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  1. Article ; Online: An update on the pathogenesis of Hashimoto's thyroiditis.

    Weetman, A P

    Journal of endocrinological investigation

    2020  Volume 44, Issue 5, Page(s) 883–890

    Abstract: It is 70 years since Noel Rose embarked on his pioneering studies that lead to the discovery of autoimmune thyroiditis and the elucidation of Hashimoto's thyroiditis. This short review to honour his passing focuses on the developments in our ... ...

    Abstract It is 70 years since Noel Rose embarked on his pioneering studies that lead to the discovery of autoimmune thyroiditis and the elucidation of Hashimoto's thyroiditis. This short review to honour his passing focuses on the developments in our understanding of the causes and pathogenesis of HT over the last five years. Recent genetic studies have reported heritability estimates for HT and associated diseases for the first time, and emphasised the complexity of the genetic factors involved, including monogenic forms of HT. Environmental factors continue to be elucidated, especially as a side effect of drugs which modulate the immune system therapeutically. Regarding pathogenetic mechanisms, multiple cytokine networks have been identified which involve the thyroid cells in a circuit of escalating proinflammatory effects, such as the expression of inflammasome components, and an array of different defects in T regulatory cells may underlie the loss of self-tolerance to thyroid autoantigens. Finally, a number of studies have revealed fresh insights into disease associations with HT which may have both pathological and clinical significance, the most intriguing of which is a possible direct role of the autoimmune process itself in causing some of the persistent symptoms reported by a minority of patients with levothyroxine-treated HT.
    MeSH term(s) Autoimmunity ; Endocrinology/methods ; Endocrinology/trends ; Environment ; Hashimoto Disease/genetics ; Hashimoto Disease/immunology ; Hashimoto Disease/physiopathology ; Humans ; Risk Factors ; Thyroid Gland/immunology ; Thyroid Gland/pathology
    Language English
    Publishing date 2020-12-17
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-020-01477-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Main Group Multiple Bonds for Bond Activations and Catalysis.

    Weetman, Catherine

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 27, Issue 6, Page(s) 1941–1954

    Abstract: ... bonds realised within the p-block, along with many heterodiatomic combinations, this Minireview examines ...

    Abstract Since the discovery that the so-called "double-bond" rule could be broken, the field of molecular main group multiple bonds has expanded rapidly. With the majority of homodiatomic double and triple bonds realised within the p-block, along with many heterodiatomic combinations, this Minireview examines the reactivity of these compounds with a particular emphasis on small molecule activation. Furthermore, whilst their ability to act as transition metal mimics has been explored, their catalytic behaviour is somewhat limited. This Minireview aims to highlight the potential of these complexes towards catalytic application and their role as synthons in further functionalisations making them a versatile tool for the modern synthetic chemist.
    Language English
    Publishing date 2020-11-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202002939
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  3. Book: Autoimmune diseases in endocrinology

    Weetman, Anthony P.

    (Contemporary endocrinology)

    2008  

    Author's details ed. by Anthony P. Weetman
    Series title Contemporary endocrinology
    Language English
    Size XII, 434 S. : Ill., graph. Darst.
    Publisher Humana
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014999515
    ISBN 1-58829-733-0 ; 978-1-58829-733-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 1124 order for loan Magazin

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  4. Book ; Online: Autoimmune Diseases in Endocrinology

    Weetman, Anthony P.

    2008  

    Author's details edited by Anthony P. Weetman
    Keywords Diabetes ; Endocrinology ; Internal medicine
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387151
    ISBN 978-1-588-29733-4 ; 978-1-597-45517-6 ; 1-588-29733-0 ; 1-597-45517-2
    DOI 10.1007/978-1-59745-517-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Feasibility of application-based psychomotor vigilance testing to assess fatigue in doctors working night shifts and correlation with smartwatch assessed shift intensity.

    Weetman, Stefan / Roche, Matthew / Leckie, Todd / Samuels, Theophilus / Hodgson, Luke

    Occupational and environmental medicine

    2024  

    Abstract: ... night shift, with a PVT mean reaction time 257 ms pre shift versus 283 ms post shift (p<0.0001 ...

    Abstract Objectives: To assess: (1) the feasibility of novel data collection methods (wearable technology and an application-based psychomotor vigilance test (PVT)), (2) the impact of night shift working on fatigue, both objective and perceived, for doctors working night shifts in acute hospital specialties and (3) the effects of shift intensity and naps obtained on participant fatigue.
    Methods: We adopted an innovative, multimodal approach to data collection allowing assessment of objective and perceived measures of fatigue, in addition to markers of shift intensity. This comprised 5 min PVT for objective quantification of fatigue (via the validated, smartphone-based NASA PVT+ application), wearable electronic devices (Fitbit Versa2) for assessment of shift intensity (step counts and active minutes) and questionnaires to elicit perceptions of fatigue and shift intensity.
    Results: Data was collected from 25 participants for a total of 145 night shifts. Objective fatigue (assessed by PVT performance) was significantly increased post night shift, with a PVT mean reaction time 257 ms pre shift versus 283 ms post shift (p<0.0001). However, differences in PVT pre and post shift were not affected by night shift intensity, nor breaks or naps taken on shift. Differences in psychomotor performance between doctors working in different specialties were also observed.
    Conclusions: The data collection methods used were found to be feasible with good participant engagement. Findings support existing evidence that night shift working in healthcare workers is associated with fatigue, with psychomotor impairment observed post shift. Lower shift intensity and napping did not appear to mitigate this effect.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1180733-7
    ISSN 1470-7926 ; 1351-0711
    ISSN (online) 1470-7926
    ISSN 1351-0711
    DOI 10.1136/oemed-2023-109311
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  6. Article ; Online: Signatures of adaptation at key insecticide resistance loci in Anopheles gambiae in Southern Ghana revealed by reduced-coverage WGS.

    Dennis, Tristan P W / Essandoh, John / Mable, Barbara K / Viana, Mafalda S / Yawson, Alexander E / Weetman, David

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8650

    Abstract: Resistance to insecticides and adaptation to a diverse range of environments present challenges to Anopheles gambiae s.l. mosquito control efforts in sub-Saharan Africa. Whole-genome-sequencing is often employed for identifying the genomic basis ... ...

    Abstract Resistance to insecticides and adaptation to a diverse range of environments present challenges to Anopheles gambiae s.l. mosquito control efforts in sub-Saharan Africa. Whole-genome-sequencing is often employed for identifying the genomic basis underlying adaptation in Anopheles, but remains expensive for large-scale surveys. Reduced coverage whole-genome-sequencing can identify regions of the genome involved in adaptation at a lower cost, but is currently untested in Anopheles mosquitoes. Here, we use reduced coverage WGS to investigate population genetic structure and identify signatures of local adaptation in Anopheles mosquitoes across southern Ghana. In contrast to previous analyses, we find no structuring by ecoregion, with Anopheles coluzzii and Anopheles gambiae populations largely displaying the hallmarks of large, unstructured populations. However, we find signatures of selection at insecticide resistance loci that appear ubiquitous across ecoregions in An. coluzzii, and strongest in forest ecoregions in An. gambiae. Our study highlights resistance candidate genes in this region, and validates reduced coverage WGS, potentially to very low coverage levels, for population genomics and exploratory surveys for adaptation in Anopheles taxa.
    MeSH term(s) Animals ; Insecticide Resistance/genetics ; Pyrethrins ; Anopheles ; Ghana/epidemiology ; Insecticides/pharmacology ; Mosquito Control
    Chemical Substances Pyrethrins ; Insecticides
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58906-x
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  7. Article ; Online: Auto-immune hypoparathyroidism.

    Weetman, Anthony P

    Annales d'endocrinologie

    2015  Volume 76, Issue 2, Page(s) 89–91

    MeSH term(s) Autoantibodies/immunology ; Autoantigens/analysis ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Humans ; Hypoparathyroidism/immunology ; Hypoparathyroidism/therapy ; Receptors, Calcium-Sensing/immunology
    Chemical Substances Autoantibodies ; Autoantigens ; Receptors, Calcium-Sensing
    Language English
    Publishing date 2015-05
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2015.03.014
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  8. Article ; Online: Thyroid abnormalities.

    Weetman, Anthony P

    Endocrinology and metabolism clinics of North America

    2014  Volume 43, Issue 3, Page(s) 781–790

    Abstract: Thyroid abnormalities and nonthyroidal illness complicate human immunodeficiency virus (HIV) infection. Among the effects that result from HIV and other opportunistic infections, distinctive features of HIV infection include early lowering of reverse tri- ...

    Abstract Thyroid abnormalities and nonthyroidal illness complicate human immunodeficiency virus (HIV) infection. Among the effects that result from HIV and other opportunistic infections, distinctive features of HIV infection include early lowering of reverse tri-iodothyromine (T3) levels, with normal free T3 levels. Later, some patients develop an isolated low free thyroxine level. After highly active antiretroviral therapy, the immune system reconstitutes in a way that leads to dysregulation of the autoimmune response and the appearance of Graves disease in 1% to 2% of patients. Opportunistic thyroid infections with unusual organisms are most commonly asymptomatic, but can lead to acute or subacute thyroiditis.
    MeSH term(s) AIDS-Related Opportunistic Infections/complications ; AIDS-Related Opportunistic Infections/immunology ; Carcinoma/etiology ; Carcinoma, Papillary ; HIV Infections/complications ; HIV Infections/immunology ; HIV Infections/physiopathology ; HIV-1 ; Humans ; Immune Reconstitution Inflammatory Syndrome/etiology ; Thyroid Cancer, Papillary ; Thyroid Diseases/etiology ; Thyroid Function Tests ; Thyroid Gland/physiopathology ; Thyroid Neoplasms/etiology
    Language English
    Publishing date 2014-06-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2014.05.006
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  9. Article ; Online: Graves' disease following immune reconstitution or immunomodulatory treatment: should we manage it any differently?

    Weetman, Anthony P

    Clinical endocrinology

    2014  Volume 80, Issue 5, Page(s) 629–632

    Abstract: Graves' disease and other disorders of thyroid function may occur following treatment with novel anticancer agents or during periods of lymphocyte recovery after lymphopenia. There are three main settings for such lymphocyte reconstitution: recovery ... ...

    Abstract Graves' disease and other disorders of thyroid function may occur following treatment with novel anticancer agents or during periods of lymphocyte recovery after lymphopenia. There are three main settings for such lymphocyte reconstitution: recovery after a bone marrow or haematopoietic stem cell transplant, alemtuzumab treatment and the use of highly active antiretroviral therapy (HAART) for human immunodeficiency virus infection. The available evidence suggests that Graves' disease behaves as normal in most of these cases and should be treated conventionally, but it may follow a more favourable course in those receiving alemtuzumab or HAART. As spontaneous or drug-induced remission may be more likely in these two settings, first-line treatment should usually consist of an antithyroid drug.
    MeSH term(s) Alemtuzumab ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiretroviral Therapy, Highly Active/adverse effects ; Bone Marrow Cells/cytology ; Endocrinology/methods ; Graves Disease/etiology ; Graves Disease/immunology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Immune System ; Lymphocytes/cytology ; Lymphopenia/immunology ; Neoplasms/complications ; Neoplasms/therapy ; Remission Induction
    Chemical Substances Antibodies, Monoclonal, Humanized ; Alemtuzumab (3A189DH42V)
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.12427
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  10. Article ; Online: Diseases associated with thyroid autoimmunity: explanations for the expanding spectrum.

    Weetman, A P

    Clinical endocrinology

    2011  Volume 74, Issue 4, Page(s) 411–418

    Abstract: Anyone who has been in an endocrine clinic will appreciate that associations exist between autoimmune thyroid disease (AITD) and other autoimmune disorders. However, the full extent of these associations is still not fully appreciated, and new ... ...

    Abstract Anyone who has been in an endocrine clinic will appreciate that associations exist between autoimmune thyroid disease (AITD) and other autoimmune disorders. However, the full extent of these associations is still not fully appreciated, and new associations are being uncovered which may shed new light on the pathogenic basis for these connections, and the underlying reasons for them are only now becoming understood. This review is based on the British Thyroid Association Pitt-Rivers Lecture 2010. The first section provides an update on studies which have detailed the strength of various autoimmune disease associations, the second section discusses the environmental and genetic factors which underlie these associations and the final section describes some recently identified, unexpected AITD associations. Unravelling these associations further will illuminate the pathogenesis of autoimmune diseases and offers the prospect of new therapeutic approaches.
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmunity/physiology ; Humans ; Polyendocrinopathies, Autoimmune/immunology ; Polyendocrinopathies, Autoimmune/pathology ; Thyroid Diseases/immunology ; Thyroid Diseases/pathology ; Thyroid Gland/immunology ; Thyroid Gland/pathology
    Language English
    Publishing date 2011-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/j.1365-2265.2010.03855.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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