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Article: Nectar Uptake of a Long-Proboscid

Krenn, Harald W / Karolyi, Florian / Lampert, Peter / Melin, Annalie / Colville, Jonathan F

Insects

2021 Volume 12, Issue 4

Abstract: ... ...

Abstract	Several
Language	English
Publishing date	2021-04-20
Publishing country	Switzerland
Document type	Journal Article
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects12040371
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Article: Induction of male production in clones of Daphnia pulex by the juvenoid hormone methyl farnesoate under short photoperiod.

Lampert, Winfried / Lampert, Kathrin P / Larsson, Petter

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

2012 Volume 156, Issue 2, Page(s) 130–133

Abstract: The juvenile hormone, methyl farnesoate (MF), and its analog insecticides have been used successfully to induce the production of males in cladocerans under long-day conditions in the laboratory. However, without hormone addition Daphnia do not usually ... ...

Abstract	The juvenile hormone, methyl farnesoate (MF), and its analog insecticides have been used successfully to induce the production of males in cladocerans under long-day conditions in the laboratory. However, without hormone addition Daphnia do not usually produce male offspring under long photoperiods, while short photoperiods are a stimulus for the induction of males. We used 21 clones of Daphnia pulex differing in their propensity to produce males under short-day conditions to test whether the treatment with MF would result in an additive effect of shifting the sex ratio towards males. Contrary to our expectations, clones with a high tendency of male production showed a reduced sex ratio in response to MF treatment under short-day conditions, but clones that produced normally few males or did not produce males were stimulated by 700 nM MF to produce up to 40% males. We suggest that the endocrine disruptive effect of MF or juvenile hormone analogs in the field may depend on the clonal composition of the cladoceran population and on the natural photoperiod. This may affect the seasonal occurrence of sexual reproduction and eventually cause a mismatch between the presence of males and ephippial females.
MeSH term(s)	Animals ; Cloning, Organism ; Daphnia/drug effects ; Endocrine Disruptors/pharmacology ; Fatty Acids, Unsaturated/pharmacology ; Female ; Insecticides/pharmacology ; Juvenile Hormones/pharmacology ; Male ; Photoperiod ; Reproduction/drug effects ; Seasons ; Sex Differentiation/drug effects ; Sex Ratio ; Time Factors
Chemical Substances	Endocrine Disruptors ; Fatty Acids, Unsaturated ; Insecticides ; Juvenile Hormones ; methyl farnesoate (10485-70-8)
Language	English
Publishing date	2012-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189285-x
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
DOI	10.1016/j.cbpc.2012.05.004
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Article ; Online: Long-term pelvic organ prolapse recurrence and mesh exposure following sacrocolpopexy.

Thomas, Tonya N / Davidson, Emily R W / Lampert, Erika J / Paraiso, Marie F R / Ferrando, Cecile A

International urogynecology journal

2020 Volume 31, Issue 9, Page(s) 1763–1770

Abstract: ... 95% CI 10.6-17.9%]; p = 0.03). After adjusting for baseline differences there was no significant ... difference among groups (p = 0.30). 5.3% experienced mesh and/or suture exposure (mesh n = 19, suture n = 10 ... robotic 3.6% [95% CI 1.7-7.6%]; laparoscopic 4.9% [95% CI 3.1-7.7%]; p = 0.20). Median time ...

Abstract	Introduction and hypothesis: Large, long-term studies are needed to compare pelvic organ prolapse (POP) recurrence and mesh exposure following all modes of sacrocolpopexy (open, robotic, and laparoscopic). We hypothesized that the prevalence of recurrent POP and mesh exposure does not differ between modes of sacrocolpopexy. Methods: This is a retrospective cohort study with a cross-sectional, prospective survey. Participants were surveyed regarding complications, retreatments, and symptoms following sacrocolpopexy. Baseline characteristics, POP recurrence, mesh exposure, and survey responses were compared. Results: A total of 709 participants met the criteria. Median time from sacrocolpopexy to last follow-up for all participants was 0.5 years (2 days to 13.4 years). 15.0% experienced recurrent stage 2 or greater POP or underwent retreatment (open 11.7% [95% CI 7.8-17.2%]; robotic 21.1% [95% CI 15.6-27.9%]; laparoscopic 13.8% [95% CI 10.6-17.9%]; p = 0.03). After adjusting for baseline differences there was no significant difference among groups (p = 0.30). 5.3% experienced mesh and/or suture exposure (mesh n = 19, suture n = 10, mesh and suture n = 8) with no significant difference among groups (open 7.7% [95% CI 4.6-12.5%]; robotic 3.6% [95% CI 1.7-7.6%]; laparoscopic 4.9% [95% CI 3.1-7.7%]; p = 0.20). Median time from sacrocolpopexy to survey completion was 6.5 (1.6-13.4) years. 9.2% reported evaluation or treatment for recurrent POP (open 6.3% [95% CI 2.1-16.8%]; robotic 12.5% [95% CI 6.9-21.5%]; laparoscopic 8.5% [5.1-13.8%]; p = 0.44). 6.9% reported evaluation or treatment for mesh exposure (open 6.0% [95% CI 2.1-16.2%]; robotic 3.9% [95% CI 1.3-10.7%]; laparoscopic 8.6% [5.2-13.9%]; p = 0.38). Conclusions: Objective and patient-reported long-term prevalence of POP recurrence and mesh exposure are low following all modes of sacrocolpopexy.
MeSH term(s)	Cross-Sectional Studies ; Female ; Gynecologic Surgical Procedures/adverse effects ; Humans ; Laparoscopy ; Pelvic Organ Prolapse/surgery ; Prospective Studies ; Retrospective Studies ; Surgical Mesh/adverse effects ; Treatment Outcome
Language	English
Publishing date	2020-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-020-04291-8
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Article ; Online: Nectar Uptake of a Long-Proboscid Prosoeca Fly (Nemestrinidae)—Proboscis Morphology and Flower Shape

Harald W. Krenn / Florian Karolyi / Peter Lampert / Annalie Melin / Jonathan F. Colville

Insects, Vol 12, Iss 371, p

2021 Volume 371

Abstract: ... natural habitat, where the long-tubed flowers of Babiana vanzijliae (Iridaceae) were the only nectar source of P ...

Abstract	Several Prosoeca (Nemestinidae) species use a greatly elongated proboscis to drink nectar from long-tubed flowers. We studied morphological adaptations for nectar uptake of Prosoeca marinusi that were endemic to the Northern Cape of South Africa. Our study site was a small isolated area of semi-natural habitat, where the long-tubed flowers of Babiana vanzijliae (Iridaceae) were the only nectar source of P. marinusi , and these flies were the only insects with matching proboscis. On average, the proboscis measured 32.63 ± 2.93 mm in length and less than 0.5 mm in diameter. The short labella at the tip are equipped with pseudotracheae that open at the apical margin, indicating that nectar is extracted out of the floral tube with closed labella. To quantify the available nectar resources, measurements of the nectar volume were taken before the flies were active and after observed flower visits. On average, an individual fly took up approximately 1 µl of nectar per flower visit. The measured nectar quantities and the flower geometry allowed estimations of the nectar heights and predictions of necessary proboscis lengths to access nectar in a range of flower tube lengths.
Keywords	mouthparts ; nectar-feeding ; insect-flower interaction ; flower morphology ; nectar quantity ; nectar level calculation ; Science ; Q
Subject code	590
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinician engagement in the ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness) trial.

Kochar, Ajar / Summers, Mary B / Benziger, Catherine P / Marquis-Gravel, Guillaume / DeWalt, Darren A / Pepine, Carl J / Gupta, Kamal / Bradley, Steven M / Dodson, John A / Lampert, Brent C / Robertson, Holly / Polonsky, Tamar S / Jones, W Schuyler / Effron, Mark B

Clinical trials (London, England)

2021 Volume 18, Issue 4, Page(s) 449–456

Abstract: Background: ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness) is a pragmatic clinical trial examining high-dose versus low-dose aspirin among patients with cardiovascular disease. ADAPTABLE is leveraging ... ...

Abstract	Background: ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness) is a pragmatic clinical trial examining high-dose versus low-dose aspirin among patients with cardiovascular disease. ADAPTABLE is leveraging novel approaches for clinical trial conduct to expedite study completion and reduce costs. One pivotal aspect of the trial conduct is maximizing clinician engagement. Methods/results: Clinician engagement can be diminished by barriers including time limitations, insufficient research infrastructure, lack of research training, inadequate compensation for research activities, and clinician beliefs. We used several key approaches to boost clinician engagement such as empowering clinician champions, including a variety of clinicians, nurses and advanced practice providers, periodic newsletters and coordinated team celebrations, and deploying novel technological solutions. Specifically, some centers generated electronic health records-based best practice advisories and research dashboards. Future large pragmatic trials will benefit from standardization of the various clinician engagement strategies especially studies leveraging electronic health records-based approaches like research dashboards. Financial or academic "credit" for clinician engagement in clinical research may boost participation rates in clinical studies. Conclusion: Maximizing clinician engagement is important for the success of clinical trials; the strategies employed in the ADAPTABLE trial may serve as a template for future pragmatic studies.
MeSH term(s)	Aspirin/administration & dosage ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Electronic Health Records ; Humans ; Patient-Centered Care ; Pragmatic Clinical Trials as Topic ; Research Design ; Research Personnel
Chemical Substances	Aspirin (R16CO5Y76E)
Language	English
Publishing date	2021-02-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138796-5
ISSN	1740-7753 ; 1740-7745
ISSN (online)	1740-7753
ISSN	1740-7745
DOI	10.1177/1740774520988838
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Article ; Online: Frequency of QTc Interval Prolongation in Children and Adults with Williams Syndrome.

Brink, Benjamin D / Feinn, Richard / Kozel, Beth A / Billington, Charles J / Liu, Delong / Yu, Eric / Sindhar, Sampat / He, Julie / Rouse, Charles / Lampert, Rachel / Pober, Barbara R / Elder, Robert W

Pediatric cardiology

2022 Volume 43, Issue 7, Page(s) 1559–1567

Abstract: ... with WS and controls was 444 ± 24 ms and 417 ± 26 ms, respectively (p < 0.001). In our WS cohort 34.4% had ... higher than controls (96 bpm vs 76 bpm, p < 0.001). Linear regression showed that HR contributed 27 ...

Abstract	QTc prolongation (≥ 460 ms), according to Bazett formula (QTcB), has been identified to be increased in Williams syndrome (WS) and suggested as a potential cause of increased risk of sudden cardiac death. The Bazett formula tends to overestimate QTc in higher heart rates. We performed a retrospective chart review of WS patients with ≥ 1 electrocardiogram (EKG) with sinus rhythm, no evidence of bundle branch blocks, and measurable intervals. A total of 280 EKGs from 147 patients with WS were analyzed and 123 EKGs from 123 controls. The QTc was calculated using Bazett formula. The average QTcB for individuals with WS and controls was 444 ± 24 ms and 417 ± 26 ms, respectively (p < 0.001). In our WS cohort 34.4% had at least 1 EKG with a QTcB ≥ 460 ms. The mean heart rate (HR) from patients with WS was significantly higher than controls (96 bpm vs 76 bpm, p < 0.001). Linear regression showed that HR contributed 27% to QTcB prolongation in the patients with WS. Patients with WS have a mean QTcB in the normal range but higher than controls, and a higher than expected frequency of QTc ≥ 460 ms compared to the general population. HR is also higher in WS and contributes modestly to the WS QTcB prolongation. Future studies are needed to assess if these findings contribute risk to sudden cardiac death but in the interim we recommend routine EKG testing, especially when starting QTc prolonging medications.
MeSH term(s)	Adult ; Child ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Electrocardiography ; Heart Rate/physiology ; Humans ; Long QT Syndrome/complications ; Long QT Syndrome/etiology ; Retrospective Studies ; Williams Syndrome/complications
Language	English
Publishing date	2022-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-022-02883-3
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Article: Nectar Uptake of a Long-Proboscid Prosoeca Fly (Nemestrinidae)—Proboscis Morphology and Flower Shape

Krenn, Harald W / Karolyi, Florian / Lampert, Peter / Melin, Annalie / Colville, Jonathan F

Insects. 2021 Apr. 20, v. 12, no. 4

2021

Abstract: ... natural habitat, where the long-tubed flowers of Babiana vanzijliae (Iridaceae) were the only nectar source of P ...

Abstract	Several Prosoeca (Nemestinidae) species use a greatly elongated proboscis to drink nectar from long-tubed flowers. We studied morphological adaptations for nectar uptake of Prosoecamarinusi that were endemic to the Northern Cape of South Africa. Our study site was a small isolated area of semi-natural habitat, where the long-tubed flowers of Babiana vanzijliae (Iridaceae) were the only nectar source of P. marinusi, and these flies were the only insects with matching proboscis. On average, the proboscis measured 32.63 ± 2.93 mm in length and less than 0.5 mm in diameter. The short labella at the tip are equipped with pseudotracheae that open at the apical margin, indicating that nectar is extracted out of the floral tube with closed labella. To quantify the available nectar resources, measurements of the nectar volume were taken before the flies were active and after observed flower visits. On average, an individual fly took up approximately 1 µL of nectar per flower visit. The measured nectar quantities and the flower geometry allowed estimations of the nectar heights and predictions of necessary proboscis lengths to access nectar in a range of flower tube lengths.
Keywords	Babiana ; flower morphology ; flowers ; geometry ; habitats ; nectar ; proboscis ; South Africa
Language	English
Dates of publication	2021-0420
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ISSN	2075-4450
DOI	10.3390/insects12040371
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The spatial self-organization within pluripotent stem cell colonies is continued in detaching aggregates.

Elsafi Mabrouk, Mohamed H / Goetzke, Roman / Abagnale, Giulio / Yesilyurt, Burcu / Salz, Lucia / Cypris, Olivia / Glück, Philipp / Liesenfelder, Sven / Zeevaert, Kira / Ma, Zhiyao / Toledo, Marcelo A S / Li, Ronghui / Costa, Ivan G / Lampert, Angelika / Pachauri, Vivek / Schnakenberg, Uwe / Zenke, Martin / Wagner, Wolfgang

Biomaterials

2022 Volume 282, Page(s) 121389

Abstract: Colonies of induced pluripotent stem cells (iPSCs) reveal aspects of self-organization even under culture conditions that maintain pluripotency. To investigate the dynamics of this process under spatial confinement, we used either polydimethylsiloxane ( ... ...

Abstract	Colonies of induced pluripotent stem cells (iPSCs) reveal aspects of self-organization even under culture conditions that maintain pluripotency. To investigate the dynamics of this process under spatial confinement, we used either polydimethylsiloxane (PDMS) pillars or micro-contact printing of vitronectin. There was a progressive upregulation of OCT4, E-cadherin, and NANOG within 70 μm from the outer rim of iPSC colonies. Single-cell RNA-sequencing and spatial reconstruction of gene expression demonstrated that OCT4
MeSH term(s)	Cell Differentiation/physiology ; Embryoid Bodies/metabolism ; Induced Pluripotent Stem Cells ; Pluripotent Stem Cells ; Up-Regulation
Language	English
Publishing date	2022-01-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2022.121389
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Article ; Online: Route of hysterectomy during minimally invasive sacrocolpopexy does not affect postoperative outcomes.

Davidson, Emily R W / Thomas, Tonya N / Lampert, Erika J / Paraiso, Marie Fidela R / Ferrando, Cecile A

International urogynecology journal

2018 Volume 30, Issue 4, Page(s) 649–655

Abstract: ... 276 vs. 324 min, p < 0.001) and had higher rates of postoperative stress incontinence (22 vs. 9%, p ...

Abstract	Introduction and hypothesis: Hysterectomy can be performed during sacrocolpopexy, but there are limited studies comparing the effect of route of hysterectomy on adverse events. We hypothesized there would be no difference in adverse events or patient-reported outcomes in women who underwent minimally invasive sacrocolpopexy with either vaginal or supracervical hysterectomy. Methods: This was a retrospective chart review with a cross-sectional survey component sent to all consenting patients. Patients were identified by procedure code for sacrocolpopexy and hysterectomy from January 2005 to June 2016. Results: Of the 161 subjects meeting the inclusion criteria, 116 underwent supracervical and 45 vaginal hysterectomy. Overall incidence of perioperative adverse events was low. Vaginal hysterectomy cases were faster (276 vs. 324 min, p < 0.001) and had higher rates of postoperative stress incontinence (22 vs. 9%, p = 0.03). Thirty-one (19%) of all subjects had recurrent prolapse; 10 (6%) underwent repeat surgery. Three (1%) subjects had a mesh exposure (no difference between groups), all treated conservatively. Ninety-six (60%) subjects responded to the survey with a median follow-up of 56 (9-134) months. Ninety-one percent (87) of respondents reported being better since surgery, and 91% (87) reported they would choose the surgery again. Twenty-eight percent (27) reported a surgery-related complication including pain, urinary and bowel symptoms; 8% (8) reported evaluation for recurrent prolapse symptoms, all treated conservatively; 4% (4) of respondents reported a mesh exposure. Conclusions: Incidence of adverse events is low and not different between patients undergoing minimally invasive sacrocolpopexy with concurrent supracervical or vaginal hysterectomy. One in three patients report pelvic floor symptoms postoperatively, but long-term satisfaction is high.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Hysterectomy, Vaginal/adverse effects ; Middle Aged ; Minimally Invasive Surgical Procedures/adverse effects ; Operative Time ; Postoperative Complications/etiology ; Recurrence ; Reoperation ; Retrospective Studies ; Sacrum/surgery ; Surgical Mesh/adverse effects ; Treatment Outcome ; Urinary Incontinence, Stress/etiology ; Uterine Prolapse/surgery ; Vagina/surgery
Language	English
Publishing date	2018-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-018-3790-4
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Article ; Online: Association of Physician Specialty With Long-Term Implantable Cardioverter-Defibrillator Complication and Reoperations Rates.

Chui, Philip W / Wang, Yongfei / Ranasinghe, Isuru / Mitiku, Teferi Y / Seto, Arnold H / Rosman, Lindsey / Lampert, Rachel / Minges, Karl E / Enriquez, Alan D / Curtis, Jeptha P

Circulation. Cardiovascular quality and outcomes

2019 Volume 12, Issue 6, Page(s) e005374

Abstract: ... surgeons, 16.4%; other specialists, 15.2%; P<0.001) and reoperations for reasons other than complications ... other specialists, 18.0%; P<0.001). Compared with patients whose ICDs were implanted by electrophysiologists ... general cardiologists: 1.13 [1.08-1.18]; thoracic surgeons: 1.20 [1.06-1.37]; all P<0.001, but not ...

Abstract	Background Patients undergoing implantable cardioverter-defibrillator (ICD) implantations have high rates of long-term device-related complications and reoperations. Whether physician specialty training is associated with differences in long-term outcomes following ICD implantation is unclear. Methods and Results We linked data from the National Cardiovascular Data Registry ICD Registry with Medicare fee-for-service claims to identify physicians who performed ≥10 index ICDs from 2006 to 2009. We used data from the American Board of Medical Specialties to group the specialty of the implanting physician into mutually exclusive categories: electrophysiologists, interventional cardiologists, general cardiologists, thoracic surgeons, and other specialties. Primary outcomes were long-term device-related complications requiring reoperations or hospitalizations and reoperations for reasons other than complications. We compared the cumulative incidence rates and case-mix adjusted rates of long-term outcomes of index ICD implantations across physician specialties. Our analysis had a median follow-up of 47 months and included 107 966 index ICD implantations. Electrophysiologists had the lowest rates of incident long-term device-related complications (14.1%; interventional cardiologists, 15.3%; general cardiologists, 15.4%; thoracic surgeons, 16.4%; other specialists, 15.2%; P<0.001) and reoperations for reasons other than complications (electrophysiologists, 16.7%; interventional cardiologists, 17.0%; general cardiologists, 18.0%; thoracic surgeons, 18.4%; other specialists, 18.0%; P<0.001). Compared with patients whose ICDs were implanted by electrophysiologists, patients with implantations performed by nonelectrophysiologists were at higher risk of having long-term device-related complications (relative risk for interventional cardiologists: 1.16 [95% CI, 1.08-1.25]; general cardiologists: 1.13 [1.08-1.18]; thoracic surgeons: 1.20 [1.06-1.37]; all P<0.001, but not other specialists: 1.08 [0.99-1.17]; P=0.07). Compared to patients with implantations performed by electrophysiologists, patients with implantations performed by general cardiologists and thoracic surgeons were at higher risk of reoperation for noncomplication causes (relative risk for general cardiologists: 1.10 [1.05-1.15]; thoracic surgeons: 1.16 [1.00-1.33]; both P<0.05). Conclusions Patients with ICD implantations performed by electrophysiologists had the lowest risks of having long-term device-related complications and reoperations for noncomplication causes. Consideration of physician specialty before ICD implantation may represent an opportunity to minimize long-term adverse outcomes.
MeSH term(s)	Aged ; Aged, 80 and over ; Clinical Competence ; Defibrillators, Implantable ; Electric Countershock/adverse effects ; Electric Countershock/instrumentation ; Electric Countershock/trends ; Fee-for-Service Plans ; Female ; Humans ; Incidence ; Male ; Medicare ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Practice Patterns, Physicians'/trends ; Registries ; Reoperation/trends ; Risk Assessment ; Risk Factors ; Specialization/trends ; Time Factors ; Treatment Outcome ; United States/epidemiology
Language	English
Publishing date	2019-06-12
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.118.005374
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