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  1. Book ; Online ; E-Book: IgG4-related disease

    Okazaki, Kazuichi

    (Current topics in microbiology and immunology ; 401)

    2017  

    Author's details Kazuichi Okazaki editor
    Series title Current topics in microbiology and immunology ; 401
    Collection
    Language English
    Size 1 Online-Ressource (vii, 128 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019396517
    ISBN 978-3-319-52542-6 ; 9783319525419 ; 3-319-52542-5 ; 3319525417
    DOI 10.1007/978-3-319-52542-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Diseases of the Gallbladder

    Chung, Jae Bock / Okazaki, Kazuichi

    2020  

    Abstract: This book provides up-to-date information on all aspects of gallbladder disease. After an introductory section on laboratory findings, pathology, and diagnostic methods, it focuses on specific conditions and their management, covering gallbladder stones, ...

    Author's details edited by Jae Bock Chung, Kazuichi Okazaki
    Abstract This book provides up-to-date information on all aspects of gallbladder disease. After an introductory section on laboratory findings, pathology, and diagnostic methods, it focuses on specific conditions and their management, covering gallbladder stones, acalculous cholecystitis, gallbladder lesions associated with IgG4-related disease and with anomalous pancreaticobiliary ductal union, and dyskinesia of the gallbladder. Moreover, it discusses incidental gallbladder carcinoma in detail, including epidemiology, risk factors, gene mutations, diagnostic imaging methods and treatment modalities. The book also features a section exploring important current issues, such as the diagnosis and therapy of polypoid lesions and gallbladder wall thickening, and the role of prophylactic cholecystectomy in patients with concomitant gallstones following removal of common bile duct stones by ERCP. It also compares endoscopic gallbladder drainage with percutaneous transhepatic gallbladder drainage. Lastly, the book offers stimulating future perspectives.
    Keywords Gastroenterology  ; Hepatology ; Oncology   ; Gastroenterology ; Oncology
    Subject code 910.02
    Language English
    Size 1 online resource (IX, 319 p. 132 illus., 80 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-6010-2 ; 981-15-6009-9 ; 978-981-15-6010-1 ; 978-981-15-6009-5
    DOI 10.1007/978-981-15-6010-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Autoimmune Pancreatitis and IgG4-Related Disease: The Storiform Discovery to Treatment.

    Okazaki, Kazuichi

    Digestive diseases and sciences

    2019  Volume 64, Issue 9, Page(s) 2385–2394

    Abstract: Autoimmune pancreatitis (AIP) is an entity that has been recognized since 1961. Prior to the discovery of elevated serum IgG4 as a useful biomarker for its diagnosis, Dr. Yoshida in 1995 first described the entity of AIP, which in retrospect closely ... ...

    Abstract Autoimmune pancreatitis (AIP) is an entity that has been recognized since 1961. Prior to the discovery of elevated serum IgG4 as a useful biomarker for its diagnosis, Dr. Yoshida in 1995 first described the entity of AIP, which in retrospect closely resembles the current concept of type 1 AIP. Since the discovery of IgG4 as a biomarker (the IgG4-era), a novel concept of IgG4-related disease (IgG4-RD) has been accepted as being comprised of two subtypes of AIP: type 1 defined as the pancreatic manifestation of IgG4-RD, and type 2 characterized by granulocytic epithelial lesions. The characteristic features of type 1 AIP are increased serum IgG4 levels, lymphoplasmacytic sclerosing pancreatitis (abundant infiltration of IgG4+ plasmocytes and lymphocytes, storiform fibrosis, and obliterative phlebitis), extrapancreatic manifestations of IgG4-RD (e.g., sclerosing cholangitis, sclerosing sialadenitis, retroperitoneal fibrosis), and steroid responsiveness. These entities can be differentiated from mimickers by a combination of serum IgG4 level, imaging features, and histopathological findings. The current first-line therapy is corticosteroids, or rituximab in high-risk patients with steroid intolerance. Although relapse rates are high, treatment of relapsed disease remains experimental.
    MeSH term(s) Autoimmune Pancreatitis/classification ; Autoimmune Pancreatitis/diagnosis ; Autoimmune Pancreatitis/drug therapy ; Autoimmune Pancreatitis/history ; History, 20th Century ; History, 21st Century ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G4-Related Disease/blood ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/history ; Induction Chemotherapy ; Maintenance Chemotherapy
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2019-07-30
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-019-05746-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The 58

    Okazaki, Kazuichi

    Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

    2017  Volume 114, Issue 6, Page(s) 969–970

    MeSH term(s) Gastroenterology ; Societies, Medical
    Language Japanese
    Publishing date 2017-06-01
    Publishing country Japan
    Document type Congress ; Editorial
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.114.969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Current status of type 1 (IgG4-related) autoimmune pancreatitis.

    Uchida, Kazushige / Okazaki, Kazuichi

    Journal of gastroenterology

    2022  Volume 57, Issue 10, Page(s) 695–708

    Abstract: In 1995, Yoshida et al. proposed first the concept of "autoimmune pancreatitis" (AIP). Since then, AIP has been accepted as a new pancreatic inflammatory disease and is now divided two subtypes. Type 1 AIP affected immunoglobulin G4 (IgG4) and implicates ...

    Abstract In 1995, Yoshida et al. proposed first the concept of "autoimmune pancreatitis" (AIP). Since then, AIP has been accepted as a new pancreatic inflammatory disease and is now divided two subtypes. Type 1 AIP affected immunoglobulin G4 (IgG4) and implicates the pancreatic manifestation of IgG4-related disease, while type 2 is characterized by neutrophil infiltration and granulocytic epithelial lesions (GEL). Recent research has clarified the clinical and pathophysiological aspects of type 1 AIP, which is more than type 2 among the Japanese population. However, many details remain unclear about the pathogenesis and progression of this disease. In this review, we discuss the current knowledge and recent advances relating to type 1 AIP.
    MeSH term(s) Autoimmune Diseases ; Autoimmune Pancreatitis/diagnosis ; Humans ; Immunoglobulin G ; Immunoglobulin G4-Related Disease/diagnosis ; Pancreatic Diseases ; Pancreatitis/diagnosis ; Pancreatitis/etiology
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-08-02
    Publishing country Japan
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-022-01891-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: IgG4-related disease

    Okazaki, Kazuichi

    (Current topics in microbiology and immunology ; Volume 401)

    2017  

    Author's details Kazuichi Okazaki, editor
    Series title Current topics in microbiology and immunology ; Volume 401
    Language English
    Size vii, 128 Seiten, 23.5 cm x 15.5 cm, 0 g
    Edition 1st ed. 2017
    Publisher Springer
    Publishing place Cham
    Document type Book
    ISBN 3319525417 ; 9783319525419 ; 9783319525426 ; 3319525425
    Database Friedrich Loeffler-Institute, Federal Research Institute for Animal Health

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  7. Article ; Online: Recent progress on the treatment of type 1 autoimmune pancreatitis and IgG4-related disease.

    Okazaki, Kazuichi / Ikeura, Tsukasa / Uchida, Kazushige

    Modern rheumatology

    2022  Volume 33, Issue 2, Page(s) 237–241

    Abstract: IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder recognized as a novel clinical entity with either synchronous or metachronous multiorgan involvement. Autoimmune pancreatitis (AIP) is classified into two types: type 1 AIP as a pancreatic ... ...

    Abstract IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder recognized as a novel clinical entity with either synchronous or metachronous multiorgan involvement. Autoimmune pancreatitis (AIP) is classified into two types: type 1 AIP as a pancreatic manifestation of IgG4-RD and type 2 AIP with granulocytic epithelial lesion and occasional association with ulcerative colitis. Although the pathogenic mechanism still remains unclear, possible multipathogenic factors such as genetic factors, disease-specific or related antigens, and abnormal innate or adaptive immunity may be involved in the development of IgG4-RD. Many immunocytes including M2 macrophages, plasmablasts, B cells, and T-cells (Th2-CD4+T, follicular helper T-cells, and CD4+SLAMF7+cytotoxic T-cells) play important roles in the pathogenesis. Conventional induction and maintenance therapies with glucocorticoid or rituximab are recommended in all symptomatic patients with active IgG4-RD. In those at risk for irreversible damage in any organs, this should be done urgently, regardless of symptoms. As no randomized clinical trials other than glucocorticoid maintenance therapy for type 1 AIP have been performed, the comprehensive management for IgG4-RD has not been established yet. Targeted treatment approaches against the plasmablast to B cell lineage and the CD4+ SLAMF7+ cytotoxic T-cell seem to be promising for the future-directed treatment.
    MeSH term(s) Humans ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/drug therapy ; Autoimmune Pancreatitis/diagnosis ; Autoimmune Pancreatitis/drug therapy ; Glucocorticoids/therapeutic use ; Pancreatitis/drug therapy ; Pancreatitis/diagnosis ; CD4-Positive T-Lymphocytes ; Autoimmune Diseases/diagnosis
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1093/mr/roac054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Programs for Continuing Medical Education: A session; 2. Recent concept of IgG4-related disease and autoimmune pancreatitis].

    Okazaki, Kazuichi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2015  Volume 104, Issue 3, Page(s) 483–489

    MeSH term(s) Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; Humans ; Immunoglobulin G/immunology ; Pancreatitis/diagnosis ; Pancreatitis/drug therapy ; Pancreatitis/immunology ; Practice Guidelines as Topic ; Steroids/therapeutic use
    Chemical Substances Immunoglobulin G ; Steroids
    Language Japanese
    Publishing date 2015-10-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.104.483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Recent advances in the management of autoimmune pancreatitis].

    Okazaki, Kazuichi / Uchida, Kazushige

    Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

    2019  Volume 116, Issue 4, Page(s) 265–278

    MeSH term(s) Acute Disease ; Autoimmune Diseases/therapy ; Chronic Disease ; Humans ; Pancreatitis, Chronic/immunology ; Pancreatitis, Chronic/therapy
    Language Japanese
    Publishing date 2019-04-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.116.265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [112th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: Recent Progress in IgG4-related Disease: Introduction].

    Okazaki, Kazuichi / Saito, Takao

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2018  Volume 104, Issue 9, Page(s) 1831

    MeSH term(s) Autoimmune Diseases/immunology ; Cholangitis, Sclerosing/immunology ; Humans ; Immunoglobulin G/immunology ; Kidney Diseases/immunology ; Mikulicz' Disease/immunology ; Pancreatitis/immunology ; Peritoneal Fibrosis/immunology ; Respiratory Tract Diseases/immunology ; Thyroid Diseases/immunology
    Chemical Substances Immunoglobulin G
    Language Japanese
    Publishing date 2018-08-30
    Publishing country Japan
    Document type Introductory Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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