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  1. Article ; Online: Dissecting skin microbiota and microenvironment for the development of therapeutic strategies.

    Ito, Yoshihiro / Amagai, Masayuki

    Current opinion in microbiology

    2023  Volume 74, Page(s) 102311

    Abstract: The skin is a pivotal barrier between the human body and the environment, and is a habitat for numerous microorganisms. While host-microbiota interactions in the skin are essential for homeostasis, disturbances in microbial composition and the abnormal ... ...

    Abstract The skin is a pivotal barrier between the human body and the environment, and is a habitat for numerous microorganisms. While host-microbiota interactions in the skin are essential for homeostasis, disturbances in microbial composition and the abnormal growth of certain bacteria are associated with various diseases. Here, we identify strains and communities of skin commensals that contribute to or impair skin barrier function. Furthermore, we discuss the skin microenvironments suitable for specific microbiota that exert therapeutic effects and suggest focus areas for the prospective development of therapeutic strategies using bacterial agents. Finally, we highlight recent efforts to treat skin diseases associated with live bacteria.
    MeSH term(s) Humans ; Prospective Studies ; Skin/microbiology ; Microbiota ; Bacteria/genetics ; Host Microbial Interactions
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2023.102311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Life Full of Surprises and Excitement through Science in Dermatology.

    Amagai, Masayuki

    The Journal of investigative dermatology

    2018  Volume 138, Issue 3, Page(s) 475–476

    MeSH term(s) Allergy and Immunology ; Dermatology ; Humans ; Science
    Language English
    Publishing date 2018-02-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2018.01.014
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  3. Article ; Online: T Helper 17/T Helper 22‒Skewed Inflammation with Epidermal Barrier Dysfunction in Nonmajor Inherited Ichthyosis Subtypes.

    Horikawa, Hiroto / Amagai, Masayuki

    The Journal of investigative dermatology

    2022  Volume 142, Issue 9, Page(s) 2303–2305

    MeSH term(s) Epidermis ; Humans ; Ichthyosis/genetics ; Ichthyosis, Lamellar ; Inflammation/genetics
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.05.001
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  4. Article ; Online: ISID 2023: Celebrating the success and impact of international collaboration in dermatological research from JSID's perspective.

    Kabashima, Kenji / Fujimoto, Manabu / Ohyama, Manabu / Amagai, Masayuki

    Journal of dermatological science

    2023  Volume 111, Issue 3, Page(s) 78–82

    Language English
    Publishing date 2023-08-19
    Publishing country Netherlands
    Document type Clinical Conference
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2023.08.004
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  5. Article ; Online: Meeting Report: ISID2023 Tokyo Satellite Meeting. International Symposium on Autoimmunity Targeting the Skin. -Pemphigus, Pemphigoid, and Beyond.

    Yamagami, Jun / Takahashi, Hayato / Amagai, Masayuki

    Journal of dermatological science

    2023  Volume 112, Issue 1, Page(s) 2–5

    MeSH term(s) Humans ; Pemphigus ; Pemphigoid, Bullous/drug therapy ; Autoimmunity ; Tokyo ; Skin
    Language English
    Publishing date 2023-08-19
    Publishing country Netherlands
    Document type Clinical Conference
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2023.08.003
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  6. Article: Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases.

    Ito, Yoshihiro / Amagai, Masayuki

    Inflammation and regeneration

    2022  Volume 42, Issue 1, Page(s) 26

    Abstract: The skin serves as the interface between the human body and the environment and interacts with the microbial community. The skin microbiota consists of microorganisms, such as bacteria, fungi, mites, and viruses, and they fluctuate depending on the ... ...

    Abstract The skin serves as the interface between the human body and the environment and interacts with the microbial community. The skin microbiota consists of microorganisms, such as bacteria, fungi, mites, and viruses, and they fluctuate depending on the microenvironment defined by anatomical location and physiological function. The balance of interactions between the host and microbiota plays a pivotal role in the orchestration of skin homeostasis; however, the disturbance of the balance due to an alteration in the microbial communities, namely, dysbiosis, leads to various skin disorders. Recent developments in sequencing technology have provided new insights into the structure and function of skin microbial communities. Based on high-throughput sequencing analysis, a growing body of evidence indicates that a new treatment using live bacteria, termed bacteriotherapy, is a feasible therapeutic option for cutaneous diseases caused by dysbiosis. In particular, the administration of specific bacterial strains has been investigated as an exclusionary treatment strategy against pathogens associated with chronic skin disorders, whereas the safety, efficacy, and sustainability of this therapeutic approach using isolated live bacteria need to be further explored. In this review, we summarize our current understanding of the skin microbiota, as well as therapeutic strategies using characterized strains of live bacteria for skin inflammatory diseases. The ecosystem formed by interactions between the host and skin microbial consortium is still largely unexplored; however, advances in our understanding of the function of the skin microbiota at the strain level will lead to the development of new therapeutic methods.
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-022-00212-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Diverse Role of OX40 on T Cells as a Therapeutic Target for Skin Diseases.

    Iriki, Hisato / Takahashi, Hayato / Amagai, Masayuki

    The Journal of investigative dermatology

    2023  Volume 143, Issue 4, Page(s) 545–553

    Abstract: OX40 is an important costimulatory molecule for T-cell expansion and survival. Because OX40 is expressed on most T-cell subsets, it is an attractive therapeutic target for a variety of T-cell‒mediated diseases. Clinical trials are already underway for ... ...

    Abstract OX40 is an important costimulatory molecule for T-cell expansion and survival. Because OX40 is expressed on most T-cell subsets, it is an attractive therapeutic target for a variety of T-cell‒mediated diseases. Clinical trials are already underway for some skin inflammatory diseases. In this review, we present various observations that improve our understanding of how OX40-targeted therapy can be applied for skin inflammatory diseases, such as atopic dermatitis and psoriasis, T helper (Th)2- and Th17-mediated diseases, respectively. The important OX40/OX40L-mediated interaction between T cells and other immune cells is also discussed in terms of skin autoimmune diseases, such as alopecia areata and pemphigus. Regulatory T cells (Tregs) highly express OX40, and the skin harbors a large Treg population; thus, understanding how OX40-targeted treatment acts on Tregs is vital for the development of therapeutic strategies for various skin diseases.
    MeSH term(s) Humans ; Autoimmune Diseases ; Dermatitis, Atopic ; Receptors, OX40 ; T-Lymphocyte Subsets ; T-Lymphocytes, Regulatory ; T-Lymphocytes/immunology
    Chemical Substances Receptors, OX40
    Language English
    Publishing date 2023-02-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.11.009
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  8. Article ; Online: Cracking the code of skin inflammation with CD1a.

    Amagai, Masayuki

    Nature immunology

    2016  Volume 17, Issue 10, Page(s) 1133–1134

    Language English
    Publishing date 2016-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.3557
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  9. Article ; Online: Modulating Immunity to Treat Autoimmune Disease.

    Amagai, Masayuki

    The New England journal of medicine

    2016  Volume 375, Issue 15, Page(s) 1487–1489

    MeSH term(s) Animals ; Antigens, CD20 ; B-Lymphocytes/immunology ; Cell Engineering ; Disease Models, Animal ; Immunosuppression/methods ; Mice ; Pemphigus/immunology ; Pemphigus/therapy ; Receptors, Antigen, T-Cell/immunology ; Recombinant Fusion Proteins/immunology ; T-Lymphocytes/immunology
    Chemical Substances Antigens, CD20 ; Receptors, Antigen, T-Cell ; Recombinant Fusion Proteins
    Language English
    Publishing date 2016-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr1608900
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  10. Article ; Online: Disruption of Post-thymic tolerance in Skin-Reactive TCR Transgenic Mice through the Interaction of Lymphopenia and Intestinal Microbiota.

    Hayabuchi, Hodaka / Tokifuji, Yukiko / Takahashi, Hayato / Amagai, Masayuki / Yoshimura, Akihiko / Chikuma, Shunsuke

    International immunology

    2024  

    Abstract: Autoimmune diseases often arise from conditions where the immune system is compromised. While lymphopenia-induced proliferation (LIP) is crucial for immune system development and maturation, it is also caused by environmental insult, such as infection ... ...

    Abstract Autoimmune diseases often arise from conditions where the immune system is compromised. While lymphopenia-induced proliferation (LIP) is crucial for immune system development and maturation, it is also caused by environmental insult, such as infection and becomes a risk factor for autoimmunity in adults. We used Dsg3H1 TCR Transgenic mice, whose T cells are designed to recognize desmogrein-3, a skin antigen, to explore the impact of lymphopenia on post-thymic tolerance. Dsg3H1 mice are known to delete the most highly autoreactive T cells in thymus, and develop only subtle immune-mediated pathology in a steady state. However, we found that a transient lymphopenia by total body irradiation or cyclophosphamide, results in massive dermatitis in Dsg3H1 mice. The symptoms included expansion and development of self-reactive T cells, their differentiation into CD44 high IL-17 producing helper T cells, and severe neutrophilic inflammation. Repopulation of FOXP3+ T regulatory cells after lymphopenia normally occurred, suggesting escape of skin-reactive conventional T cells from control by regulatory T cell. Furthermore, we found that a depletion of the intestinal microbiota by antibiotics prevents the cyclophosphamide induced dermatitis, indicating roles of commensal intestinal microbiota in LIP and Th17 development in vivo. The current data suggested that post thymic tolerance of Dsg3H1 mice is established on a fragile balance in lymphoreplete immune environment and broken by interplay between lymphopenia and intestinal microbiota. The dynamic phenotypes observed in Dsg3H1 mice prompts a reevaluation of opportunistic lymphopenia together with microbiota as pivotal environmental factors, impacting individuals with genetic predispositions of autoimmune diseases.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxae018
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