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  1. Article: Impact of Low-Burden

    Lazarian, Gregory / Cymbalista, Florence / Baran-Marszak, Fanny

    Frontiers in oncology

    2022  Volume 12, Page(s) 841630

    Abstract: In chronic lymphocytic leukemia (CLL), ...

    Abstract In chronic lymphocytic leukemia (CLL),
    Language English
    Publishing date 2022-02-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.841630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Post-SARS-CoV-2 vaccination acute hemolysis in an older man: don't forget to look at the blood smear.

    Duchemann, Boris / Lazarian, Gregory

    Blood

    2021  Volume 138, Issue 21, Page(s) 2153

    MeSH term(s) Aged ; Antibodies, Monoclonal/therapeutic use ; Blood Transfusion ; COVID-19 Vaccines/adverse effects ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Diagnosis, Differential ; Glucosephosphate Dehydrogenase Deficiency/complications ; Hemolysis ; Humans ; Jaundice/etiology ; Lung Neoplasms/blood ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Male ; Vaccination/adverse effects ; Vicia faba/adverse effects
    Chemical Substances Antibodies, Monoclonal ; COVID-19 Vaccines ; durvalumab (28X28X9OKV)
    Language English
    Publishing date 2021-11-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: A rare case of leukemic anaplastic large cell lymphoma with the variant translocation t(X;2).

    Tueur, Giulia / Lazarian, Gregory

    Blood

    2019  Volume 134, Issue 17, Page(s) 1480

    MeSH term(s) Adult ; Anaplastic Lymphoma Kinase/genetics ; Female ; Humans ; Lymphoma, Large-Cell, Anaplastic/genetics ; Lymphoma, Large-Cell, Anaplastic/pathology ; Microfilament Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Translocation, Genetic
    Chemical Substances Microfilament Proteins ; Oncogene Proteins, Fusion ; moesin (144131-77-1) ; ALK protein, human (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1)
    Language English
    Publishing date 2019-11-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2019002519
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  4. Article ; Online: Inflammation is predictive of outcome in Waldenström macroglobulinemia treated by Bruton tyrosine kinase inhibitors: a multicentric real-life study.

    Debureaux, Pierre-Edouard / Forgeard, Nathalie / Elessa, Dikelele / Harel, Stéphanie / Frenzel, Laurent / Royer, Bruno / Talbot, Alexis / Choquet, Sylvain / Davi, Frederic / Nguyen-Khac, Florence / Cuccuini, Wendy / Cheminant, Morgane / Bravetti, Clotilde / Lazarian, Gregory / Kaltenbach, Sophie / Hermine, Olivier / Roos-Weil, Damien / Espéli, Marion / Balabanian, Karl /
    Arnulf, Bertrand

    Haematologica

    2024  Volume 109, Issue 1, Page(s) 325–330

    MeSH term(s) Humans ; Waldenstrom Macroglobulinemia/drug therapy ; Tyrosine Kinase Inhibitors ; Agammaglobulinaemia Tyrosine Kinase ; Inflammation ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Tyrosine Kinase Inhibitors ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283141
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  5. Article ; Online: Clinical Implications of Novel Genomic Discoveries in Chronic Lymphocytic Leukemia.

    Lazarian, Gregory / Guièze, Romain / Wu, Catherine J

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2017  Volume 35, Issue 9, Page(s) 984–993

    Abstract: Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy with a remarkably heterogeneous course, ranging from indolent disease with no need for immediate therapy to rapidly progressive disease associated with therapeutic resistance. The recent US ...

    Abstract Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy with a remarkably heterogeneous course, ranging from indolent disease with no need for immediate therapy to rapidly progressive disease associated with therapeutic resistance. The recent US Food and Drug Administration approvals of novel targeted therapies such as inhibitors of B-cell receptor signaling and B-cell lymphoma 2 have opened up new opportunities in the clinical management of patients with CLL and heralded a new era in the clinical treatment of this disease. In parallel, the implementation of novel sequencing technologies has provided new insights into CLL complexity, identifying a growing list of putative drivers that underlie inter- and intratumor heterogeneities in CLL affecting disease progression and resistance. The identification of these novel genomic features that can indicate future drug resistance or guide therapeutic management is now becoming a major goal in CLL so that patients can best benefit from the increasingly diverse available therapies, as discussed herein.
    MeSH term(s) Genomics/methods ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy
    Language English
    Publishing date 2017-02-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2016.71.0822
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  6. Article ; Online: Identification of the Axis β-Catenin-BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment.

    Mihoub, Imane / Rharass, Tareck / Ouriemmi, Souhaïl / Oudar, Antonin / Aubard, Laure / Gratio, Valérie / Lazarian, Gregory / Ferreira, Jordan / Dondi, Elisabetta / Cymbalista, Florence / Levy, Vincent / Baran-Marszak, Fanny / Varin-Blank, Nadine / Ledoux, Dominique / Le Roy, Christine / Gardano, Laura

    International journal of molecular sciences

    2023  Volume 24, Issue 24

    Abstract: In the microenvironment, cell interactions are established between different cell types to regulate their migration, survival and activation. β-Catenin is a multifunctional protein that stabilizes cell-cell interactions and regulates cell survival ... ...

    Abstract In the microenvironment, cell interactions are established between different cell types to regulate their migration, survival and activation. β-Catenin is a multifunctional protein that stabilizes cell-cell interactions and regulates cell survival through its transcriptional activity. We used chronic lymphocytic leukemia (CLL) cells as a cellular model to study the role of β-catenin in regulating the adhesion of tumor cells to their microenvironment, which is necessary for tumor cell survival and accumulation. When co-cultured with a stromal cell line (HS-5), a fraction of the CLL cells adhere to stromal cells in a dynamic fashion regulated by the different levels of β-catenin expression. In non-adherent cells, β-catenin is stabilized in the cytosol and translocates into the nucleus, increasing the expression of cyclin D1. In adherent cells, the level of cytosolic β-catenin is low but membrane β-catenin helps to stabilize the adhesion of CLL to stromal cells. Indeed, the overexpression of β-catenin enhances the interaction of CLL with HS-5 cells, suggesting that this protein behaves as a regulator of cell adhesion to the stromal component and of the transcriptional regulation of cell survival. Inhibitors that block the stabilization of β-catenin alter this equilibrium and effectively disrupt the support that CLL cells receive from the cross-talk with the stroma.
    MeSH term(s) Humans ; beta Catenin/genetics ; beta Catenin/metabolism ; Cell Communication ; Cell Line, Tumor ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Stromal Cells/metabolism ; Tumor Microenvironment ; Agammaglobulinaemia Tyrosine Kinase/metabolism
    Chemical Substances beta Catenin ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2)
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242417623
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  7. Article ; Online: Identification of the Axis β-Catenin–BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment

    Imane Mihoub / Tareck Rharass / Souhaïl Ouriemmi / Antonin Oudar / Laure Aubard / Valérie Gratio / Gregory Lazarian / Jordan Ferreira / Elisabetta Dondi / Florence Cymbalista / Vincent Levy / Fanny Baran-Marszak / Nadine Varin-Blank / Dominique Ledoux / Christine Le Roy / Laura Gardano

    International Journal of Molecular Sciences, Vol 24, Iss 24, p

    2023  Volume 17623

    Abstract: In the microenvironment, cell interactions are established between different cell types to regulate their migration, survival and activation. β-Catenin is a multifunctional protein that stabilizes cell–cell interactions and regulates cell survival ... ...

    Abstract In the microenvironment, cell interactions are established between different cell types to regulate their migration, survival and activation. β-Catenin is a multifunctional protein that stabilizes cell–cell interactions and regulates cell survival through its transcriptional activity. We used chronic lymphocytic leukemia (CLL) cells as a cellular model to study the role of β-catenin in regulating the adhesion of tumor cells to their microenvironment, which is necessary for tumor cell survival and accumulation. When co-cultured with a stromal cell line (HS-5), a fraction of the CLL cells adhere to stromal cells in a dynamic fashion regulated by the different levels of β-catenin expression. In non-adherent cells, β-catenin is stabilized in the cytosol and translocates into the nucleus, increasing the expression of cyclin D1. In adherent cells, the level of cytosolic β-catenin is low but membrane β-catenin helps to stabilize the adhesion of CLL to stromal cells. Indeed, the overexpression of β-catenin enhances the interaction of CLL with HS-5 cells, suggesting that this protein behaves as a regulator of cell adhesion to the stromal component and of the transcriptional regulation of cell survival. Inhibitors that block the stabilization of β-catenin alter this equilibrium and effectively disrupt the support that CLL cells receive from the cross-talk with the stroma.
    Keywords β-catenin ; microenvironment ; CLL ; BTK ; stromal cells ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Autoimmune haemolytic anaemia associated with COVID-19 infection.

    Lazarian, Gregory / Quinquenel, Anne / Bellal, Mathieu / Siavellis, Justine / Jacquy, Caroline / Re, Daniel / Merabet, Fatiha / Mekinian, Arsene / Braun, Thorsten / Damaj, Gandhi / Delmer, Alain / Cymbalista, Florence

    British journal of haematology

    2020  Volume 190, Issue 1, Page(s) 29–31

    MeSH term(s) Aged ; Anemia, Hemolytic, Autoimmune/epidemiology ; Anemia, Hemolytic, Autoimmune/etiology ; Anemia, Hemolytic, Autoimmune/therapy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16794
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  9. Article ; Online: TP53 mutations at codon 234 are associated with chlorambucil treatment in chronic lymphocytic leukemia.

    Lazarian, Grégory / Theves, Floriane / Hormi, Myriam / Letestu, Rémi / Eclache, Virginie / Bidet, Audrey / Cornillet-Lefebvre, Pascale / Davi, Frédéric / Delabesse, Eric / Estienne, Marie-Hélène / Etancelin, Pascaline / Kosmider, Olivier / Laibe, Sophy / Lode, Laurence / Muller, Marc / Nadal, Nathalie / Naguib, Dina / Pastoret, Cédric / Poulain, Stéphanie /
    Sujobert, Pierre / Veronese, Lauren / Imache, Samia / Lefebvre, Valérie / Cymbalista, Florence / Baran-Marszak, Fanny / Soussi, Thierry

    American journal of hematology

    2022  Volume 97, Issue 4, Page(s) E159–E162

    MeSH term(s) Chlorambucil/therapeutic use ; Codon ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Mutation ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Codon ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Chlorambucil (18D0SL7309)
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26479
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  10. Article ; Online: Prevalence, distribution and predictive value of XPO1 mutation in a real-life chronic lymphocytic leukaemia cohort.

    Tueur, Giulia / Lazarian, Gregory / Eclache, Virginie / Fleury, Carole / Letestu, Rémi / Lévy, Vincent / Lefebvre, Valérie / Collon, Jean-Francois / Zini, Jean-Marc / Thieblemont, Catherine / Soussi, Thierry / Cymbalista, Florence / Baran-Marszak, Fanny

    British journal of haematology

    2020  Volume 191, Issue 3, Page(s) e90–e94

    MeSH term(s) Alleles ; Biomarkers, Tumor ; Clonal Evolution ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Karyopherins/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/mortality ; Mutation ; Prevalence ; Prognosis ; Receptors, Cytoplasmic and Nuclear/genetics ; Exportin 1 Protein
    Chemical Substances Biomarkers, Tumor ; Karyopherins ; Receptors, Cytoplasmic and Nuclear
    Language English
    Publishing date 2020-08-13
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17046
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