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  1. Article: On the role of anti-cN1A antibodies in sporadic inclusion body myositis and beyond: a challenging task full of surprises.

    Patrikiou, Eleni / Liaskos, Christos / Bogdanos, Dimitrios P

    Reumatologia

    2024  Volume 61, Issue 6, Page(s) 411–413

    Language English
    Publishing date 2024-01-05
    Publishing country Poland
    Document type Editorial
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum/177075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Artificial Intelligence and Prediction of Response to Biologics in Psoriatic Disease Using Immunophenotype Data: A Mini Review.

    Tsiogkas, Sotirios G / Dvir, Yoad M / Shoenfeld, Yehuda / Bogdanos, Dimitrios P

    The Israel Medical Association journal : IMAJ

    2024  Volume 26, Issue 2, Page(s) 114–119

    MeSH term(s) Humans ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Artificial Intelligence ; Arthritis, Psoriatic ; Psoriasis/drug therapy
    Chemical Substances Biological Products
    Language English
    Publishing date 2024-02-29
    Publishing country Israel
    Document type Review ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mediterranean Journal of Rheumatology June 2019 Highlights.

    Bogdanos, Dimitrios P

    Mediterranean journal of rheumatology

    2019  Volume 30, Issue 2, Page(s) 84–85

    Language English
    Publishing date 2019-06-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 3019943-8
    ISSN 2529-198X ; 2459-3516
    ISSN (online) 2529-198X
    ISSN 2459-3516
    DOI 10.31138/mjr.30.2.84
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies.

    Gkouvi, Arriana / Tsiogkas, Sotirios G / Bogdanos, Dimitrios P / Gika, Helen / Goulis, Dimitrios G / Grammatikopoulou, Maria G

    Current pain and headache reports

    2024  

    Abstract: Purpose of review: Fibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria. Proteomic analysis can provide significant biological information for the pathophysiology of the ... ...

    Abstract Purpose of review: Fibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria. Proteomic analysis can provide significant biological information for the pathophysiology of the disease but may also reveal biomarkers for diagnosis or therapeutic targets. The present systematic review aims to synthesize the evidence regarding the proteome of adult patients with FMS using data from observational studies.
    Recent findings: An extensive literature search was conducted in MEDLINE/PubMed, CENTRAL, and clinicaltrials.gov from inception until November 2022. The study protocol was published in OSF. Two independent reviewers evaluated the studies and extracted data. The quality of studies was assessed using the modified Newcastle-Ottawa scale adjusted for proteomic research. Ten studies fulfilled the protocol criteria, identifying 3328 proteins, 145 of which were differentially expressed among patients with FMS against controls. The proteins were identified in plasma, serum, cerebrospinal fluid, and saliva samples. The control groups included healthy individuals and patients with pain (inflammatory and non-inflammatory). The most important proteins identified involved transferrin, α-, β-, and γ-fibrinogen chains, profilin-1, transaldolase, PGAM1, apolipoprotein-C3, complement C4A and C1QC, immunoglobin parts, and acute phase reactants. Weak correlations were observed between proteins and pain sensation, or quality of life scales, apart from the association of transferrin and a2-macroglobulin with moderate-to-severe pain sensation. The quality of included studies was moderate-to-good. FMS appears to be related to protein dysregulation in the complement and coagulation cascades and the metabolism of iron. Several proteins may be dysregulated due to the excessive oxidative stress response.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055062-5
    ISSN 1534-3081 ; 1531-3433
    ISSN (online) 1534-3081
    ISSN 1531-3433
    DOI 10.1007/s11916-024-01244-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of autoantibodies in the clinical management of primary biliary cholangitis.

    Rigopoulou, Eirini I / Bogdanos, Dimitrios P

    World journal of gastroenterology

    2022  Volume 29, Issue 12, Page(s) 1795–1810

    Abstract: Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by immune-driven destruction of small intrahepatic bile ducts leading a proportion of patients to hepatic failure over the years. Diagnosis at early stages in concert ... ...

    Abstract Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by immune-driven destruction of small intrahepatic bile ducts leading a proportion of patients to hepatic failure over the years. Diagnosis at early stages in concert with ursodeoxycholic acid treatment has been linked with prevention of disease progression in the majority of cases. Diagnosis of PBC in a patient with cholestasis relies on the detection of disease-specific autoantibodies, including anti-mitochondrial antibodies, and disease-specific anti-nuclear antibodies targeting sp100 and gp210. These autoantibodies assist the diagnosis of the disease, and are amongst few autoantibodies the presence of which is included in the diagnostic criteria of the disease. They have also become important tools evaluating disease prognosis. Herein, we summarize existing data on detection of PBC-related autoantibodies and their clinical significance. Moreover, we provide insight on novel autoantibodies and their possible prognostic role in PBC patients.
    MeSH term(s) Humans ; Autoantibodies ; Liver Cirrhosis, Biliary/diagnosis ; Liver Cirrhosis, Biliary/drug therapy ; Antibodies, Antinuclear ; Cholestasis ; Ursodeoxycholic Acid/therapeutic use ; Cholangitis/diagnosis ; Cholangitis/drug therapy
    Chemical Substances Autoantibodies ; Antibodies, Antinuclear ; Ursodeoxycholic Acid (724L30Y2QR)
    Language English
    Publishing date 2022-10-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i12.1795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mediterranean Journal of Rheumatology September 2018 Highlights.

    Bogdanos, Dimitrios P

    Mediterranean journal of rheumatology

    2018  Volume 29, Issue 3, Page(s) 118–119

    Language English
    Publishing date 2018-09-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 3019943-8
    ISSN 2529-198X ; 2459-3516
    ISSN (online) 2529-198X
    ISSN 2459-3516
    DOI 10.31138/mjr.29.3.118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mediterranean Journal of Rheumatology June 2017 Highlights.

    Bogdanos, Dimitrios P

    Mediterranean journal of rheumatology

    2017  Volume 28, Issue 2, Page(s) 62–63

    Language English
    Publishing date 2017-06-27
    Publishing country Greece
    Document type Editorial
    ZDB-ID 3019943-8
    ISSN 2529-198X ; 2459-3516
    ISSN (online) 2529-198X
    ISSN 2459-3516
    DOI 10.31138/mjr.28.2.62
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Searching for Possible Links between Alzheimer's Disease and Systemic Sclerosis.

    Dardiotis, Efthymios / Bogdanos, Dimitrios P

    Mediterranean journal of rheumatology

    2020  Volume 31, Issue 4, Page(s) 378–381

    Language English
    Publishing date 2020-12-28
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 3019943-8
    ISSN 2529-198X ; 2459-3516
    ISSN (online) 2529-198X
    ISSN 2459-3516
    DOI 10.31138/mjr.31.4.378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficacy of tyrosine-kinase-2 and phosphodiesterase-4 inhibitors for scalp psoriasis: a systematic review and meta-analysis.

    Tsiogkas, Sotirios G / Karamitrou, Eleni K / Grammatikopoulou, Maria G / Zafiriou, Efterpi / Bogdanos, Dimitrios P

    Current medical research and opinion

    2024  Volume 40, Issue 2, Page(s) 155–163

    Abstract: Objectives: Psoriasis of the scalp is challenging to manage. The only approved oral tyrosine kinase 2 and phosphodiesterase 4 inhibitors for psoriasis are deucravacitinib and apremilast. The aim of this study was to explore their efficacy for scalp ... ...

    Abstract Objectives: Psoriasis of the scalp is challenging to manage. The only approved oral tyrosine kinase 2 and phosphodiesterase 4 inhibitors for psoriasis are deucravacitinib and apremilast. The aim of this study was to explore their efficacy for scalp psoriasis utilizing data from randomized controlled trials.
    Methods: We searched Medline, Scopus, Web of Science, CENTRAL, and ClinicalTrials.gov up to August 4, 2023. To determine risk of bias, the revised Risk of Bias assessment tool 2.0 was used. Inverse variance random effects meta-analyses were executed. Heterogeneity was assessed utilizing Q and I
    Results: Ten RCTs fulfilled inclusion criteria. Both apremilast (RR = 2.41, 95% CI = 2.08-2.79, Tau
    Conclusions: Apremilast and deucravacitinib are effective for scalp psoriasis. Deucravacitinib may be more efficient in clearing the scalp.
    MeSH term(s) Humans ; Phosphodiesterase 4 Inhibitors/therapeutic use ; Cyclic Nucleotide Phosphodiesterases, Type 4/therapeutic use ; TYK2 Kinase/therapeutic use ; Scalp ; Psoriasis/drug therapy ; Tyrosine/therapeutic use ; Severity of Illness Index ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Thalidomide/analogs & derivatives
    Chemical Substances apremilast (UP7QBP99PN) ; Phosphodiesterase 4 Inhibitors ; Cyclic Nucleotide Phosphodiesterases, Type 4 (EC 3.1.4.17) ; TYK2 Kinase (EC 2.7.10.2) ; Tyrosine (42HK56048U) ; Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2023.2288280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The role of B cells in the pathogenesis of systemic sclerosis: an update.

    Sakkas, Lazaros I / Katsiari, Christina G / Daoussis, Dimitrios / Bogdanos, Dimitrios P

    Rheumatology (Oxford, England)

    2022  Volume 62, Issue 5, Page(s) 1780–1786

    Abstract: The pathogenesis of SSc is incompletely understood, but several lines of evidence suggest that B cells are involved. Effector B (Beff) cells are hyperactivated and produce autoantibodies (autoAbs), and regulatory B cells (Bregs) are decreased, although a ...

    Abstract The pathogenesis of SSc is incompletely understood, but several lines of evidence suggest that B cells are involved. Effector B (Beff) cells are hyperactivated and produce autoantibodies (autoAbs), and regulatory B cells (Bregs) are decreased, although a recent study reported a defect in central B cell tolerance. AutoAbs appear before fibrosis, and some have direct profibrotic effects, while others also induce microvasculopathy. Recently, a study found that B cells reactive to topo I with high affinity produce IL-6 and cause fibrosis in mice, whereas B cells with low affinity for topo I produce IL-10 and inhibit fibrosis. Ibrutinib, a Bruton's tyrosine kinase inhibitor, promoted B cells with low affinity for topo I and decreased fibrosis. These findings provide a rationale for innovative B cell-directed strategies for managing SSc, such as ibrutinib or chimeric antigen receptor T cells, particularly in the early inflammatory stage of the disease.
    MeSH term(s) Animals ; Mice ; Scleroderma, Systemic ; Autoantibodies ; Fibrosis ; B-Lymphocytes, Regulatory
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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