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  1. Article ; Online: Connect the Dots-May 2020.

    Miller, Hayley E / Gentile, Nicole D / Holton, Siri M / Chescheir, Nancy C

    Obstetrics and gynecology

    2020  Volume 135, Issue 5, Page(s) 1222–1223

    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000003831
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  2. Article ; Online: The Incidence of Microscopic Colitis: Microscopic No More.

    Gentile, Nicole M / Yen, Eugene F

    Digestive diseases and sciences

    2017  Volume 62, Issue 6, Page(s) 1394–1395

    MeSH term(s) Colitis, Microscopic/epidemiology ; Humans ; Incidence
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-017-4484-3
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  3. Article ; Online: Postacute Sequelae of SARS-CoV-2: Musculoskeletal Conditions and Pain.

    Copley, Michelle / Kozminski, Barbara / Gentile, Nicole / Geyer, Rachel / Friedly, Janna

    Physical medicine and rehabilitation clinics of North America

    2023  Volume 34, Issue 3, Page(s) 585–605

    Abstract: Musculoskeletal and pain sequelae of COVID-19 are common in both the acute infection and patients experiencing longer term symptoms associated with recovery, known as postacute sequelae of COVID-19 (PASC). Patients with PASC may experience multiple ... ...

    Abstract Musculoskeletal and pain sequelae of COVID-19 are common in both the acute infection and patients experiencing longer term symptoms associated with recovery, known as postacute sequelae of COVID-19 (PASC). Patients with PASC may experience multiple manifestations of pain and other concurrent symptoms that complicate their experience of pain. In this review, the authors explore what is currently known about PASC-related pain and its pathophysiology as well as strategies for diagnosis and management.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/complications ; Musculoskeletal Diseases/diagnosis ; Musculoskeletal Diseases/etiology ; Pain ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196791-2
    ISSN 1558-1381 ; 1047-9651
    ISSN (online) 1558-1381
    ISSN 1047-9651
    DOI 10.1016/j.pmr.2023.04.008
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  4. Article: PRO: Patients With Hepatitis C Virus With Pretreatment Metavir Stage 3 Fibrosis Do Not Require Hepatocellular Carcinoma Surveillance After Sustained Virological Response.

    Yeboah-Korang, Amoah / Gentile, Nicole M / Fimmel, Claus J

    Clinical liver disease

    2018  Volume 12, Issue 5, Page(s) 133–136

    Language English
    Publishing date 2018-12-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.649
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  5. Article ; Online: Bile Acid Sequestrant Therapy in Microscopic Colitis.

    Northcutt, Michael J / Gentile, Nicole M / Goldstein, Jay L / Yen, Eugene F

    Journal of clinical gastroenterology

    2020  Volume 56, Issue 2, Page(s) 161–165

    Abstract: Goals: There is an unmet need in investigating corticosteroid-sparing treatments for induction and maintenance of remission in microscopic colitis (MC). The authors' aim was to evaluate the outcomes of patients with MC treated with bile acid ... ...

    Abstract Goals: There is an unmet need in investigating corticosteroid-sparing treatments for induction and maintenance of remission in microscopic colitis (MC). The authors' aim was to evaluate the outcomes of patients with MC treated with bile acid sequestrants (BAS).
    Background: MC is a common chronic diarrheal illness. Budesonide is effective induction therapy, but relapses are high after cessation of treatment.
    Study: Our cohort consisted of patients enrolled in our institutional MC registry, a biorepository of histology-confirmed diagnoses of MC. Patients receiving BAS for the treatment of MC were reviewed at each clinical visit for efficacy or ability to decrease budesonide maintenance dosing.
    Results: The authors included 79 patients (29 collagenous colitis and 50 lymphocytic colitis) with a median follow-up period of 35 months (range, 1 to 120). Most patients were female individuals (78%) and the median age was 69 years (range, 29 to 87). BAS therapy was used in 21 patients who were budesonide-naive, with a response rate of 76% (16/21). In patients treated previously with budesonide, 46 patients were budesonide-dependent and given BAS as maintenance therapy. Of these patients, 23 (50%) were able to decrease their budesonide dosing and 9 (20%) were able to stop budesonide completely. Seven of 46 patients (15%) stopped BAS because of intolerance, perceived lack of benefit, or treatment of concomitant diarrhea illness.
    Conclusions: BAS may be an effective corticosteroid-sparing option in the treatment of MC and should be considered after budesonide induction. Larger controlled studies are needed to confirm the efficacy for long-term maintenance and tolerability of BAS in patients with MC.
    MeSH term(s) Aged ; Bile Acids and Salts ; Budesonide/adverse effects ; Colitis, Collagenous/drug therapy ; Colitis, Lymphocytic/drug therapy ; Colitis, Microscopic/drug therapy ; Female ; Humans
    Chemical Substances Bile Acids and Salts ; Budesonide (51333-22-3)
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001496
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  6. Article ; Online: Nonsteroidal anti-inflammatory drug exposure and the risk of microscopic colitis.

    Yen, Eugene F / Amusin, Daniel B / Yoo, Janet / Ture, Asantewaa / Gentile, Nicole M / Goldberg, Michael J / Goldstein, Jay L

    BMC gastroenterology

    2022  Volume 22, Issue 1, Page(s) 367

    Abstract: Background: Medication consumption has been suggested as a risk factor for microscopic colitis (MC), but studies of varying design have yielded inconsistent results. Our aim was to evaluate the association between medications and MC.: Methods: A ... ...

    Abstract Background: Medication consumption has been suggested as a risk factor for microscopic colitis (MC), but studies of varying design have yielded inconsistent results. Our aim was to evaluate the association between medications and MC.
    Methods: A hybrid cohort of prospectively identified patients undergoing colonoscopy with biopsies for suspicion of MC (N = 144) and patients with MC enrolled within three months of diagnosis into an MC registry (N = 59) were surveyed on medication use. Medication use was compared between patients with and without diagnosis of MC by chi-squared test and binomial logistic regression adjusted for known risk factors of MC: age and gender.
    Results: In total, 80 patients with MC (21 new, 59 registry) were enrolled. Patients with MC were more likely to be older (p = 0.03) and female (p = 0.01) compared to those without MC. Aspirin and other non-steroidal anti-inflammatory drugs were more commonly used among patients who developed MC (p < 0.01). After controlling for age and gender, these medications remained independent predictors of MC with odds ratio for any non-steroidal anti-inflammatory drug use of 3.04 (95% CI: 1.65-5.69). No association between MC and other previously implicated medications including proton pump inhibitors and selective serotonin reuptake inhibitors was found.
    Conclusions: In this cohort of patients with chronic diarrhea, we found use of aspirin and non-steroidal anti-inflammatory drugs, but not other implicated medications to be associated with the development of MC. Whether these drugs trigger colonic inflammation in predisposed hosts or worsen diarrhea in undiagnosed patients is unclear. However, we feel that these findings are sufficient to discuss potential non-steroidal anti-inflammatory drug cessation in patients newly diagnosed with MC.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Aspirin ; Colitis, Microscopic/chemically induced ; Colitis, Microscopic/epidemiology ; Colonoscopy/adverse effects ; Diarrhea/etiology ; Female ; Humans ; Risk Factors
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-022-02438-z
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  7. Article: Educational and Clinical Outcome Measures in an Integrated Hand Service

    Kozusko, Steven D. / Breyer, Garrett M. / Wright, Branden J. / Gentile, Pietro M. / Fuller, David A. / Bonawitz, Steven C. / Deal, Dylan Nicole / Franco, Michael J.

    Journal of Hand and Microsurgery

    2023  

    Abstract: Background: We recently sought to integrate our orthopaedic and plastic hand surgeons with the goal of improving education, patient care, and providing seamless, continuous coverage for our trauma center. Our hypothesis was that integration could serve ... ...

    Abstract Background: We recently sought to integrate our orthopaedic and plastic hand surgeons with the goal of improving education, patient care, and providing seamless, continuous coverage for our trauma center. Our hypothesis was that integration could serve both the orthopaedic and plastic surgery training programs well and provide more consistent care for the trauma patients.
    Materials and Methods: Program director approval was granted for blinded analysis of case logs from plastic and orthopaedic surgery programs from 2012 through 2019. Data on mean and total number of hand cases were analyzed and compared for both specialties. Institutional Review Board approval was granted for a retrospective review of patient outcomes.
    Results: For both orthopaedic and plastics resident trainees, the mean number of hand cases increased during this study period suggesting that the integration had a favorable impact on both programs. The mean number of hand cases for orthopaedic residents rose from 163 to 246. The mean number of hand cases for plastic surgery residents rose from 218 to 295. Patient outcomes as reflected in length of stay and time to consultation also improved.
    Conclusion: To improve hand surgical training and patient care, an integrated orthoplastics approach to hand surgery was implemented at our institution. Plastic surgery trainees are completing more hand surgery cases in an integrated model ( p  < 0.001), including fracture care ( p  < 0.047). Orthopaedic surgery trainees have doubled the percentage of integumentary and microsurgery cases in the integrated model ( p  < 0.001). The educational and clinical changes affected in an integrated model have changed the paradigm for educating future hand surgeons at our institution.
    Keywords fellowship ; training ; hand ; reconstructive ; plastic and hand surgeon
    Language English
    Publishing date 2023-03-13
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 0974-6897 ; 0974-3227
    ISSN (online) 0974-6897
    ISSN 0974-3227
    DOI 10.1055/s-0043-1760841
    Database Thieme publisher's database

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  8. Article ; Online: The impact of a rapid home test on telehealth decision-making for influenza: a clinical vignette study.

    Cai, Xinyan / Ebell, Mark H / Geyer, Rachel E / Thompson, Matthew / Gentile, Nicole L / Lutz, Barry

    BMC primary care

    2022  Volume 23, Issue 1, Page(s) 75

    Abstract: Background: Home testing for influenza has the potential to aid triage and management decisions for patients with influenza-like illness. As yet, little is known about the effect of the home influenza testing on clinical decision-making via telehealth. ... ...

    Abstract Background: Home testing for influenza has the potential to aid triage and management decisions for patients with influenza-like illness. As yet, little is known about the effect of the home influenza testing on clinical decision-making via telehealth. The goal of this study was to determine the clinicians' decision thresholds for influenza and whether the availability of a home influenza test affects clinical decisions.
    Methods: We identified primary care physicians at 4 different sites in the US, largely via in-person continuing education meetings. Clinicians were asked for each vignette whether to treat empirically ("rule in"), ask the patient come to the clinic for further evaluation ("test"), or neither test nor treat ("rule out"). They were then given the results of a home influenza test, and were again asked to select from these three options. We measured the agreement of physician estimates of the likelihood of influenza with the probability based on a clinical prediction model. The test and treatment thresholds of influenza were determined based on mixed-effect logistic regressions.
    Results: In total, 202 clinicians made 570 sets of clinical decisions. Agreement between estimated and actual probability of influenza was fair. The test and treatment thresholds were 24% (95% CI: 22% to 25%) and 63% (95% CI: 58% to 65%) before revealing the actual likelihood of influenza. After providing the results of a home flu test the thresholds were similar, 26% (95% CI: 24% to 29%) and 59% (95% CI: 56% to 62%). However, approximately half of clinicians changed their cliical management decision after being given the home influenza test result, largely by categorizing more patients in the "rule out" and "rule in" groups, and reducing the need for in-person evaluation from 41% of patients to only 20%.
    Conclusion: In the context of a telehealth visit for a patient with influenza-like illness, we identified a test threshold of approximately 25% and a treatment threshold of approximately 60%. Adding the home influenza test results reduced uncertainty and significantly decreased the need for in-person visits.
    MeSH term(s) Clinical Decision-Making ; Humans ; Influenza, Human/diagnosis ; Models, Statistical ; Prognosis ; Telemedicine
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2731-4553
    ISSN (online) 2731-4553
    DOI 10.1186/s12875-022-01675-1
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  9. Article ; Online: 66-year-old woman with painless jaundice.

    Gentile, Nicole M / Greenlund, Andrew C

    Mayo Clinic proceedings

    2012  Volume 87, Issue 10, Page(s) 1021–1024

    MeSH term(s) Aged ; Anti-Inflammatory Agents/therapeutic use ; Diagnosis, Differential ; Female ; Hepatitis, Autoimmune/complications ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/drug therapy ; Humans ; Jaundice, Obstructive/diagnosis ; Jaundice, Obstructive/etiology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Function Tests ; Urticaria/etiology
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2012-10-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2012.03.018
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  10. Article ; Online: 88-Year-Old Man With Mental Status Changes and Vesicular Lesions.

    Kim, Hidong / Gentile, Nicole M / Poterucha, Thomas H

    Mayo Clinic proceedings

    2015  Volume 90, Issue 8, Page(s) 1131–1134

    MeSH term(s) Aged, 80 and over ; Antiviral Agents/therapeutic use ; Forehead ; Herpes Zoster/diagnosis ; Herpes Zoster/drug therapy ; Herpes Zoster/psychology ; Humans ; Male ; Mental Disorders/etiology ; Mental Disorders/pathology
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2015.02.022
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