into DOAC monotherapy and DOAC + APT cohorts. Primary outcomes included DOAC + APT prescribing rate as well as rates of major bleeding and clinically relevant non-major bleeding (CRNMB) within six months after hospital discharge. Secondary outcomes included rates of thromboembolism and all-cause mortality. Of 407 patients receiving DOAC therapy, 78 (19.2%) also received APT at hospital discharge. Common indications for APT included secondary cardiovascular event prevention (57.7%) and primary cardiovascular event prevention (29.5%). The indication for APT could not be determined in 12.8% of patients. The major bleeding rate was 1.3% for DOAC + APT and 1.2% for DOAC monotherapy (p = 0.95). The CRNMB rate was 10.2% for DOAC + APT and 6.4% for DOAC monotherapy (p = 0.23). Thromboembolism and mortality were infrequent in both cohorts. DOAC + APT was documented in approximately 1 of 5 patients. Adding APT to DOAC therapy did not significantly increase the major bleeding or CRNMB rates compared to DOAC monotherapy but the sample size limits drawing conclusions about the safety of these regimens. Targeting primary prevention or unclear indications for APT could be a focus of future interventions.
MeSH term(s)	Administration, Oral ; Aged ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Drug Prescriptions ; Drug Therapy, Combination ; Female ; Hemorrhage/blood ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/adverse effects ; Retrospective Studies ; Thromboembolism/blood ; Thromboembolism/drug therapy ; Thromboembolism/epidemiology ; Warfarin/administration & dosage ; Warfarin/adverse effects
Chemical Substances	Anticoagulants ; Platelet Aggregation Inhibitors ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2020-03-18
Publishing country	Netherlands
Document type	Clinical Trial ; Comparative Study ; Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-019-01999-3
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Zs.A 4352: Show issues

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Article ; Online: Presence of Microplastics in the Vaquita Marina Protection Zone in Baja California, Mexico

Arely Areanely Cruz-Salas / Juan Carlos Alvarez-Zeferino / Jocelyn Tapia-Fuentes / Sheila Liliana Dafne Lobato-Rocha / Alethia Vázquez-Morillas / Sara Ojeda-Benítez / Samantha E. Cruz-Sotelo

Microplastics, Vol 2, Iss 4, Pp 422-

2023 Volume 436

Abstract: Microplastics (MP) have been evidenced in marine and coastal areas worldwide, including the Gulf of California in Mexico, where the Vaquita Marina refuge area is located, which in turn borders the protected natural area Alto Golfo de California y Delta ... ...

Abstract	Microplastics (MP) have been evidenced in marine and coastal areas worldwide, including the Gulf of California in Mexico, where the Vaquita Marina refuge area is located, which in turn borders the protected natural area Alto Golfo de California y Delta del Rio Colorado. This research aimed to determine the concentrations of microplastics in the Vaquita protection zone, analyzing samples of ten transects of surface water and samples in the sand of five beaches on the coast surrounding the Vaquita protection polygon. The total concentrations of MP in the surface water transects were from 0.000 to 0.020 MP/m 3 and their most recurrent characteristics were fragments (69.0%), the chemical composition of polyethylene (60.0%), the blue color (39.0%) and a size of 2.1–3.0 mm (31.0%). While for the beaches, these corresponded to averages ranging from 28.2 ± 36.4; 17.6 to 200.7 ± 77.9; 193.7 MP/m 2 , the most common characteristics of MP from beaches were filaments (33.2%), PE (32.3%), white (28.0%), and a size of 4.1–5.0 mm (32.0%). The results suggest that part of the MP on the beaches and in the Vaquita Marina refuge area could come from urban areas such as the Gulf of California and activities such as fishing. It is recommended to study all the transects of the Vaquita Marina polygon and more beaches surrounding it in different seasons to better understand the status of MP pollution.
Keywords	fragments ; Gulf of California ; natural protected area ; polyethylene ; Biology (General) ; QH301-705.5 ; Microbiology ; QR1-502 ; Biochemistry ; QD415-436
Subject code	333
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mpox: Fifty-Nine Consecutive Cases from a Mexican Public Hospital; Just the Tip of the STIs Iceberg.

González-Díaz, Esteban / Rodríguez-Lugo, Christian E / Quintero-Luce, Sergio / Esparza-Ahumada, Sergio / Pérez-Gómez, Héctor Raúl / Morfín-Otero, Rayo / Kasten-Monges, Marina de Jesus / Aguirre-Díaz, Sara A / Vázquez-León, Marisela / Rodríguez-Noriega, Eduardo

Infectious disease reports

2023 Volume 15, Issue 3, Page(s) 319–326

Abstract: Monkeypox (Mpox) is a zoonotic viral infection endemic to Africa, which has caused a global outbreak since April 2022. The global Mpox outbreak is related to Clade IIb. The disease has primarily affected men who have sex with men. Skin lesions are ... ...

Abstract	Monkeypox (Mpox) is a zoonotic viral infection endemic to Africa, which has caused a global outbreak since April 2022. The global Mpox outbreak is related to Clade IIb. The disease has primarily affected men who have sex with men. Skin lesions are concentrated in the genital area, with lymphadenopathy as well as concurrent sexually transmitted infections (STIs). This is an observational study of adult patients with a recent development of skin lesions and systemic symptoms, which could not be explained by other diseases present. Fifty-nine PCR-positive patients with prominent skin lesions in the genital area (77.9%), inguinal lymphadenopathy (49.1%), and fever (83.0%) were included. Twenty-five (42.3%) were known to be living with human immunodeficiency virus (HIV), and 14 of the HIV-naïve subjects (51.9%) were found to be positive during workup, totaling 39 (66.1%) patients with HIV. Eighteen patients (30.5%) had concurrent syphilis infections. It is worrisome that Mpox is present in large metropolitan areas of Mexico, but the underlying growth of cases of HIV infection and other STIs has not been well studied and should be evaluated in all at-risk adults and their contacts.
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Journal Article
ISSN	2036-7430
ISSN	2036-7430
DOI	10.3390/idr15030032
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Article ; Online: Síndrome de Herlyn-Werner-Wünderlich de diagnóstico neonatal.

Vázquez Gómez, Julio Alberto / Sanz López, Ester / Vigil Vázquez, Sara / Aguado Del Hoyo, Alejandra

Anales de pediatria

2020 Volume 94, Issue 4, Page(s) 263–264

Title translation	Herlyn-Werner-Wünderlich syndrome of neonatal diagnosis.
MeSH term(s)	Female ; Humans ; Pregnancy ; Prenatal Diagnosis ; Syndrome ; Urogenital Abnormalities ; Uterus
Language	Spanish
Publishing date	2020-10-07
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpedi.2020.06.005
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Article: Is This Patient With Metastatic Bladder Cancer a Candidate for Second-Line Immunotherapy Treatment?

Bourlon, María T / Velázquez, Hugo E / Luna-Santiago, Rodrigo / Vázquez-Manjarrez, Sara / Bourlon, Christianne

Oncology (Williston Park, N.Y.)

2018 Volume 32, Issue 2, Page(s) 64–68

MeSH term(s)	Aged ; B7-H1 Antigen/antagonists & inhibitors ; Humans ; Immunotherapy ; Male ; Neoplasm Metastasis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Tomography, X-Ray Computed ; Urinary Bladder Neoplasms/diagnostic imaging ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology
Chemical Substances	B7-H1 Antigen ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2018--15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1067950-9
ISSN	0890-9091
ISSN	0890-9091
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Zs.A 3168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 372: Show issues

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